Tissue-to-blood distribution coefficients in the rat: Utility for estimation of the volume of distribution in man

European Journal of Pharmaceutical Sciences

Volumn 50, Issue 3-4, 2013, Pages 526-543

  Paixão, Paulo ^a   Aniceto, Natália ^b   Gouveia, Luís F ^a   Morais, José A G ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIAS   (Portugal)

Author keywords

Animal extrapolations; In vitro and in vivo methods for drug distribution; Tissue to blood partition coefficient; Trend analysis of distribution; Volume of distribution

Indexed keywords

1 NITROPROPANE; 1,2 DICHLOROETHYLENE; 1,2 EPOXY 3 BUTENE; ALCOHOL; BUTANOL; CYCLOHEXANE; CYCLOSPORIN; DASATINIB; DECANE; DIAZEPAM; DIBROMOMETHANE; DISOPYRAMIDE; DODECANE; ERYTHROMYCIN; ESTRADIOL; FLUINDOSTATIN; FUROSEMIDE; GLYCOLIC ACID; HALOTHANE; HEPTANE; HEXACHLOROETHANE; HEXANE; IMIPRAMINE; IRINOTECAN; KETOCONAZOLE; LIDOCAINE; LINDANE; PENTANOL; TETRACHLOROETHANE; UNINDEXED DRUG;

ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; BONE; BRAIN; DRUG DISTRIBUTION; HEART; IN VITRO STUDY; INTESTINE; KIDNEY; LIVER; LUNG; MUSCLE; NONHUMAN; PANCREAS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN; SPLEEN; STOMACH; TISSUE DISTRIBUTION;

ANIMAL EXTRAPOLATIONS; IN VITRO AND IN VIVO METHODS FOR DRUG DISTRIBUTION; TISSUE-TO-BLOOD PARTITION COEFFICIENT; TREND ANALYSIS OF DISTRIBUTION; VOLUME OF DISTRIBUTION;

ANIMALS; DATABASES, FACTUAL; HUMANS; LINEAR MODELS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; TISSUE DISTRIBUTION;

EID: 84883721885     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.08.020     Document Type: Article

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