Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise

Toxicological Sciences

Volumn 72, Issue 1, 2003, Pages 3-18

  Reddy, Micaela B ^a   Andersen, Melvin E ^a   Morrow, Paul E ^b   Dobrev, Ivan D ^a   Varaprath, Sudarsanan ^c   Plotzke, Kathleen P ^c   Utell, Mark J ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c DOW CORNING CORPORATION   (United States)

Author keywords

D4; Flow limited metabolism; Inhalation pharmacokinetics; Lipid sequestration; Octamethylcylcotetrasiloxane; PBPK modeling; Vapor retention

Indexed keywords

LIVER EXTRACT; OCTAMETHYLCYCLOTETRASILOXANE; ORGANOSILICON DERIVATIVE; SILOXANE; UNCLASSIFIED DRUG;

ADULT; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BREATH ANALYSIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEMETHYLATION; EXERCISE; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; INHALATION; LIPOPHILICITY; LIVER CLEARANCE; LUNG VENTILATION PERFUSION RATIO; MALE; METABOLISM; NONHUMAN; NORMAL HUMAN; PROCESS MODEL; RAT; REST; STEADY STATE; TISSUE LEVEL; TOXICOKINETICS; URINARY EXCRETION; URINE LEVEL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INHALATION; ALGORITHMS; ANIMALS; CARBON RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXERCISE; FATS; HUMANS; LIVER; MALE; MODELS, BIOLOGICAL; RATS; REPRODUCIBILITY OF RESULTS; REST; SILOXANES;

ANIMALIA;

EID: 0037341742     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg001     Document Type: Article

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