Predicting age-appropriate pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically based pharmacokinetic modeling

Toxicological Sciences

Volumn 98, Issue 1, 2007, Pages 43-56

  Rodriguez, Chester E ^a   Mahle, Deirdre A ^b   Gearhart, Jeff M ^c   Mattie, David R ^b   Lipscomb, John C ^a   Cook, Robert S ^b   Barton, Hugh A ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

Author keywords

Age dependent pharmacokinetics; Physiologically based pharmacokinetic (PBPK) modeling; Rat; Volatile organic compounds (VOCs)

Indexed keywords

2 BUTANONE; BENZENE; CHLOROFORM; DICHLOROMETHANE; TETRACHLOROETHYLENE; TRICHLOROETHYLENE;

AGE; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BREATHING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; LIVER SIZE; METABOLIC CAPACITY; NONHUMAN; PARTITION COEFFICIENT; PERINATAL PERIOD; PREDICTION; RAT; SIMULATION; STEADY STATE; TOXICOKINETICS;

ADIPOSE TISSUE; AGING; ALGORITHMS; ANIMALS; BLOOD-AIR BARRIER; CYTOCHROME P-450 ENZYME SYSTEM; FORECASTING; MODELS, STATISTICAL; ORGANIC CHEMICALS; PHARMACOKINETICS; RATS; REGIONAL BLOOD FLOW; RESPIRATORY MECHANICS; TISSUE DISTRIBUTION;

ANIMALIA; RATTUS;

EID: 34447572994     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm082     Document Type: Article

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