Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR)

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 6, 2011, Pages 333-342

  Li, Haiyan ^a   Chen, Zhuxi ^a   Xu, Xuejun ^a   Sui, Xiaofan ^b   Guo, Tao ^a   Liu, Wei ^c   Zhang, Jiwen ^a,d  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Liaoning Provincial Institute for Drug and Food Control   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d PEKING UNIVERSITY   (China)

Author keywords

human plasma protein binding; inter molecular descriptors; intra molecular descriptors; plasma protein interaction QSAR analysis; prediction

Indexed keywords

AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; AZIDOCILLIN; AZLOCILLIN; BACAMPICILLIN; CARBENICILLIN; CEFACETRILE; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFAMANDOLE; CEFATRIZINE; CEFAZOLIN; CEFDINIR; CEFIXIME; CEFMETAZOLE; CEFODIZIME; CEFOPERAZONE; CEFORANIDE; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFTAZIDIME; CEFTIZOXIME; CEFUROXIME; HUMAN SERUM ALBUMIN; MECILLINAM; PLASMA PROTEIN; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; HUMAN; MOLECULAR DOCKING; MOLECULAR INTERACTION; PLASMA PROTEIN INTERACTION QUANTITATIVE STRUCTURE ACTIVITY RELATION; POLARIZATION; PROTEIN BINDING; PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BLOOD PROTEINS; COMPUTER SIMULATION; FORECASTING; HUMANS; LINEAR MODELS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PLASMA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 80051871865     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.762     Document Type: Article

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