Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Journal of Pharmaceutical Sciences

Volumn 95, Issue 6, 2006, Pages 1238-1257

  Rodgers, Trudy ^a   Rowland, Malcolm ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

In silico modelling; Partition coefficients; PBPK modelling; Pharmacokinetics; Phospholipids; Physicochemical properties; Physiological model; QSAR; Tissue partition

Indexed keywords

ACID; ALFENTANIL; ALPRAZOLAM; AMPHOLYTE; BASE; CEFAZOLIN; CEFTAZIDIME; CHLORDIAZEPOXIDE; CYCLOSPORIN; DIAZEPAM; DIDANOSINE; DIGOXIN; ETHENZAMIDE; ETODOLAC; FLUNITRAZEPAM; LOMEFLOXACIN; MIDAZOLAM; NALIDIXIC ACID; OFLOXACIN; PEFLOXACIN; PENICILLIN G; PHENYTOIN; PIPEMIDIC ACID; SALICYLIC ACID; TEGAFUR; TENOXICAM; THIOPENTAL; TOLBUTAMIDE; TRIAZOLAM; VALPROIC ACID;

ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DISSOLUTION; DRUG DISTRIBUTION; IONIZATION; NONHUMAN; PARTITION COEFFICIENT; PLASMA PROTEIN BINDING; RAT; TISSUE CULTURE; TISSUE DISTRIBUTION;

EID: 33745055239     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20502     Document Type: Article

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