Magnitude and mechanistic determinants of the interspecies toxicokinetic uncertainty factor for organic chemicals

Regulatory Toxicology and Pharmacology

Volumn 40, Issue 3, 2004, Pages 264-271

  Pelekis, Michael ^a   Krishnan, Kannan ^b  

^a Pelekis Group   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Pharmacokinetics; Rat human; Toxicokinetics; Uncertainty factors; VOCs

Indexed keywords

CARBON TETRACHLORIDE; CHLOROFORM; DICHLOROMETHANE; DIOXANE; ETHYLBENZENE; STYRENE; TETRACHLOROETHYLENE; TOLUENE; TRICHLOROETHYLENE; VINYL CHLORIDE; VOLATILE ORGANIC COMPOUND; XYLENE;

ALGORITHM; ANIMAL TISSUE; ARTICLE; BLOOD; BODY WEIGHT; CONTROLLED STUDY; EXTRACTION; HEALTH HAZARD; HEART OUTPUT; HUMAN; HUMAN TISSUE; LIVER; LUNG VENTILATION; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SPECIES DIFFERENCE; STEADY STATE; TOXICOKINETICS;

ALGORITHMS; ANIMALS; BODY WEIGHT; CARDIAC OUTPUT; CHEMISTRY, PHYSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIVER; LIVER CIRCULATION; ORGANIC CHEMICALS; PHARMACOKINETICS; PULMONARY ALVEOLI; RATS; SPECIES SPECIFICITY;

EID: 8844228316     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2004.07.004     Document Type: Article

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