Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced Drug Delivery Reviews

Volumn 64, Issue SUPPL., 2012, Pages 4-17

  Lipinski, Christopher A ^a   Lombardo, Franco ^a   Dominy, Beryl W ^a   Feeney, Paul J ^a  

^a PFIZER INC   (United States)

Author keywords

Computational alert; H Bond donors and acceptors; MLogP; MWT; Poor absorption or permeation; Rule of 5; Solubility calculation; Thermodynamic solubility; Turbidimetric solubility

Indexed keywords

COMPUTATIONAL ALERT; H-BOND DONORS AND ACCEPTORS; MLOGP; MWT; RULE OF 5; SOLUBILITY CALCULATIONS; THERMODYNAMIC SOLUBILITY;

COMPUTATIONAL METHODS; DRUG PRODUCTS; KNOWLEDGE BASED SYSTEMS;

SOLUBILITY;

ACETYLSALICYLIC ACID; ACICLOVIR; ALPRAZOLAM; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ATENOLOL; AZITHROMYCIN; CANDOXATRIL; CAPTOPRIL; CARBAMAZEPINE; CARDIAC GLYCOSIDE; CHLORAMPHENICOL; CIMETIDINE; CLONIDINE; CYCLOSPORIN; DESIPRAMINE; DEXAMETHASONE; DIAZEPAM; DICLOFENAC; DILTIAZEM; DOXORUBICIN; ENALAPRIL MALEATE; ERYTHROMYCIN; FAMOTIDINE; FELODIPINE; HYDROGEN; PENICILLIN G; UNINDEXED DRUG; VITAMIN; ZIDOVUDINE;

BIOEQUIVALENCE; DRUG ABSORPTION; DRUG DESIGN; DRUG ELIMINATION; DRUG METABOLISM; DRUG PENETRATION; DRUG RESEARCH; DRUG SOLUBILITY; EXPERIMENTAL DESIGN; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; MATHEMATICAL COMPUTING; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; THERMODYNAMICS; TURBIDIMETRY;

EID: 84870249445     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.09.019     Document Type: Review

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