A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung

Toxicology Letters

Volumn 138, Issue 1-2, 2003, Pages 75-102

  Csanády, Gy A ^a,b   Kessler, W ^a,b   Hoffmann, H D ^c   Filser, J G ^a,b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c BASF SE   (Germany)

Author keywords

DNA adducts; GSH depletion; Hemoglobin adducts; Humans; Physiological toxicokinetic model; Pulmonary metabolism; Rodents; Styrene; Styrene 7,8 oxide

Indexed keywords

EPOXIDE; HEMOGLOBIN; HYDROLASE; STYRENE; STYRENE OXIDE;

ANIMAL EXPERIMENT; ARTICLE; CELL FRACTIONATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; ENZYME BLOOD LEVEL; HUMAN; LUNG; LUNG ALVEOLUS CELL; MODEL; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; SPECIES DIFFERENCE; STEADY STATE; TISSUE DISTRIBUTION; TOXICOKINETICS;

ADMINISTRATION, INHALATION; ANIMALS; CARCINOGENS; DNA ADDUCTS; EPOXY COMPOUNDS; HEMOGLOBINS; HUMANS; LUNG; MICE; MODELS, BIOLOGICAL; RATS; SPECIES SPECIFICITY; STYRENE;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0037452416     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00409-5     Document Type: Article

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