Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 46, 2010, Pages 20009-20014

  Kojima, Yasushi ^a   Acar, Ahmet ^a   Eaton, Elinor Ng ^b   Mellody, Kieran T ^a   Scheel, Christina ^b   Ben Porath, Ittai ^b   Onder, Tamer T ^b,c   Wang, Zhigang C ^d   Richardson, Andrea L ^e   Weinberg, Robert A ^b,c   Orimo, Akira ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Alpha smooth muscle actin; CXCR4; Smad; Tumor microenvironment

Indexed keywords

STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA;

AUTOCRINE EFFECT; BREAST CANCER; BREAST CELL; CARCINOGENESIS; CARCINOMA ASSOCIATED FIBROBLAST; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR INTERACTION; MYOFIBROBLAST; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR PROMOTION; TUMOR XENOGRAFT;

EID: 78650563018     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013805107     Document Type: Article

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