Identification and characterization of the promoter of fibroblast activation protein

Frontiers in Bioscience - Elite

Volumn 2 E, Issue 3, 2010, Pages 1154-1163

  Zhang, Jiping ^a   Valianou, Matthildi ^a   Cheng, Jonathan D ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Fibroblast activation protein; Promoter

Indexed keywords

DNA; GELATINASE; MEMBRANE PROTEIN; PRIMER DNA; SEPRASE; SERINE PROTEINASE;

ANIMAL; ARTICLE; CELL LINE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GELATINASES; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SERINE ENDOPEPTIDASES; TRANSCRIPTION, GENETIC;

EID: 77957326048     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. W. J. Rettig, P. G. Chesa, H. R. Beresford, H. J. Feickert, M. T. Jennings, J. Cohen, H. F. Oettgen and L. J. Old: Differential expression of cell surface antigens and glial fibrillary acidic protein in human astrocytoma subsets. Cancer Res, 46(12 Pt 1), 6406-12 (1986) (Pubitemid 17221792)
2. J. Niedermeyer, B. Enenkel, J. E. Park, M. Lenter, W. J. Rettig, K. Damm and A. Schnapp: Mouse fibroblastactivation protein-conserved Fap gene organization and biochemical function as a serine protease. Eur J Biochem, 254(3), 650-4 (1998) (Pubitemid 28308118)
3. J. E. Park, M. C. Lenter, R. N. Zimmermann, P. Garin-Chesa, L. J. Old and W. J. Rettig: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem, 274(51), 36505-12 (1999)
4. S. Mathew, M. J. Scanlan, B. K. Mohan Raj, V. V. Murty, P. Garin-Chesa, L. J. Old, W. J. Rettig and R. S. Chaganti: The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23. Genomics, 25(1), 335-7 (1995)
5. D. D. Brown, Z. Wang, J. D. Furlow, A. Kanamori, R. A. Schwartzman, B. F. Remo and A. Pinder: The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis. Proc Natl Acad Sci U S A, 93(5), 1924-9 (1996) (Pubitemid 26079856)
6. P. Garin-Chesa, L. J. Old and W. J. Rettig: Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Natl Acad Sci U S A, 87(18), 7235-9 (1990)
7. M. J. Scanlan, B. K. Raj, B. Calvo, P. Garin-Chesa, M. P. Sanz-Moncasi, J. H. Healey, L. J. Old and W. J. Rettig: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci U S A, 91(12), 5657-61 (1994) (Pubitemid 24174387)
8. W. J. Rettig, P. Garin-Chesa, H. R. Beresford, H. F. Oettgen, M. R. Melamed and L. J. Old: Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells. Proc Natl Acad Sci U S A, 85(9), 3110-4 (1988)
9. J. D. Cheng and L. M. Weiner: Tumors and their microenvironments: tilling the soil. Commentary re: A. M. Scott et al., A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 9:1639-1647, 2003.
10. Clin Cancer Res, 9(5), 1590-5 (2003)
11. T. Kelly: Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resist Updat, 8(1-2), 51-8 (2005) (Pubitemid 40797956)
12. S. C. Mueller, G. Ghersi, S. K. Akiyama, Q. X. Sang, L. Howard, M. Pineiro-Sanchez, H. Nakahara, Y. Yeh and W. T. Chen: A novel protease-docking function of integrin at invadopodia. J Biol Chem, 274(35), 24947-52 (1999)
13. W. T. Chen and T. Kelly: Seprase complexes in cellular invasiveness. Cancer Metastasis Rev, 22(2-3), 259-69 (2003) (Pubitemid 36561061)
14. G. Ghersi, H. Dong, L. A. Goldstein, Y. Yeh, L. Hakkinen, H. S. Larjava and W. T. Chen: Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex. J Biol Chem, 277(32), 29231-41 (2002)
15. G. Ghersi, Q. Zhao, M. Salamone, Y. Yeh, S. Zucker and W. T. Chen: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices. Cancer Res, 66(9), 4652-61 (2006)
16. V. V. Artym, A. L. Kindzelskii, W. T. Chen and H. R. Petty: Molecular proximity of seprase and the urokinasetype plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton. Carcinogenesis, 23(10), 1593-601 (2002)
17. S. Bauer, M. C. Jendro, A. Wadle, S. Kleber, F. Stenner, R. Dinser, A. Reich, E. Faccin, S. Godde, H. Dinges, U. Muller-Ladner and C. Renner: Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. Arthritis Res Ther, 8(6), R171 (2006)
18. M. T. Levy, G. W. McCaughan, C. A. Abbott, J. E. Park, A. M. Cunningham, E. Muller, W. J. Rettig and M. D. Gorrell: Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis. Hepatology, 29(6), 1768-78 (1999) (Pubitemid 29247051)
19. P. S. Acharya, A. Zukas, V. Chandan, A. L. Katzenstein and E. Pure: Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis. Hum Pathol, 37(3), 352-60 (2006) (Pubitemid 43277524)
20. X. M. Wang, D. M. Yu, G. W. McCaughan and M. D. Gorrell: Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology, 42(4), 935-45 (2005) (Pubitemid 41401132)
21. J. Niedermeyer, M. J. Scanlan, P. Garin-Chesa, C. Daiber, H. H. Fiebig, L. J. Old, W. J. Rettig and A. Schnapp: Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Int J Cancer, 71(3), 383-9 (1997) (Pubitemid 27224302)
22. H. Dolznig, N. Schweifer, C. Puri, N. Kraut, W. J. Rettig, D. Kerjaschki and P. Garin-Chesa: Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. Cancer Immun, 5, 10 (2005)
23. L. M. Halvorson, M. Ito, J. L. Jameson and W. W. Chin: Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. J Biol Chem, 273(24), 14712-20 (1998) (Pubitemid 28272755)
24. J. D. Cheng, R. L. Dunbrack, Jr., M. Valianou, A. Rogatko, R. K. Alpaugh and L. M. Weiner: Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. Cancer Res, 62(16), 4767-72 (2002)
25. Y. Huang, S. Wang and T. Kelly: Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer. Cancer Res, 64(8), 2712-6 (2004) (Pubitemid 38500606)
26. L. R. Henry, H. O. Lee, J. S. Lee, A. Klein-Szanto, P. Watts, E. A. Ross, W. T. Chen and J. D. Cheng: Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res, 13(6), 1736-41 (2007) (Pubitemid 46952939)
27. T. Ramirez-Montagut, N. E. Blachere, E. V. Sviderskaya, D. C. Bennett, W. J. Rettig, P. Garin-Chesa and A. N. Houghton: FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. Oncogene, 23(32), 5435-46 (2004) (Pubitemid 39044054)
28. W. J. Rettig, P. Garin-Chesa, J. H. Healey, S. L. Su, H. L. Ozer, M. Schwab, A. P. Albino and L. J. Old: Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin. Cancer Res, 53(14), 3327-35 (1993) (Pubitemid 23223305)
29. W. J. Rettig, S. L. Su, S. R. Fortunato, M. J. Scanlan, B. K. Raj, P. Garin-Chesa, J. H. Healey and L. J. Old: Fibroblast activation protein: purification, epitope mapping and induction by growth factors. Int J Cancer, 58(3), 385-92 (1994) (Pubitemid 24254649)
30. J. M. Milner, L. Kevorkian, D. A. Young, D. Jones, R. Wait, S. T. Donell, E. Barksby, A. M. Patterson, J. Middleton, B. F. Cravatt, I. M. Clark, A. D. Rowan and T. E. Cawston: Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. Arthritis Res Ther, 8(1), R23 (2006)
31. V. Baron, E. D. Adamson, A. Calogero, G. Ragona and D. Mercola: The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther, 13(2), 115-24 (2006) (Pubitemid 43113412)
32. L. M. Khachigian: Early growth response-1 in cardiovascular pathobiology. Circ Res, 98(2), 186-91 (2006)
33. M. Braddock: The transcription factor Egr-1: a potential drug in wound healing and tissue repair. Ann Med, 33(5), 313-8 (2001) (Pubitemid 32675370)
34. S. A. Abdulkadir: Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1. Ann N Y Acad Sci, 1059, 33-40 (2005) (Pubitemid 43211608)
35. J. A. Tuxhorn, G. E. Ayala, M. J. Smith, V. C. Smith, T. D. Dang and D. R. Rowley: Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res, 8(9), 2912-23 (2002) (Pubitemid 35025739)
36. R. T. Aimes, A. Zijlstra, J. D. Hooper, S. M. Ogbourne, M. L. Sit, S. Fuchs, D. C. Gotley, J. P. Quigley and T. M. Antalis: Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost, 89(3), 561-72 (2003) (Pubitemid 36329249)
37. M. V. Barbolina, B. P. Adley, E. V. Ariztia, Y. Liu and M. S. Stack: Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. J Biol Chem, 282(7), 4924-31 (2007) (Pubitemid 47100955)
38. A. Kennedy, H. Dong, D. Chen and W. T. Chen: Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells. Int J Cancer, 124(1), 27-35 (2009)
39. A. M. Scott, G. Wiseman, S. Welt, A. Adjei, F. T. Lee, W. Hopkins, C. R. Divgi, L. H. Hanson, P. Mitchell, D. N. Gansen, S. M. Larson, J. N. Ingle, E. W. Hoffman, P. Tanswell, G. Ritter, L. S. Cohen, P. Bette, L. Arvay, A. Amelsberg, D. Vlock, W. J. Rettig and L. J. Old: A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation proteinpositive cancer. Clin Cancer Res, 9(5), 1639-47 (2003) (Pubitemid 36554586)
40. K. Narra, S. R. Mullins, H. O. Lee, B. Strzemkowski-Brun, K. Magalong, V. J. Christiansen, P. A. McKee, B. Egleston, S. J. Cohen, L. M. Weiner, N. J. Meropol and J. D. Cheng: Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther, 6(11), 1691-9 (2007) (Pubitemid 351590302)