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Volumn 12, Issue 10, 2007, Pages 1183-1193

The role of bevacizumab in the treatment of non-small cell lung cancer: Current indications and future developments

Author keywords

Angiogenesis; Bevacizumab; NSCLC; Targeted therapy

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CISPLATIN; DOCETAXEL; ERLOTINIB; GEMCITABINE; OXALIPLATIN; PACLITAXEL; PEMETREXED; PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 36148992949     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.12-10-1183     Document Type: Review
Times cited : (50)

References (51)
  • 2
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin DM, Bray F, Ferlay J et al. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153-156.
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3
  • 3
    • 34250356427 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for non-small cell lung cancer
    • Bria E, Cuppone F, Cecere FL et al. Adjuvant chemotherapy for non-small cell lung cancer. J Thorac Oncol 2007;2(5 suppl):S7-S11.
    • (2007) J Thorac Oncol , vol.2 , Issue.5 SUPPL.
    • Bria, E.1    Cuppone, F.2    Cecere, F.L.3
  • 4
    • 34250855750 scopus 로고    scopus 로고
    • Current treatment paradigms for locally advanced non-small cell lung cancer
    • Rigas JR, Kelly K. Current treatment paradigms for locally advanced non-small cell lung cancer. J Thorac Oncol 2007;2(suppl 2):S77-S85.
    • (2007) J Thorac Oncol , vol.2 , Issue.SUPPL. 2
    • Rigas, J.R.1    Kelly, K.2
  • 5
    • 34250876923 scopus 로고    scopus 로고
    • Optimizing chemotherapy for patients with advanced non-small cell lung cancer
    • Scagliotti G. Optimizing chemotherapy for patients with advanced non-small cell lung cancer. J Thorac Oncol 2007;2(suppl 2):S86-S91.
    • (2007) J Thorac Oncol , vol.2 , Issue.SUPPL. 2
    • Scagliotti, G.1
  • 6
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small cell lung cancer. N Engl J Med 2005;353:123-132.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 7
    • 33748312018 scopus 로고    scopus 로고
    • New antiangiogenetic agents and non-small cell lung cancer
    • Gridelli C, Rossi A, Maione P. New antiangiogenetic agents and non-small cell lung cancer. Crit Rev Oncol Hematol 2006;60:76-86.
    • (2006) Crit Rev Oncol Hematol , vol.60 , pp. 76-86
    • Gridelli, C.1    Rossi, A.2    Maione, P.3
  • 8
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 9
    • 36148958375 scopus 로고    scopus 로고
    • Manegold C, von Pawel J, Zatloukal P et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007;25(18 suppl):LBA7514.
    • Manegold C, von Pawel J, Zatloukal P et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007;25(18 suppl):LBA7514.
  • 10
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 11
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971;285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 12
    • 0025515489 scopus 로고    scopus 로고
    • Folkman J. Endothelial cells and angiogenic growth factors in cancer growth and metastasis. Introduction. Cancer Metastasis Rev 1990;9:171-174.
    • Folkman J. Endothelial cells and angiogenic growth factors in cancer growth and metastasis. Introduction. Cancer Metastasis Rev 1990;9:171-174.
  • 13
    • 19844364244 scopus 로고    scopus 로고
    • Angiogenesis and lung cancer: Prognostic and therapeutic implications
    • Herbst RS, Onn A, Sandler A. Angiogenesis and lung cancer: Prognostic and therapeutic implications. J Clin Oncol 2005;23:3243-3256.
    • (2005) J Clin Oncol , vol.23 , pp. 3243-3256
    • Herbst, R.S.1    Onn, A.2    Sandler, A.3
  • 14
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 15
    • 0037163738 scopus 로고    scopus 로고
    • The role of microvessel density on the survival of patients with lung cancer: A systematic review of the literature with meta-analysis
    • Meert AP, Paesmans M, Martin B et al. The role of microvessel density on the survival of patients with lung cancer: A systematic review of the literature with meta-analysis. Br J Cancer 2002;87:694-701.
    • (2002) Br J Cancer , vol.87 , pp. 694-701
    • Meert, A.P.1    Paesmans, M.2    Martin, B.3
  • 16
    • 0030996171 scopus 로고    scopus 로고
    • Angiogenesis as a prognostic indicator of survival in non-small-cell carcinoma: A prospective study
    • Fontanini G, Lucchi M, Vignati S et al. Angiogenesis as a prognostic indicator of survival in non-small-cell carcinoma: A prospective study. J Natl Cancer Inst 1997;89:881-886.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 881-886
    • Fontanini, G.1    Lucchi, M.2    Vignati, S.3
  • 17
    • 0034781856 scopus 로고    scopus 로고
    • High vascularity in the peripheral region of non-small cell lung cancer tissue is associated with tumor progression
    • Ushijima C, Tsukamoto S, Yamazaki K et al. High vascularity in the peripheral region of non-small cell lung cancer tissue is associated with tumor progression. Lung Cancer 2001;34:233-241.
    • (2001) Lung Cancer , vol.34 , pp. 233-241
    • Ushijima, C.1    Tsukamoto, S.2    Yamazaki, K.3
  • 18
    • 34249307226 scopus 로고    scopus 로고
    • Microvessel density as a prognostic factor in non-small-cell lung carcinoma: A meta-analysis of individual patient data
    • Trivella M, Pezzella F, Pastorino U et al. Microvessel density as a prognostic factor in non-small-cell lung carcinoma: A meta-analysis of individual patient data. Lancet Oncol 2007;8:488-499.
    • (2007) Lancet Oncol , vol.8 , pp. 488-499
    • Trivella, M.1    Pezzella, F.2    Pastorino, U.3
  • 19
    • 0033454716 scopus 로고    scopus 로고
    • Anticancer drug targets: Approaching angiogenesis
    • Keshet E, Ben-Sasson SA. Anticancer drug targets: Approaching angiogenesis. J Clin Invest 1999;104:1497-1501.
    • (1999) J Clin Invest , vol.104 , pp. 1497-1501
    • Keshet, E.1    Ben-Sasson, S.A.2
  • 20
    • 0032713925 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions
    • Zebrowski BK, Yano S, Liu W et al. Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions. Clin Cancer Res 1999;5:3364-3368.
    • (1999) Clin Cancer Res , vol.5 , pp. 3364-3368
    • Zebrowski, B.K.1    Yano, S.2    Liu, W.3
  • 21
    • 0033050656 scopus 로고    scopus 로고
    • Markedly elevated levels of vascular endothelial growth factor in malignant ascites
    • Zebrowski BK, Liu W, Ramirez K et al. Markedly elevated levels of vascular endothelial growth factor in malignant ascites. Ann Surg Oncol 1999;6:373-378.
    • (1999) Ann Surg Oncol , vol.6 , pp. 373-378
    • Zebrowski, B.K.1    Liu, W.2    Ramirez, K.3
  • 22
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 23
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck K, Ferrara N, Winer J et al. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991;5:1806-1814.
    • (1991) Mol Endocrinol , vol.5 , pp. 1806-1814
    • Houck, K.1    Ferrara, N.2    Winer, J.3
  • 24
    • 0027487087 scopus 로고
    • Vascular endothelial growth factor
    • Ferrera N. Vascular endothelial growth factor. Trends Cardiovasc Med 1993;3:244-250.
    • (1993) Trends Cardiovasc Med , vol.3 , pp. 244-250
    • Ferrera, N.1
  • 25
    • 0028938746 scopus 로고
    • Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
    • Kaipainen A, Korhonen J, Mustonen T et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A 1995;92:3566-3570.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3566-3570
    • Kaipainen, A.1    Korhonen, J.2    Mustonen, T.3
  • 26
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
    • Paavonen K, Puolakkainen P, Jussila L et al. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 2000;156:1499-1504.
    • (2000) Am J Pathol , vol.156 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2    Jussila, L.3
  • 27
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 29
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 30
    • 35948954665 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer (NSCLC)
    • William WN, Kies MS, Fossella SV et al. Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(18 suppl):691S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • William, W.N.1    Kies, M.S.2    Fossella, S.V.3
  • 31
    • 35948932525 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer
    • Dalsania CJ, Hageboutros A, Harris E et al. Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer. J Clin Oncol 2007;25(18 suppl):697S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Dalsania, C.J.1    Hageboutros, A.2    Harris, E.3
  • 32
    • 35948938878 scopus 로고    scopus 로고
    • Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): Preliminary results
    • Patel JD, Hensing TA, Villafor V. Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): Preliminary results. J Clin Oncol 2007;25(18 suppl):409S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Patel, J.D.1    Hensing, T.A.2    Villafor, V.3
  • 33
    • 34547427567 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC)
    • Davila E, Lilenbaum R, Raez L et al. Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006;24(18 suppl):673S.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Davila, E.1    Lilenbaum, R.2    Raez, L.3
  • 34
    • 35949004337 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer
    • Waples JM, Auerbach M, Boccia R et al. A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer. J Clin Oncol 2007;25(18 suppl):685S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Waples, J.M.1    Auerbach, M.2    Boccia, R.3
  • 35
    • 42649143421 scopus 로고    scopus 로고
    • An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in first-line patients with advanced non-squamous non-small cell lung cancer (NSCLC)
    • Reynolds C, Barrera D, Vu DQ. An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in first-line patients with advanced non-squamous non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(18 suppl):611S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Reynolds, C.1    Barrera, D.2    Vu, D.Q.3
  • 36
    • 57349104030 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin, pemetrexed, and bevacizumab in previously-treated advanced non-small cell lung cancer (NSCLC)
    • Heist RS, Fidias P, Huberman M. Phase II trial of oxaliplatin, pemetrexed, and bevacizumab in previously-treated advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(18 suppl):634S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Heist, R.S.1    Fidias, P.2    Huberman, M.3
  • 37
    • 0028021894 scopus 로고
    • The National Institute on Aging and the National Cancer Institute SEER collaborative study on comorbidity and early diagnosis of cancer in the elderly
    • Havlik RJ, Yancik R, Long S et al. The National Institute on Aging and the National Cancer Institute SEER collaborative study on comorbidity and early diagnosis of cancer in the elderly. Cancer 1994;74(7 suppl):2101-2106.
    • (1994) Cancer , vol.74 , Issue.7 SUPPL. , pp. 2101-2106
    • Havlik, R.J.1    Yancik, R.2    Long, S.3
  • 38
    • 35948963593 scopus 로고    scopus 로고
    • Exclusions to use of bevacizumab in elderly veterans with advanced non-small cell lung cancer (NSCLC)
    • Merza T, Howard LM, Junagadhwalla M. Exclusions to use of bevacizumab in elderly veterans with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(18 suppl):687S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Merza, T.1    Howard, L.M.2    Junagadhwalla, M.3
  • 39
    • 0037420202 scopus 로고    scopus 로고
    • Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial
    • Gridelli C, Perrone F, Gallo C et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 2003;95:362-372.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 362-372
    • Gridelli, C.1    Perrone, F.2    Gallo, C.3
  • 40
    • 35948980319 scopus 로고    scopus 로고
    • Outcomes for elderly advanced stage non-small cell lung cancer (NSCLC) patients (pts) treated with bevacizumab (B) in combination with carboplatin (C) and paclitaxel (P): Analysis of Eastern Cooperative Oncology Group (ECOG) 4599 study
    • Ramalingam SS, Dahlberg SE, Langer CJ et al. Outcomes for elderly advanced stage non-small cell lung cancer (NSCLC) patients (pts) treated with bevacizumab (B) in combination with carboplatin (C) and paclitaxel (P): Analysis of Eastern Cooperative Oncology Group (ECOG) 4599 study. J Clin Oncol 2007;25(18 suppl):393S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 41
    • 33645051467 scopus 로고    scopus 로고
    • Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC
    • Maione P, Gridelli C, Troiani T et al. Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. The Oncologist 2006;11:274-284.
    • (2006) The Oncologist , vol.11 , pp. 274-284
    • Maione, P.1    Gridelli, C.2    Troiani, T.3
  • 42
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A, Ogawa S, Kometani T et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 2002;62:2554-2560.
    • (2002) Cancer Res , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 43
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 2003;9:1546-1556.
    • (2003) Clin Cancer Res , vol.9 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 44
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000;6:3739-3747.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 45
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:2544-2555.
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 46
    • 24644500551 scopus 로고    scopus 로고
    • Phase I/II trial of bevacizumab plus erlotinib for patients with recurrent non-small cell lung cancer: Correlation of treatment response with mutations of the EGFR tyrosine kinase gene
    • 643s
    • Tsao AS, Herbst R, Sandler A et al. Phase I/II trial of bevacizumab plus erlotinib for patients with recurrent non-small cell lung cancer: Correlation of treatment response with mutations of the EGFR tyrosine kinase gene. J Clin Oncol 2005;23(16 suppl):643s.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Tsao, A.S.1    Herbst, R.2    Sandler, A.3
  • 47
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 48
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004;304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 49
    • 33750625979 scopus 로고    scopus 로고
    • A phase II, multicenter, randomized clinical trial to evacuate the efficacy and safety of bevacizumab in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride compared with chemotherapy alone for treatment of recurrent or refractory non-small cell lung cancer
    • Fehrenbacher L, O'Neill V, Belani C et al. A phase II, multicenter, randomized clinical trial to evacuate the efficacy and safety of bevacizumab in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride compared with chemotherapy alone for treatment of recurrent or refractory non-small cell lung cancer. J Clin Oncol 2006;24(suppl 18S):379S.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Fehrenbacher, L.1    O'Neill, V.2    Belani, C.3
  • 50
    • 35948989620 scopus 로고    scopus 로고
    • A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC)
    • Groen HJ, Smit EF, Dingemans A. A phase II study of erlotinib (E) and bevacizumab (B) in patients (pts) with previously untreated stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(18 suppl):415S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Groen, H.J.1    Smit, E.F.2    Dingemans, A.3
  • 51
    • 35948995260 scopus 로고    scopus 로고
    • Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer
    • Rizvi NA, Rusch V, Zhao B. Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer. J Clin Oncol 2007;25 (18 suppl):687S.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Rizvi, N.A.1    Rusch, V.2    Zhao, B.3


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