메뉴 건너뛰기




Volumn 17, Issue 5, 1997, Pages 2458-2467

Transforming growth factor β stabilizes p15(INK4B) protein, increases p15(INK4B)-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; MESSENGER RNA; PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030974040     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.5.2458     Document Type: Article
Times cited : (167)

References (77)
  • 1
    • 0028228907 scopus 로고
    • Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein
    • Bates, S., D. Parry, L. Bonetta, K. Vousden, C. Dickson, and G. Peters. 1994. Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9:1633-1640.
    • (1994) Oncogene , vol.9 , pp. 1633-1640
    • Bates, S.1    Parry, D.2    Bonetta, L.3    Vousden, K.4    Dickson, C.5    Peters, G.6
  • 2
    • 0029063742 scopus 로고
    • Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells
    • Brenner, A. J., and C. M. Aldaz. 1995. Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res. 55:2892-2895.
    • (1995) Cancer Res. , vol.55 , pp. 2892-2895
    • Brenner, A.J.1    Aldaz, C.M.2
  • 4
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases
    • Chirgwin, J. M. A. E. Przybyla, R. J. Macdonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases. Biochemistry 18:5294-5299.
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.E.2    Macdonald, R.J.3    Rutter, W.J.4
  • 5
    • 0029073142 scopus 로고
    • Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Y. Li, J. F. Panus, D. J. Howe, Y. Xiong, and X.-F. Wang. 1995. Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92:5545-5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.-F.6
  • 6
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., W. K. Kaufman, S. J. Wilson, T. D. Tlsty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufman, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 8
    • 0028092122 scopus 로고
    • Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells
    • Elbendary, A., A. Berchuck, P. Davis, L. Havrilesky, R. C. Bast, Jr., J. D. Iglehart and J. R. Marks. 1994. Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ. 5:1301-1307.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1301-1307
    • Elbendary, A.1    Berchuck, A.2    Davis, P.3    Havrilesky, L.4    Bast Jr., R.C.5    Iglehart, J.D.6    Marks, J.R.7
  • 10
    • 0029963169 scopus 로고
    • p16 inhibition of transformed and primary squamous epithelial cells
    • Enders, G. H., J. Koh, A. K. Rustigi, C. Missero, and E. Harlow. 1995. p16 inhibition of transformed and primary squamous epithelial cells. Oncogene 12:1239-1245.
    • (1995) Oncogene , vol.12 , pp. 1239-1245
    • Enders, G.H.1    Koh, J.2    Rustigi, A.K.3    Missero, C.4    Harlow, E.5
  • 11
    • 0027374766 scopus 로고
    • TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest
    • Ewen, M. E., H. K. Sluss, L. L. Whitehouse, and D. M. Livingston. 1993. TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell 74: 1009-1020.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sluss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 13
    • 0027981476 scopus 로고
    • Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme
    • Flores-Rosas, H., Z. Kelman, F. B. Dean, Z. Pan, J. W. Harper, S. J. Elledge, M. O'Donnell, and J. Hurwitz. 1994. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. USA 91:8655-8659.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8655-8659
    • Flores-Rosas, H.1    Kelman, Z.2    Dean, F.B.3    Pan, Z.4    Harper, J.W.5    Elledge, S.J.6    O'Donnell, M.7    Hurwitz, J.8
  • 14
    • 0027421280 scopus 로고
    • Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis
    • Fynan, T. M., and M. Reiss. 1993. Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis. Crit. Rev. Oncog. 4:493-540.
    • (1993) Crit. Rev. Oncog. , vol.4 , pp. 493-540
    • Fynan, T.M.1    Reiss, M.2
  • 15
    • 0027486303 scopus 로고
    • Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinases
    • Geng, Y., and R. A. Weinberg. 1993. Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc. Natl. Acad. Sci. USA 90:10315-10319.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10315-10319
    • Geng, Y.1    Weinberg, R.A.2
  • 18
    • 0028875086 scopus 로고
    • Evidence for different modes of action of cyclin-dependent kinase inhibitors: P15 and p16 bind to kinases, p21 and p27 bind to cyclins
    • Hall, M., S. Bates, and G. Peters. 1995. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11:1581-1588.
    • (1995) Oncogene , vol.11 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 19
    • 0345178412 scopus 로고
    • Serum-free growth of human mammary epithelial cells: Rapid clonal growth in defined medium and extended serial passage with pituitary extract
    • Hammond, S. L., R. G. Ham, and M. R. Stampfer. 1984. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc. Natl. Acad. Sci. USA 81:5435-5439.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5435-5439
    • Hammond, S.L.1    Ham, R.G.2    Stampfer, M.R.3
  • 20
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 21
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 23
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the senomic instability of cancer cells
    • Hartwell, L. 1992. Defects in a cell cycle checkpoint may be responsible for the senomic instability of cancer cells. Cell 71:543-546.
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 25
    • 0029670477 scopus 로고    scopus 로고
    • Kip1 accumulation durina the cell cycle
    • Kip1 accumulation durina the cell cycle. Science 271:1861-1864.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.2
  • 26
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18. are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai, H., M. F. Roussel, J.-Y. Kato, R. A. Ashmun, and C. J. Sherr. 1995. Novel INK4 proteins, p19 and p18. are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15:2672-2681.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.-Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 27
    • 0024420188 scopus 로고
    • Effects of the transforming growth factor β on growth of human mammary epithelial cells in culture
    • Hosobuchi, M., and M. Stampfer. 1989. Effects of the transforming growth factor β on growth of human mammary epithelial cells in culture. In Vitro Cell. Dev. Biol. 25:705-713.
    • (1989) In Vitro Cell. Dev. Biol. , vol.25 , pp. 705-713
    • Hosobuchi, M.1    Stampfer, M.2
  • 30
    • 0026731462 scopus 로고
    • Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer: Malignant melanoma as a paradigm
    • Kerbel, R. S. 1992. Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer: malignant melanoma as a paradigm. Am. J. Pathol. 141:519-524.
    • (1992) Am. J. Pathol. , vol.141 , pp. 519-524
    • Kerbel, R.S.1
  • 31
    • 0028877583 scopus 로고
    • Transforming growth factor-β1 inhibits cyclin D1 expression in intestinal epithelial cells
    • Ko, T. C., H. M. Sheng, D. Reisman, E. A. Thompson, and R. D. Beauchamp; 1995. Transforming growth factor-β1 inhibits cyclin D1 expression in intestinal epithelial cells. Oncogene 10:177-184.
    • (1995) Oncogene , vol.10 , pp. 177-184
    • Ko, T.C.1    Sheng, H.M.2    Reisman, D.3    Thompson, E.A.4    Beauchamp, R.D.5
  • 32
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
    • Koff, A., M. Ohtsuki, K. Polyak, J. M. Roberts, and J. Massague. 1993. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 260:536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 34
    • 0025326725 scopus 로고
    • Growth inhibition by TGF-β1 linked to suppression of retinoblastoma protein phosphorylation
    • Laiho, M., J. A. DeCaprio, J. W. Ludlow, D. M. Livingston, and J. Massague. 1990. Growth inhibition by TGF-β1 linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175-185.
    • (1990) Cell , vol.62 , pp. 175-185
    • Laiho, M.1    DeCaprio, J.A.2    Ludlow, J.W.3    Livingston, D.M.4    Massague, J.5
  • 35
    • 0028988158 scopus 로고
    • KIP2, a cyclin-dependent kinase inhibitor with a unique domain structure and tissue distribution
    • KIP2, a cyclin-dependent kinase inhibitor with a unique domain structure and tissue distribution. Genes Dev. 9:639-649.
    • (1995) Genes Dev. , vol.9 , pp. 639-649
    • Lee, M.-H.1    Reynisdottir, I.2    Massague, J.3
  • 36
    • 0028074603 scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
    • Li, R., S. Waga, G. Hannon, D. Beach, and B. Stillman. 1994. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371:534-537.
    • (1994) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.3    Beach, D.4    Stillman, B.5
  • 37
    • 0028365708 scopus 로고
    • Cell cycle expression and p53 regulation of the cyclin-dependent inhibitor p21
    • Li, Y., C. W. Jenkins, M. A. Nichols, and X. Xiong. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent inhibitor p21. Oncogene 9:2261-2268.
    • (1994) Oncogene , vol.9 , pp. 2261-2268
    • Li, Y.1    Jenkins, C.W.2    Nichols, M.A.3    Xiong, X.4
  • 43
    • 0028931265 scopus 로고
    • Principles of Cdk regulation
    • Morgan, D. O. 1995. Principles of Cdk regulation. Nature 374:131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 44
    • 0026703325 scopus 로고
    • Creative blocks: Cell cycle checkpoints and feedback controls
    • Murray, A. W. 1992. Creative blocks: cell cycle checkpoints and feedback controls. Nature 359:599-604.
    • (1992) Nature , vol.359 , pp. 599-604
    • Murray, A.W.1
  • 46
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 47
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury, C. and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61:441-470.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 53
    • 0028105914 scopus 로고
    • Stifled by inhibitors
    • Peters, G. 1994. Stifled by inhibitors. Nature 371:204-205.
    • (1994) Nature , vol.371 , pp. 204-205
    • Peters, G.1
  • 55
  • 56
    • 0025348820 scopus 로고
    • TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
    • Pietenpol, J. A., R. W. Stein, E. Moran, P. Yaciuk, R. Schlegel, R. M. Lyons, M. R. Pittelkow, K. Munger, P. M. Howley, and H. L. Moses. 1990. TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61:777-785.
    • (1990) Cell , vol.61 , pp. 777-785
    • Pietenpol, J.A.1    Stein, R.W.2    Moran, E.3    Yaciuk, P.4    Schlegel, R.5    Lyons, R.M.6    Pittelkow, M.R.7    Munger, K.8    Howley, P.M.9    Moses, H.L.10
  • 59
    • 0029145975 scopus 로고
    • Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet light
    • Poon, R., H. Toyoshima, and T. Hunter. 1995. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet light. Mol. Biol. Cell 6:1197-1213.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1197-1213
    • Poon, R.1    Toyoshima, H.2    Hunter, T.3
  • 61
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Revnisdottir, I., K. Polyak, A. Iavarone, and J. Massague. 1995. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9:1831-1845.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Revnisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 62
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/Cdk4
    • Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/Cdk4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 63
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551-553.
    • (1994) Cell , vol.79 , pp. 551-553
    • Sherr, C.J.1
  • 65
    • 0023251107 scopus 로고
    • Reversible inhibition of mammary gland growth by transforming growth factor-β
    • Silbertein, G. B., and C. W. Daniel. 1987. Reversible inhibition of mammary gland growth by transforming growth factor-β. Science 237:291-293.
    • (1987) Science , vol.237 , pp. 291-293
    • Silbertein, G.B.1    Daniel, C.W.2
  • 66
    • 0028928036 scopus 로고
    • Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
    • Skapek, S. X., J. Rhee, D. B. Spicer, and D. B. Lassar. 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267:1022-1024.
    • (1995) Science , vol.267 , pp. 1022-1024
    • Skapek, S.X.1    Rhee, J.2    Spicer, D.B.3    Lassar, D.B.4
  • 67
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells
    • Slingerland, J. M., L. Hengst, C.-H. Pan, D. Alexander, M. R. Stampfer, and S. I. Reed. 1994. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol. 14:3683-3694.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.-H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 68
    • 0027587321 scopus 로고
    • Activation of the various cyclin/cdc2 protein kinases
    • Solomon, M. J. 1993. Activation of the various cyclin/cdc2 protein kinases. Curr. Opin. Cell Biol. 5:180-186.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 180-186
    • Solomon, M.J.1
  • 69
    • 0022388785 scopus 로고
    • Isolation and growth of human mammary epithelial cells
    • Stampfer, M. 1985. Isolation and growth of human mammary epithelial cells. J. Tissue Cult. Methods 9:107-115.
    • (1985) J. Tissue Cult. Methods , vol.9 , pp. 107-115
    • Stampfer, M.1
  • 70
    • 0006312841 scopus 로고
    • Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene
    • Stampfer, M. R., and J. C. Bartley. 1985. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene. Proc. Natl. Acad. Sci. USA 82:2392-2398.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2392-2398
    • Stampfer, M.R.1    Bartley, J.C.2
  • 71
    • 0027283717 scopus 로고
    • Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous re-entry into the cell cycle
    • Stampfer, M. R., C.-H. Pan, J. Hosoda, J. Bartholomew, J. Mendelsohn, and P. Yaswen. 1993. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous re-entry into the cell cycle. Exp. Cell Res. 208:175-188.
    • (1993) Exp. Cell Res. , vol.208 , pp. 175-188
    • Stampfer, M.R.1    Pan, C.-H.2    Hosoda, J.3    Bartholomew, J.4    Mendelsohn, J.5    Yaswen, P.6
  • 72
    • 84920294536 scopus 로고    scopus 로고
    • Stampfer, M. R., and J. M. Slingerland. Unpublished results
    • Stampfer, M. R., and J. M. Slingerland. Unpublished results.
  • 73
    • 0027535320 scopus 로고
    • TGF-β induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects
    • Stampfer, M. R., P. Yaswen, M. Alhadeff, and J. Hosoda. 1993. TGF-β induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects. J. Cell. Physiol. 155:210-221.
    • (1993) J. Cell. Physiol. , vol.155 , pp. 210-221
    • Stampfer, M.R.1    Yaswen, P.2    Alhadeff, M.3    Hosoda, J.4
  • 74
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
    • Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78:67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 75
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., G. J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 77
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang, H., G. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
    • (1994) Genes Dev. , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.2    Beach, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.