Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells

Endocrinology

Volumn 140, Issue 7, 1999, Pages 3219-3227

  Stephens, Leigh A ^a   Thomas, Helen E ^a   Ming, Li ^a   Darwiche, Matthias Grell Rima ^a   Volodin, Leonid ^a   Kay, Thomas W H ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0033305236     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.7.6873     Document Type: Article

References (57)

1. CD4(+) and CD8(+) T lymphocytes - Clarification of their pathogenic roles in diabetes in the NOD mouse
2. Cell death mediators in autoimmune diabetes-no shortage of suspects
3. Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM
4. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic β cells
5. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic β-cell cytotoxicity
6. TNF-α and IFN-gamma potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide
7. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells
8. DNA fragmentation is an early event in cytokine-induced islet β-cell destruction
9. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in haman pancreatic islet cells
10. Tumor necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement
11. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
12. β cell apoptosis in T cell-mediated autoimmune diabetes
13. Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase
14. Two TNF receptors
15. Molecular mechanisms of tumour necrosis factor-induced cytotoxicity. What we do understand and what we do not
16. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
17. Apoptosis by death factor
18. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme
19. Suicide by order: Some open questions about the cell-killing activities of the TNF ligand and receptor families
20. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 β converting enzyme
21. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35
22. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
23. Involvement of an ICE-like protease in Fas-mediated apoptosis
24. Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway
25. A novel domain within the 55 kd TNF receptor signals cell death
26. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
27. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
28. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
29. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
30. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signalling complex
31. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
32. NIT-1, a pancreatic β-cell line established from a transgenic NOD/Lt mouse
33. Rip-beta(2)-microglobulin transgene expression restores insulitis, but not diabetes, in β(2)-microglobulin(null) nonobese diabetic mice
34. Bovine serum albumin density gradient isolation of rat pancreatic islets
35. A new in vitro model for the study of pancreatic A and B cells
36. Monoclonal antibody to a plasma membrane antigen of neurons
37. Insulin secretion from perifused rat pancreatic pseudoislets
38. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
39. TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis
40. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
41. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
42. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
43. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
44. Genomic organization and promoter function of the murine tumor necrosis factor receptor β gene
45. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis
46. Mouse islet cell lysis mediated by interleukin-1-induced Fas
47. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
48. T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1
49. The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 β converting enzyme (ICE)
50. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
51. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
52. Molecular cloning of the murine IL-1 β converting enzyme cDNA
53. Accelerated β-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-α and granzyme A in the intra-islet infiltrates
54. Prevention of autoimmune diabetes mellitus in nod mice by transgenic expression of soluble tumor necrosis factor receptor p55
55. Expression of a tumor necrosis factor α transgene in murine pancreatic β cells results in severe and permanent insulitis without evolution towards diabetes
56. Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis
57. The role of TNFa and related cytokines in the development and function of the autoreactive T-cell repertoire