Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase

Journal of Biological Chemistry

Volumn 281, Issue 15, 2006, Pages 10214-10221

  Li, Changhong ^b   Allen, Aron ^a   Kwagh, Jae ^b   Doliba, Nicolai M ^c   Qin, Wei ^c   Najafi, Habiba ^c   Collins, Heather W ^c   Matschinsky, Franz M ^c   Stanley, Charles A ^b   Smith, Thomas J ^a  

^a DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; CELLS; ENZYME INHIBITION; GLUCOSE; MOLECULAR BIOLOGY;

DEHYDROGENASE; GLUTAMATE DEHYDROGENASE (GDH); GLUTAMINE OXIDATION; POLYPHENOLS;

INSULIN;

BETA 2 AMINOBICYCLE[2.2.1]HEPTANE 2 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; GUANOSINE TRIPHOSPHATE; INSULIN; LEUCINE; POLYPHENOL; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS;

ALLOSTERISM; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG INHIBITION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MALE; METABOLIC REGULATION; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; TEA; ANIMAL; BIOLOGICAL MODEL; CATTLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; HYPERAMMONEMIA; KINETICS; METABOLISM; PANCREAS ISLET; PERFUSION; PROTEIN CONFORMATION; SECRETION; TIME; WISTAR RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; GLUTAMATE DEHYDROGENASE; GUANOSINE TRIPHOSPHATE; HYPERAMMONEMIA; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KINETICS; LEUCINE; MALE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; OXYGEN CONSUMPTION; PERFUSION; PHENOLS; PROTEIN CONFORMATION; RATS; RATS, WISTAR; TEA; TIME FACTORS;

EID: 33744527647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512792200     Document Type: Article

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