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Volumn 140, Issue 1, 2013, Pages 31-38

'All things considered': Transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation

Author keywords

CD4 Helper T cells; Cytokines; Transcription factors

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; JAGGED1; NOTCH RECEPTOR; PROTEIN; PROTEIN JAGGED 2; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

EID: 84883253431     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12121     Document Type: Review
Times cited : (40)

References (99)
  • 1
    • 4844221210 scopus 로고    scopus 로고
    • Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    • Finkelman FD, Shea-Donohue T, Morris SC et al. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev 2004; 201:139-55.
    • (2004) Immunol Rev , vol.201 , pp. 139-155
    • Finkelman, F.D.1    Shea-Donohue, T.2    Morris, S.C.3
  • 3
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 4
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W-p, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89:587-96.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.-p.1    Flavell, R.A.2
  • 5
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang W, Lohning M, Gao Z et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000; 12:27-37.
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1    Lohning, M.2    Gao, Z.3
  • 6
    • 84867858181 scopus 로고    scopus 로고
    • The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation
    • Carpenter AC, Grainger JR, Xiong Y et al. The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation. Immunity 2012; 37:622-33.
    • (2012) Immunity , vol.37 , pp. 622-633
    • Carpenter, A.C.1    Grainger, J.R.2    Xiong, Y.3
  • 7
    • 0036569803 scopus 로고    scopus 로고
    • Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development
    • Kurata H, Lee HJ, McClanahan T, Coffman RL, O'Garra A, Arai N. Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development. J Immunol 2002; 168:4538-45.
    • (2002) J Immunol , vol.168 , pp. 4538-4545
    • Kurata, H.1    Lee, H.J.2    McClanahan, T.3    Coffman, R.L.4    O'Garra, A.5    Arai, N.6
  • 9
    • 0037815268 scopus 로고    scopus 로고
    • + T cells into the Th2 lineage by repressing GATA3 expression
    • + T cells into the Th2 lineage by repressing GATA3 expression. J Exp Med 2003; 198:51-61.
    • (2003) J Exp Med , vol.198 , pp. 51-61
    • Komine, O.1    Hayashi, K.2    Natsume, W.3
  • 10
    • 5444237577 scopus 로고    scopus 로고
    • Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
    • Spilianakis CG, Flavell RA. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 2004; 5:1017-27.
    • (2004) Nat Immunol , vol.5 , pp. 1017-1027
    • Spilianakis, C.G.1    Flavell, R.A.2
  • 11
  • 12
    • 10344234192 scopus 로고    scopus 로고
    • Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
    • Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 2004; 21:865-76.
    • (2004) Immunity , vol.21 , pp. 865-876
    • Fields, P.E.1    Lee, G.R.2    Kim, S.T.3    Bartsevich, V.V.4    Flavell, R.A.5
  • 13
    • 8644220507 scopus 로고    scopus 로고
    • Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3
    • Lee DU, Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci USA 2004; 101:16010-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16010-16015
    • Lee, D.U.1    Rao, A.2
  • 16
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min B, Prout M, Hu-Li J et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 2004; 200:507-17.
    • (2004) J Exp Med , vol.200 , pp. 507-517
    • Min, B.1    Prout, M.2    Hu-Li, J.3
  • 18
    • 33646407864 scopus 로고    scopus 로고
    • Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    • Gregory GD, Raju SS, Winandy S, Brown MA. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Investig 2006; 116:1327-36.
    • (2006) J Clin Investig , vol.116 , pp. 1327-1336
    • Gregory, G.D.1    Raju, S.S.2    Winandy, S.3    Brown, M.A.4
  • 19
    • 48849102176 scopus 로고    scopus 로고
    • Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection
    • Ierna MX, Scales HE, Saunders KL, Lawrence CE. Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. Mucosal Immunol 2008; 1:147-55.
    • (2008) Mucosal Immunol , vol.1 , pp. 147-155
    • Ierna, M.X.1    Scales, H.E.2    Saunders, K.L.3    Lawrence, C.E.4
  • 20
    • 0028177589 scopus 로고
    • pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994; 179:1285-95.
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 22
    • 51549095217 scopus 로고    scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • Le Gros G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Immunol 2008; 181:2943-51.
    • (2008) J Immunol , vol.181 , pp. 2943-2951
    • Le Gros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 23
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2 like helper effectors
    • Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2 like helper effectors. J Immunol 1990; 145:3796-806.
    • (1990) J Immunol , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 24
    • 25144476332 scopus 로고    scopus 로고
    • + T cells to generate a Th2-inducing cytokine environment
    • + T cells to generate a Th2-inducing cytokine environment. J Exp Med 2005; 202:793-804.
    • (2005) J Exp Med , vol.202 , pp. 793-804
    • Yamane, H.1    Zhu, J.2    Paul, W.E.3
  • 25
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu J, Cote-Sierra J, Guo L, Paul WE. Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003; 19:739-48.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4
  • 26
    • 1642398043 scopus 로고    scopus 로고
    • Interleukin 2 plays a central role in Th2 differentiation
    • Cote-Sierra J, Foucras G, Guo L et al. Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci USA 2004; 101:3880-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3880-3885
    • Cote-Sierra, J.1    Foucras, G.2    Guo, L.3
  • 27
    • 79955574671 scopus 로고    scopus 로고
    • Transcriptional regulation by STAT6
    • Goenka S, Kaplan MH. Transcriptional regulation by STAT6. Immunol Res 2011; 50:87-96.
    • (2011) Immunol Res , vol.50 , pp. 87-96
    • Goenka, S.1    Kaplan, M.H.2
  • 28
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996; 4:313-9.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 29
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996; 380:630-3.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    van Deursen, J.2    Sangster, M.Y.3
  • 30
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K, Tanaka T, Shi W et al. Essential role of Stat6 in IL-4 signalling. Nature 1996; 380:627-30.
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1    Tanaka, T.2    Shi, W.3
  • 31
    • 59149092952 scopus 로고    scopus 로고
    • Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor
    • Scheinman EJ, Avni O. Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor. J Biol Chem 2009; 284:3037-48.
    • (2009) J Biol Chem , vol.284 , pp. 3037-3048
    • Scheinman, E.J.1    Avni, O.2
  • 32
    • 0036568950 scopus 로고    scopus 로고
    • Cutting edge: identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human
    • Asnagli H, Afkarian M, Murphy KM. Cutting edge: identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol 2002; 168:4268-71.
    • (2002) J Immunol , vol.168 , pp. 4268-4271
    • Asnagli, H.1    Afkarian, M.2    Murphy, K.M.3
  • 34
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells
    • Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells. Cell 2004; 117:515-26.
    • (2004) Cell , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3    Tanigaki, K.4    Honjo, T.5    Flavell, R.A.6
  • 35
    • 50949094678 scopus 로고    scopus 로고
    • Th2 differentiation is unaffected by Jagged2 expression on dendritic cells
    • Krawczyk CM, Sun J, Pearce EJ. Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. J Immunol 2008; 180:7931-7.
    • (2008) J Immunol , vol.180 , pp. 7931-7937
    • Krawczyk, C.M.1    Sun, J.2    Pearce, E.J.3
  • 36
    • 34447634411 scopus 로고    scopus 로고
    • Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    • Amsen D, Antov A, Jankovic D et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 2007; 27:89-99.
    • (2007) Immunity , vol.27 , pp. 89-99
    • Amsen, D.1    Antov, A.2    Jankovic, D.3
  • 38
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006; 7:678-89.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 40
    • 50949091487 scopus 로고    scopus 로고
    • Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
    • Ong CT, Sedy JR, Murphy KM, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS ONE 2008; 3:e2823.
    • (2008) PLoS ONE , vol.3
    • Ong, C.T.1    Sedy, J.R.2    Murphy, K.M.3    Kopan, R.4
  • 41
    • 26844538164 scopus 로고    scopus 로고
    • Notch signaling is an important regulator of type 2 immunity
    • Tu L, Fang TC, Artis D et al. Notch signaling is an important regulator of type 2 immunity. J Exp Med 2005; 202:1037-42.
    • (2005) J Exp Med , vol.202 , pp. 1037-1042
    • Tu, L.1    Fang, T.C.2    Artis, D.3
  • 42
    • 70449707113 scopus 로고    scopus 로고
    • Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    • Yang XO, Angkasekwinai P, Zhu J et al. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol 2009; 10:1260-6.
    • (2009) Nat Immunol , vol.10 , pp. 1260-1266
    • Yang, X.O.1    Angkasekwinai, P.2    Zhu, J.3
  • 43
    • 0032212793 scopus 로고    scopus 로고
    • Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
    • Ouyang W, Ranganath SH, Weindel K et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998; 9:745-55.
    • (1998) Immunity , vol.9 , pp. 745-755
    • Ouyang, W.1    Ranganath, S.H.2    Weindel, K.3
  • 44
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci USA 2004; 101:1993-8.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 46
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998; 9:765-75.
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 47
    • 0000344022 scopus 로고    scopus 로고
    • GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
    • Lee HJ, Takemoto N, Kurata H et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 2000; 192:105-15.
    • (2000) J Exp Med , vol.192 , pp. 105-115
    • Lee, H.J.1    Takemoto, N.2    Kurata, H.3
  • 48
    • 0034671565 scopus 로고    scopus 로고
    • Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster
    • Takemoto N, Kamogawa Y, Jun Lee H et al. Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster. J Immunol 2000; 165:6687-91.
    • (2000) J Immunol , vol.165 , pp. 6687-6691
    • Takemoto, N.1    Kamogawa, Y.2    Jun Lee, H.3
  • 49
    • 80051885764 scopus 로고    scopus 로고
    • Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
    • Wei G, Abraham BJ, Yagi R et al. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011; 35:299-311.
    • (2011) Immunity , vol.35 , pp. 299-311
    • Wei, G.1    Abraham, B.J.2    Yagi, R.3
  • 50
    • 0036830465 scopus 로고    scopus 로고
    • Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus
    • Yamashita M, Ukai-Tadenuma M, Kimura M et al. Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem 2002; 277:42399-408.
    • (2002) J Biol Chem , vol.277 , pp. 42399-42408
    • Yamashita, M.1    Ukai-Tadenuma, M.2    Kimura, M.3
  • 51
    • 0037963472 scopus 로고    scopus 로고
    • Regulation of the Th2 cytokine locus by a locus control region
    • Lee GR, Fields PE, Griffin TJ, Flavell RA. Regulation of the Th2 cytokine locus by a locus control region. Immunity 2003; 19:145-53.
    • (2003) Immunity , vol.19 , pp. 145-153
    • Lee, G.R.1    Fields, P.E.2    Griffin, T.J.3    Flavell, R.A.4
  • 52
    • 84871948166 scopus 로고    scopus 로고
    • Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation
    • Hwang SS, Kim YU, Lee S et al. Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation. Proc Natl Acad Sci USA 2013; 110:276-81.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 276-281
    • Hwang, S.S.1    Kim, Y.U.2    Lee, S.3
  • 53
    • 0037100265 scopus 로고    scopus 로고
    • Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation
    • Fields PE, Kim ST, Flavell RA. Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J Immunol 2002; 169:647-50.
    • (2002) J Immunol , vol.169 , pp. 647-650
    • Fields, P.E.1    Kim, S.T.2    Flavell, R.A.3
  • 54
    • 57649131050 scopus 로고    scopus 로고
    • Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation
    • Shinnakasu R, Yamashita M, Kuwahara M et al. Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J Biol Chem 2008; 283:28216-25.
    • (2008) J Biol Chem , vol.283 , pp. 28216-28225
    • Shinnakasu, R.1    Yamashita, M.2    Kuwahara, M.3
  • 55
    • 0345735834 scopus 로고    scopus 로고
    • Basal chromatin modification at the IL-4 gene in helper T cells
    • Grogan JL, Wang ZE, Stanley S et al. Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol 2003; 171:6672-9.
    • (2003) J Immunol , vol.171 , pp. 6672-6679
    • Grogan, J.L.1    Wang, Z.E.2    Stanley, S.3
  • 56
    • 78650304399 scopus 로고    scopus 로고
    • The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells
    • Tanaka S, Motomura Y, Suzuki Y et al. The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol 2011; 12:77-85.
    • (2011) Nat Immunol , vol.12 , pp. 77-85
    • Tanaka, S.1    Motomura, Y.2    Suzuki, Y.3
  • 57
    • 78649715384 scopus 로고    scopus 로고
    • Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production
    • Grausenburger R, Bilic I, Boucheron N et al. Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol 2010; 185:3489-97.
    • (2010) J Immunol , vol.185 , pp. 3489-3497
    • Grausenburger, R.1    Bilic, I.2    Boucheron, N.3
  • 59
    • 36749029364 scopus 로고    scopus 로고
    • Demethylation of a specific hypersensitive site in the Th2 locus control region
    • Kim ST, Fields PE, Flavell RA. Demethylation of a specific hypersensitive site in the Th2 locus control region. Proc Natl Acad Sci USA 2007; 104:17052-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17052-17057
    • Kim, S.T.1    Fields, P.E.2    Flavell, R.A.3
  • 61
    • 0036279221 scopus 로고    scopus 로고
    • Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene
    • Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 2002; 16:649-60.
    • (2002) Immunity , vol.16 , pp. 649-660
    • Lee, D.U.1    Agarwal, S.2    Rao, A.3
  • 62
    • 0032906187 scopus 로고    scopus 로고
    • GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
    • Ferber IA, Lee HJ, Zonin F et al. GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin Immunol 1999; 91:134-44.
    • (1999) Clin Immunol , vol.91 , pp. 134-144
    • Ferber, I.A.1    Lee, H.J.2    Zonin, F.3
  • 66
    • 31144446876 scopus 로고    scopus 로고
    • Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and th2 cell differentiation
    • Mikhalkevich N, Becknell B, Caligiuri MA, Bates MD, Harvey R, Zheng WP. Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and th2 cell differentiation. J Immunol 2006; 176:1553-60.
    • (2006) J Immunol , vol.176 , pp. 1553-1560
    • Mikhalkevich, N.1    Becknell, B.2    Caligiuri, M.A.3    Bates, M.D.4    Harvey, R.5    Zheng, W.P.6
  • 67
    • 0037342749 scopus 로고    scopus 로고
    • GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet
    • Usui T, Nishikomori R, Kitani A, Strober W. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet. Immunity 2003; 18:415-28.
    • (2003) Immunity , vol.18 , pp. 415-428
    • Usui, T.1    Nishikomori, R.2    Kitani, A.3    Strober, W.4
  • 68
    • 77951920474 scopus 로고    scopus 로고
    • The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-γ
    • Yagi R, Junttila IS, Wei G, Urban JF Jr, Zhao K, Paul WE, Zhu J. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-γ. Immunity 2010; 32:507-17.
    • (2010) Immunity , vol.32 , pp. 507-517
    • Yagi, R.1    Junttila, I.S.2    Wei, G.3    Urban Jr, J.F.4    Zhao, K.5    Paul, W.E.6    Zhu, J.7
  • 69
    • 34250762587 scopus 로고    scopus 로고
    • Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells
    • Chang S, Aune TM. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells. Nat Immunol 2007; 8:723-31.
    • (2007) Nat Immunol , vol.8 , pp. 723-731
    • Chang, S.1    Aune, T.M.2
  • 70
    • 38449087549 scopus 로고    scopus 로고
    • Temporal and spatial changes of histone 3K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation
    • Hamalainen-Laanaya HK, Kobie JJ, Chang C, Zeng WP. Temporal and spatial changes of histone 3K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation. J Immunol 2007; 179:6410-5.
    • (2007) J Immunol , vol.179 , pp. 6410-6415
    • Hamalainen-Laanaya, H.K.1    Kobie, J.J.2    Chang, C.3    Zeng, W.P.4
  • 71
    • 34250773899 scopus 로고    scopus 로고
    • Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ
    • Schoenborn JR, Dorschner MO, Sekimata M et al. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ. Nat Immunol 2007; 8:732-42.
    • (2007) Nat Immunol , vol.8 , pp. 732-742
    • Schoenborn, J.R.1    Dorschner, M.O.2    Sekimata, M.3
  • 72
    • 4344574045 scopus 로고    scopus 로고
    • Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells
    • Shnyreva M, Weaver WM, Blanchette M et al. Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells. Proc Natl Acad Sci USA 2004; 101:12622-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12622-12627
    • Shnyreva, M.1    Weaver, W.M.2    Blanchette, M.3
  • 73
    • 70349756895 scopus 로고    scopus 로고
    • CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-γ locus
    • Sekimata M, Perez-Melgosa M, Miller SA et al. CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-γ locus. Immunity 2009; 31:551-64.
    • (2009) Immunity , vol.31 , pp. 551-564
    • Sekimata, M.1    Perez-Melgosa, M.2    Miller, S.A.3
  • 75
    • 12344250807 scopus 로고    scopus 로고
    • Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions
    • Lee GR, Spilianakis CG, Flavell RA. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 2005; 6:42-8.
    • (2005) Nat Immunol , vol.6 , pp. 42-48
    • Lee, G.R.1    Spilianakis, C.G.2    Flavell, R.A.3
  • 76
    • 0035887640 scopus 로고    scopus 로고
    • The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3
    • Kishikawa H, Sun J, Choi A, Miaw S-C, Ho I-C. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J Immunol 2001; 167:4414-20.
    • (2001) J Immunol , vol.167 , pp. 4414-4420
    • Kishikawa, H.1    Sun, J.2    Choi, A.3    Miaw, S.-C.4    Ho, I.-C.5
  • 77
    • 0032031412 scopus 로고    scopus 로고
    • Characterization of cis-regulatory and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein
    • Lee HJ, O'Garra A, Arai K-I, Arai N. Characterization of cis-regulatory and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein. J Immunol 1998; 160:2343-52.
    • (1998) J Immunol , vol.160 , pp. 2343-2352
    • Lee, H.J.1    O'Garra, A.2    Arai, K.-I.3    Arai, N.4
  • 78
    • 0032531605 scopus 로고    scopus 로고
    • Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
    • Zhang DH, Yang L, Ray A. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 1998; 161:3817-21.
    • (1998) J Immunol , vol.161 , pp. 3817-3821
    • Zhang, D.H.1    Yang, L.2    Ray, A.3
  • 79
    • 40049088206 scopus 로고    scopus 로고
    • Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses
    • Zhao X, Zheng B, Huang Y, Yang D, Katzman S, Chang C, Zeng W. Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. J Immunol 2007; 179:8297-304.
    • (2007) J Immunol , vol.179 , pp. 8297-8304
    • Zhao, X.1    Zheng, B.2    Huang, Y.3    Yang, D.4    Katzman, S.5    Chang, C.6    Zeng, W.7
  • 80
    • 0035041537 scopus 로고    scopus 로고
    • Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
    • Lee GR, Fields PE, Flavell RA. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 2001; 14:447-59.
    • (2001) Immunity , vol.14 , pp. 447-459
    • Lee, G.R.1    Fields, P.E.2    Flavell, R.A.3
  • 81
    • 0032531544 scopus 로고    scopus 로고
    • GATA-3-dependent enhancer activity in IL-4 gene regulation
    • Ranganath S, Ouyang W, Bhattarcharya D et al. GATA-3-dependent enhancer activity in IL-4 gene regulation. J Immunol 1998; 161:3822-6.
    • (1998) J Immunol , vol.161 , pp. 3822-3826
    • Ranganath, S.1    Ouyang, W.2    Bhattarcharya, D.3
  • 82
    • 0033696204 scopus 로고    scopus 로고
    • ROG, repressor of GATA, regulates the expression of cytokine genes
    • Miaw SC, Choi A, Yu E, Kishikawa H, Ho IC. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 2000; 12:323-33.
    • (2000) Immunity , vol.12 , pp. 323-333
    • Miaw, S.C.1    Choi, A.2    Yu, E.3    Kishikawa, H.4    Ho, I.C.5
  • 83
    • 0035555263 scopus 로고    scopus 로고
    • Deletion of a coordinate regulator of type 2 cytokine expression in mice
    • Mohrs M, Blankespoor CM, Wang ZE et al. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol 2001; 2:842-7.
    • (2001) Nat Immunol , vol.2 , pp. 842-847
    • Mohrs, M.1    Blankespoor, C.M.2    Wang, Z.E.3
  • 84
    • 0033667895 scopus 로고    scopus 로고
    • Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
    • Agarwal S, Avni O, Rao A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 2000; 12:643-52.
    • (2000) Immunity , vol.12 , pp. 643-652
    • Agarwal, S.1    Avni, O.2    Rao, A.3
  • 85
    • 0035984591 scopus 로고    scopus 로고
    • A 3′ enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells
    • Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3′ enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity 2002; 17:41-50.
    • (2002) Immunity , vol.17 , pp. 41-50
    • Solymar, D.C.1    Agarwal, S.2    Bassing, C.H.3    Alt, F.W.4    Rao, A.5
  • 86
    • 33846489173 scopus 로고    scopus 로고
    • Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
    • Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 2007; 8:145-53.
    • (2007) Nat Immunol , vol.8 , pp. 145-153
    • Djuretic, I.M.1    Levanon, D.2    Negreanu, V.3    Groner, Y.4    Rao, A.5    Ansel, K.M.6
  • 87
    • 34547727747 scopus 로고    scopus 로고
    • Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf β binding to the Il4 silencer
    • Naoe Y, Setoguchi R, Akiyama K et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf β binding to the Il4 silencer. J Exp Med 2007; 204:1749-55.
    • (2007) J Exp Med , vol.204 , pp. 1749-1755
    • Naoe, Y.1    Setoguchi, R.2    Akiyama, K.3
  • 88
    • 0029030775 scopus 로고
    • Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
    • Rooney JW, Hoey T, Glimcher LH. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 1995; 2:473-83.
    • (1995) Immunity , vol.2 , pp. 473-483
    • Rooney, J.W.1    Hoey, T.2    Glimcher, L.H.3
  • 89
    • 0032212631 scopus 로고    scopus 로고
    • Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
    • Ranger AM, Oukka M, Rengarajan J, Glimcher LH. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 1998; 9:627-35.
    • (1998) Immunity , vol.9 , pp. 627-635
    • Ranger, A.M.1    Oukka, M.2    Rengarajan, J.3    Glimcher, L.H.4
  • 90
    • 0031933037 scopus 로고    scopus 로고
    • Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
    • Ranger AM, Hodge MR, Gravallese EM et al. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998; 8:125-34.
    • (1998) Immunity , vol.8 , pp. 125-134
    • Ranger, A.M.1    Hodge, M.R.2    Gravallese, E.M.3
  • 91
    • 0031951071 scopus 로고    scopus 로고
    • The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
    • Yoshida H, Nishina H, Takimoto H et al. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 1998; 8:115-24.
    • (1998) Immunity , vol.8 , pp. 115-124
    • Yoshida, H.1    Nishina, H.2    Takimoto, H.3
  • 92
    • 0036773634 scopus 로고    scopus 로고
    • NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription
    • Monticelli S, Rao A. NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription. Eur J Immunol 2002; 32:2971-8.
    • (2002) Eur J Immunol , vol.32 , pp. 2971-2978
    • Monticelli, S.1    Rao, A.2
  • 94
    • 0030604714 scopus 로고    scopus 로고
    • The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
    • Ho I-C, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 1996; 85:973-83.
    • (1996) Cell , vol.85 , pp. 973-983
    • Ho, I.-C.1    Hodge, M.R.2    Rooney, J.W.3    Glimcher, L.H.4
  • 95
    • 0033152267 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
    • Kim JI, Ho IC, Grusby MJ, Glimcher LH. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 1999; 10:745-51.
    • (1999) Immunity , vol.10 , pp. 745-751
    • Kim, J.I.1    Ho, I.C.2    Grusby, M.J.3    Glimcher, L.H.4
  • 97
    • 77649243260 scopus 로고    scopus 로고
    • NIP45 controls the magnitude of the type 2 T helper cell response
    • Fathman JW, Gurish MF, Hemmers S et al. NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci USA 2010; 107:3663-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3663-3668
    • Fathman, J.W.1    Gurish, M.F.2    Hemmers, S.3
  • 99
    • 3843148505 scopus 로고    scopus 로고
    • NF-κB synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells
    • Li-Weber M, Giaisi M, Baumann S, Palfi K, Krammer PH. NF-κB synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells. Eur J Immunol 2004; 34:1111-8.
    • (2004) Eur J Immunol , vol.34 , pp. 1111-1118
    • Li-Weber, M.1    Giaisi, M.2    Baumann, S.3    Palfi, K.4    Krammer, P.H.5


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