A 3′ enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells

Immunity

Volumn 17, Issue 1, 2002, Pages 41-50

  Solymar, Deborah C ^a,c   Agarwal, Suneet ^a,c   Bassing, Craig H ^b,c,d   Alt, Frederick W ^b,c,d   Rao, Anjana ^a,c  

^a Department of Pathology ^*  (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CENTER FOR BLOOD RESEARCH   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; INTERLEUKIN 4; MESSENGER RNA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; INTERLEUKIN 13; NFATC2 PROTEIN, MOUSE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENHANCER REGION; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; T LYMPHOCYTE; TH2 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; DNA FLANKING REGION; GENETICS; IMMUNOLOGY; KINETICS; MOUSE MUTANT; MULTIGENE FAMILY; PHYSIOLOGY;

3' FLANKING REGION; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DEOXYRIBONUCLEASE I; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; INTERLEUKIN-13; INTERLEUKIN-4; KINETICS; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIGENE FAMILY; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; RNA, MESSENGER; SEQUENCE DELETION; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 0035984591     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00334-5     Document Type: Article

References (53)

1. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
2. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
3. T cell differentiation: A mechanistic view
4. Functions of IL-4 and control of its expression
5. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
6. Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region
7. New concepts about the mast cell
8. Mast cell and basophil development
9. Mast cell clones: A model for the analysis of cellular maturation
10. Lineage commitment in the immune system: The T helper lymphocyte grows up
11. The Ig(κ) enhancer influences the ratio of Ig(κ) versus Ig(λ) B lymphocytes
12. PU.1 and GATA: Components of a mast cell-specific interleukin 4 intronic enhancer
13. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer
14. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system
15. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice
16. A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice
17. An intron transcriptional enhancer element regulates IL-4 gene locus accessibility in mast cells
18. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
19. Downregulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1
20. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
21. Heterogeneity of mast cells and phenotypic change between subpopulations
22. KIF3A is a new microtubule-based anterograde motor in the nerve axon
23. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
24. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene
25. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
26. Expression of NFAT-family proteins in normal human T cells
27. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages
28. Mast cells in innate immunity
29. Deletion of a coordinate regulator of type 2 cytokine expression in mice
30. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
31. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
32. Signaling and transcription in T helper development
33. v mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells
34. Cytokines induce the development of functionally heterogeneous T helper cell subsets
35. The molecular basis of T helper 1 and T helper 2 cell differentiation
36. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
37. Lymphokine production by human T cells in disease states
38. + T cells from T cell receptor transgenic mice
39. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells
40. Regulation of immunity to parasites by T cells and T cell-derived cytokines
41. Cutting edge: IL-4 production by mast cells does not require c-maf
42. STAT6-independent production of IL-4 by mast cells
43. Essential role of Stat6 in IL-4 signalling
44. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
45. Eosinophils: Biology and role in disease
46. GATA transcription factors: Key regulators of hematopoiesis
47. Regulation of IL-4 production in mast cells: A paradigm for cell-type-specific gene expression
48. An enhanced immune response in mice lacking the transcription factor NFAT1
49. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
50. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
51. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
52. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene
53. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells