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Volumn 37, Issue 4, 2012, Pages 622-633

The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell Differentiation

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LRF; TRANSCRIPTION FACTOR THPOK; UNCLASSIFIED DRUG;

EID: 84867858181     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2012.06.019     Document Type: Article
Times cited : (37)

References (65)
  • 1
    • 53849098346 scopus 로고    scopus 로고
    • T-cell recruitment to the intestinal mucosa
    • Agace W.W. T-cell recruitment to the intestinal mucosa. Trends Immunol. 2008, 29:514-522.
    • (2008) Trends Immunol. , vol.29 , pp. 514-522
    • Agace, W.W.1
  • 2
    • 38749094821 scopus 로고    scopus 로고
    • Development of all CD4 T lineages requires nuclear factor TOX
    • Aliahmad P., Kaye J. Development of all CD4 T lineages requires nuclear factor TOX. J. Exp. Med. 2008, 205:245-256.
    • (2008) J. Exp. Med. , vol.205 , pp. 245-256
    • Aliahmad, P.1    Kaye, J.2
  • 4
    • 80053063773 scopus 로고    scopus 로고
    • The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system
    • Beaulieu A.M., Sant'Angelo D.B. The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system. J. Immunol. 2011, 187:2841-2847.
    • (2011) J. Immunol. , vol.187 , pp. 2841-2847
    • Beaulieu, A.M.1    Sant'Angelo, D.B.2
  • 6
    • 70350569404 scopus 로고    scopus 로고
    • Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections
    • Behnke J.M., Menge D.M., Noyes H. Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections. Parasitology 2009, 136:1565-1580.
    • (2009) Parasitology , vol.136 , pp. 1565-1580
    • Behnke, J.M.1    Menge, D.M.2    Noyes, H.3
  • 8
    • 0031981961 scopus 로고    scopus 로고
    • Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells
    • Belkaid Y., Butcher B., Sacks D.L. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells. Eur. J. Immunol. 1998, 28:1389-1400.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1389-1400
    • Belkaid, Y.1    Butcher, B.2    Sacks, D.L.3
  • 9
    • 0034661692 scopus 로고    scopus 로고
    • A natural model of Leishmania major infection reveals a prolonged " silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity
    • Belkaid Y., Mendez S., Lira R., Kadambi N., Milon G., Sacks D. A natural model of Leishmania major infection reveals a prolonged " silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. J. Immunol. 2000, 165:969-977.
    • (2000) J. Immunol. , vol.165 , pp. 969-977
    • Belkaid, Y.1    Mendez, S.2    Lira, R.3    Kadambi, N.4    Milon, G.5    Sacks, D.6
  • 10
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420:502-507.
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 12
    • 77950484789 scopus 로고    scopus 로고
    • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
    • Chong M.M., Simpson N., Ciofani M., Chen G., Collins A., Littman D.R. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010, 24:659-669.
    • (2010) Genes Dev. , vol.24 , pp. 659-669
    • Chong, M.M.1    Simpson, N.2    Ciofani, M.3    Chen, G.4    Collins, A.5    Littman, D.R.6
  • 16
    • 33846489173 scopus 로고    scopus 로고
    • Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
    • Djuretic I.M., Levanon D., Negreanu V., Groner Y., Rao A., Ansel K.M. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 2007, 8:145-153.
    • (2007) Nat. Immunol. , vol.8 , pp. 145-153
    • Djuretic, I.M.1    Levanon, D.2    Negreanu, V.3    Groner, Y.4    Rao, A.5    Ansel, K.M.6
  • 17
    • 52549101132 scopus 로고    scopus 로고
    • ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    • Egawa T., Littman D.R. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 2008, 9:1131-1139.
    • (2008) Nat. Immunol. , vol.9 , pp. 1131-1139
    • Egawa, T.1    Littman, D.R.2
  • 18
    • 80052557419 scopus 로고    scopus 로고
    • Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
    • Egawa T., Littman D.R. Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc. Natl. Acad. Sci. USA 2011, 108:14873-14878.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 14873-14878
    • Egawa, T.1    Littman, D.R.2
  • 19
    • 34547744867 scopus 로고    scopus 로고
    • The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    • Egawa T., Tillman R.E., Naoe Y., Taniuchi I., Littman D.R. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J. Exp. Med. 2007, 204:1945-1957.
    • (2007) J. Exp. Med. , vol.204 , pp. 1945-1957
    • Egawa, T.1    Tillman, R.E.2    Naoe, Y.3    Taniuchi, I.4    Littman, D.R.5
  • 20
    • 0032539865 scopus 로고    scopus 로고
    • Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis
    • Flamand L., Crowley R.W., Lusso P., Colombini-Hatch S., Margolis D.M., Gallo R.C. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc. Natl. Acad. Sci. USA 1998, 95:3111-3116.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3111-3116
    • Flamand, L.1    Crowley, R.W.2    Lusso, P.3    Colombini-Hatch, S.4    Margolis, D.M.5    Gallo, R.C.6
  • 21
    • 0026044013 scopus 로고
    • Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice
    • Grusby M.J., Johnson R.S., Papaioannou V.E., Glimcher L.H. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 1991, 253:1417-1420.
    • (1991) Science , vol.253 , pp. 1417-1420
    • Grusby, M.J.1    Johnson, R.S.2    Papaioannou, V.E.3    Glimcher, L.H.4
  • 22
    • 14544288635 scopus 로고    scopus 로고
    • The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    • He X., He X., Dave V.P., Zhang Y., Hua X., Nicolas E., Xu W., Roe B.A., Kappes D.J. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 2005, 433:826-833.
    • (2005) Nature , vol.433 , pp. 826-833
    • He, X.1    He, X.2    Dave, V.P.3    Zhang, Y.4    Hua, X.5    Nicolas, E.6    Xu, W.7    Roe, B.A.8    Kappes, D.J.9
  • 23
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: networks of gene expression in immune cells
    • Heng T.S., Painter M.W. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 2008, 9:1091-1094.
    • (2008) Nat. Immunol. , vol.9 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2
  • 24
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    • Jones M.E., Zhuang Y. Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 2007, 27:860-870.
    • (2007) Immunity , vol.27 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 25
    • 84862796934 scopus 로고    scopus 로고
    • E protein transcription factors are required for the development of CD4(+) lineage T cells
    • Jones-Mason M.E., Zhao X., Kappes D., Lasorella A., Iavarone A., Zhuang Y. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 2012, 36:348-361.
    • (2012) Immunity , vol.36 , pp. 348-361
    • Jones-Mason, M.E.1    Zhao, X.2    Kappes, D.3    Lasorella, A.4    Iavarone, A.5    Zhuang, Y.6
  • 26
    • 0029933509 scopus 로고    scopus 로고
    • Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
    • Kamanaka M., Yu P., Yasui T., Yoshida K., Kawabe T., Horii T., Kishimoto T., Kikutani H. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996, 4:275-281.
    • (1996) Immunity , vol.4 , pp. 275-281
    • Kamanaka, M.1    Yu, P.2    Yasui, T.3    Yoshida, K.4    Kawabe, T.5    Horii, T.6    Kishimoto, T.7    Kikutani, H.8
  • 28
  • 30
    • 33746069706 scopus 로고    scopus 로고
    • Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
    • Lesley R., Kelly L.M., Xu Y., Cyster J.G. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl. Acad. Sci. USA 2006, 103:10717-10722.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10717-10722
    • Lesley, R.1    Kelly, L.M.2    Xu, Y.3    Cyster, J.G.4
  • 33
    • 0029988961 scopus 로고    scopus 로고
    • MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
    • Matechak E.O., Killeen N., Hedrick S.M., Fowlkes B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 1996, 4:337-347.
    • (1996) Immunity , vol.4 , pp. 337-347
    • Matechak, E.O.1    Killeen, N.2    Hedrick, S.M.3    Fowlkes, B.J.4
  • 34
    • 34548038390 scopus 로고    scopus 로고
    • Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • Moon J.J., Chu H.H., Pepper M., McSorley S.J., Jameson S.C., Kedl R.M., Jenkins M.K. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 2007, 27:203-213.
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1    Chu, H.H.2    Pepper, M.3    McSorley, S.J.4    Jameson, S.C.5    Kedl, R.M.6    Jenkins, M.K.7
  • 37
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea J.J., Paul W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010, 327:1098-1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 39
    • 77954886412 scopus 로고    scopus 로고
    • TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes
    • Park K., He X., Lee H.O., Hua X., Li Y., Wiest D., Kappes D.J. TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes. EMBO J. 2010, 29:2329-2341.
    • (2010) EMBO J. , vol.29 , pp. 2329-2341
    • Park, K.1    He, X.2    Lee, H.O.3    Hua, X.4    Li, Y.5    Wiest, D.6    Kappes, D.J.7
  • 42
    • 0027293241 scopus 로고
    • The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells
    • Roy M., Waldschmidt T., Aruffo A., Ledbetter J.A., Noelle R.J. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J. Immunol. 1993, 151:2497-2510.
    • (1993) J. Immunol. , vol.151 , pp. 2497-2510
    • Roy, M.1    Waldschmidt, T.2    Aruffo, A.3    Ledbetter, J.A.4    Noelle, R.J.5
  • 43
    • 77951284245 scopus 로고    scopus 로고
    • The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
    • Sakaguchi S., Hombauer M., Bilic I., Naoe Y., Schebesta A., Taniuchi I., Ellmeier W. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat. Immunol. 2010, 11:442-448.
    • (2010) Nat. Immunol. , vol.11 , pp. 442-448
    • Sakaguchi, S.1    Hombauer, M.2    Bilic, I.3    Naoe, Y.4    Schebesta, A.5    Taniuchi, I.6    Ellmeier, W.7
  • 45
    • 52949145604 scopus 로고    scopus 로고
    • Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
    • Singer A., Adoro S., Park J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat. Rev. Immunol. 2008, 8:788-801.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 788-801
    • Singer, A.1    Adoro, S.2    Park, J.H.3
  • 46
    • 33645077332 scopus 로고    scopus 로고
    • Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
    • Suffia I.J., Reckling S.K., Piccirillo C.A., Goldszmid R.S., Belkaid Y. Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 2006, 203:777-788.
    • (2006) J. Exp. Med. , vol.203 , pp. 777-788
    • Suffia, I.J.1    Reckling, S.K.2    Piccirillo, C.A.3    Goldszmid, R.S.4    Belkaid, Y.5
  • 48
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 2007, 204:1775-1785.
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 49
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi I., Osato M., Egawa T., Sunshine M.J., Bae S.C., Komori T., Ito Y., Littman D.R. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002, 111:621-633.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1    Osato, M.2    Egawa, T.3    Sunshine, M.J.4    Bae, S.C.5    Komori, T.6    Ito, Y.7    Littman, D.R.8
  • 50
    • 0028326103 scopus 로고
    • CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major
    • Wang Z.E., Reiner S.L., Zheng S., Dalton D.K., Locksley R.M. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J. Exp. Med. 1994, 179:1367-1371.
    • (1994) J. Exp. Med. , vol.179 , pp. 1367-1371
    • Wang, Z.E.1    Reiner, S.L.2    Zheng, S.3    Dalton, D.K.4    Locksley, R.M.5
  • 51
    • 57449108862 scopus 로고    scopus 로고
    • The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    • Wang L., Wildt K.F., Castro E., Xiong Y., Feigenbaum L., Tessarollo L., Bosselut R. The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 2008, 29:876-887.
    • (2008) Immunity , vol.29 , pp. 876-887
    • Wang, L.1    Wildt, K.F.2    Castro, E.3    Xiong, Y.4    Feigenbaum, L.5    Tessarollo, L.6    Bosselut, R.7
  • 53
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei G., Wei L., Zhu J., Zang C., Hu-Li J., Yao Z., Cui K., Kanno Y., Roh T.Y., Watford W.T., et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 2009, 30:155-167.
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3    Zang, C.4    Hu-Li, J.5    Yao, Z.6    Cui, K.7    Kanno, Y.8    Roh, T.Y.9    Watford, W.T.10
  • 54
    • 38949192274 scopus 로고    scopus 로고
    • The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer
    • Wildt K.F., Sun G., Grueter B., Fischer M., Zamisch M., Ehlers M., Bosselut R. The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer. J. Immunol. 2007, 179:4405-4414.
    • (2007) J. Immunol. , vol.179 , pp. 4405-4414
    • Wildt, K.F.1    Sun, G.2    Grueter, B.3    Fischer, M.4    Zamisch, M.5    Ehlers, M.6    Bosselut, R.7
  • 55
    • 27144486144 scopus 로고    scopus 로고
    • Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    • Wilson M.S., Taylor M.D., Balic A., Finney C.A., Lamb J.R., Maizels R.M. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J. Exp. Med. 2005, 202:1199-1212.
    • (2005) J. Exp. Med. , vol.202 , pp. 1199-1212
    • Wilson, M.S.1    Taylor, M.D.2    Balic, A.3    Finney, C.A.4    Lamb, J.R.5    Maizels, R.M.6
  • 57
    • 79951797840 scopus 로고    scopus 로고
    • The enigma of CD4-lineage specification
    • Xiong Y., Bosselut R. The enigma of CD4-lineage specification. Eur. J. Immunol. 2011, 41:568-574.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 568-574
    • Xiong, Y.1    Bosselut, R.2
  • 58
    • 84859159573 scopus 로고    scopus 로고
    • CD4-CD8 differentiation in the thymus: connecting circuits and building memories
    • Xiong Y., Bosselut R. CD4-CD8 differentiation in the thymus: connecting circuits and building memories. Curr. Opin. Immunol. 2012, 24:139-145.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 139-145
    • Xiong, Y.1    Bosselut, R.2
  • 60
    • 73349107484 scopus 로고    scopus 로고
    • The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
    • Zamisch M., Tian L., Grenningloh R., Xiong Y., Wildt K.F., Ehlers M., Ho I.C., Bosselut R. The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J. Exp. Med. 2009, 206:2685-2699.
    • (2009) J. Exp. Med. , vol.206 , pp. 2685-2699
    • Zamisch, M.1    Tian, L.2    Grenningloh, R.3    Xiong, Y.4    Wildt, K.F.5    Ehlers, M.6    Ho, I.C.7    Bosselut, R.8
  • 61
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y., Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 2007, 8:457-462.
    • (2007) Nat. Immunol. , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 62
    • 65349172388 scopus 로고    scopus 로고
    • Transcriptional regulatory networks in Th17 cell differentiation
    • Zhou L., Littman D.R. Transcriptional regulatory networks in Th17 cell differentiation. Curr. Opin. Immunol. 2009, 21:146-152.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 146-152
    • Zhou, L.1    Littman, D.R.2


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