Deletion of a coordinate regulator of type 2 cytokine expression in mice

Nature Immunology

Volumn 2, Issue 9, 2001, Pages 842-847

  Mohrs, Markus ^a   Blankespoor, Catherine M ^b   Wang, Zhi En ^a   Loots, Gaby G ^b   Afzal, Veena ^b   Hadeiba, Husein ^a   Shinkai, Kanade ^a   Rubin, Edward M ^b   Locksley, Richard M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; SPACER DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL MATURATION; CELL SPECIFICITY; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; HELPER CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MALE; MAST CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REGULATORY SEQUENCE; SIGNAL TRANSDUCTION; TH2 CELL; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; ASPERGILLOSIS; CELLS, CULTURED; CONSERVED SEQUENCE; CYTOKINES; DNA, INTERGENIC; GENE TARGETING; INTERLEUKIN-4; LEISHMANIASIS, CUTANEOUS; MAST CELLS; MICE; MICE, KNOCKOUT; RNA, MESSENGER; SEQUENCE DELETION; STRONGYLIDA INFECTIONS; TH2 CELLS;

EID: 0035555263     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0901-842     Document Type: Article

References (49)

1. Lineage commitment in the immune system: The T helper lymphocyte grows up
2. Early transcription and silencing of cytokine genes underlie polarization of T helper subsets
3. H2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
4. Helper T cell differentiation is controlled by the cell cycle
5. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
6. +T lymphocytes
7. H2 cytokine gene expression in CD4 T cells
8. H1 lineage commitment
9. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
10. Locus control regions: Coming of age at a decade plus
11. Identification of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparisons
12. H2 clones revealed by allelic expression patterns
13. Genomic strategies to identify mammalian regulatory sequences
14. Stat6-independent production of IL-4 by mast cells
15. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene
16. Cutting edge: IL-4 production by mast cells does not require c-maf
17. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
18. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
19. Interleukin 10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
20. The regulation of immunity to leishmania major
21. Molecular dissection of the mouse interleukin-4 promoter
22. Identification of fis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
23. Regulation of cytokine gene expression in T helper cell subsets
24. Multiple closely-linked NFAT/octamer and HMG 1 (Y) binding sites are part of the interleukin-4 promoter
25. Transcription of the interleukin 4 gene is regulated by multiple promoter elements
26. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
27. H2 cytokine production
28. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
29. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation
30. H2-restricted expression during T helper cell subset development
31. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
32. H2 development and commitment
33. H2-specific cytokine gene cluster
34. H1 cells
35. H1 cells
36. Looping, linking, and chromatin activity: New insights into β-globin locus regulation
37. Stable propagation of the active transcriptional state of an immunoglobulin μ gene requires continuous enhancer function
38. B cell-specific demethylation: A novel role for the intronic kappa chain enhancer sequence
39. A role of nuclear NF-κB in B-cell-specific demethylation of the Igκ locus
40. Gene-targeted deletion and replacement mutations of the T cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility
41. Function of the TCR α enhancer in α/β and γ/δ T cells
42. An intron transcriptional enhancer element regulates IL-4 gene locus accessibility in mast cells
43. Lethal α-thalassaemia created by gene targeting in mice and its genetic rescue
44. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
45. Cre-mediated gene deletion in the mammary gland
46. + cells
47. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells
48. Mast cell clones: A model for analysis of cellular maturation
49. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice