NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

European Journal of Immunology

Volumn 32, Issue 10, 2002, Pages 2971-2978

  Monticelli, Silvia ^a   Rao, Anjana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Gene regulation; T lymphocyte; Transcription factor

Indexed keywords

ALANINE; INTERLEUKIN 4; SERINE; TRANSCRIPTION FACTOR NFAT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; IMMUNOCOMPETENT CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; MICE; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036773634     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2002010)32:10<2971::AID-IMMU2971>3.0.CO;2-G     Document Type: Article

References (32)

1. Feske, S., Giltnane, J., Dolmetsch, R., Staudt, L. M. and Rao A., Gene regulation mediated by calcium signals in T lymphocytes. Nat. Immunol. 2001. 2: 316-324.
2. Macian, F., Lopez-Rodriguez, C. and Rao, A., Partners in transcription: NFAT and AP-1. Oncogene 2001. 20: 2476-2489.
3. Rao, A., Luo, C. and Hogan, P. G., Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 1997. 15: 707-747.
4. Kiani, A., Rao, A. and Aramburu, J., Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 2000. 12: 359-372.
5. 2+ calcineurin and NF-AT. Cell 1999. 96: 611-614.
6. Lopez-Rodriguez, C., Aramburu, J., Rakeman, A. S. and Rao, A., NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc. Natl. Acad. Sci. USA 1999. 96: 7214-7219.
7. Viola, J. P. and Rao, A., Molecular regulation of cytokine gene expression during the immune response. J. Clin. Immunol. 1999. 19: 98-108.
8. Ranger, A. M., Grusby, M. J., Hodge, M. R., Gravallese, E. M., de la Brousse, F. C., Hoey, T., Mickanin, C., Baldwin, H. S. and Glimcher, L. H., The transcription factor NFATc is essential for cardiac valve formation. Nature 1998. 392: 186-190.
9. de la Pompa, J. L., Timmerman, L. A., Takimoto, H., Yoshida, H., Elia, A. J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B. L., Crabtree, G. R. and Mak, T. W., Role of NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 1998. 392: 182-186.
10. Ranger, A. M., Hodge, M. R., Gravallese, E. M., Oukka, M., Davidson, L., Alt, F. W., de la Brousse, F. C., Hoey, T., Grusby, M. and Glimcher, L. H., Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998. 8: 125-134.
11. Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E., Wakeham, A. C., Bouchard, D., Kong, Y. Y., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, P. S., Penninger, J. M., Crabtree, G. R. and Mak, T. W., The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 1998. 8: 115-124.
12. Kiani, A., Viola, J. P. B., Lichtman, A. H. and Rao, A., Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 1997. 7: 849-860.
13. Viola, J. P. B., Kiani, A., Bozza, P. T. and Rao, A., Regulation of allergic inflammation and eosinophils recruitment in mice lacking the transcription factor NFAT1: role of interleukin-4 (IL-4) and IL-5. Blood 1998. 91: 2223-2230.
14. Hodge, M. R., Ranger, A. M., de la Brousse, F. C., Hoey, T., Grusby, M. J. and Glimcher, L. H., Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 1996. 4: 397-405.
15. Schuh, K., Kneitz, B., Heyer, J., Siebelt, F., Fischer, C., Jankevics, E., Rude, E., Schmitt, E., Schimpl, A. and Serfling, E., NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines. Immunol. Lett. 1997. 57: 171-175.
16. Schuh, K., Kneitz, B., Heyer, J., Bommhardt, U., Jankevics, E., Berberich-Siebelt, F., Pfeffer, K., Muller-Hermelink, H. K., Schimpl, A. and Serfling, E., Retarted thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur. J. Immunol. 1998. 28: 2456-2466.
17. Peng, S. L., Gerth, A. J., Ranger, A. M. and Glimcher, L. H., NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 2001. 14: 13-20.
18. Okamura, H., Aramburu, J., Garcia-Rodriguez, C., Viola, J. P. B., Raghavan, A., Tahiliani, M., Zhang, X., Qin, J., Hogan, P. G. and Rao, A., Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell 2000. 6: 539-550.
19. Shaw, K. T., Ho, A. M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A. and Hogan, P. G., Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. USA 1995. 92: 11205-11209.
20. Porter, C. M., Havens, M. A. and Clipstone, N. A., Identification of amino acid residues and protein kinases; involved in the regulation of NFATc subcellular localization. J. Biol. Chem. 2000. 275: 3543-3551.
21. Neal, J. W. and Clipstone, N. A., Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc. J. Biol. Chem. 2001. 276: 3666-3673.
22. Chen, L., Glover, J. N., Hogan, P. G., Rao, A. and Harrison, S. C., Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 1998. 392: 42-48.
23. Serfling, E., Berberich-Siebelt, F., Chuvpilo, S., Jankevics, E., Klein-Hessling, S., Twardzik, T. and Avots, A., The role of NFAT transcription factors in T cell activation and differentiation. Biochim. Biophys. Acta 2000. 1498: 1-18.
24. Northrop, J. P., Ho, S. N., Chen, L., Thomas, D. J., Timmerman, L. A., Nolan, G. P., Admon, A. and Crabtree, G. R., NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 1994. 369: 497-502.
25. Kiani, A., Garcia-Cozar, F. J., Habermann, I., Laforsch, S., Aebischer, T., Ehninger, G. and Rao, A., Regulation of interferon-gamma gene expression by nuclear factor of activated T cells. Blood 2001. 98: 1480-1488.
26. Loh, C., Carew, J. A., Kim, J., Hogan, P. G. and Rao, A., T cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol. Cell. Biol. 1996. 16: 3945-3954.
27. + T cells. J. Immunol. 2002. 168: 3825-3832.
28. Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J. and Flavell, R. A., Defective T cell differentiation in the absence of Jnk1. Science 1998. 282: 2092-2095.
29. Ranger, A. M., Oukka, M., Rengarajan, J. and Glimcher, L. H., Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 1998. 9: 627-635.
30. Kaye, J., Porcelli, S., Tite, J., Jones, B. and Janeway, C. A. Jr, Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 1983. 158: 836-856.
31. Agarwal, S. and Rao, A., Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998. 9: 765-775.
32. Aramburu, J., Azzoni, L., Rao, A. and Perussia, B., Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding. J. Exp. Med. 1995. 182: 801-810.