-
1
-
-
0030890586
-
Cellular responses to interferon-γ
-
Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15: 749-795.
-
(1997)
Annu. Rev. Immunol
, vol.15
, pp. 749-795
-
-
Boehm, U.1
Klamp, T.2
Groot, M.3
Howard, J.C.4
-
2
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
3
-
-
0036301997
-
Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction
-
Mullen, A. C., A. S. Hutchins, F. A. High, H. W. Lee, K. J. Sykes, L. A. Chodosh, and S. L. Reiner. 2002. Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction. Nat. Immunol. 3: 652-658.
-
(2002)
Nat. Immunol
, vol.3
, pp. 652-658
-
-
Mullen, A.C.1
Hutchins, A.S.2
High, F.A.3
Lee, H.W.4
Sykes, K.J.5
Chodosh, L.A.6
Reiner, S.L.7
-
4
-
-
0347364695
-
Up-regulation of Hlx in immature Th cells induces IFN-γ expression
-
Zheng, W. P., Q. Zhao, X. Zhao, B. Li, M. Hubank, D. G. Schatz, and R. A. Flavell. 2004. Up-regulation of Hlx in immature Th cells induces IFN-γ expression. J. Immunol. 172: 114-122.
-
(2004)
J. Immunol
, vol.172
, pp. 114-122
-
-
Zheng, W.P.1
Zhao, Q.2
Zhao, X.3
Li, B.4
Hubank, M.5
Schatz, D.G.6
Flavell, R.A.7
-
5
-
-
0032212793
-
Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
-
Ouyang, W., S. H. Ranganath, K. Weindel, D. Bhattacharya, T. L. Murphy, W. C. Sha, and K. M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9: 745-755.
-
(1998)
Immunity
, vol.9
, pp. 745-755
-
-
Ouyang, W.1
Ranganath, S.H.2
Weindel, K.3
Bhattacharya, D.4
Murphy, T.L.5
Sha, W.C.6
Murphy, K.M.7
-
6
-
-
0032906187
-
GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
-
Ferber, I. A., H. J. Lee, F. Zonin, V. Heath, A. Mui, N. Arai, and A. O'Garra. 1999. GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin. Immunol. 91:134-144.
-
(1999)
Clin. Immunol
, vol.91
, pp. 134-144
-
-
Ferber, I.A.1
Lee, H.J.2
Zonin, F.3
Heath, V.4
Mui, A.5
Arai, N.6
O'Garra, A.7
-
7
-
-
0000344022
-
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
-
Lee, H. J., N. Takemoto, H. Kurata, Y. Kamogawa, S. Miyatake, A. O'Garra, and N. Arai. 2000. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med. 192:105-115.
-
(2000)
J. Exp. Med
, vol.192
, pp. 105-115
-
-
Lee, H.J.1
Takemoto, N.2
Kurata, H.3
Kamogawa, Y.4
Miyatake, S.5
O'Garra, A.6
Arai, N.7
-
8
-
-
0027364319
-
Two essential regulatory elements in the human interferon γ promoter confer activation specific expression in T cells
-
Penix, L., W. M. Weaver, Y. Pang, H. A. Young, and C. B. Wilson. 1993. Two essential regulatory elements in the human interferon γ promoter confer activation specific expression in T cells. J. Exp. Med. 178: 1483-1496.
-
(1993)
J. Exp. Med
, vol.178
, pp. 1483-1496
-
-
Penix, L.1
Weaver, W.M.2
Pang, Y.3
Young, H.A.4
Wilson, C.B.5
-
9
-
-
0141506101
-
Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-γ promoter
-
Cho, J. Y., V. Grigura, T. L. Murphy, and K. Murphy. 2003. Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-γ promoter. Int. Immunol. 15: 1149-1160.
-
(2003)
Int. Immunol
, vol.15
, pp. 1149-1160
-
-
Cho, J.Y.1
Grigura, V.2
Murphy, T.L.3
Murphy, K.4
-
10
-
-
1042278131
-
A distal enhancer in the interferon-γ (IFN-γ) locus revealed by genome sequence comparison
-
Lee, D. U., O. Avni, L. Chen, and A. Rao. 2004. A distal enhancer in the interferon-γ (IFN-γ) locus revealed by genome sequence comparison. J. Biol. Chem. 279:4802- 4810.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 4802-4810
-
-
Lee, D.U.1
Avni, O.2
Chen, L.3
Rao, A.4
-
11
-
-
34250773899
-
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ
-
Schoenborn, J. R., M. O. Dorschner, M. Sekimata, D. M. Santer, M. Shnyreva, D. R. Fitzpatrick, J. A. Stamatoyonnapoulos, and C. B. Wilson. 2007. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ. Nat. Immunol. 8: 732-742.
-
(2007)
Nat. Immunol
, vol.8
, pp. 732-742
-
-
Schoenborn, J.R.1
Dorschner, M.O.2
Sekimata, M.3
Santer, D.M.4
Shnyreva, M.5
Fitzpatrick, D.R.6
Stamatoyonnapoulos, J.A.7
Wilson, C.B.8
-
12
-
-
4344574045
-
Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells
-
Shnyreva, M., W. M. Weaver, M. Blanchette, S. L. Taylor, M. Tompa, D. R. Fitzpatrick, and C. B. Wilson. 2004. Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells. Proc. Natl. Acad. Sci. USA 101: 12622-12627.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12622-12627
-
-
Shnyreva, M.1
Weaver, W.M.2
Blanchette, M.3
Taylor, S.L.4
Tompa, M.5
Fitzpatrick, D.R.6
Wilson, C.B.7
-
13
-
-
0035879281
-
Unexpected characteristics of the IFN-γ reporters in nontransformed T cells
-
Zhu, H., J. Yang, T. L. Murphy, W. Ouyang, F. Wagner, A. Saparov, C. T. Weaver, and K. M. Murphy. 2001. Unexpected characteristics of the IFN-γ reporters in nontransformed T cells. J. Immunol. 167: 855-865.
-
(2001)
J. Immunol
, vol.167
, pp. 855-865
-
-
Zhu, H.1
Yang, J.2
Murphy, T.L.3
Ouyang, W.4
Wagner, F.5
Saparov, A.6
Weaver, C.T.7
Murphy, K.M.8
-
14
-
-
0037114123
-
Cutting edge: Distal regulatory elements are required to achieve selective expression of IFN-γ in Th1/Tc1 effector cells
-
Soutto, M., W. Zhou, and T. M. Aune. 2002. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-γ in Th1/Tc1 effector cells. J. Immunol. 169: 6664-6667.
-
(2002)
J. Immunol
, vol.169
, pp. 6664-6667
-
-
Soutto, M.1
Zhou, W.2
Aune, T.M.3
-
15
-
-
0346458664
-
Dynamic alterations in the conformation of the IFN-γ gene region during T helper cell differentiation
-
Eivazova, E. R., and T. M. Aune. 2004. Dynamic alterations in the conformation of the IFN-γ gene region during T helper cell differentiation. Proc. Natl. Acad. Sci. USA 101: 251-256.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 251-256
-
-
Eivazova, E.R.1
Aune, T.M.2
-
16
-
-
0032412441
-
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
-
Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9: 765-775.
-
(1998)
Immunity
, vol.9
, pp. 765-775
-
-
Agarwal, S.1
Rao, A.2
-
17
-
-
0035839136
-
Translating the histone code
-
Jenuwein, T., and C. D. Allis. 2001. Translating the histone code. Science 293: 1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
18
-
-
0035070195
-
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
-
Grogan, J. L., M. Mohrs, B. Harmon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14: 205-215.
-
(2001)
Immunity
, vol.14
, pp. 205-215
-
-
Grogan, J.L.1
Mohrs, M.2
Harmon, B.3
Lacy, D.A.4
Sedat, J.W.5
Locksley, R.M.6
-
19
-
-
0036305450
-
TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
-
Avni, O., D. Lee, F. Macian, S. J. Szabo, L. H. Glimcher, and A. Rao. 2002. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3: 643-651.
-
(2002)
Nat. Immunol
, vol.3
, pp. 643-651
-
-
Avni, O.1
Lee, D.2
Macian, F.3
Szabo, S.J.4
Glimcher, L.H.5
Rao, A.6
-
20
-
-
0037100265
-
Cutting edge: Changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation
-
Fields, P. E., S. T. Kim, and R. A. Flavell. 2002. Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J. Immunol. 169: 647-650.
-
(2002)
J. Immunol
, vol.169
, pp. 647-650
-
-
Fields, P.E.1
Kim, S.T.2
Flavell, R.A.3
-
21
-
-
0037236203
-
Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes
-
Messi, M., I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, and F. Sallusto. 2003. Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes. Nat. Immunol. 4: 78-86.
-
(2003)
Nat. Immunol
, vol.4
, pp. 78-86
-
-
Messi, M.1
Giacchetto, I.2
Nagata, K.3
Lanzavecchia, A.4
Natoli, G.5
Sallusto, F.6
-
22
-
-
4644292455
-
A distal region in the interferon-γ gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2
-
Bream, J. H., D. L. Hodge, R. Gonsky, R. Spolski, W. J. Leonard, S. Krebs, S. Targan, A. Morinobu, J. J. O'Shea, and H. A. Young. 2004. A distal region in the interferon-γ gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J. Biol. Chem. 279: 41249-41257.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 41249-41257
-
-
Bream, J.H.1
Hodge, D.L.2
Gonsky, R.3
Spolski, R.4
Leonard, W.J.5
Krebs, S.6
Targan, S.7
Morinobu, A.8
O'Shea, J.J.9
Young, H.A.10
-
23
-
-
4644320690
-
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression
-
Morinobu, A., Y. Kanno, and J. J. O'Shea. 2004. Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. J. Biol. Chem. 279: 40640-40646.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 40640-40646
-
-
Morinobu, A.1
Kanno, Y.2
O'Shea, J.J.3
-
24
-
-
28044433631
-
Histone hyperacetylated domains across the IFN-γ gene region in natural killer cells and T cells
-
Chang, S., and T. M. Aune. 2005. Histone hyperacetylated domains across the IFN-γ gene region in natural killer cells and T cells. Proc. Natl. Acad. Sci. USA 102: 17095-17100.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17095-17100
-
-
Chang, S.1
Aune, T.M.2
-
25
-
-
34250762587
-
Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells
-
Chang, S., and T. M. Aune. 2007. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells. Nat. Immunol. 8: 723-731.
-
(2007)
Nat. Immunol
, vol.8
, pp. 723-731
-
-
Chang, S.1
Aune, T.M.2
-
26
-
-
34250781598
-
Epigenetic regulation of IFN-γ expression
-
Spilianakis, C. G., and R. A. Flavell. 2007. Epigenetic regulation of IFN-γ expression. Nat Immunol. 8: 681-683.
-
(2007)
Nat Immunol
, vol.8
, pp. 681-683
-
-
Spilianakis, C.G.1
Flavell, R.A.2
-
27
-
-
3242733265
-
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions
-
Yang, L., and T. Mosmann. 2004. Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions. Eur. J. Immunol. 34: 1617-1626.
-
(2004)
Eur. J. Immunol
, vol.34
, pp. 1617-1626
-
-
Yang, L.1
Mosmann, T.2
-
28
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
29
-
-
31144446876
-
Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation
-
Mikhalkevich, N., B. Becknell, M. A. Caligiuri, M. D. Bates, R. Harvey, and W. P. Zheng. 2006. Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation. J. Immunol. 176: 1553-1560.
-
(2006)
J. Immunol
, vol.176
, pp. 1553-1560
-
-
Mikhalkevich, N.1
Becknell, B.2
Caligiuri, M.A.3
Bates, M.D.4
Harvey, R.5
Zheng, W.P.6
-
30
-
-
19944430797
-
Genomic maps and comparative analysis of histone modifications in human and mouse
-
Bernstein, B. E., M. Kamal, K. Lindblad-Toh, S. Bekiranov, D. K. Bailey, D. J. Huebert, S. McMahon, E. K. Karlsson, E. J. Kulbokas, III, T. R. Gingeras, S. L. Schreiber, and E. S. Lander. 2005. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120: 169-181.
-
(2005)
Cell
, vol.120
, pp. 169-181
-
-
Bernstein, B.E.1
Kamal, M.2
Lindblad-Toh, K.3
Bekiranov, S.4
Bailey, D.K.5
Huebert, D.J.6
McMahon, S.7
Karlsson, E.K.8
Kulbokas III, E.J.9
Gingeras, T.R.10
Schreiber, S.L.11
Lander, E.S.12
-
31
-
-
18744373853
-
MLL targets SET domain methyltransferase activity to Hox gene promoters
-
Milne, T. A., S. D. Briggs, H. W. Brock, M. E. Martin, D. Gibbs, C. D. Allis, and J. L. Hess. 2002. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol. Cell. 10: 1107-1117.
-
(2002)
Mol. Cell
, vol.10
, pp. 1107-1117
-
-
Milne, T.A.1
Briggs, S.D.2
Brock, H.W.3
Martin, M.E.4
Gibbs, D.5
Allis, C.D.6
Hess, J.L.7
-
33
-
-
0029732843
-
The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells
-
Penix, L. A., M. T. Sweetser, W. M. Weaver, J. P. Hoeffler, T. K. Kerppola, and C. B. Wilson. 1996. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J. Biol. Chem. 271: 31964-31972.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 31964-31972
-
-
Penix, L.A.1
Sweetser, M.T.2
Weaver, W.M.3
Hoeffler, J.P.4
Kerppola, T.K.5
Wilson, C.B.6
-
34
-
-
4043172850
-
A determining influence for CpG dinucleotides on nucleosome positioning in vitro
-
Davey, C. S., S. Pennings, C. Reilly, R. R. Meehan, and J. Allan. 2004. A determining influence for CpG dinucleotides on nucleosome positioning in vitro. Nucleic Acids Res. 32: 4322-4331.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 4322-4331
-
-
Davey, C.S.1
Pennings, S.2
Reilly, C.3
Meehan, R.R.4
Allan, J.5
-
35
-
-
1942489758
-
Nucleosomal locations of dominant DNA sequence motifs for histone-DNA interactions and nucleosome positioning
-
Thastrom, A., L. M. Bingham, and J. Widom. 2004. Nucleosomal locations of dominant DNA sequence motifs for histone-DNA interactions and nucleosome positioning. J. Mol. Biol. 338: 695-709.
-
(2004)
J. Mol. Biol
, vol.338
, pp. 695-709
-
-
Thastrom, A.1
Bingham, L.M.2
Widom, J.3
-
36
-
-
0035997908
-
+ T cells (see comment)
-
+ T cells (see comment). Nat. Immunol. 3: 549-557.
-
(2002)
Nat. Immunol
, vol.3
, pp. 549-557
-
-
Afkarian, M.1
Sedy, J.R.2
Yang, J.3
Jacobson, N.G.4
Cereb, N.5
Yang, S.Y.6
Murphy, T.L.7
Murphy, K.M.8
-
37
-
-
3843060051
-
Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development
-
Baguet, A., and M. Bix. 2004. Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc. Natl. Acad. Sci. USA 101: 11410-11415.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 11410-11415
-
-
Baguet, A.1
Bix, M.2
-
38
-
-
29144461548
-
Intergenic transcription is not required in Th2 cells to maintain histone acetylation and transcriptional permissiveness at the IL4-IL13 locus
-
Baguet, A., X. Sun, T. Arroll, A. Krumm, and M. Bix. 2005. Intergenic transcription is not required in Th2 cells to maintain histone acetylation and transcriptional permissiveness at the IL4-IL13 locus. J. Immunol. 175: 8146-8153.
-
(2005)
J. Immunol
, vol.175
, pp. 8146-8153
-
-
Baguet, A.1
Sun, X.2
Arroll, T.3
Krumm, A.4
Bix, M.5
-
39
-
-
0345735834
-
Basal chromatin modification at the IL-4 gene in helper T cells
-
Grogan, J. L., Z. E. Wang, S. Stanley, B. Harmon, G. G. Loots, E. M. Rubin, and R. M. Locksley. 2003. Basal chromatin modification at the IL-4 gene in helper T cells. J. Immunol. 171: 6672-6679.
-
(2003)
J. Immunol
, vol.171
, pp. 6672-6679
-
-
Grogan, J.L.1
Wang, Z.E.2
Stanley, S.3
Harmon, B.4
Loots, G.G.5
Rubin, E.M.6
Locksley, R.M.7
-
40
-
-
1442281449
-
Long-range histone acetylation of the IFN-γ gene is an essential feature of T cell differentiation
-
Zhou, W., S. Chang, and T. M. Aune. 2004. Long-range histone acetylation of the IFN-γ gene is an essential feature of T cell differentiation. Proc. Natl. Acad. Sci. USA 101: 2440-2445.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2440-2445
-
-
Zhou, W.1
Chang, S.2
Aune, T.M.3
-
41
-
-
0035341465
-
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
-
Litt, M. D., M. Simpson, F. Recillas-Targa, M. N. Prioleau, and G. Felsenfeld. 2001. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J. 20: 2224-2235.
-
(2001)
EMBO J
, vol.20
, pp. 2224-2235
-
-
Litt, M.D.1
Simpson, M.2
Recillas-Targa, F.3
Prioleau, M.N.4
Felsenfeld, G.5
-
42
-
-
0035839110
-
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
-
Noma, K., C. D. Allis, and S. I. Grewal. 2001. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293: 1150-1155.
-
(2001)
Science
, vol.293
, pp. 1150-1155
-
-
Noma, K.1
Allis, C.D.2
Grewal, S.I.3
-
43
-
-
4444234841
-
Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments
-
Rastegar, M., L. Kobrossy, E. N. Kovacs, I. Rambaldi, and M. Featherstone. 2004. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Mol. Cell. Biol. 24: 8090-8103.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 8090-8103
-
-
Rastegar, M.1
Kobrossy, L.2
Kovacs, E.N.3
Rambaldi, I.4
Featherstone, M.5
|