The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4414-4420

  Kishikawa, H ^a   Sun, J ^a   Choi, A ^a   Miaw, S ^a   Ho, I C ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR GATA 3;

ALLERGIC ASTHMA; ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; STAINING; TH2 CELL; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 0035887640     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4414     Document Type: Article

References (30)

1. Immunologic basis of antigen-induced airway hyperresponsiveness
2. Th2 cells and GATA-3 in asthma: New insights into the regulation of airway inflammation
3. Interleukin 13 is a B cell stimulating factor
4. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
5. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea
6. Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
7. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
8. Interleukin-13: Central mediator of allergic asthma
9. Requirement for IL-13 independently of IL-4 in experimental asthma
10. Interleukin-4 is required for the induction of lung Th2 mucosal immunity
11. The cattle interleukin-13 gene: Genomic organization, chromosomal location, and evolution of the promoter
12. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
13. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
14. + T-cell phenotype development
15. + T cells activated in a T helper type 2-like response in vivo
16. + T cell populations
17. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
18. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
19. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
20. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin-4-dependent and -independent mechanisms
21. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
22. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
23. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
24. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
25. ROG, repressor of GATA, regulates the expression of cytokine genes
26. Chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster
27. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
28. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns
29. An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3
30. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets