DNA vaccines for mucosal immunity to infectious diseases

Mucosal Immunology, Two-Volume Set

Volumn , Issue , 2005, Pages 1073-1084

  Herrmann, John E ^a   Robinson, Harriet L ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882822821     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012491543-5/50064-4     Document Type: Chapter

References (156)

1. Amara R.R., Villinger F., Altman J.D., Lydy S.L., O'Neil S.P., Staprans S.I., Montefiori D.C., Xu Y., Herndon J.G., Wyatt L.S., Candido M.A., Kozyr N.L., Earl P.L., Smith J.M., Ma H.L., Grimm B.D., Hulsey M.L., McClure H.M., McNicholl J.M., Moss B., Robinson H.L. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine 2002, 20:1949-1955.
2. Asakura Y., Hinkula J., Leandersson A.C., Fukushima J., Okuda K., Wahren B. Induction of HIV-1 specific mucosal immune responses by DNA vaccination. Scand. J. Immunol. 1997, 46:326-330.
3. Asakura Y., Liu L.J., Shono N., Hinkula J., Kjerrstrom A., Aoki I., Okuda K., Wahren B., Fukushima J. Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production. Clin. Exp. Immunol. 2000, 119:130-139.
4. Anderson E.D., Mourich D.V., Fahrenkrug S.C., LaPatra S., Shepherd J., Leong J.A. Genetic immunization of rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis virus. Mol. Mar. Biol. Biotechnol. 1996, 5:114-122.
5. Babiuk L.A., Pontarollo R., Babiuk S., Loehr B., van Drunen Littel-van den Hurk S. Induction of immune responses by DNA vaccines in large animals. Vaccine 2003, 21:649-658.
6. Bagarazzi M.L., Boyer J.D., Javadian M.A., Chattergoon M., Dang K., Kim G., Shah J., Wang B., Weiner D.B. Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees. J. Med. Primatol. 1997, 26:27-33.
7. Ban E.M., van Ginkel F.W., Simecka J.W., Kiyono H., Robinson H.L., McGhee J.R. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine 1997, 15:811-813.
8. Barnfield C., Brew R., Tilling R., Rae A., Wheeler C., Klavinskis L.S. The cellular basis of immune induction at mucosal surfaces by DNA vaccination. Dev. Biol. (Basel) 2000, 104:159-164.
9. Barry M.A., Barry M.E., Johnston S.A. Production of monoclonal antibodies by genetic immunization. Bio Techniques 1994, 16:616-620.
10. Barry M.A., Lai W.C., Johnston S.A. Protection against mycoplasma infection using expression-library immunization. Nature 1995, 377:632-635.
11. Bot A., Bot S., Garcia-Sastre A., Bona C. DNA immunization of newborn mice with a plasmid-expressing nucleoprotein of influenza virus. Viral Immunol. 1996, 9:207-210.
12. Bourne N., Milligan G.N., Schleiss M.R., Bernstein D.I., Stanberry L.R. DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2. Vaccine 1996, 14:1230-1234.
13. Bourne N., Stanberry L.R., Bernstein D.I., Lew D. DNA immunization against experimental genital herpes simplex virus infection. J. Infect. Dis 1996, 173:800-807.
14. Boyer J.D., Ugen K.E., Wang B., Agadjanyan M., Gilbert L., Bagarazzi M.L., Chattergoon M., Frost P., Javadian A., Williams W.V., Refaeli Y., Ciccarelli R.B., McCallus D., Coney L., Weiner D.B. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat. Med. 1997, 3:526-532.
15. Chen S.C., Fynan E.F., Greenberg H.B., Herrmann J.E. Immunity obtained by gene-gun inoculation of a rotavirus DNA vaccine to the abdominal epidermis or anorectal epithelium. Vaccine 1999, 17:3171-3176.
16. Chen S.C., Jones D.H., Fynan E.F., Farrar G.H., Clegg J.C., Greenberg H.B., Herrmann J.E. Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles. J. Virol. 1998, 72:5757-5761.
17. Cusi M.G., Zurbriggen R., Valassina M., Bianchi S., Durrer P., Valensin P.E., Donati M., Gluck R. Intranasal immunization with mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity. Virology 2000, 277:111-118.
18. Daheshia M., Kuklin N., Manickan E., Chun S., Rouse B.T. Immune induction and modulation by topical ocular administration of plasmid DNA encoding antigens and cytokines. Vaccine 1998, 16:1103-1110.
19. Darji A., zur Lage S., Garbe A.I., Chakraborty T., Weiss S. Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier. FEMS Immunol. Med. Microbiol. 2000, 27:341-349.
20. De Rose R., Tennent J., McWaters P., Chaplin P.J., Wood P.R., Kimpton W., Cahill R., Scheerlinck J.P. Efficacy of DNA vaccination by different routes of immunisation in sheep. Vet. Immunol. Immunopathol. 2002, 90:55-63.
21. Devico A.L., Fouts T.R., Shata M.T., Kamin-Lewis R., Lewis G.K., Hone D.M. Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1. Vaccine 2002, 20:1968-1974.
22. Dietrich G., Bubert A., Gentschev I., Sokolovic Z., Simm A., Catic A., Kaufmann S.H., Hess J., Szalay A.A., Goebel W. Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat. Biotechnol. 1998, 16:181-185.
23. Donnelly J.J., Friedman A., Martinez D., Montgomery D.L., Shiver J.W., Motzel S.L., Ulmer J.B., Liu M.A. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nat. Med. 1995, 1:583-587.
24. Donnelly J.J., Martinez D., Jansen K.U., Ellis R.W., Montgomery D.L., Liu M.A. Protection against papillomavirus with a polynucleotide vaccine. J. Infect. Dis. 1996, 713:314-320.
25. + cell-, interferon γ-, and nitric oxide-dependent immunity. J. Exp. Med. 1996, 183:1739-1746.
26. Eastman S.J., Lukason M.J., Tousignant J.D., Murray H., Lane M.D., St.George J.A., Akita G.Y., Cherry M., Cheng S.H., Scheule R.K. A concentrated and stable aerosol formulation of cationic lipid: DNA complexes giving high-level gene expression in mouse lung. Hum. Gene. Ther. 1997, 8:765-773.
27. Eo S.K., Gierynska M., Kamar A.A., Rouse B.T. Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules. J. Immunol. 2001, 166:5473-5479.
28. Epstein J.E., Gorak E.J., Charoenvit Y., Wang R., Freydberg N., Osinowo O., Richie T.L., Stoltz E.L., Trespalacios F., Nerges J., Ng J., Fallarme-Majam V., Abot E., Goh L., Parker S., Kumar S., Hedstrom R.C., Norman J., Stout R., Hoffman S.L. Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes. Hum. Gene Ther. 2002, 13:1551-1560.
29. Etchart N., Buckland R., Liu M.A., Wild T.F., Kaiserlian D. Class I-restricted CTL induction by mucosal immunization with naked DNA encoding measles virus haemagglutinin. J. Gen. Virol. 1997, 78:1577-1580.
30. Feltquate D.M., Heaney S., Webster R.G., Robinson H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 1997, 158:2278-2284.
31. Fennelly G.J., Khan S.A., Abadi M.A., Wild T.F., Bloom B.R. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector. J. Immunol. 1999, 162:1603-1610.
32. Fooks A.R., Sharpe S.A., Shallcross J.A., Clegg J.C., Cranage M.P. Induction of immunity using oral DNA vaccines expressing the measles virus nucleocapsid protein. Dev. Biol. (Basel) 2000, 104:65-71.
33. Fortunati E., Bout A., Zanta M.A., Valerio D., Scarpa M. In vitro and in vivo gene transfer to pulmonary cells mediated by cationic liposomes. Biochem. Biophys. Acta. 1996, 1306:55-62.
34. Fynan E.F., Webster R.G., Fuller D.H., Haynes J.R., Santoro J.C., Robinson H.L. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 1993, 90:11478-11482.
35. Garcia F., Petry K.U., Muderspach L., Gold M.A., Braly P., Crum C.P., Magill M., Silverman M., Urban R., Hedley M.L., Beach K.J. 2YC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trial. Obstet. Gynecol. 2004, 103:317-326.
36. Gerdts V., Snider M., Brownlie R., Babiuk L.A., Griebel P.J. Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate. J. Immunol. 2002, 168:1877-1885.
37. Ghiasi H., Cai S., Slanina S., Nesburn A.B., Wechsler S.L. Vaccination of mice with herpes simplex virus type 1 gly-coprotein D DNA produces low levels of protection against lethal HSV-1 challenge. Antiviral Res. 1995, 28:147-157.
38. Gonzalez Armas J.C., Morello C.S., Cranmer L.D., Spector D.H. DNA immunization confers protection against murine cytomegalovirus infection. J. Virol. 1996, 70:7921-7928.
39. Gramzinski R.A., Maris D.C., Obaldia N., Rossan R., Sedegah M., Wang R., Hobart P., Margalith M., Hoffman S. Optimization of antibody responses of a malaria DNA vaccine in Aotus monkeys. Vaccine Res. 1996, 5:173-184.
40. Gregoriadis G., Saffie R., de Souza J.B. Liposome-mediated DNA vaccination. FEBS Lett. 1997, 402:107-110.
41. Gregoriadis G., Bacon A., Caparros-Wanderley W., McCormack B. A role for liposomes in genetic vaccination. Vaccine 2002, 20(Suppl 5):B1-B9.
42. Gurunathan S., Klinman D.M., Seder R.A. DNA vaccines: immunology, application, and optimization. Annu. Rev. Immunol. 2000, 18:927-974.
43. Hamajima K., Hoshino Y., Xin K.Q., Hayashi F., Tadokoro K., Okuda K. Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine. Clin. Immunol. 2002, 102:12-18.
44. Hamajima K., Sasaki S., Fukushima J., Kaneko T., Xin K.Q., Kudoh I., Okuda K. Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response. Clin. Immunol. Immunopathol. 1998, 88:205-210.
45. Herrmann J.E., Chen S.C., Fynan E.F., Santoro J.C., Greenberg H.B., Wang S., Robinson H.L. Protection against rotavirus infections by DNA vaccination. J. Infect. Dis. 1996, 174(Suppl. 1):S93-S97.
46. Herrmann J.E., Chen S.C., Fynan E.F., Santoro J.C., Greenberg H.B., Robinson H.L. DNA vaccines against rotavirus infections. Arch. Virol. Suppl. 1996, 12:207-215.
47. Herrmann J.E., Chen S.C., Jones D.H., Tinsley-Bown A., Fynan E.F., Greenberg H.B., Farrar G.H. Immune responses and protection obtained by oral immunization with rotavirus VP4 and VP7 DNA vaccines encapsulated in microparticles. Virology 1999, 259:148-153.
48. Higgins T.J., Herold K.M., Arnold R.L., McElhiney S.P., Shroff K.E., Pachuk C.J. Plasmid DNA-expressed secreted and nonsecreted forms of herpes simplex virus glycoprotein D2 induce different types of immune responses. J. Infect. Dis. 2000, 182:1311-1320.
49. Hinkula J., Lundholm P., Wahren B. Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses. Vaccine 1997, 15:874-878.
50. Hooper J.W., Custer D.M., Thompson E. Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates. Virology 2003, 306:181-195.
51. Hsu C.H., Chua K.Y., Tao M.H., Lai Y.L., Wu H.D., Huang S.K., Hsieh K.H. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat. Med. 1996, 2:540-544.
52. Huygen K., Content J., Denis O., Montgomery D.L., Yawman A.M., Deck R.R., DeWitt C.M., Orme I.M., Baldwin S., D'Souza C., Drowart A., Lozes E., Vandenbussche P., Van Vooren J-P., Liu M.A., Ulmer J.B. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 1996, 2:893-898.
53. Ishii N., Fukushima J., Kaneko T., Okada E., Tani K., Tanaka S.I., Hamajima K., Xin K.Q., Kawamoto S., Koff W., Nishioka K., Yasuda T., Okuda K. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses 1997, 13:1421-1428.
54. Jiao X., Wang R.Y., Feng Z., Alter H.J., Shih J.W. Modulation of cellular immune response against hepatitis C virus nonstructural protein 3 by cationic liposome encapsulated DNA immunization. Hepatology 2003, 37:452-460.
55. Jones D.H., Corris S., McDonald S., Clegg J.C., Farrar G.H. Poly (DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine 1997, 15:814-817.
56. Jones D.H., Clegg J.C., Farrar G.H. Oral delivery of micro-encapsulated DNA vaccines. Dev. Biol. Stand. 1998, 92:149-155.
57. Kaneko H., Bednarek I., Wierzbicki A., Kiszka I., Dmochowski M., Wasik T.J., Kaneko Y., Kozbor D. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Virology 2000, 267:8-16.
58. Klavinskis L.S., Barnfield C., Gao L., Parker S. Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts. J. Immunol. 1999, 162:254-262.
59. Kriesel J.D., Spruance S.L., Daynes R.A., Araneo B.A. Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. J. Infect. Dis. 1996, 173:536-541.
60. Kuklin N., Daheshia M., Karem K., Manickan E., Rouse B.T. Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J. Virol. 1997, 71:3138-3145.
61. Larsen D.L., Karasin A., Olsen C.W. Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed-virus vaccine boosting. Vaccine 2001, 19:2842-2853.
62. Larsen D.L., Olsen C.W. Effects of DNA dose, route of vaccination, and coadministration of porcine interleukin-6 DNA on results of DNA vaccination against influenza virus infection in pigs. Am. J. Vet. Res. 2002, 63:653-659.
63. Le T.P., Coonan K.M., Hedstrom R.C., Charoenvit Y., Sedegah M., Epstein J.E., Kumar S., Wang R., Doolan D.L., Maguire J.D., Parker S.E., Hobart P., Norman J., Hoffman S.L. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine 2000, 18:1893-1901.
64. Ledwith B.J., Manam S., Troilo P.J., Barnum A.B., Pauley C.J., Griffiths T.G., Harper L.B., Beare C.M., Bagdon W.J., Nichols W.W. Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice. Intervirology 2000, 43:258-272.
65. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 2002, 20:709-760.
66. Lewis P.J., Babiuk L.A. DNA vaccines: a review. Adv. Virus Res. 1999, 54:129-188.
67. Livingston J.B., Lu S., Robinson H.L., Anderson D.J. The induction of mucosal immunity in the female genital tract using gene-gun technology. Part 1: Antigen expression. Ann. N.Y. Acad. Sci. 1995, 772:265-267.
68. Livingston J.B., Lu S., Robinson H., Anderson D.J. Immunization of the female genital tract with a DNA-based vaccine. Infect. Immun. 1998, 66:322-329.
69. Lodmell D.L., Ray N.B., Parnell M.J., Ewalt L.C., Hanlon C.A., Shaddock J.H., Sanderlin D.S., Rupprecht C.E. DNA immunization protects nonhuman primates against rabies virus. Nat. Med. 1998, 4:949-952.
70. Loehr B.I., Willson P., Babiuk L.A., van Drunen Littel-van den Hurk S. Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpesvirus 1 in cattle. J. Virol. 2000, 74:6077-6086.
71. Loehr B.I., Pontarollo R., Rankin R., Latimer L., Willson P., Babiuk L.A., van Drunen Littel-van den Hurk S. Priming by DNA immunization augments T-cell responses induced by modified live bovine herpesvirus vaccine. J. Gen. Virol. 2001, 82:3035-3043.
72. Loehr B.I., Rankin R., Pontarollo R., King T., Willson P., Babiuk L.A., van Drunen Littel-van den Hurk S. Suppository-mediated DNA immunization induces mucosal immunity against bovine herpesvirus-1 in cattle. Virology 2001, 289:327-333.
73. Lu S., Arthos J., Montefiori D.C., Yasutomi Y., Manson K., Mustafa F., Johnson E., Santoro J.C., Wissink J., Mullins J.I., Haynes J.R., Letvin N.L., Wyand M., Robinson H.L. Simian immunodeficiency virus DNA vaccine trial in macaques. J. Virol. 1996, 70:3978-3991.
74. Luke C.J., Carner K., Liang X., Barbour A.G. An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi. J. Infect. Dis. 1997, 175:91-97.
75. Lundholm P., Asakura Y., Hinkula J., Lucht E., Wahren B. Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA. Vaccine 1999, 17:2036-2042.
76. MacGregor R.R., Boyer J.D., Ugen K.E., Lacy K.E., Gluckman S.J., Bagarazzi M.L., Chattergoon M.A., Baine Y., Higgins T.J., Ciccarelli R.B., Coney L.R., Ginsberg R.S., Weiner D.B. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J. Infect. Dis. 1998, 178:92-100.
77. Macklin M.D., McCabe D., McGregor M.W., Neumann V., Meyer T., Callan R., Hinshaw V.S., Swain W.F. Immunization of pigs with a particle-mediated DNA vaccine to influenza A virus protects against challenge with homologous virus. J. Virol. 1998, 72:1491-1496.
78. + T lymphocytes. J. Immunol. 1995, 155:259-265.
79. Manickan E., Karem K.L., Rouse BT. DNA vaccines: a modern gimmick or a boon to vaccinology?. Crit. Rev. Immunol. 1997, 17:139-154.
80. Martin T., Parker S.E., Hedstrom R., Le T., Hoffman S.L., Norman J., Hobart P., Lew D. Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection. Hum. Gene Ther. 1999, 10:759-768.
81. Martins L.P., Lau L.L., Asano M.S., Ahmed R. DNA vaccination against persistent viral infection. J. Virol. 1995, 69:2574-2582.
82. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 1997, 386:410-414.
83. McClements W.L., Armstrong M.E., Keys R.D., Liu M.A. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc. Natl. Acad. Sci. USA 1996, 93:11414-11420.
84. McCluskie M.J., Brazolot Millan C.L., Gramzinski R.A., Robinson H.L., Santoro J.C., Fuller J.T., Widera G., Haynes J.R., Purcell R.H., Davis H.L. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol. Med. 1999, 5:287-300.
85. McCluskie M.J., Weeratna R.D., Davis H.L. The potential of oligodeoxynucleotides as mucosal and parenteral adjuvants. Vaccine 2001, 19:2657-2660.
86. Michalek S.M., Eldrige J.H., Curtiss R., Rosenthal K.L. Antigen delivery systems: New approaches to mucosal immunization. Handbook of Mucosal Immunology 1994, 373-390. Academic Press, San Diego. P.L. Ogra, M.L. Lamm, J.R. McGhee, J. Mestecky, W. Strober, J. Bienenstock (Eds.).
87. Michalek S.M., O'Hagen D.T., Gould-Fogerite S., Rimmelzwaan G.F., Osterhaus A.D.M.E. Antigen delivery systems: nonliving microparticles, liposomes, cochleates, and ISCOMs. Mucosal Immunology 1999, 759-778. Academic Press, San Diego. 2nd ed. P.L. Ogra, J. Mestecky, M.L. Lamm, W. Strober, J.R. McGhee, J. Bienenstock (Eds.).
88. Mitchell W.M., Rosenbloom S.T., Gabriel J. Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes. Immunotechnology 1995, 1:211-219.
89. Montgomery D.L., Shiver J.W., Leander K.R., Perry H.C., Friedman A., Martinez D., Ulmer J.B., Donnelly J.J., Liu M.A. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell. Biol. 1993, 12:777-783.
90. Mor G., Yamshchikov G., Sedegah M., Takeno M., Wang R., Houghten R.A., Hoffman S., Klinman D.M. Induction of neonatal tolerance by plasmid DNA vaccination of mice. J. Clin. Invest. 1996, 98:2700-2705.
91. Mor G., Singla M., Steinberg A.D., Hoffman S.L., Okuda K., Klinman D.M. Do DNA vaccines induce autoimmune disease?. Hum. Gene Ther. 1997, 8:293-300.
92. Nichols W.W., Ledwith B.J., Manam S.V., Troilo P.J. Potential DNA vaccine integration into host cell genome. Ann. N.Y. Acad. Sci. 1995, 772:30-39.
93. Oh Y.K., Kim J.P., Hwang T.S., Ko J.J., Kim J.M., Yang J.S., Kim C.K. Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery. Vaccine 2001, 19:4519-4525.
94. O'Hagen T. Microparticles as oral vaccines. Novel Delivery Systems for Oral Vaccines 1994, 175-205. CRC Press, Boca Raton, Florida. D.T. O'Hagen (Ed.).
95. Okada E., Sasaki S., Ishii N., Aoki I., Yasuda T., Nishioka K., Fukushima J., Miyazaki J., Wahren B., Okuda K. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J. Immunol. 1997, 159:3638-3647.
96. Pasetti M.F., Barry E.M., Losonsky G., Singh M., Medina-Moreno S.M., Polo J.M., Ulmer J., Robinson H., Sztein M.B., Levine M.M. Attenuated Salmonella enterica serovar typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats. J. Virol. 2003, 77:5209-5217.
97. Perrie Y., Frederik P.M., Gregoriadis G. Liposome-mediated DNA vaccination: the effect of vesicle composition. Vaccine 2001, 19:3301-3310.
98. Perrie Y., Obrenovic M., McCarthy D., Gregoriadis G. Liposome (Lipodine)-mediated DNA vaccination by the oral route. J. Liposome Res. 2002, 12:185-197.
99. Pertmer T.M., Roberts T.R., Haynes J.R. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J. Virol. 1996, 70:6119-6125.
100. Pertmer T.M., Robinson H.L. Studies on antibody responses following neonatal immunization with influenza hemagglutinin DNA or protein. Virology 1999, 257:406-414.
101. Phillpotts R.J., Venugopal K., Brooks T. Immunisation with DNA polynucleotides protects mice against lethal challenge with St. Louis encephalitis virus. Arch. Virol. 1996, 141:743-749.
102. Prince A.M., Whalen R., Brotman B. Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine 1997, 15:916-919.
103. Raz E., Tighe H., Sato Y., Corr M., Dudler J.A., Roman M., Swain S.L., Spiegelberg H.L., Carson D.A. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl. Acad. Sci. USA 1996, 93:5141-5145.
104. Ramshaw I.A., Ramsay A.J. The prime-boost strategy: exciting prospects for improved vaccination. Immunol. Today 2000, 21:163-165.
105. Robinson H.L., Hunt L.A., Webster R.G. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine 1993, 11:957-960.
106. Robinson W.H., Prohaska S.S., Santoro J.C., Robinson H.L., Parnes J.R. Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. J. Immunol. 1995, 155:4739-4748.
107. Robinson H.L., Boyle C.A., Feltquate D.M., Morin M.J., Santoro J.C., Webster R.G. DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs. J. Infect. Dis. 1997, 176(Suppl 1):S50-S55.
108. Robinson H.L., Torres C.A. DNA vaccines. Semin. Immunol. 1997, 9:271-283.
109. Robinson H.L., Montefiori D.C., Johnson R.P., Manson K.H., Kalish M.L., Lifson J.D., Rizvi T.A., Lu S., Hu S.L., Mazzara G.P., Panicali D.L., Herndon J.G., Glickman R., Candido M.A., Lydy S.L., Wyand M.S., McClure H.M. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations. Nat. Med. 1999, 5:526-534.
110. Rothel J.S., Boyle D.B., Both G.W., Pye A.D., Waterkeyn J.G., Wood P.R., Lightowlers M.W. Sequential nucleic acid and recombinant adenovirus vaccination induces host-protective immune responses against Taenia ovis infection in sheep. Parasite Immunol. 1997, 19:221-227.
111. Roy K., Mao H.Q., Huang S.K., Leong K.W. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 1999, 5:387-391.
112. Roy M.J., Wu M.S., Barr L.J., Fuller J.T., Tussey L.G., Speller S., Culp J., Burkholder J.K., Swain W.F., Dixon R.M., Widera G., Vessey R., King A., Ogg G., Gallimore A., Haynes J.R., Heydenburg Fuller D. Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine 2000, 19:764-778.
113. Sankar V., Baccaglini L., Sawdey M., Wheeler C.J., Pillemer S.R., Baum B.J., Atkinson J.C. Salivary gland delivery of pDNA-cationic lipoplexes elicits systemic immune responses. Oral Dis. 2002, 8:275-281.
114. Sasaki S., Hamajima K., Fukushima J., Ihata A., Ishii N., Gorai I., Hirahara F., Mohri H., Okuda K. Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine. Infect. Immun. 1998, 66:823-826.
115. Schneider J., Gilbert S.C., Hannan C.M., Degano P., Prieur E., Sheu E.G., Plebanski M., Hill A.V. Induction of CD8+ T cells using heterologous prime-boost immunisation strategies. Immunol. Rev. 1999, 170:29-38.
116. Sedegah M., Hedstrom R., Hobart P., Hoffman S.L. Protection against malaria by immunization with plasmid DNA encoding circusmporozoite protein. Proc. Natl. Acad. Sci. USA 1994, 91:9866-9870.
117. Shata M.T., Hone D.M. Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8 (+) T cells and antiviral protective immunity. J. Virol. 2001, 75:9665-9670.
118. Sharpe S., Hanke T., Tinsley-Bown A., Dennis M., Dowall S., McMichael A., Cranage M. Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara. Virology 2003, 313:13-21.
119. Shiver J.W., Fu T.M., Chen L., Casimiro D.R., Davies M.E., Evans R.K., Zhang Z.Q., Simon A.J., Trigona W.L., Dubey S.A., Huang L., Harris V.A., Long R.S., Liang X., Handt L., Schleif W.A., Zhu L., Freed D.C., Persaud N.V., Guan L., Punt K.S., Tang A., Chen M., Wilson K.A., Collins K.B., Heidecker G.J., Fernandez V.R., Perry H.C., Joyce J.G., Grimm K.M., Cook J.C., Keller P.M., Kresock D.S., Mach H., Troutman R.D., Isopi L.A., Williams D.M., Xu Z., Bohannon K.E., Volkin D.B., Montefiori D.C., Miura A., Krivulka G.R., Lifton M.A., Kuroda M.J., Schmitz J.E., Letvin N.L., Caulfield M.J., Bett A.J., Youil R., Kaslow D.C., Emini E.A. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 2002, 415:331-335.
120. + cells in Peyer's patches and mucosal antibody responses in mice following DNA immunization by both parenteral and mucosal administration. Vaccine 1999, 18:222-230.
121. Simon M.M., Gern L., Hauser P., Zhong W., Nielsen P.J., Kramer M.D., Brenner C., Wallich R. Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter. Eur. J. Immunol. 1996, 26:2831-2840.
122. Singh M., Vajdy M., Gardner J., Briones M., O'Hagan D. Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity. Vaccine 2001, 20:594-602.
123. Sizemore D.R., Branstrom A.A., Sadoff J.C. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization. Science 1995, 270:299-302.
124. Sizemore D.R., Branstrom A.A., Sadoff J.C. Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization. Vaccine 1997, 15:804-807.
125. Skinner M.A., Ramsay A.J., Buchan G.S., Keen D.L., Ranasinghe C., Slobbe L., Collins D.M., de Lisle G.W., Buddle B.M. A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis. Immunology 2003, 108:548-555.
126. Sundaram P., Xiao W., Brandsma J.L. Particle-mediated delivery of recombinant expression vectors to rabbit skin induces high-titered polyclonal antisera (and circumvents purification of a protein immunogen). Nucleic Acid. Res. 1996, 24:1375-1377.
127. Syrengelas A.D., Chen T.T., Levy R. DNA immunization induces protective immunity against B-cell lymphoma. Nat. Med. 1996, 2:1038-1041.
128. Tang D.C., DeVit M., Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356:152-154.
129. Tascon R.E., Colston M.J., Ragno S., Stavropoulos E., Gregory D., Lowrie D.B. Vaccination against tuberculosis by DNA injection. Nat. Med. 1996, 2:888-892.
130. Torres C.A., Yang K., Mustafa F., Robinson H.L. DNA immunization: effect of secretion of DNA-expressed hemagglutinins on antibody responses. Vaccine 1999, 18:805-814.
131. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., Gromkowski S.H., Deck R.R., DeWitt C.M., Friedman A., Hawe L.A., Leander K.R., Martinez D., Perry H.C., Shiver J.W., Montogmery D.L., Liu M.A. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993, 259:1745-1749.
132. Vanrompay D., Cox E., Volckaert G., Goddeeris B. Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein. Clin. Exp. Immunol. 1999, 118:49-55.
133. van Rooij E.M., Haagmans B.L., de Visser Y.E., de Bruin M.G., Boersma W., Bianchi AT. Effect of vaccination route and composition of DNA vaccine on the induction of protective immunity against pseudorabies infection in pigs. Vet. Immunol. Immunopathol. 1998, 66:113-126.
134. Vecino W.H., Morin P.M., Agha R., Jacobs W.R., Fennelly GJ. Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV. Immunol. Lett. 2002, 82:197-204.
135. Waisman A., Ruiz P.J., Hirschberg D.L., Gelman A., Oksenberg J.R., Brocke S., Mor F., Cohen I.R., Steinman L. Suppressive vaccination with DNA encoding available region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat. Med. 1996, 2:899-905.
136. Wang B., Dang K., Agadjanyan M.G., Srikantan V., Li F., Ugen K.E., Boyer J., Merva M., Williams W.V., Weiner D.B. Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site. Vaccine 1997, 15:821-825.
137. Wang Y., Xiang Z., Pasquini S., Ertl H.C. Immune response to neonatal genetic immunization. Virology 1997, 228:278-284.
138. Wang R., Doolan D.L., Le T.P., Hedstrom R.C., Coonan K.M., Charoenvit Y., Jones T.R., Hobart P., Margalith M., Ng J., Weiss W.R., Sedegah M., de Taisne C., Norman J.A., Hoffman S.L. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 1998, 282:476-480.
139. Wang S.W., Kozlowski P.A., Schmelz G., Manson K., Wyand M.S., Glickman R., Montefiori D., Lifson J.D., Johnson R.P., Neutra M.R., Aldovini A. Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. J. Virol. 2000, 74:10514-10522.
140. Wang R., Epstein J., Baraceros F.M., Gorak E.J., Charoenvit Y., Carucci D.J., Hedstrom R.C., Rahardjo N., Gay T., Hobart P., Stout R., Jones T.R., Richie T.L., Parker S.E., Doolan D.L., Norman J., Hoffman S.L. Induction of CD4 (+) T cell-dependent CD8 (+) type 1 responses in humans by a malaria DNA vaccine. Proc. Natl. Acad. Sci. USA 2001, 98:10817-10822.
141. Wang Q., Sun S., Hu Z., Wu D., Wang Z. Immune response and protection elicited by DNA immunisation against Taenia cysticercosis. Vaccine 2003, 21:1672-1680.
142. Webster D.E., Cooney M.L., Huang Z., Drew D.R., Ramshaw I.A., Dry I.B., Strugnell R.A., Martin J.L., Wesselingh S.L. Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine. J. Virol. 2002, 76:7910-7912.
143. Webster R.G., Fynan E.F., Santoro J.C., Robinson H. Protection of ferrets against influenza challenge with a DNA vaccine to the haemagglutinin. Vaccine 1994, 12:1495-1498.
144. Wheeler C.J., Felgner PL., Tsai Y.J., Marshall J., Sakhu L., Doh S.G., Hartikka J., Nietupski J., Manthorpe M., Nichols M., Plewe M., Liang X., Norman J., Smith A., Cheng S.H. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc. Natl. Acad. Sci. USA 1996, 93:11454-11459.
145. Wierzbicki A., Kiszka I., Kaneko H., Kmieciak D., Wasik T.J., Gzyl J., Kaneko Y., Kozbor D. Immunization strategies to augment oral vaccination with DNA and viral vectors expressing HIV envelope glycoprotein. Vaccine 2002, 20:1295-1307.
146. Winchell J.M., Routray S., Betts P.W., Van Kruiningen H.J., Silbart L.K. Mucosal and systemic antibody responses to a C4/V3 construct following DNA vaccination of rabbits via the Peyer's patch. J. Infect. Dis. 1998, 178:850-853.
147. Wolff J.A., Malone R.W., Williams P., Chong W., Acsadi G., Jani A., Felgner P.L. Direct gene transfer into mouse muscle in vivo. Science 1990, 247:1465-1468.
148. Wong J.P., Zabielski M.A., Schmaltz F.L., Brownlee G.G., Bussey L.A., Marshall K., Borralho T., Nagata L.P. DNA vaccination against respiratory influenza virus infection. Vaccine 2001, 19:2461-2467.
149. Xiang Z.Q., Spitalnik S., Tran M., Wunner W.H., Cheng J., Ertl H.C. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994, 199:132-140.
150. Xiang Z.Q., Spitalnik S.L., Cheng J., Erikson J., Wojczyk B., Ertl H.C. Immune responses to nucleic acid vaccines to rabies virus. Virology 1995, 209:569-579.
151. Xin K.Q., Hamajima K., Sasaki S., Tsuji T., Watabe S., Okada E., Okuda K. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine 1999, 17:858-866.
152. Xiong S., Gerloni M., Zanetti M. In vivo role of B lymphocytes in somatic transgene immunization. Proc. Natl. Acad. Sci. USA 1997, 94:6352-6357.
153. Xu D., Liew F.Y. Genetic vaccination against leishmaniasis. Vaccine 1994, 12:1534-1536.
154. Yokoyama M., Zhang J., Whitton J.L. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J. Virol. 1995, 69:2684-2688.
155. Zarozinski C.C., Fynan E.F., Selin L.K., Robinson H.L., Welsh R.M. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J. Immunol. 1995, 154:4010-4017.
156. Zhong W., Wiesmuller K.H., Kramer M.D., Wallich R., Simon M.M. Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo. Eur. J. Immunol. 1996, 26:2749-2757.