Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination

Nature Medicine

Volumn 3, Issue 5, 1997, Pages 526-532

  Boyer, Jean D ^a   Ugen, Kenneth E ^b   Wang, Bin ^a   Agadjanyan, Michael ^a   Gilbert, Lori ^a   Bagarazzi, Mark L ^a   Chattergoon, Michael ^a   Frost, Patrice ^c   Javadian, Ali ^a   Williams, Williams V ^d   Refaeli, Yosef ^e   Ciccarelli, Richard B ^f   Mccallus, Daniel ^f   Coney, Leslie ^f   Weiner, David B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Alamogordo Primate Facility   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Apollon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; PAN (APE); PAN TROGLODYTES;

EID: 16944363710     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0597-526     Document Type: Article

References (15)

1. Haynes, B.F., Pantaleo, G. & Fauci, A.S. Toward an understanding of the correlates of protective immunity to HIV infection. Science 271, 324-328 (1996).
2. Pantaleo, G. et al. Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N. Engl, J. Med. 332, 209-216 (1995).
3. Rinaldo, C. et al. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1 infected long-term nonprogressors. J. Virol. 69, 5838-5842 (1995).
4. Rowland-Jones, S. et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Cambian women. Nature Med. 1, 59-64 (1995).
5. Rowland-Jones, S., Nixon, D. & Aldhous, M. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 341, 860-861 (1993).
6. Ugen, K.E. et al. Vertical transmission of immunodeficiency virus type 1: Seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope. J. Infect. Dis. 175, 61-69 (1997).
7. Ugen, K.E. et al. Vertical transmission of human immunodeficiency virus (HIV) infection: Reactivity of maternal sera with glycoprotein 120 and 41 peptides from HIV type 1. J. Clin. Invest. 89, 1923-1930 (1992).
8. Rossi, P. et al. Presence of maternal antibodies to human immunodeficiency virus 1 envelope glycoprotein gp120 epitopes correlates with the uninfected status of children born to seropositive mothers. Proc. Natl. Acad. Sci. USA 86, 8055-8058 (1989).
9. Goedert, J. et al. Mother-to-infant transmission of human immunodeficiency virus type 1: Association with prematurity or low anti-gp120. Lancet 2, 1351-1354 (1989).
10. Dubensky, T., Campell, B. & Villarreal, L. Direct transfection of viral and plasmid DNA into the liver of spleen of mice. Proc. Natl. Acad. Sci. USA 81, 7529-7533 (1984).
11. Raz, E. et al. Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc. Natl. Acad. Sci. USA 90, 4523 (1993).
12. Wolff, J.A. et al. Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468 (1990).
13. Wang, B. et al. Immunization by direct DNA inoculation induces rejection of tumor cell challenge. Hum. Gene Ther. 6, 407-418 (1995).
14. Ulmer, J.B. et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1749 (1993).
15. Tang, D.C., Devit, M. & Johnston, S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152-154 (1992).