Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8+ T cells and antiviral protective immunity

Journal of Virology

Volumn 75, Issue 20, 2001, Pages 9665-9670

  Shata, M T ^a   Hone, D M ^a  

^a INSTITUTE OF HUMAN VIROLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DNA VACCINE; GLYCOPROTEIN GP 120; VACCINIA VACCINE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNITY; IMMUNOGENICITY; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHIGELLA; VACCINATION;

ADMINISTRATION, INTRANASAL; AIDS VACCINES; ANIMALS; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; GENETIC VECTORS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; SHIGELLA; VACCINATION; VACCINES, DNA;

EID: 0034807384     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.20.9665-9670.2001     Document Type: Article

References (34)

1. Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies
2. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage
3. + T cells produce antiviral cytokines but are impaired in cytolytic function
4. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
5. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge
6. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector
7. Construction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120
8. Highly attenuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques
9. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
10. Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen
11. Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus
12. Safety and immunogenicity study of the auxotrophic shigella flexneri 2a vaccine SFL1070 with a deleted aroD gene in adult Swedish volunteers
13. Auxotrophic live oral Shigella flexneri vaccine protects monkeys against challenge with S. flexneri of different serotypes
14. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
15. Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2
16. Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG
17. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
18. Protective mucosal immunity elicited by targeted lilac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
19. + T cells using an ELISPOT assay
20. Construction and characterization of attenuated ΔaroA ΔvirG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine
21. Quantitation of HIV-1-specific cytotoxie T lymphocytes and plasma load of viral RNA
22. Cloning and expression of foreign genes in vaccinia virus, using a host range selection system
23. Introduction of eukaryotic expression cassettes into animal cells using a bacterial vector delivery system
24. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
25. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization
26. Acute effects of pathogenic simian-human immunodeficiency virus challenge on vaccine-induced cellular and humoral immune responses to Gag in rhesus macaques
27. Induction of SIV capsid-specific CTL and mucosal sIgA in mice immunized with a recombinant S. typhimurium aroA mutant Vaccine
28. Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection
29. Enumeration of IFN-gamma-producing human lymphocytes by spot-ELISA. A method to detect lymphokine-producing lymphocytes at the single-cell level
30. + cells varies among infected individuals
31. Direct gene transfer into mouse muscle in vivo
32. Induction of mucosal and systemic responses against human immunodeficiency virus type 1 glycoprotein 120 in mice after oral immunization with a single dose of a Salmonella-HIV vector