Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell- mediated immune response

Clinical Immunology and Immunopathology

Volumn 88, Issue 2, 1998, Pages 205-210

  Hamajima, Kenji ^a   Sasaki, Shin ^a   Fukushima, Jun ^a   Kaneko, Tamiko ^a   Xin, Ke Qin ^b   Kudoh, Ichidai ^a   Okuda, Kenji ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b NONE

Author keywords

Carboxymethylcellulose sodium; HIV DNA vaccine; Intranasal administration; Mucosal immunity

Indexed keywords

CARBOXYMETHYLCELLULOSE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; POLYMER; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION;

EID: 0031657208     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1998.4566     Document Type: Article

References (36)

1. Bukawa, H., Sekigawa, K.-I., Hamajima, K., Fukushima, J., Yamada, Y., Kiyono, H., and Okuda, K., Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat. Med. 1, 681-685, 1996.
2. Staats, F. H., Nichos, W. G., and Palker, T. J., Systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10MN(A). J. Immunol. 157, 462-472, 1996.
3. Okada, E., Sasaki, S., Ishii, N., Aoki, I., Yasuda, T., Nishioka, K., Fukushima, J., Miyazaki, J., Wahren, B., and Okuda, K., Intranasal immunization of a DNA vaccine with IL-12 and granulocytemacrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell mediated immune responses against HIV-1 antigens. J. Immunol. 159, 3638-3647, 1997.
4. Lue, C., van Den Wall Bake, A. W. L., Prince, S. J., Julian, B. A., Tseng, M.-L., Radl, J., Eison, C. O., and Mestecky, J., Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit secretory IgA responses. Clin. Exp. Immunol. 96, 356-363, 1994.
5. Lehner, T., Bergmeier, L. A., Panagiotidi, C., Tao, L., Brookes, R., Kavinskis, L. S., Walker, P., Walker, J., Ward, R. G., Hussain, L., Gearing, A. J. H., and Adams, S. E., Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein. Science 258, 1365-1369, 1992.
6. Marinaro, M., Staats, H. F., Hiroi, T., Jackson, R. J., Coste, M., Bayaka, P. N. M., Okahashi, N., Yamamoto, M., Kiyono, H., Bluethmann, H., Fujihashi, K., and McGhee, J. R., Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155, 4621-4629, 1995.
7. Tamura, S.-I., Asanuma, H., Ito, Y., Hirabayashi, Y., Suzuki, Y., Nagamine, T., Aizawa, C., Kurata, T., and Oya, Y., Superior cross-protective effect of nasal vaccination to subcutaneous with influenza HA vaccine. Eur. J. Immunol. 22, 477-481, 1992.
8. Wolf, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., and Felgner, P. L., Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468, 1990.
9. Acsadi, G., Dickson, G., Love, D. R., Jani, A., Walsh, F. S., Gurusinghe, A., Wolff, J. A., and Davies, K., Human systrophin expression in mdx mice after intramuscular injection of DNA constructs. Nature 352, 815-818, 1991.
10. Eisenbaun, M. D., Fuller, D. H., and Haynes, J. R., Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization. DNA Cell Biol. 12, 791-797, 1993.
11. Wang, B., Ugen, K. E., Srikantan, V., Agadjanyan, M. G., Dang, K., Refaeli, Y., Sato, A. I., Boyer, J., Williams, W. V., and Weiner, D. B., Gene inoculation generates immunoresponses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90, 4156-4160, 1993.
12. Okuda, K., Bukawa, H., Hamajima, K., Kawamoto, S., Sekigawa, K.-I., Yamada, Y., Tanaka, S.-L, Ishii, N., Aoki, I., Nakamura, M., Yamamoto, H., Cullen, B. R., and Fukushima, J., Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene product. AIDS Res. Hum. Retroviruses 11, 933-943, 1995.
13. Tsuji, T., Fukushima, J., Hamajima, K., Ishii, N., Aoki, I., Xin, K.-Q., Bukawa, H., Ishigatsubo, Y., Tani, K., Okubo, T., Dorf, M. E., and Okuda, K., HIV-1-specific cell-mediated immunity is enhanced by co-inoculation of TCA3 expression plasmid with DNA vaccine. Immunology 90, 1-6, 1997.
14. Tsuji, T., Hamajima, K., Fukushima, J., Xin, K.-Q., Ishii, N., Aoki, I., Ishigatsubo, Y., Tani, K., Kawamoto, S., Nitta, Y., Miyazaki, J., Koff, W. C., Okubo, T., and Okuda, K., Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12. J. Immunol. 158, 4008-4014, 1997.
15. Tsuji, T., Hamajima, K., Ishii, N., Aoki, I., Fukushima, J., Xin, K.-Q., Kawamoto, S., Sasaki, S., Matsunaga, K., Ishigatsubo, Y., Tani, K., Okubo, T., and Okuda, K., Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen. Eur. J. Immunol. 27, 782-787, 1997.
16. Sasaki, S., Tsuji, T., Hamajima, K., Fukushima, J., Ishii, N., Kaneko, T., Xin, K.-Q., Mohri, H., Aoki, I., Okubo, T., Nishioka, K., and Okuda, K., Monophosphoryl lipid A enhances both humoral and cell-mediated immunoresponses to DNA vaccination against human immunodeficiency virus type 1. Infect. Immun. 65, 3520-3528, 1997.
17. ten Hagen, T. L. M., Sulzer, A. J., Kidd, M. R., Lal, A. A., and Hunter, R. L., Role of adjuvants in the modulation of antibody isotype, specificity, and induction of protection by whole blood-stage Plasmodium yoelii vaccines. J. Immunol. 151, 7077-7085, 1993.
18. Zigterman, G. J. W. J., Snippe, H., Jansze, M., Ernste, E. B. H. W., De Reuver, M. J., and Willers, J. M. N., Nonionic block polymers surfactants enhance immunogenicity of pneumococcal hexasaccharide-conjugate vaccines. Infect. Immun. 56, 1391-1393, 1998.
19. Van Dam, G. J., Verheul, A. F. M., Zigterman, G. J. W. J., De Reuver, M. J., and Snippe, H., Nonionic block polymer surfactants enhance the avidity of antibodies in polyclonal antisera against Streptococcus pneumoniae type 2 in normal and Xid mice. J. Immunol. 143, 3049-3053, 1989.
20. Okuda, K., Kaneko, T., Yamakawa, T., Tanaka, S., Shigematsu, T., Yamamoto, A., Hamajima, K., Nakajima, K., Kawamoto, S., and Phanuphak, P., Strong immunogenicity of a multicomponent vaccine developed with the branched lysine oligopeptide (BLO) method for human immunodeficiency virus-1 (HIV-1) infection. J. Mol. Recognit. 6, 101-109, 1993.
21. Nehete, P. N., Casement, K. S., Arlinghaus, P. B., and Sastry, K. J., Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp120. Cell. Immunol. 160, 217-223, 1995.
22. Okuda, K., Twinig, S. S., David, C. S., and Atassi, M. Z., Genetic control of immune response to sperm whale myoglobin in mice. J. Immunol. 123, 182-188, 1979.
23. Okuda, K., Ishii, N., Ikezawa, Z., Takahashi, T., Arai, K., and Tadokoro, I., Delayed-type hypersensitivity to hen egg-white lysozyme. I. The surface phenotypes of suppressor T cells induced by intravenous injection of lysozyme-modified spleen cells, and their molecular interaction. Microbiol. Immunol. 26, 897-911, 1982.
24. Hamajima, K., Fukushima, J., Bukawa, H., Kaneko, T., Tsuji, T., Asakura, Y., Sasaki, S., Xin, K.-Q., and Okuda, K., Strong augment effect of IL-12 expression plasmid on the induction of HIV-specific cytotoxic T lymphocyte activity by a peptide vaccine candidate. Clin. Immunol. Immunopathol. 83, 179-184, 1997.
25. Fynan, E. F., Webster, R. G., Fuller, D. H., Haynes, J. R., Santoroo, J. C., and Robinson, H. L., DNA vaccines-Protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90, 11478-11482, 1993.
26. Petmer, T. M., Roberts, T. R., and Haynes, J. R., Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J. Virol. 70, 6119-6125.
27. Chow, Y.-H., Huang, W.-L., Chi, W.-K., Chu, Y.-D., and Tao, M.-H., Improvement of hepatitis B virus DNA vaccine by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J. Virol. 71, 169-178, 1997.
28. Xiang, Z. Q., and Ertl, H. C. J., Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2, 129-135, 1995.
29. Gallichan, W. S., Johnson, D. C., Graham, F. L., and Rosenthal, K. L., Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein-b. J. Infect. Dis. 168, 622-629, 1993.
30. Kuklin, N., Daheshia, M., Karem, K., Manickan, A., and Rouse, B. T., Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J. Virol. 71, 3138-3145, 1997.
31. Lue, C., van Den Wall Bake, A. W. L., Prince, S. J., Julian, B. A., Tseng, M.-L., Radl, J., Eison, C. O., and Mestecky, J., Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit secretory IgA responses. Clin. Exp. Immunol. 96, 356-363, 1994.
32. Vogel, F. R., Immunologic adjuvants for modern vaccine formulations. Ann. N. Y. Acad. Sci. 754, 153-160.
33. Hirabayashi, Y., Kurata, H., Funato, H., Nagamine, T., Aizawa, C., Tamura, S., Shimada, K., and Kurata, T., Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination. Vaccine 8, 243-248, 1990.
34. Pal, S., Fielder, T. J., Peterson, E. M., and De La Maza, L. M., Protection against infertility in a BALB/c mouse salpingitis model by intranasal immunization with the mouse pneumonitis biovar of Chlamydia trachomatis. Infect. Immun. 62, 3354-3362, 1994.
35. Kats, J., Harmon, C. C., Buckner, G. P., Richardson, G. J., Russell, M. W., and Michalek, S. M., Protective salivary immunoglobulin A responses against Streptococcus mutans infection after intranasal immunization with S. mutans antigen I/II coupled to the B subunit of cholera toxin. Infect. Immun. 61, 1964-1971, 1993.
36. Takahashi, I., Okahashi, N., Kanamoto, T., Asakawa, H., and Koga, T., Intranasal immunization of mice with recombinant protein antigen of serotype C Streptococcus mutans and cholera toxin B subunit. Arch. Oral Biol. 35, 475-477, 1990.