An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi

Journal of Infectious Diseases

Volumn 175, Issue 1, 1997, Pages 91-97

  Luke, Catherine J ^a   Carner, Kristin ^b   Liang, Xiaowu ^b   Barbour, Alan G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BORRELIA BURGDORFERI; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; IMMUNIZATION; IMMUNOGENICITY; INTRAMUSCULAR DRUG ADMINISTRATION; LYME DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTECTION; PROTEIN EXPRESSION;

EID: 0031023559     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/175.1.91     Document Type: Article

References (21)

1. Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990;247:1465-8.
2. Wolff JA, Williams P, Ascadi G, Jiao S, Jani A, Chong W. Conditions affecting direct gene transfer into rodent muscle in vivo. BioTechniques 1991;11:474-85.
3. Robinson HL, Feltquate DM, Morin MJ, Haynes JR, Webster RG. DNA vaccines: a new approach to immunization. In: Chanock RM, Brown F, Ginsberg US, Norrby E, eds. Vaccines 95. Molecular approaches to the control of infectious diseases. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1995:69-75.
4. Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259:1745-9.
5. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: a novel approach to immunization. Int J Immunopharmacol 1995;17:79-83.
6. Vogel FR, Sarver N. Nucleic acid vaccines. Clin Microbiol Rev 1995;8:406-10.
7. Bourne N, Stanberry R, Bernstein DI, Lew D. DNA immunization against experimental genital herpes simplex virus infection. J Infect Dis 1996;173:800-7.
8. Yokoyama M, Zhang J, Whitton JL. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J Virol 1995;69:2684-8.
9. Huffman SL, Sedegah M, Hedstrom RC. Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine. Vaccine 1994;12:1529-33.
10. Xu D, Liew FY. Genetic vaccination against leishmaniasis. Vaccine 1994; 12:1534-6.
11. Lowrie DB, Tascon RE, Colston MJ, DeSilva CL. Towards a DNA vaccine against tuberculosis. Vaccine 1994;12:1537-40.
12. Lai WC, Bennett M, Johnston SA, Barry MA, Pakes SP. Protection against Mycoplasma pulmonis infection by genetic vaccination. DNA Cell Biol 1995;14:643-51.
13. Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease - a tick-borne spirochetosis? Science 1982;216:1317-9.
14. Barbour AG, Tessier SL, Todd WJ. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect Immun 1983;41:795-804.
15. Howe TR, LaQuier FR, Barbour AG. Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgilorferi within a single transcriptional unit. Infect Immun 1986;54:207-12.
16. Brandt MS, Riley BS, Radolf JD, Norgard MV. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect Immun 1990;58:983-91.
17. Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 1990;250:553-6.
18. Erdile LF, Brandt M, Warakomski DJ, et al. Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA. Infect Immun 1993;61: 81-90.
19. Keller D, Koster FT, Marks DU, Hosbach P, Erdile LF, Mays JP. Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine. JAMA 1994;271:1764-8.
20. Fikrig E, Barthold SW, Marcantonio N, Deponte K, Kantor FS, Flavell RA. Roles of OspA, OspB and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect Immun 1992;60:657-61.
21. Schaible UE, Kramer MD, Eichmann K, Modolell M, Museteanu C, Simon MM. Monoclonal antibodies specific for the outer surface protein (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (SCID) mice. Proc Natl Acad Sci USA 1990; 87:3768-72.