Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo

European Journal of Immunology

Volumn 26, Issue 11, 1996, Pages 2749-2757

  Zhong, Weimin ^a   Wiesmüller, Karl Heinz ^b   Kramer, Michael D ^c   Wallich, Reinhard ^c   Simon, Markus M ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Borrelia burgdorferi; Lyme disease; Plasmid DNA protein immunization outer surface protein A

Indexed keywords

BACTERIUM ANTIBODY; EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; LIPOPROTEIN A; OUTER MEMBRANE PROTEIN; PLASMID DNA; PROTEIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BORRELIA BURGDORFERI; FEMALE; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; BORRELIA BURGDORFERI GROUP; DNA, BACTERIAL; FEMALE; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN G; LIPOPROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED AKR; MOLECULAR SEQUENCE DATA; PLASMIDS; T-LYMPHOCYTES, HELPER-INDUCER; VACCINES, SYNTHETIC;

EID: 0029857266     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830261130     Document Type: Article

References (57)

1. Brandt, M. E., Siley, B. S., Radolf, J. D. and Norgard, M. V., Infect. Immun. 1990. 58: 983.
2. Fikrig, E., Barthold, S. W., Kantor, F. S. and Flavell, R. A., Science 1990, 250: 553.
3. Simon, M. M., Schaible, U. E., Kramer, M. D., Eckerskorm, C., Museteanu, C., Müller-Hermelink, H. K. and Wallich, R., J. Infect. Dis. 1991, 164: 123.
4. Keller, D., Koster, F. T., Marks, K. H., Hosbach, P., Erdile, L. F. and Mays, J. P., JAMA 1994, 271: 1764.
5. Schaible, U. E., Wallich, R., Kramer, M. D., Nerz, G., Stehle, T., Museteanu, C. and Simon, M. M., Int. Immunol. 1994. 6: 671.
6. Rao, T. D. and Frey, A. B., Cell. Immunol. 1995, 162: 225.
7. Schaible, U. E., Kramer, M. D., Justus, W. E., Museteanu, C. and Simon, M. M., Infect. Immun. 1989, 57: 41.
8. Keane-Myers, A. and Nickel, S., J. Immunol. 1995, 154: 1770.
9. Martin, R., Ortlauf, J., Sticht-Groh, V., Bogdahn, U., Gold-mann, S. F. and Mertens, H. G., Ann. Neurol. 1988, 24: 509.
10. Buechner, S. A., Rufli, T. and Erb, P., J. Am. Acad. Dermatol. 1993, 28: 399.
11. Lengl-Janßen, B., Strauss, A. F., Steere, A. C. and Kamradt, T., J. Exp. Med. 1994. 180: 2069.
12. Kamradt, T., Lengl-Janßen, B., Strauss, A. F., Bansal, G. and Steere, A. C., Infect. Immun. 1996, 64: 1248.
13. Fikrig, E., Tao, H., Chen, M., Barthold, S. W. and Flavell, R. A., J. Clin. Invest. 1995, 96: 1706.
14. Simon, M. M., Gern, L., Hauser, P., Zhong, W., Nielsen, P. J., Kramer, M. D., Prenner, C. and Wallich, R., Eur. J. Immunol. 1996, 26: in press.
15. Gern, L., Rais, O., Capiau, C., Hauser, P., Lobet, Y., Simoen, E., Voet, P. and Pêtre, J., Immunol. Lett. 1994, 39: 249.
16. Golde, W. T., Burdot, T. R., Piesman, J., Dolan, M. C., Capiau, C., Hauser, P., Dequesne, G. and Lobet, Y., Vaccine 1995, 13: 435.
17. Wallich, R., Schaible, U. E., Simon, M. M., Heiberger, A. and Kramer, M. D., Nucleic Acid Res. 1989, 17: 8864.
18. Wiesmüller, K.-H., Spahn, G., Handtmann, D., Schneider, F., Jung, G. and Muller, C. P. J. Gen. Virol. 1992, 73: 2211.
19. Street, N. E., Schumacher, J. H., Fong, A. N., Bass, H., Fiorentino, D. F., Leverah, J. A. and Mosmann, T. R., J. Immunol. 1990, 144: 1629.
20. Kramer, M. D., Schaible, U. E., Wallich, R., Motor, S. E., Petzoldt, D. and Simon, M. M., Immunobiology 1990, 181: 357.
21. Rammensee, H.-G., Friede, T. and Stevanovic, S., Immunogenetics 1995, 41: 178.
22. Schödel, F., Aguado, M.-T. and Lamber, P.-H., Vaccine 1994. 12: 1491.
23. Danko, I. and Wolff, J. A., Vaccine 1994, 12: 1499.
24. Zarozinski, C. C., Fynan, E. F., Selin, L. K., Robinson, H. L. and Welsh, R. M., J. Immunol. 1995, 154: 4010.
25. Davis, H. L., Michel, M.-L. and Whalen, R. G., Hum. Mol. Genet. 1993, 2: 1847.
26. Davis, H. L., Schirmbeck, R., Reimann, J. and Whalen, R. G., Hum. Gene Ther. 1995, 6: 1447.
27. Ulmer, J. B., Donnelly, J. J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. L., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., Hawe, L. A., Leander, K. R., Martinez, D., Perry, H. C., Shiver, J. W., Montgmoery, D. L. and Liu, M. A., Science 1993, 259; 1745.
28. Raz, E., Carson, D., Parker, S. E., Parr, T. B., Abai, A. M., Aichinger, G., Gromkowski, S. H., Singh, M., Lew, D., Yan-kauckas, M. A., Barid, S. M. and Rhodes, G. H., Proc. Natl. Acad. Sci. USA 1994, 91: 9519.
29. Schirmbeck, R., Böhm, W., Ando, K., Chisari, F. V. and Reimann, J., J. Virol. 1995, 69: 5929.
30. Manickan, E., Rouse, R. J.,Yu, Z., Wire, W. S. and Rouse, B. T., J. Immunol. 1995, 155: 259.
31. Sears, J. E., Fikrig, E., Nakagawa, T. Y., Deponte, K., Marcantonio, N., Kantor, F. S. and Flavell, R. A., J. Immunol. 1991, 147: 1995.
32. Schubach, W. H., Mudri, S., Dattwyler, R. J. and Luft, B. J., Infect. Immun. 1991, 59: 1911.
33. Ma, J., Gingrich-Baker, C., Franchi, P. M., Bulger, P. and Coughlin, R. T., Infect. Immun. 1995, 63: 2221.
34. Fikrig, E., Telford, S. R. III, Wallich, R., Chen, M., Lobet, Y., Matuschka, F. R., Kimsey, R. B., Kantor, F. S., Barthold, S. W., Spielman, A. and Flavell, R. A., J. Exp. Med. 1995, 181: 215.
35. Shanafelt, M.-C., Anzola, J., Soderberg, C., Yssel, H., Turck, C. W. and Peltz, G., J. Immunol. 1992, 148: 218.
36. Kalish, R. A., Leong, J. M. and Steere, A. C., Infect. Immun. 1995, 63: 2228.
37. Adorini, L., Appella, E., Doria, G. and Nagy, Z. A., J. Exp. Med. 1988, 168: 2091.
38. Viner, N., Nelson, C. A. and Unanue, E. R., Proc. Natl. Acad. Sci. US 1995, 92: 2214.
39. Comerford, S., MacCance, D. J., Dougan, G. and Tite, J. P., J. Virol. 1991, 65: 4681.
40. Ferrari, C., Bertoletti, A., Penna, A., Cavalli, A., Missale, G., Pilli, M., Fowler, P., Giuberti, T., Chisari, F. V. and Fiacca-dori, F., J. Clin. Invest. 1991, 88: 214.
41. Nikcevich, K. M., Kopielski, D. and Finnegan, A., J. Immunol. 1994, 153: 1015.
42. Safley, S., Jensen, P. E., Reay, P. A. and Ziegler, H. K., J. Immunol 1995, 155: 4355.
43. Matyniak, J. E. and Reiner, S., J. Exp. Med. 1995, 181: 1251.
44. Keane-Myers, A. and Nickel, S., J. Immunol. 1995, 155: 2020.
45. Yssel, H., Shanafelt. M.-C., Soderberg, C., Schneider, P. V., Anzola, J. and Peltz, G., J. Exp. Med. 1991, 174: 593.
46. Forsberg, P., Ernerrudh, J., Ekerfelt, C., Roberg, M., Vrethem, M. and Bergström, S., Clin. Exp. Immunol. 1995, 101: 453.
47. Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G. and Lepper, H., Nature 1995, 373: 255.
48. Simon, M. M., Nerz, G., Kramer, M. D., Hurtenbach, U., Schaible, U. E. and Wallich, R., Immunol. Lett. 1995, 45: 137.
49. Knigge, H., Simon, M. M., Meucr, S. C., Kramer, M. D. and Wallich, R., Eur. J. Immunol. 1996. in press.
50. Milich, D. R., McLachlan, A., Thorton, G. B. and Hughes, J. L., Nature 1987, 329: 547.
51. Hosmalin, A. P. L. N., Zweig, M., Lerche, N. W., Cease, K. B., Gard, E. A., Markham, P. D., Putney, S. D., Daniel, M. D., Desrosiers, R. C. and Berzofsky, J. A., J. Immunol. 1991. 146: 1667.
52. Greenstein, J. L., Schad, V. C., Goodwin, W. H., Brauer, A. B., Bolinger, B. K., Chin. R. D. and Kuo, M. C., J. Immunol. 1992, 148: 3970.
53. Roehrig, J. T., Johnson, A., Hunt, A. R., Beaty, B. J. and Mathews, J. H., J. Virol. 1992, 66: 3385.
54. Purkerson, J. and Isakson, P., FASEB J. 1992, 6: 3245.
55. Coffman, R. L., Seymour, B. W. P., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelkoul, H. F. J., Finkelman, F. D., Bond, M. W. and Mosmann, T. R., Immunol. Rev. 1988, 102: 5.
56. Baranton, G., Int. J. Syst. Bacteriol. 1992, 42: 378.
57. Wallich, R., Infect. Immun. 1992, 60: 4856.