The potential of oligodeoxynucleotides as mucosal and parenteral adjuvants

Vaccine

Volumn 19, Issue 17-19, 2001, Pages 2657-2660

  McCluskie, Michael J ^a   Weeratna, Risini D ^a   Davis, Heather L ^a,b,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c PFIZER INC   (United States)

Author keywords

Mucosal and parenteral adjuvants; Oligodeoxynucleotides; Potential

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYNUCLEOTIDE; POLYCYTIDYLIC POLYGUANYLIC ACID; POLYTHYMIDYLIC ACID; TETANUS TOXOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; CONFERENCE PAPER; CONTROLLED STUDY; CPG ISLAND; DRUG EFFECT; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; BASE SEQUENCE; CPG ISLANDS; FEMALE; HEPATITIS B SURFACE ANTIGENS; IMMUNITY, MUCOSAL; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; TETANUS TOXOID; TH1 CELLS; TH2 CELLS; VACCINES;

EID: 0035925576     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00496-5     Document Type: Conference Paper

References (17)

1. CpG motifs in bacterial DNA trigger direct B-cell activation
2. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant Hepatitis B surface antigen
3. CpG DNA is a novel non-toxic adjuvant which induces stronger immune responses than many conventional adjuvants
4. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
5. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
6. CpG ODN is safe and highly effective in humans as adjuvant to HBV vaccine: Preliminary results of Phase I trial with CpG ODN 7909
7. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
8. CpG DNA as mucosal adjuvant
9. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
10. CpG DNA is an effective oral adjuvant to protein antigens in mice
11. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
12. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ
13. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
14. Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
15. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
16. Th1/Th2 cells
17. The paradigm of Th1 and Th2 cytokines: Its relevance to autoimmunity and allergy