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Volumn 119, Issue 1, 2000, Pages 130-139

Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production

Author keywords

DNA based immunization; IL 12; Interferon ; Th1 biased immune responses professional antigen presenting cells

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PLASMID DNA; RECOMBINANT PROTEIN;

EID: 0033979001     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01041.x     Document Type: Article
Times cited : (14)

References (57)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • 1 Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787-93.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogenous T helper cell subsets
    • 2 O'Garra A. Cytokines induce the development of functionally heterogenous T helper cell subsets. Immunity 1998; 8:275-83.
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 3
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4 T cells
    • 3 Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4 T cells. Annu Rev Immunol 1994; 12:635-73.
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.A.1    Paul, W.E.2
  • 4
    • 0029802971 scopus 로고    scopus 로고
    • Resistance to Leishmania major in mice
    • 4 Demant P, Lipoldova M, Svobodova M. Resistance to Leishmania major in mice. Science 1996; 274:1392.
    • (1996) Science , vol.274 , pp. 1392
    • Demant, P.1    Lipoldova, M.2    Svobodova, M.3
  • 6
    • 0030023112 scopus 로고    scopus 로고
    • Susceptibility to Leishmania major infection in interleukin-4-deficient mice
    • 6 Noben-Trauth N, Kropf P, Müller I. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 1996; 271:987-90.
    • (1996) Science , vol.271 , pp. 987-990
    • Noben-Trauth, N.1    Kropf, P.2    Müller, I.3
  • 7
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • 7 Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995; 13:151-77.
    • (1995) Annu Rev Immunol , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 8
    • 0028963901 scopus 로고
    • Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1 -type CD4+ T cell response
    • 8 Swihart K, Fruth U, Messmer M et al. Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1 -type CD4+ T cell response. J Exp Med 1995; 181:961-71.
    • (1995) J Exp Med , vol.181 , pp. 961-971
    • Swihart, K.1    Fruth, U.2    Messmer, M.3
  • 9
    • 0025965050 scopus 로고
    • Immunization of chimpanzees confer protection against challenge with human immunodeficiency virus
    • 9 Girard M, Kieny MP, Pinter A et al. Immunization of chimpanzees confer protection against challenge with human immunodeficiency virus. Proc Natl Acad Sci USA 1991; 88:542-6.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 542-546
    • Girard, M.1    Kieny, M.P.2    Pinter, A.3
  • 10
    • 0030571189 scopus 로고    scopus 로고
    • HIV vaccines: Where we are and where we are going
    • 10 Haynes BF. HIV vaccines: where we are and where we are going. Lancet 1996; 348:933-7.
    • (1996) Lancet , vol.348 , pp. 933-937
    • Haynes, B.F.1
  • 12
    • 16044372353 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
    • 12 Huygen K, Content J, Denis O et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Med 1996; 2:893-8.
    • (1996) Nature Med , vol.2 , pp. 893-898
    • Huygen, K.1    Content, J.2    Denis, O.3
  • 14
    • 0030865220 scopus 로고    scopus 로고
    • Immunity to Plasmodium falciparum malaria sporozoites by somatic transgene immunization
    • 14 Gerloni M, Ballou WR, Billetta R, Zanetti M. Immunity to Plasmodium falciparum malaria sporozoites by somatic transgene immunization. Nat Biotechnol 1997; 15:876-81.
    • (1997) Nat Biotechnol , vol.15 , pp. 876-881
    • Gerloni, M.1    Ballou, W.R.2    Billetta, R.3    Zanetti, M.4
  • 15
    • 16944363710 scopus 로고    scopus 로고
    • Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
    • 15 Boyer JD, Ugen KE, Wang B et al. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature Med 1997; 3:526-32.
    • (1997) Nature Med , vol.3 , pp. 526-532
    • Boyer, J.D.1    Ugen, K.E.2    Wang, B.3
  • 16
    • 0029051152 scopus 로고
    • Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus
    • 16 Donnelly JJ, Friedman A, Martinez D et al. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nature Med 1995; 1:583-7.
    • (1995) Nature Med , vol.1 , pp. 583-587
    • Donnelly, J.J.1    Friedman, A.2    Martinez, D.3
  • 17
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • 17 Ulmer JB, Donnelly JJ, Parker SE et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259:1745-9.
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3
  • 18
    • 0030985847 scopus 로고    scopus 로고
    • Particle bombardment-mediated DNA vaccination with rotavirus VP6 induces high levels of serum rotavirus IgG but fails to protect mice against challenge
    • 18 Choi AH, Knowlton DR, McNeal MM, Ward RL. Particle bombardment-mediated DNA vaccination with rotavirus VP6 induces high levels of serum rotavirus IgG but fails to protect mice against challenge. Virology 1997; 232:129-38.
    • (1997) Virology , vol.232 , pp. 129-138
    • Choi, A.H.1    Knowlton, D.R.2    McNeal, M.M.3    Ward, R.L.4
  • 19
    • 9044225149 scopus 로고    scopus 로고
    • Simian immunodeficiency virus DNA vaccine trial in macaques
    • 19 Lu S, Arthos J, Montefiori DC et al. Simian immunodeficiency virus DNA vaccine trial in macaques. J Virol 1996; 70:3978-91.
    • (1996) J Virol , vol.70 , pp. 3978-3991
    • Lu, S.1    Arthos, J.2    Montefiori, D.C.3
  • 20
    • 0032566907 scopus 로고    scopus 로고
    • Immune response but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts
    • 20 Putkonen P, Quesada-Rolander M, Leandersson AC et al. Immune response but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts. Virology 1998; 250:293-301.
    • (1998) Virology , vol.250 , pp. 293-301
    • Putkonen, P.1    Quesada-Rolander, M.2    Leandersson, A.C.3
  • 21
    • 0031197121 scopus 로고    scopus 로고
    • DNA increases the potency of vaccination against infectious diseases
    • 21 Wahren B, Brytting M. DNA increases the potency of vaccination against infectious diseases. Curr Opin Chem Biol 1997; 1:183-9.
    • (1997) Curr Opin Chem Biol , vol.1 , pp. 183-189
    • Wahren, B.1    Brytting, M.2
  • 22
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA. Mechanism of CTL priming
    • 22 Corr M, Lee DJ, Carson DA, Tighe H. Gene vaccination with naked plasmid DNA. Mechanism of CTL priming. J Exp Med 1996; 184:1555-60.
    • (1996) J Exp Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 23
    • 0029737350 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
    • 23 Doe B, Selby M, Barnett S, Baenziger J, Walker CM. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc Natl Acad Sci USA 1996; 93:8578-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8578-8583
    • Doe, B.1    Selby, M.2    Barnett, S.3    Baenziger, J.4    Walker, C.M.5
  • 24
    • 0032526344 scopus 로고    scopus 로고
    • Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophage/antigen-presenting cells
    • 24 Chattergoon MA, Robinson TM, Boyer JD, Weiner DB. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophage/antigen-presenting cells. J Immunol 1998; 160:5708-18.
    • (1998) J Immunol , vol.160 , pp. 5708-5718
    • Chattergoon, M.A.1    Robinson, T.M.2    Boyer, J.D.3    Weiner, D.B.4
  • 25
    • 0031178797 scopus 로고    scopus 로고
    • The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
    • 25 Iwasaki A, Torres CA, Ohashi PS, Robinson HL, Barber BH. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J Immunol 1997; 159:11-4.
    • (1997) J Immunol , vol.159 , pp. 11-14
    • Iwasaki, A.1    Torres, C.A.2    Ohashi, P.S.3    Robinson, H.L.4    Barber, B.H.5
  • 26
    • 0031093543 scopus 로고    scopus 로고
    • Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
    • 26 Feltquate DM, Heaney S, Webster RG, Robinson HL. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 1997; 158:2278-84.
    • (1997) J Immunol , vol.158 , pp. 2278-2284
    • Feltquate, D.M.1    Heaney, S.2    Webster, R.G.3    Robinson, H.L.4
  • 27
    • 0029813303 scopus 로고    scopus 로고
    • Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
    • 27 Pertmer TM, Roberts TR, Haynes JR. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J Virol 1996; 70:6119-25.
    • (1996) J Virol , vol.70 , pp. 6119-6125
    • Pertmer, T.M.1    Roberts, T.R.2    Haynes, J.R.3
  • 29
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA. A new genetic code
    • 29 Pisetsky DS. Immune activation by bacterial DNA. A new genetic code. Immunity 1996; 5:303-10.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 30
    • 0031926264 scopus 로고    scopus 로고
    • Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes
    • 30 Sasaki S, Sumino K, Hamajima K et al. Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes. J Virol 1998; 72:4931-9.
    • (1998) J Virol , vol.72 , pp. 4931-4939
    • Sasaki, S.1    Sumino, K.2    Hamajima, K.3
  • 31
    • 0031569459 scopus 로고    scopus 로고
    • Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12
    • 31 Tsuji T, Hamajima K, Fukushima J et al. Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12. J Immunol 1997; 158:4008-13.
    • (1997) J Immunol , vol.158 , pp. 4008-4013
    • Tsuji, T.1    Hamajima, K.2    Fukushima, J.3
  • 33
    • 0027411525 scopus 로고
    • The molecular cell biology of interferon-γ and its receptor
    • 33 Farrar MA, Schreiber RD. The molecular cell biology of interferon-γ and its receptor. Annu Rev Immunol 1993; 11:571-661.
    • (1993) Annu Rev Immunol , vol.11 , pp. 571-661
    • Farrar, M.A.1    Schreiber, R.D.2
  • 36
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-γ genes
    • 36 Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 1993; 259:1739-42.
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 38
    • 0027464928 scopus 로고
    • Immune responses in mice that lack the interferon-γ receptor
    • 38 Huang S, Hendriks W, Althage A et al. Immune responses in mice that lack the interferon-γ receptor. Science 1993; 259:1742-5.
    • (1993) Science , vol.259 , pp. 1742-1745
    • Huang, S.1    Hendriks, W.2    Althage, A.3
  • 39
    • 0029093070 scopus 로고
    • Upregulation of class I major histocompatibility complex antigens by interferon-gamma is necessary for T cell mediated elimination of recombinant adenovirus infected hepatocytes in vivo
    • 39 Yang Y, Xiang Z, Ertl HC, Wilson JM. Upregulation of class I major histocompatibility complex antigens by interferon-gamma is necessary for T cell mediated elimination of recombinant adenovirus infected hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92:7257-61.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7257-7261
    • Yang, Y.1    Xiang, Z.2    Ertl, H.C.3    Wilson, J.M.4
  • 41
    • 0023005976 scopus 로고
    • Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism
    • 41 Cullen BR. Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 1986; 46:973-82.
    • (1986) Cell , vol.46 , pp. 973-982
    • Cullen, B.R.1
  • 43
    • 0028978722 scopus 로고
    • Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products
    • 43 Okuda K, Bukawa H, Hamajima K et al. Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products. AIDS Res Hum Retrovirus 1995; 11:933-43.
    • (1995) AIDS Res Hum Retrovirus , vol.11 , pp. 933-943
    • Okuda, K.1    Bukawa, H.2    Hamajima, K.3
  • 44
    • 0028177650 scopus 로고
    • 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype
    • 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype. J Immunol 1994; 153:1246-53.
    • (1994) J Immunol , vol.153 , pp. 1246-1253
    • Sarawar, S.R.1    Sangster, M.2    Coffman, R.L.3    Doherty, P.C.4
  • 46
    • 0030741433 scopus 로고    scopus 로고
    • Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
    • 46 Taki S, Sato T, Ogasawara K, Fukuda T et al. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 1997; 6:673-9.
    • (1997) Immunity , vol.6 , pp. 673-679
    • Taki, S.1    Sato, T.2    Ogasawara, K.3    Fukuda, T.4
  • 47
    • 17444447880 scopus 로고    scopus 로고
    • Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type I regulatory genes
    • 47 Hinkula J, Svanholm C, Schwartz S et al. Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type I regulatory genes. J Virol 1997; 71:5528-39.
    • (1997) J Virol , vol.71 , pp. 5528-5539
    • Hinkula, J.1    Svanholm, C.2    Schwartz, S.3
  • 48
    • 0033537868 scopus 로고    scopus 로고
    • Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA
    • 48 Lundholm P, Asakura Y, Hinkula J, Lucht E, Wahren B. Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA. Vaccine 1999; 17:2036-42.
    • (1999) Vaccine , vol.17 , pp. 2036-2042
    • Lundholm, P.1    Asakura, Y.2    Hinkula, J.3    Lucht, E.4    Wahren, B.5
  • 49
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degradades DNA during apoptosis, and its inhibitor ICAD
    • 49 Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degradades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391:43-50.
    • (1998) Nature , vol.391 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 50
    • 0025022393 scopus 로고
    • An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself
    • 50 Takahashi H, Germain RN, Moss B, Berzofsky JA. An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself. J Exp Med 1990; 171:571-6.
    • (1990) J Exp Med , vol.171 , pp. 571-576
    • Takahashi, H.1    Germain, R.N.2    Moss, B.3    Berzofsky, J.A.4
  • 51
    • 0029861313 scopus 로고    scopus 로고
    • Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine
    • 51 Asakura Y, Hamajima K, Fukushima J, Mohri H, Okubo T, Okuda K. Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine. Am J Hematol 1996; 53:116-7.
    • (1996) Am J Hematol , vol.53 , pp. 116-117
    • Asakura, Y.1    Hamajima, K.2    Fukushima, J.3    Mohri, H.4    Okubo, T.5    Okuda, K.6
  • 52
    • 0033014091 scopus 로고    scopus 로고
    • DNA-plasmids of HIV-1 induce systemic and mucosal immune responses
    • 52 Asakura Y, Lundholm P, Kjerrström A et al. DNA-plasmids of HIV-1 induce systemic and mucosal immune responses. Biol Chem 1999; 380:375-9.
    • (1999) Biol Chem , vol.380 , pp. 375-379
    • Asakura, Y.1    Lundholm, P.2    Kjerrström, A.3
  • 53
    • 0029789751 scopus 로고    scopus 로고
    • Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells; antigen presentation by non-muscle cells
    • 53 Ulmer JB, Deck RR, Dewitt CM, Donnelly JJ, Liu MA. Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells; antigen presentation by non-muscle cells. Immunology 1996; 89:59-67.
    • (1996) Immunology , vol.89 , pp. 59-67
    • Ulmer, J.B.1    Deck, R.R.2    Dewitt, C.M.3    Donnelly, J.J.4    Liu, M.A.5
  • 54
    • 0023475193 scopus 로고
    • Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining
    • 54 Akira S, Okazaki K, Sakano H. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining. Science 1987; 238:1134.
    • (1987) Science , vol.238 , pp. 1134
    • Akira, S.1    Okazaki, K.2    Sakano, H.3
  • 55
    • 0020077493 scopus 로고
    • Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
    • 55 Keene JA, Forman J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med 1982; 155:768-82.
    • (1982) J Exp Med , vol.155 , pp. 768-782
    • Keene, J.A.1    Forman, J.2
  • 56
    • 0031569963 scopus 로고    scopus 로고
    • Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
    • 56 Iwasaki A, Stiernholm BJ, Chan AK, Bernstein NL, Barber BH. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 1997; 158:4591-601.
    • (1997) J Immunol , vol.158 , pp. 4591-4601
    • Iwasaki, A.1    Stiernholm, B.J.2    Chan, A.K.3    Bernstein, N.L.4    Barber, B.H.5
  • 57
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • 57 Kim JJ, Ayyavoo V, Bagarazzi ML et al. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 1997; 158:816-26.
    • (1997) J Immunol , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3


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