Biologically erodable microspheres as potential oral drug delivery systems

Nature

Volumn 386, Issue 6623, 1997, Pages 410-414

  Mathiowitz, Edith ^a   Jacob, Jules S ^a   Jong, Yong S ^a   Carino, Gerardo P ^a   Chickering, Donald E ^b   Chaturvedi, Pravin ^c   Santos, Camilla A ^a   Vijayaraghavan, Kavita ^a   Montgomery, Sean ^a   Bassett, Michael ^a   Morrell, Craig ^a  

^a BROWN UNIVERSITY   (United States)

^b Sulzer Carbomedics   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICOUMAROL; INSULIN; MICROSPHERE; PLASMID DNA; POLYMER;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; GENE TRANSFER; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADHESIVENESS; ADMINISTRATION, ORAL; AREA UNDER CURVE; BETA-GALACTOSIDASE; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; DECANOIC ACIDS; DICARBOXYLIC ACIDS; DICUMAROL; DRUG DELIVERY SYSTEMS; FUMARATES; GENE TRANSFER TECHNIQUES; INSULIN; INTESTINAL MUCOSA; MICROSCOPY, ELECTRON; MICROSPHERES; MUCOUS MEMBRANE; PEYER'S PATCHES; PLASMIDS; POLYMERS; TISSUE DISTRIBUTION;

EID: 0030949396     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386410a0     Document Type: Article

References (30)

1. Lenaerts, V., Couvreur, P., Grislain, L. & Maincent, P. in Bioadhesive Drug Delivery Systems (eds Lenaerts, V. & Gurny, R.) 93-104 (CRC Press, Boca Raton, FL, 1990).
2. Peppas, N. A. Hydrogels in Medicine and Pharmacy (CRC Press, Boca Raton, FL, 1987).
3. Ponchel, G. & Duchêne, D. in High Performance Biomaterials (ed. Szycher, M.) 231-242 (Technomic, Lancaster, PA, 1991).
4. Davis, S. S. & Illum, L. Biomaterials 9, 111-115 (1988).
5. Frisbie, C. D., Lawrence, F., Rozsnyai, A. N., Wrighton, M. S. & Charles, M. L. Science 265, 2071-2073 (1994).
6. Langer, R. & Chasin, M. Biodegradable Polymers as Drug Delivery Systems (Marcel Decker, New York, 1990).
7. Checkering, D. E., Jacob, J. S. & Mathiowitz, E. React. Polym. 25, 189-206 (1995).
8. Mathiowitz, E., Jacob, J., Chickering, D. & Pekarek, K. Macromolecules 26, 6756-6765 (1993).
9. Chickering, D. E. & Mathiowitz, E. J. Control. Release 34, 251-261 (1995).
10. Jacob, J., Santos, C., Carino, G., Chickering, D. & Mathiowitz, E. Proc. 22nd Int. Symp. Controlled Release of Bioactive Materials, 312-313 (Controlled Release Society, Inc., Deerfield, IL, 1995).
11. Chickering, D. E. III, Jacob, J. S. & Mathiowitz, E. Biotechnol. Bioeng. 52, 96-101 (1996).
12. Carino, G., Santos, C., Chen, C. J. & Mathiowitz, E. Proc. 22nd Int. Symp. Controlled Release of Bioactive Materials, 314-315 (Controlled Release Society, Inc., Deerfield, IL, 1995).
13. Sanders, E. & Ashworth, C. T. Exp. Cell Res. 22, 137-145 (1961).
14. Ermak, T. H., Dougherty, E. P., Bhagat, H. R., Kabok, Z. & Pappo, J. Cell Tissue Res. 279, 433-436 (1995).
15. Florence, A. & Jani, P. U. Drug Safety 10, 233-266 (1994).
16. Florence, A. T., Hillery, A. M., Hussain, N. & Jani, P. U. J. Control. Release 36, 39-46 (1995).
17. LeFevre, M. E., Olivo, R., Vanderhoff, J. W. & Joel, D. D. Proc. Soc. Exp. Biol. Med. 159, 298-302 (1978).
18. Lefevre, M. E., Joel, D. D. & Schidlovsky, G. Proc. Soc. Exp. Biol. Med. 179, 522-528 (1985).
19. Jani, P., Halbert, G. W., Langridge, J. & Florence, A. T. J. Pharm. Pharmacol. 41, 809-812 (1989).
20. Jani, P., Halbert, G. W., Langridge, J. & Florence, A. T. J. Pharm. Pharmacol. 42, 821-826 (1990).
21. Hillery, A. M., Jani, P. U. & Florence, A. T. J. Drug Target. 2, 151-156 (1994).
22. Bockman, D. E. & Cooper, M. D. Am. J. Anat. 136, 455-478 (1973).
23. Akers, M. J., Lach, J. L. & Fischer, L. J. J. Pharma. Sci. 62, 391-395 (1973).
24. Goodman, L. S. & Gilman, A. The Pharmacological Basis of Therapeutics (Macmillan, New York, 1975).
25. Tutwiler, G. F., Kirsch, T. & Bridi, G. Diabetes 27, 856-867 (1978).
26. Wolff, J. A. et al. Biotechniques 11, 474-485 (1991).
27. Lau, C. et al. Hum. Gene Ther. 6, 1145-1151 (1995).
28. Domb, A., Mathiowitz, E., Ron, E., Giannos, S. & Langer, R. J. Polym. Sci. 29, 571-579 (1991).
29. Wolff, J. A. et al. Science 247, 1465-1468 (1990).
30. Lee, S. W., Trapnell, B. C., Rade, J. J., Virmani, R. & Dichek, D. A. Circ. Res. 73, 797-807 (1993).