Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier

FEMS Immunology and Medical Microbiology

Volumn 27, Issue 4, 2000, Pages 341-349

  Darji, Ayub ^a   Zur Lage, Susanne ^a   Garbe, Annette I ^a   Chakraborty, Trinad ^b   Weiss, Siegfried ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Antibody response; DNA vaccine; Immunological memory; Mucosal vaccine; Salmonella typhimurium; Virulence

Indexed keywords

BACTERIAL DNA; CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; VIRULENCE FACTOR;

ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL VIRULENCE; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; IMMUNIZATION; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SALMONELLA TYPHIMURIUM; VACCINATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; FEMALE; IMMUNITY, MUCOSAL; IMMUNOLOGIC MEMORY; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; PLASMIDS; SALMONELLA TYPHIMURIUM; T-LYMPHOCYTES; VACCINATION; VACCINES, DNA; VIRULENCE;

EID: 0034060571     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00212-6     Document Type: Article

References (40)

1. Donnelly J.J., Ulmer J.B., Shiver J.W., Liu M.A. DNA vaccines. Annu. Rev. Immunol. 15:1997;617-648.
2. Lai W.C., Bennett M. DNA vaccines. Crit. Rev. Immunol. 18:1998;449-484.
3. Dougan G., Chatfield S., Roberts M., Charles I., Comerford S., Li L.J., Fairweather N. Bacterial pathogens - a route to oral drug delivery. Biochem. Soc. Trans. 18:1990;746-748.
4. Fairweather N.F., Chatfield S.N., Charles I.G., Roberts M., Lipscombe M., Li L.J., Strugnell D., Comerford S., Tite J., Dougan G. Use of live attenuated bacteria to stimulate immunity. Res. Microbiol. 141:1990;769-773.
5. Hormaeche C.E. Live attenuated Salmonella vaccines and their potential as oral combined vaccines carrying heterologous antigens. J. Immunol. Methods. 142:1991;113-120.
6. Higgins D.E., Portnoy D.A. Bacterial delivery of DNA evolves. Nat. Biotechnol. 16:1998;138-139.
7. Lowrie D.B. DNA vaccination exploits normal biology. Nat. Med. 4:1998;147-148.
8. + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat. Med. 4:1998;397-402.
9. Darji A., Guzman C.A., Gerstel B., Wachholz P., Timmis K.N., Wehland J., Chakraborty T., Weiss S. Oral somatic transgene vaccination using attenuated S. thyphimurium. Cell. 91:1997;765-775.
10. Dunstan S.J., Simmons C.P., Strugnell R.A. Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen. Infect. Immun. 66:1998;732-740.
11. Valentine P.J., Devore B.P., Heffron F. Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant. Infect. Immun. 66:1998;3378-3383.
12. Neutra M.R., Pringault E., Kraehenbuhl J.P. Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 24:1996;275-300.
13. Darji A., Bruder D., zur Lage S., Gerstel B., Chakraborty T., Wehland J., Weiss S. The role of the bacterial membrane protein ActA in immunity and protection against Listeria monocytogenes. J. Immunol. 161:1998;2414-2420.
14. Bruder D., Darji A., Gakamsky D.M., Chakraborty T., Pecht I., Wehland J., Weiss S. Efficient induction of cytotoxic CD8+ T cells against exogenous proteins: establishment and characterization of a T cell line specific for the membrane protein ActA of Listeria monocytogenes. Eur. J. Immunol. 28:1998;2630-2639.
15. Galan J.E., Curtiss R.D. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc. Natl. Acad. Sci. USA. 86:1989;6383-6387.
16. Galan J.E., Curtiss R.D. Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling. Infect. Immun. 58:1990;1879-1885.
17. Plant J., Glynn A.A. Genetics of resistance to infection with Salmonella typhimurium in mice. J. Infect. Dis. 133:1976;72-78.
18. Plant J., Glynn A.A. Locating Salmonella resistance gene on mouse chromosome 1. Clin. Exp. Immunol. 37:1979;1-6.
19. Benjamin W.H. Jr., Hall P., Roberts S.J., Briles D.E. The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing. J. Immunol. 144:1990;3143-3151.
20. Gruenheid S., Pinner E., Desjardins M., Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185:1997;717-730.
21. Hormaeche J.E. Natural resistance to Salmonella typhimurium in different inbred mouse strains. Immunology. 37:1979;311-318.
22. Rudin S., Johansson E.L., Bergquist C., Holmgren J. Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66:1998;3390-3396.
23. Jones B.D., Falkow S. Salmonellosis: host immune responses and bacterial virulence determinants. Annu. Rev. Immunol. 14:1996;533-561.
24. Sizemore D.R., Branstrom A.A., Sadoff J.C. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization. Science. 270:1995;299-302.
25. Dietrich G., Bubert A., Gentschev I., Sokolovic Z., Simm A., Catic A., Kaufmann S.H., Hess J., Szalay A.A., Goebel W. Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat. Biotechnol. 16:1998;181-185.
26. Hense, M., Wachholz, P., Chakraborty, T. and Weiss, S. Eukaryotic expression plasmid transfer from the intracellular bacterium Listeria monocytogenes to host cells (unpublished).
27. Courvalin P., Goussard S., Grillot C.-C. Gene transfer from bacteria to mammalian cells. C.R. Acad. Sci. III. 318:1995;1207-1212.
28. Grillot Courvalin C., Goussard S., Huetz F., Ojcius D.M., Courvalin P. Functional gene transfer from intracellular bacteria to mammalian cells. Nat. Biotechnol. 16:1998;862-866.
29. Fennelly G.J., Khan S.A., Abadi M.A., Wild T.F., Bloom B.R. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vactor. J. Immunol. 162:1999;1603-1610.
30. Sizemore D.R., Branstrom A.A., Sadoff J.C. Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization. Vaccine. 15:1997;804-807.
31. Paglia P., Medina E., Arioli I., Guzman C.A., Colombo M.P. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma. Blood. 92:1998;3172-3176.
32. Freudenberg M.A., Kumazawa Y., Meding S., Langhorne J., Galanos C. Gamma interferon production in endotoxin-responder and -nonresponder mice during infection. Infect. Immun. 59:1991;3484-3491.
33. Kita E., Emoto M., Oku D., Nishikawa F., Hamuro A., Kamikaidou N., Kashiba S. Contribution of interferon γ and membrane-associated interleukin 1 to the resistance to murine typhoid of ityr mice. J. Leukoc. Biol. 51:1992;244-250.
34. Qin L., Ding Y., Pahud D.R., Chang E., Imperiale M.J., Bromberg J.S. Promoter attenuation in gene therapy: interferon-γ and tumor necrosis factor-α inhibit transgene expression. Hum. Gene Ther. 8:1997;2019-2029.
35. Matzinger P. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods. 145:1991;185-192.
36. Pamer E.G., Harty J.T., Bevan M.J. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature. 353:1991;852-855.
37. Darji A., Chakraborty T., Wehland J., Weiss S. TAP-dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin. Eur. J. Immunol. 27:1997;1353-1359.
38. Darji A., Chakraborty T., Wehland J., Weiss S. Listeriolysin generates a route for the presentation of exogenous antigens by major histocompatibility complex class I. Eur. J. Immunol. 25:1995;2967-2971.
39. Holtel A., Timmis K.N., Ramos J.L. Upstream binding sequences of the XylR activator protein and integration host factor in the xylS gene promoter region of the Pseudomonas TOL plasmid. Nucleic Acids Res. 20:1992;1755-1762.
40. Rammensee H.G., Schild H., Theopold U. Protein-specific cytotoxic T lymphocytes. Recognition of transfectants expressing intracellular, membrane-associated or secreted forms of β-galactosidase. Immunogenetics. 30:1989;296-302.