Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 254-262

  Klavinskis, Linda S ^a,c   Barnfield, Christina ^a   Gao, Liquan ^a   Parker, Suezanne ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b VICAL INC   (United States)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; LUCIFERASE; PLASMID DNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; IMMUNIZATION; IMMUNOMODULATION; INFECTION RESISTANCE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RECTUM MUCOSA;

ADMINISTRATION, INTRANASAL; ANIMALS; BODY FLUIDS; CYTOTOXICITY, IMMUNOLOGIC; EPITHELIUM; FEMALE; GENITALIA, FEMALE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; IMMUNOGLOBULIN G; LUCIFERASES; LYMPH NODES; MICE; MICE, INBRED BALB C; NASAL MUCOSA; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; RECTUM; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; VACCINES, DNA; VAGINA;

EID: 0032909237     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Bukawa, H., K.-I. Sekigawa, K. Hamajima, K., J. Fukushima, Y. Yamada, H. Kiyono, and K. Okuda. 1995. Neutralisation of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multcomponent peptide vaccine candidate. Nat. Med. 1:681.
2. McGhee, J. R., J. Mestecky, M. T. Dertzbaugh, J. Eldridge, M. Hirasawa, and H. Kiyono. 1992. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10:75.
3. Mazanec, J. R., C. S. Kaetzel, M. E. Lamm, D. Fletcher, and J. G. Nedrud. 1992. Intracellular neutralization of virus by immunoglobulin A antibodies. Proc. Natl. Acad. Sci. USA 89:6901.
4. Lohman, B. L., C. J. Miller, and M. B. McChesney. 1995. Antiviral cytotoxic T-lymphocytes in the vaginal mucosa of Simian immunodeficiency virus infected rhesus macaques. J. Immunol. 155:5855.
5. Musey, L., Y. Hu, L. Eckert, M. Christensen, T. Karchmer, and M. J. McElrath. 1997. HIV-1 induces cytotoxic T lymphocytes in the cervix of infected women. J. Exp. Med. 185:293.
6. McDermott, M. R., C. H. Goldsmith, K. L. Rosenthal, and L. J. Brais. 1989. T-lymphocytes in the genital lymph nodes protect mice from intravaginal infection with herpes simplex virus type 2. J. Infect. Dis. 159:460.
7. Milligan, F. N., and D. Bernstein. 1995. Generation of humoral immune responses against herpes simplex type 2 in the murine female genital tract. Virology 206:234.
8. Mitchell, E. A., L. A. Bergmeier, C. Doyle, R. Brookes, Y. Wang, and T. Lehner. 1998. Homing of mononuclear cells from iliac lymph nodes to the genital and rectal mucosa in non-human primates. Eur. J. Immunol. 28:3066.
9. Marthas, M. S., S. Sutjipto, C. Miller, J. Higgins, H. Kiyono, J. McGhee, P. Marx, and N. Pederson. 1992. Efficacy of live attenuated and whole-inactivated SIV vaccines against intravenous and vaginal challenge. In Vaccines. F. Brown, R. M. Chanock, and R. A. Lerner, eds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, p. 117.
10. Gallichan, W. S., D. C. Johnson, F. L. Graham, and K. L. Rosenthal. 1993 Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing HSV gpB. J. Infect. Dis. 168:622.
11. Klavinskis, L. S., L. A. Bergmeier, L. Gao, E. Mitchell, and T. Lehner. 1996. A mucosal or targeted lymph node immunization of macaques with a particulate SIV p27 protein elicits virus specific cytotoxic T lymphocytes in the genito-rectal mucosa and draining lymph nodes. J. Immunol 157:2521.
12. + Th1 cells. Vaccine 13:1741.
13. Partidos, C., D. P. Vohra, D. Joones, G. Farrar, and M. W. Steward. 1997. CTL responses induced by a single immunization with peptide encapsulated in biodegradable microparticles. J Immunol. Methods 206:143.
14. Wang, B., J. Boyer, V. Srikantan, K. Ugen, L. Gilbert, C. Phan, K. Dang, M. Merva, M. G. Agadjanyan, M. Newman, et al. 1995. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in non-human primates by in vivo DNA inoculation. Virology 211:102.
15. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. DeWiott, A. Friedman, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745.
16. Tascon, R. E., M. J. Colston, S. Ragno, E. Stavropoulos, D. Gregory, and D. Lowrie. 1996. Vaccination against tuberculosis by DNA injection. Nat. Med. 8:888.
17. Michael, M. L., H. L. Davis, M. Schleef, M. Mancini, P. Tiollais, and R. E. Whalen. 1995. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimics hepatitis B viral infection in humans. Proc. Natl. Acad. Sci. USA 92:5307.
18. Xiang, Z. Q., M. Spitalnik, M. Tran, W. H. Wunner, J. Cheng, and H. C. J. Ertl. 1994. Vaccination with a plasmid vector carrying the rabies glycoprotein gene induces protective immunity against rabies virus. Virology 199:132.
19. Tang, D. C., M. Devil, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152.
20. Lu, S., J. C. Santoro, D. H. Fuller, J. R. Haynes, and H. L. Robinson. 1995. Use of DNA's expressing HIV env and non-infectious HIV-1 particles to raise antibody responses in mice. Virology 209:147.
21. Fynan, E. F., R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro, and H. L. Robinson. 1993. DNA vaccines: protective immunizations by parental mucosal and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90:11478.
22. Wang, B. M. Merva, K. Dang, K. E. Ugen, J. Boyer, W. W. Williams, and D. B. Weiner. 1994. DNA inoculation induces protective in vivo immune responses against cellular challenge with HIV-1 antigen expressing cells. AIDS Res. Hum. Retroviruses 10(Suppl. 2):S35.
23. Craig, C. W., and J. J. Cebra. 1971. An enriched source of precursors for IgA-producing immunocytes in the rabbit. J. Exp. Med. 134:188.
24. Rudzik, O., R. L. Clancy, D. Y. E. Percy, R. P. Day, and J. Bienenstock, 1975. Repopulation with IgA-containing cells of bronchial and intestinal lamina propria after transfer of homologous Peyer's patches and bronchial lymphocytes. J. Immunol. 114:1599.
25. Spit, B. J., E. G. J. Hendriksen, J. P. Bruijntjes, and C. F. Kuper. 1987. Nasal lymphoid tissue in the rat. Cell Tissue Res. 255:1993.
26. McDermott, M. R., and J. Bienenstock. 1975. Evidence for a common mucosal immunologic system. I. Migration of B Immunoblasts into intestinal, respiratory and genital tissues. J. Immunol. 122:1992.
27. Weisz-Carrington, P., N. E. Roux, M. E. McWilliams, J. M. Phillips-Quagliatta, and M. E. Lamm. 1979. Organ and isotope distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system. J. Immunol. 123:1705.
28. Montgomery, D. L., J. W. Shriver, K. R. Leander, H. C. Perry, A. Friedman, D. Martinez, J. B. Ulmer, J. J. Donnelly, and M. A. Liu. 1993. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell Biol. 12:777.
29. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbour, NY.
30. Wheeler, C. J., L. Sukhu, G. Yang, Y. Tsai, C. Bustamente, P. Felgner, J. Norman, and M. Manthorpe. 1996. Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes. Bioch. Biophys. Acta 1280:1.
31. Felgner, J. H., R. Kumar, C. N. Sridhar, C. J. Wheeler, Y. S. Tsai, R. Border, P. Ramsey, M. Martin and P. L. Felgner. 1994. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269:2550.
32. White, K. N., and L. Fu. 1995. Analysis of nuclear-cytoplasmic export of mRNA expressed from transfected cDNAs using riboprobes for fluorescence in situ hybridization. Methods Mol. Cell. Biol. 5:222.
33. Vaerman, J. P., J. F. Heremans, H. Bazin, and A. Beckers. 1975. Identification and some properties of rat secretory component. J. Immunol. 114:265.
34. Mittal, S. K., M. R. McDermott, D. C. Johnson, L. Prevec, and F. L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using firefly luciferase gene as a reporter. Virus Res. 28:67.
35. Klavinskis, L. S., J. L. Whitton, E. Joly, and M. B. A. Oldstone. 1990. Vaccination and protection from a lethal virus: identification, incorporation and use of a cytotoxic T-lymphocyte giycoprotein epitope. Virology 178:393.
36. Rodriguez, J. F., D. Rodriguez, J. R. Rodriguez, E. B. McGowan, and M. Esteban. 1988. Expression of the firefly luciferase gene in vaccinia virus: a highly sensitive gene marker to follow virus dissemination in tissues of infected animals. Proc. Natl. Acad. Sci. USA 85:1667.
37. Brandtzaeg, P. 1988. Immunobarriers of the mucosa of the upper respiratory and digestive pathways. Acta Otolaryngol. (Stockh.) 105:172.
38. Ascadi, G., S. S. Jia, A. Jani, D. Duke, P. Williams, W. Chong, and J. A. Wolff. 1991. Direct gene transfer and expression into rat heart in vivo. New Biol. 3:71.
39. Mazzoli, S., D. Trabattoni, S. Lo Caput, S. Piconi, C. Ble, F. Meacci, S. Ruzzante, A. Salvi, A. F. Semplici, R. Longhi, et al. 1997. HIV-specific mucosal and cellular immunity in HIV-1 seronegative individuals. Nat. Med. 11: 1250.
40. McChesney, M. B., J. R. Collins, and C. J. Miller. 1997 Mucosal phenotype of antiviral cytotoxic T lymphocytes in the vaginal mucosa of SIV-infected rhesus macaques. AIDS Res. Hum. Retroviruses 23(Suppl 1):S1.
41. Gallichian, W. S., and K. L. Rosenthal. 1996. Long lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunisation. J. Exp. Med. 184:1879.
42. Pal, S., E. M. Peterson, and L. M. de la Maza. 1996. Intranasal immunization induces long term protection in mice against a Chlamydia trachomatis genital challenge. Infect. Immun. 64:5341.
43. Wang, B., K. Dang, M. G. Agadjanyan, V. Srikantan, F. Li, K. E. Ugen, J. Boyer, M. Merva, W. V. Williams, and D. B. Weiner. 1997. Mucosal immunisation with a DNA vaccine induces immune responses against HIV-1 at a mucosal site. Vaccine 15:821.
44. Thapar, M. A., E. L. Parr, and M. B. Parr. 1990. Secretory immune responses in mouse vaginal fluid after pelvic, parenteral or vaginal immunisation. Immunology 70:121.
45. Staats, H. F., R. J. Jackson., M. Mariano, I. Takahoshi, H. Kiyono, and J. R. McGhee. 1994. Mucosal immunity to infection with implications for vaccine development. Curr. Opin. Immunol. 6:572.
46. Parr, M. B., and E. L. Parr. 1994. Mucosal immunity in the female and male reproductive tracts. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mesteky, M. E. Lamm, J. R. Strober, J. R. McGhee, and J. Bienenstock, eds. Academic Press, San Diego, p. 667.
47. Parr, M. B., and E. L. Parr. 1990. Antigen recognition in the female reproductive tract. I. Uptake of intraluminal tracers in the mouse vagina. J. Reprod. Immunol. 17:101.
48. Wheeler, C. J., P. L. Felgner, Y. J. Tsai, J. Marshall, L. Sukhu, S. G. Doh, J. Hartikka, J. Nietupski, M. Manthorpe, M. Nichols, et al. 1996. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc. Natl. Acad. Sci. USA 93:11454.
49. Alton, E. W. F. W., P. G. Middleton, N. J. Caplen, S. N. Smith, F. M. Munkonge, P. K. Jeffery, D. M. Geddes, S. L. Hart, R. Williamson, and D. J. Porteus. 1993. Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat. Genet. 5:135.
50. Logan, J. J., Z. Bebok, L. C. Walker, S. Peng, P. L. Felgner, G. P. Siegal, R. A. Frizzell, J. Dong, M. Howard, J. R. Lindsaey, et al. 1995. Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. Gene Ther. 2:38.
51. Ban, E. M., F. W. van Ginkel, J. W. Simecka, H. Kiyono, H. L. Robinson, and J. R. McGhee. 1997. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine 15:811.
52. Childers, N. K., D. R. Francis, N. F. McGhee, and S. M. Michalek. 1990. Ultrastructural study of liposome uptake by M cells of rat Peyer's patch: an oral vaccine oral vaccine system for delivery of purified antigen. Reg. Immunol. 3:8.
53. Childers, N. K., S. M. Michalek., D. G. Pritchard, and J. R. McGhee. 1991. Mucosal and systemic responses to an oral liposome-Streptococcus mutans carbohydrate vaccine in humans. Reg. Immunol. 3:289.
54. Okada, E., S. Sasaki, N. Ishii, I. Aoki, T. Yasuda, K. Nishioka, J. Fukushima, J.-I. Miyazaki, B. Wahren, and K. Okuda. 1997. Intranasal immunization of a DNA vaccine with IL-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF) expressing plasmids in liposome induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J. Immunol. 159:3638.
55. Ishi, N., J. Fukushima, T. Kaneko, E. Okada, K. Tani, S.-I. Tanaka, K. Hamajima, K.-Q. Xin, S. Kawamoto, W. Kolf, et al. 1997. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses 13:1421.
56. Kuklin, N., M. Daheshia, K. Karem, E. Manickan, and B. T. Rouse. 1997. Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J. Virol. 71:3138.
57. Lehner, T., Y. Wang, M. Cranage, L. A. Bergmeier, E. Mitchell, L. S. Klavinskis, L. Tao, G. Hall, M. Dennis, R. Brookes, et al. 1996. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat. Med. 2:767.
58. Oku, N., and Y. Namba. 1994. Long circulating liposomes. Crit. Rev. Therapeut. Drug Carrier Systems 11:23.
59. Neutra, M. R., E. Pringault, and J.-P. Kraehenbuhl. 1996. Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 14:275.
60. Sedgwick, J. D., and P. G Holt. 1985. Induction of IgE-secreting cells and IgE isotype specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen. Cell. Immunol. 94:182.