Smoking and COPD and Other Respiratory Diseases

Cigarette Smoke Toxicity: Linking Individual Chemicals to Human Diseases

Volumn , Issue , 2011, Pages 167-190

  Sussan, Thomas E ^a   Biswal, Shyam ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

a1AT; Antioxidant response element; Asthma; Genetic determinants; Inflammatory disease; MMP12; NF ?B; Nrf2; Oxidative stress; ROS; TSNA

Indexed keywords

EID: 84882810571     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527635320.ch9     Document Type: Chapter

References (124)

1. Heron, M.P. (2007) Deaths: Leading Causes for 2004 in National Vital Statistics Reports, vol. 56, National Center for Health Statistics, Hyattsville, MD.
2. Centers for Disease Control and Prevention (2007) National Center for Health Statistics: National Health Interview Survey Raw Data, Centers for Disease Control and Prevention, Atlanta, GA
3. Pryor, W.A., Prier, D.G., and Church, D.F. (1983) Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ. Health Perspect., 47, 345-355.
4. Kostikas, K., Papatheodorou, G., Psathakis, K., Panagou, P., and Loukides, S. (2003) Oxidative stress in expired breath condensate of patients with COPD. Chest, 124 (4), 1373-1380.
5. Rahman, I., van Schadewijk, A.A., Crowther, A.J., Hiemstra, P.S., Stolk, J., MacNee, W., and De Boer, W.I. (2002) 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 166 (4), 490-495.
6. Rahman, I., Morrison, D., Donaldson, K., and MacNee, W. (1996) Systemic oxidative stress in asthma, COPD, and smokers. A m. J. Respir. Crit. Care Med., 154 (4 Pt 1), 1055-1060.
7. Sahin, U., Unlu, M., Ozguner, F., Sutcu, R., Akkaya, A., and Delibas, N. (2001) Lipid peroxidation and glutathione peroxidase activity in chronic obstructive pulmonary disease exacerbation: prognostic value of malondialdehyde. J. Basic Clin. Physiol. Pharmacol., 12 (1), 59-68.
8. MacNee, W. and Rahman, I. (2001) Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends Mol. Med., 7 (2), 55-62.
9. Ito, K., Ito, M., Elliott, W.M., Cosio, B., Caramori, G., Kon, O.M., Barczyk, A., Hayashi, S., Adcock, I.M., Hogg, J.C., and Barnes, P.J. (2005) Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med., 352 (19), 1967-1976.
10. Ito, K., Hanazawa, T., Tomita, K., Barnes, P.J., and Adcock, I.M. (2004) Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. B iochem. Biophys. Res. Commun., 315 (1), 240-245.
11. Willemse, B.W., Hacken, N.H., Rutgers, B., Lesman-Leegte, I.G., Postma, D.S., and Timens, W. (2005) Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers. Eur. Respir. J., 26 (5), 835-845.
12. Houghton, A.M., Quintero, P.A., Perkins, D.L., Kobayashi, D.K., Kelley, D.G., Marconcini, L.A., Mecham, R.P., Senior, R.M., and Shapiro, S.D. (2006) Elastin fragments drive disease progression in a murine model of emphysema. J. Clin. Invest., 116 (3), 753-759.
13. Eriksson, S. (1964) Pulmonary emphysema and alpha1-antitrypsin deficiency. Acta Med. Scand., 175, 197-205.
14. Lieberman, J., Winter, B., and Sastre, A. (1986) Alpha 1-antitrypsin Pi-types in 965 COPD patients. Chest, 89 (3), 370-373.
15. Wright, J.L., Cosio, M., and Churg, A. (2008) Animal models of chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol., 295 (1), L1-15.
16. Eidelman, D., Saetta, M.P., Ghezzo, H., Wang, N.S., Hoidal, J.R., King, M., and Cosio, M.G. (1990) Cellularity of the alveolar walls in smokers and its relation to alveolar destruction. Functional implications. Am. Rev. Respir. Dis., 141 (6), 1547-1552.
17. Lagente, V., Le Quement, C., and Boichot, E. (2009) Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases. Expert. Opin. Ther. Targets, 13 (3), 287-295.
18. Shapiro, S.D., Goldstein, N.M., Houghton, A.M., Kobayashi, D.K., Kelley, D., and Belaaouaj, A. (2003) Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am. J. Pathol., 163 (6), 2329-2335.
19. Molet, S., Belleguic, C., Lena, H., Germain, N., Bertrand, C.P., Shapiro, S.D., Planquois, J.M., Delaval, P., and Lagente, V. (2005) Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm. Res., 54 (1), 31-36.
20. Babusyte, A., Stravinskaite, K., Jeroch, J., Lotvall, J., Sakalauskas, R., and Sitkauskiene, B. (2007) Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir. Res., 8, 81.
21. Demedts, I.K., Morel-Montero, A., Lebecque, S., Pacheco, Y., Cataldo, D., Joos, G.F., Pauwels, R.A., and Brusselle, G.G. (2006) Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax, 61 (3), 196-201.
22. Hautamaki, R.D., Kobayashi, D.K., Senior, R.M., and Shapiro, S.D. (2002) 1997) Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science, 277 (5334), 4.
23. Russell, R.E., Culpitt, S.V., DeMatos, C., Donnelly, L., Smith, M., Wiggins, J., and Barnes, P.J. (2002) Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol., 26 (5), 602-609.
24. Foronjy, R., Nkyimbeng, T., Wallace, A., Thankachen, J., Okada, Y., Lemaitre, V., and D ' Armiento, J. (2008) Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin. Am. J. Physiol. Lung Cell. Mol. Physiol., 294 (6), L1149-L1157.
25. Foronjy, R.F., Okada, Y., Cole, R., and D'Armiento, J. (2003) Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol, 284 (5), L727-L737.
26. Shiomi, T., Okada, Y., Foronjy, R., Schiltz, J., Jaenish, R., Krane, S., and D'Armiento, J. (2003) Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp. Lung Res., 29 (1), 1-15.
27. Churg, A., Zay, K., Shay, S., Xie, C., Shapiro, S.D., Hendricks, R., and Wright, J.L. (2002) Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am. J. Respir. Cell Mol. Biol., 27 (3), 368-374.
28. Fera, T., Abboud, R.T., Richter, A., and Johal, S.S. (1986) Acute effect of smoking on elastaselike esterase activity and immunologic neutrophil elastase levels in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis., 133 (4), 568-573.
29. Wang, Z., Zheng, T., Zhu, Z., Homer, R.J., Riese, R.J., Chapman, H.A., Jr, Shapiro, S.D., and Elias, J.A. (2000) Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med., 192 (11), 1587-1600.
30. Fujita, M., Shannon, J.M., Irvin, C.G., Fagan, K.A., Cool, C., Augustin, A., and Mason, R.J. (2001) Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol, 280 (1), L39-L49.
31. Lappalainen, U., Whitsett, J.A., Wert, S.E., Tichelaar, J.W., and Bry, K. (2005) Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am. J. Respir. Cell Mol. Biol., 32 (4), 311-318.
32. Hoshino, T., Kato, S., Oka, N., Imaoka, H., Kinoshita, T., Takei, S., Kitasato, Y., Kawayama, T., Imaizumi, T., Yamada, K., Young, H.A., and Aizawa, H. (2007) Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am. J. Respir. Crit. Care Med., 176 (1), 49-62.
33. Brozyna, S., Ahern, J., Hodge, G., Nairn, J., Holmes, M., Reynolds, P.N., and Hodge, S. (2009) Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. COPD, 6 (1), 4-16.
34. Zhang, X., Shan, P., Jiang, G., Cohn, L., and Lee, P.J. (2006) Toll-like receptor 4 deficiency causes pulmonary emphysema. J. Clin. Invest., 116 (11), 3050-3059.
35. Barnes, P.J., and Karin, M. (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med., 336 (15), 1066-1071.
36. Di Stefano, A., Caramori, G., Oates, T., Capelli, A., Lusuardi, M., Gnemmi, I., Ioli, F., Chung, K.F., Donner, C.F., Barnes, P.J., and Adcock, I.M. (2002) Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur. Respir. J., 20 (3), 556-563.
37. Caramori, G., Romagnoli, M., Casolari, P., Bellettato, C., Casoni, G., Boschetto, P., Chung, K.F., Barnes, P.J., Adcock, I.M., Ciaccia, A., Fabbri, L.M., and Papi, A. (2003) Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax, 58 (4), 348-351.
38. Szulakowski, P., Crowther, A.J., Jimenez, L.A., Donaldson, K., Mayer, R., Leonard, T.B., MacNee, W., and Drost, E.M. (2006) The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit Care. Med., 174 (1), 41-50.
39. Yang, S.R., Chida, A.S., Bauter, M.R., Shafiq, N., Seweryniak, K., Maggirwar, S.B., Kilty, I., and Rahman, I. (2006) Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol., 291 (1), L46-L57.
40. Yang, S.R., Wright, J., Bauter, M., Seweryniak, K., Kode, A., and Rahman, I. (2007) Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell. Mol. Physiol., 292 (2), L567-L576.
41. Karimi, K., Sarir, H., Mortaz, E., Smit, J.J., Hosseini, H., De Kimpe, S.J., Nijkamp, F.P., and Folkerts, G. (2006) Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir. Res., 7, 66.
42. Pauwels, R.A., Lofdahl, C.G., Laitinen, L.A., Schouten, J.P., Postma, D.S., Pride, N.B., and Ohlsson, S.V. (1999) Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N. Engl. J. Med., 340 (25), 1948-1953.
43. Burge, P.S., Calverley, P.M., Jones, P.W., Spencer, S., Anderson, J.A., and Maslen, T.K. (2000) Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ, 320 (7245), 1297-1303.
44. Lung Health Study Research Group (2000) Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N. Engl. J. Med., 343 (26), 1902-1909.
45. Drummond, M.B., Dasenbrook, E.C., Pitz, M.W., Murphy, D.J., and Fan, E. (2008) Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA, 300 (20), 2407-2416.
46. Rennard, S.I., Fogarty, C., Kelsen, S., Long, W., Ramsdell, J., Allison, J., Mahler, D., Saadeh, C., Siler, T., Snell, P., Korenblat, P., Smith, W., Kaye, M., Mandel, M., Andrews, C., Prabhu, R., Donohue, J.F., Watt, R., Lo, K.H., Schlenker-Herceg, R., Barnathan, E.S., and Murray, J. (2007) The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 175 (9), 926-934.
47. Marwick, J.A., Kirkham, P.A., Stevenson, C.S., Danahay, H., Giddings, J., Butler, K., Donaldson, K., Macnee, W., and Rahman, I. (2004) Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am. J. Respir. Cell Mol. Biol., 31 (6), 633-642.
48. Kirkham, P.A., Spooner, G., Ffoulkes -Jones, C., and Calvez, R. (2003) Cigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptor. Free Radic. Biol. Med., 35 (7), 697-710.
49. Rahman, I. and MacNee, W. (2000) Oxidative stress and regulation of glutathione in lung inflammation. Eur. Respir. J., 16 (3), 534-554.
50. Taggart, C., Cervantes-Laurean, D., Kim, G., McElvaney, N.G., Wehr, N., Moss, J., and Levine, R.L. (2000) Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J. Biol. Chem., 275 (35), 27258-27265.
51. Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W., Yamamoto, M., Petrache, I., Tuder, R.M., and Biswal, S. (2004) Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest., 114 (9), 1248-1259.
52. Prestera, T., Talalay, P., Alam, J., Ahn, Y.I., Lee, P.J., and Choi, A.M. (1995) Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant -responsive elements (ARE). Mol. Med., 1 (7), 827-837.
53. Primiano, T., Kensler, T.W., Kuppusamy, P., Zweier, J.L., and Sutter, T.R. (1996) Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones. Carcinogenesis, 17 (11), 2291-2296.
54. Hayes, J.D., Flanagan, J.U., and Jowsey, I.R. (2005) Glutathione transferases. Annu. Rev. Pharmacol. Toxicol., 45, 51-88.
55. Moinova, H.R. and Mulcahy, R.T. (1999) Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. Biochem. Biophys. Res. Commun., 261 (3), 661-668.
56. Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M., and Biswal, S. (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res., 62 (18), 5196-5203.
57. Hayashi, A., Suzuki, H., Itoh, K., Yamamoto, M., and Sugiyama, Y. (2003) Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem. Biophys. Res. Commun., 310 (3), 824-829.
58. Primiano, T., Li, Y., Kensler, T.W., Trush, M.A., and Sutter, T.R. (1998) Identification of dithiolethione -inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention. Carcinogenesis, 19 (6), 999-1005.
59. Kwak, M.K., Wakabayashi, N., Greenlaw, J.L., Yamamoto, M., and Kensler, T.W. (2003) Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell. Biol., 23 (23), 8786-8794.
60. Mohler, J., Mahaffey, J.W., Deutsch, E., and Vani, K. (1995) Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development, 121 (1), 237-247.
61. Wakabayashi, N., Dinkova-Kostova, A.T., Holtzclaw, W.D., Kang, M.I., Kobayashi, A., Yamamoto, M., Kensler, T.W., and Talalay, P. (2004) Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. U. S. A., 101 (7), 2040-2045.
62. Dinkova-Kostova, A.T., Liby, K.T., Stephenson, K.K., Holtzclaw, W.D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G.W., Sporn, M.B., and Talalay, P. (2005) Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc. Natl. Acad. Sci. U. S. A., 102 (12), 4584-4589.
63. Kensler, T.W., Wakabayashi, N., and Biswal, S. (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol., 47, 89-116.
64. Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R.M., and Biswal, S. (2008) Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am. J. Respir. Crit. Care Med., 178 (6), 592-604.
65. Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Nasuhara, Y., Kaga, K., Kondo, S., and Nishimura, M. (2008) Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol., 39 (6), 673-682.
66. Goven, D., Boutten, A., Lecon-Malas, V., Marchal-Somme, J., Amara, N., Crestani, B., Fournier, M., Leseche, G., Soler, P., Boczkowski, J., and Bonay, M. (2008) Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax, 63 (10), 916-924.
67. Iizuka, T., Ishii, Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A.E., Homma, S., Nomura, A., Sakamoto, T., Shimura, M., Yoshida, A., Yamamoto, M., and Sekizawa, K. (2005) Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells, 10 (12), 1113-1125.
68. Decramer, M., Rutten-van Molken, M., Dekhuijzen, P.N., Troosters, T., van Herwaarden, C., Pellegrino, R., van Schayck, C.P., Olivieri, D., Del Donno, M., De Backer, W., Lankhorst, I., and Ardia, A. (2005) Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet, 365 (9470), 1552-1560.
69. Sussan, T.E., Rangasamy, T., Blake, D.J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M.S., Kombairaju, P., Yamamoto, M., Liby, K.T., Sporn, M.B., Gabrielson, K.L., Champion, H.C., Tuder, R.M., Kensler, T.W., and Biswal, S. (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc. Natl. Acad. Sci. U. S. A., 106 (1), 250-255.
70. Tirumalai, R., Rajesh Kumar, T., Mai, K.H., and Biswal, S. (2002) Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol. Lett., 132 (1), 27-36.
71. Veeramachaneni, S.B. and Sethi, S. (2006) Pathogenesis of bacterial exacerbations of COPD. COPD, 3 (2), 109-115.
72. Wedzicha, J.A. and Seemungal, T.A. (2007) COPD exacerbations: defining their cause and prevention. Lancet, 370 (9589), 786-796.
73. Donaldson, G.C., Seemungal, T.A., Bhowmik, A., and Wedzicha, J.A. (2002) Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax, 57 (10), 847-852.
74. Kanner, R.E., Anthonisen, N.R., and Connett, J.E. (2001) Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the lung health study. Am. J. Respir. Crit. Care Med., 164 (3), 358-364.
75. Anzueto, A., Sethi, S., and Martinez, F.J. (2007) Exacerbations of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc., 4 (7), 554-564.
76. Bhowmik, A., Seemungal, T.A., Sapsford, R.J., and Wedzicha, J.A. (2000) Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax, 55 (2), 114-120.
77. Drost, E.M., Skwarski, K.M., Sauleda, J., Soler, N., Roca, J., Agusti, A., and MacNee, W. (2005) Oxidative stress and airway inflammation in severe exacerbations of COPD. Thorax, 60 (4), 293-300.
78. Qiu, Y., Zhu, J., Bandi, V., Atmar, R.L., Hattotuwa, K., Guntupalli, K.K., and Jeffery, P.K. (2003) Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 168 (8), 968-975.
79. Sethi, S., Evans, N., Grant, B.J., and Murphy, T.F. (2002) New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N. Engl. J. Med., 347 (7), 465-471.
80. Chin, C.L., Manzel, L.J., Lehman, E.E., Humlicek, A.L., Shi, L., Starner, T.D., Denning, G.M., Murphy, T.F., Sethi, S., and Look, D.C. (2005) Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers. Am. J. Respir. Crit. Care Med., 172 (1), 85-91.
81. Sethi, S. and Murphy, T.F. (2008) Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N. Engl. J. Med., 359 (22), 2355-2365.
82. Berenson, C.S., Garlipp, M.A., Grove, L.J., Maloney, J., and Sethi, S. (2006) Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease. J. Infect. Dis., 194 (10), 1375-1384.
83. MacRedmond, R.E., Greene, C.M., Dorscheid, D.R., McElvaney, N.G., and O ' Neill, S.J. (2007) Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir. Res., 8, 84.
84. Drannik, A.G., Pouladi, M.A., Robbins, C.S., Goncharova, S.I., Kianpour, S., and Stampfli, M.R. (2004) Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection. Am. J. Respir. Crit. Care Med., 170 (11), 1164-1171.
85. Chen, H., Cowan, M.J., Hasday, J.D., Vogel, S.N., and Medvedev, A.E. (2007) Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J. Immunol., 179 (9), 6097-6106.
86. King, T.E., Jr, Savici, D., and Campbell, P.A. (1988) Phagocytosis and killing of Listeria monocytogenes by alveolar macrophages: smokers versus nonsmokers. J. Infect. Dis., 158 (6), 1309-1316.
87. Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M., Kensler, T.W., and Biswal, S. (2006) Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Invest., 116 (4), 984-995.
88. Stanley, P.J., Wilson, R., Greenstone, M.A., MacWilliam, L., and Cole, P.J. (1986) Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax, 41 (7), 519-523.
89. Jaakkola, J.J. and Jaakkola, M.S. (2002) Effects of environmental tobacco smoke on the respiratory health of children. Scand. J. Work Environ. Health, 28 (Suppl 2), 71-83.
90. Pietinalho, A., Pelkonen, A., and Rytila, P. (2009) Linkage between smoking and asthma. Allergy, 64 (12), 1722-1727.
91. Van Hove, C.L., Moerloose, K., Maes, T., Joos, G.F., and Tournoy, K.G. (2008) Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance. Respir. Res., 9, 42.
92. Andreadis, A.A., Hazen, S.L., Comhair, S.A., and Erzurum, S.C. (2003) Oxidative and nitrosative events in asthma. Free Radic. Biol. Med., 35 (3), 213-225.
93. Henricks, P.A. and Nijkamp, F.P. (2001) Reactive oxygen species as mediators in asthma. Pulm. Pharmacol. Ther., 14 (6), 409-420.
94. Sanders, S.P., Zweier, J.L., Harrison, S.J., Trush, M.A., Rembish, S.J., and Liu, M.C. (1995) Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects. Am. J. Respir. Crit. Care Med., 151 (6), 1725-1733.
95. Kelly, F.J., Mudway, I., Blomberg, A., Frew, A., and Sandstrom, T. (1999) Altered lung antioxidant status in patients with mild asthma. Lancet, 354 (9177), 482-483.
96. Comhair, S.A., Bhathena, P.R., Dweik, R.A., Kavuru, M., and Erzurum, S.C. (2000) Rapid loss of superoxide dismutase activity during antigen -induced asthmatic response. Lancet, 355 (9204), 624.
97. Boldogh, I., Bacsi, A., Choudhury, B.K., Dharajiya, N., Alam, R., Hazra, T.K., Mitra, S., Goldblum, R.M., and Sur, S. (2005) ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J. Clin. Invest., 115 (8), 2169-2179.
98. Rangasamy, T., Guo, J., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D., Yamamoto, M., Kensler, T.W., Tuder, R.M., Georas, S.N., and Biswal, S. (2005) Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J. Exp. Med., 202 (1), 47-59.
99. Carrington, C.B., Gaensler, E.A., Coutu, R.E., FitzGerald, M.X., and Gupta, R.G. (1978) Natural history and treated course of usual and desquamative interstitial pneumonia. N. Engl. J. Med., 298 (15), 801-809.
100. Ryu, J.H., Myers, J.L., Capizzi, S.A., Douglas, W.W., Vassallo, R., and Decker, P.A. (2005) Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. Chest, 127 (1), 178-184.
101. Moon, J., Bois, R.M., Colby, T.V., Hansell, D.M., and Nicholson, A.G. (1999) Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax, 54 (11), 1009-1014.
102. Vassallo, R., Ryu, J.H., Schroeder, D.R., Decker, P.A., and Limper, A.H. (2002) Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults. N. Engl. J. Med., 346 (7), 484-490.
103. Baumgartner, K.B., Samet, J.M., Stidley, C.A., Colby, T.V., and Waldron, J.A. (1997) Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med., 155 (1), 242-248.
104. Cho, H.Y., Reddy, S.P., Yamamoto, M., and Kleeberger, S.R. (2004) The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J., 18 (11), 1258-1260.
105. Watanabe, K., Fujimura, M., Kasahara, K., Yasui, M., Myou, S., Kita, T., Watanabe, A., and Nakao, S. (2002) Acute eosinophilic pneumonia following cigarette smoking: a case report including cigarette-smoking challenge test. Intern. Med., 41 (11), 1016-1020.
106. Richens, T.R., Linderman, D.J., Horstmann, S.A., Lambert, C., Xiao, Y.Q., Keith, R.L., Boe, D.M., Morimoto, K., Bowler, R.P., Day, B.J., Janssen, W.J., Henson, P.M., and Vandivier, R.W. (2009) Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am. J. Respir. Crit. Care Med., 179 (11), 1011-1021.
107. Nyunoya, T., Monick, M.M., Klingelhutz, A., Yarovinsky, T.O., Cagley, J.R., and Hunninghake, G.W. (2006) Cigarette smoke induces cellular senescence. Am. J. Respir. Cell Mol. Biol., 35 (6), 681-688.
108. Su, X., Lee, J.W., Matthay, Z.A., Mednick, G., Uchida, T., Fang, X., Gupta, N., and Matthay, M.A. (2007) Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am. J. Respir. Cell Mol. Biol., 37 (2), 186-192.
109. Giebelen, I.A., Leendertse, M., Florquin, S., and van der Poll, T. (2009) Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia. Eur. Respir. J., 33 (2), 375-381.
110. Razani-Boroujerdi, S., Singh, S.P., Knall, C., Hahn, F.F., Pena-Philippides, J.C., Kalra, R., Langley, R.J., and Sopori, M.L. (2004) Chronic nicotine inhibits inflammation and promotes influenza infection. Cell. Immunol., 230 (1), 1-9.
111. Helen, A., Krishnakumar, K., Vijayammal, P.L., and Augusti, K.T. (2003) A comparative study of antioxidants S-allyl cysteine sulfoxide and vitamin E on the damages induced by nicotine in rats. Pharmacology, 67 (3), 113-117.
112. Kovacic, P. and Cooksy, A. (2005) Iminium metabolite mechanism for nicotine toxicity and addiction: Oxidative stress and electron transfer. Med. Hypotheses, 64 (1), 104-111.
113. El-Sokkary, G.H., Cuzzocrea, S., and Reiter, R.J. (2007) Effect of chronic nicotine administration on the rat lung and liver: beneficial role of melatonin. Toxicology, 239 (1-2), 60-67.
114. Schuller, H.M. (2007) Nitrosamines as nicotinic receptor ligands. Life Sci., 80 (24-25), 2274-2280.
115. Dairou, J., Petit, E., Ragunathan, N., Baeza-Squiban, A., Marano, F., Dupret, J.M., and Rodrigues-Lima, F. (2009) Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidants. Toxicol. Appl. Pharmacol., 236 (3), 366-371.
116. Ovrevik, J., Arlt, V.M., Oya, E., Nagy, E., Mollerup, S., Phillips, D.H., Lag, M., and Holme, J.A. (2010) Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. Toxicol. Appl. Pharmacol., 242 (3), 270-280.
117. Hasnis, E., Bar-Shai, M., Burbea, Z., and Reznick, A.Z. (2007) Mechanisms underlying cigarette smoke-induced NF-kappaB activation in human lymphocytes: the role of reactive nitrogen species. J. Physiol. Pharmacol., 58 (Suppl 5 Pt 1), 275-287.
118. Pouli, A.E., Hatzinikolaou, D.G., Piperi, C., Stavridou, A., Psallidopoulos, M.C., and Stavrides, J.C. (2003) The cytotoxic effect of volatile organic compounds of the gas phase of cigarette smoke on lung epithelial cells. Free Radic. Biol. Med., 34 (3), 345-355.
119. Ghilarducci, D.P. and Tjeerdema, R.S. (1995) Fate and effects of acrolein. Rev. Environ. Contam. Toxicol., 144, 95-146.
120. Biswal, S., Acquaah-Mensah, G., Datta, K., Wu, X., and Kehrer, J.P. (2002) Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications. Chem. Res. Toxicol., 15 (2), 180-186.
121. Yasuda, H., Yamaya, M., Nakayama, K., Ebihara, S., Sasaki, T., Okinaga, S., Inoue, D., Asada, M., Nemoto, M., and Sasaki, H. (2005) Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 171 (11), 1246-1251.
122. Jarup, L., Berglund, M., Elinder, C.G., Nordberg, G., and Vahter, M. (1998) Health effects of cadmium exposure-a review of the literature and a riskestimate. S cand. J. Work Environ. Health, 24 (Suppl 1), 1-51.
123. Bernhard, D., Rossmann, A., and Wick, G. (2005) Metals in cigarette smoke. IUBMB Life, 57 (12), 805-809.
124. Ghio, A.J., Hilborn, E.D., Stonehuerner, J.G., Dailey, L.A., Carter, J.D., Richards, J.H., Crissman, K.M., Foronjy, R.F., Uyeminami, D.L., and Pinkerton, K.E. (2008) Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am. J. Respir. Crit. Care Med., 178 (11), 1130-1138.