Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells

Toxicology Letters

Volumn 132, Issue 1, 2002, Pages 27-36

  Tirumalai, R ^a   Rajesh Kumar, T ^a   Mai, Kim Hue ^a   Biswal, Shyam ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acrolein; Antioxidant response element; Glutathione; Nrf2; Phase II genes

Indexed keywords

ACROLEIN; CELL EXTRACT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MESSENGER RNA; NUCLEAR PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL LEVEL; CELL NUCLEUS; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL TYPE 2; PRIORITY JOURNAL; PROTEIN BINDING; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACROLEIN; ANTIOXIDANTS; BLOTTING, WESTERN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; HUMANS; IN SITU HYBRIDIZATION; LUCIFERASES; LUNG; NF-E2-RELATED FACTOR 2; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; UP-REGULATION;

EID: 0037035942     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00055-3     Document Type: Article

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