Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations

Thorax

Volumn 55, Issue 2, 2000, Pages 114-120

  Bhowmik, Angshu ^a   Seemungal, Terence A R ^a   Sapsford, Raymond J ^a   Wedzicha, Jadwiga A ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Chronic obstructive pulmonary disease; Cytokines; Induced sputum

Indexed keywords

CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; SALBUTAMOL;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMON COLD; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE DIFFERENTIAL COUNT; LUNG FUNCTION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SPUTUM ANALYSIS; SYMPTOM;

AGED; COHORT STUDIES; CYTOKININS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; SPUTUM; VITAL CAPACITY;

EID: 0034018102     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.55.2.114     Document Type: Article

References (30)

1. Seemungal TAR, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:1418-22.
2. Anthonisen NR, Manfreda J, Warren CPW, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987;106:196-204.
3. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47:25-9.
4. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994;150:1646-52.
5. Bhowmik A, Seemungal TAR, Sapsford RJ, et al. Comparison of spontaneous and induced sputum for investigation of airway inflammation in chronic obstructive pulmonary disease. Thorax 1998;53:953-6.
6. Keatings VM, Collins PD, Scott DM, et al. Differences in interleukin-8 and tumour necrosis factor in induced sputum from patients with chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med 1996;153: 530-4.
7. British Thoracic Society. BTS guidelines for the management of chronic obstructive pulmonary disease. Thorax 1997;52(Suppl 5):S1-12.
8. Pitkin AD, Roberts CM, Wedzicha JA. Arterialised ear lobe blood gas analysis: An underused technique. Thorax 1994;49:364-6.
9. Popov T, Gottschalk R, Kolendowicz R, et al. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy 1994;24:778-83.
10. Pizzichini E, Pizzichini MMM, Efthimiadis A, et al. Measurement of inflammatory indices in induced sputum: Effects of selection of sputum to minimize salivary contamination. Eur Respir J 1996;9:1174-80.
11. Gosset P, Tsicopoulos A, Wallaert B, et al. Increased secretion of tumour necrosis factor α and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J Allergy Clin Immunol 1991;88:561-71.
12. Cromwell O, Hamid Q, Corrigan CJ, et al. Expression and generation of interleukin-8, IL-6 and granulocyte colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1β and tumour necrosis factor α. Immunology 1992;77:330-7.
13. Bagglioni M, Walz A, Kunkel SL. Neutrophil activating peptide-1/interleukin-8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-9.
14. Wilson R. Bacterial infection and chronic obstructive pulmonary disease. Eur Respir J 1999;13:233-5.
15. Gump DW, Phillips CA, Forsyth BR, et al. Role of infection in chronic bronchitis. Am Rev Respir Dis 1976;113:465-73.
16. Seemungal TAR, Donaldson GC, Breuer J, et al. Rhinoviruses are associated with exacerbations of COPD. Am J Respir Crit Care Med 1998;157:A173.
17. Subauste M, Jacoby D, Richards S, et al. Infection of a human respiratory epithelial cell line with rhinovirus. J Clin Invest 1995;96:549-57.
18. Stockley RA. Role of bacteria in the pathogenesis and progression of acute and chronic lung infection. Thorax 1998;53:58-62.
19. Khair OA, Devalia JL, Abdelaziz MM, et al. Effect of Haemophilus influenzae endotoxin on the synthesis of IL-6, IL-8, TNF-α and expression of ICAM 1 in cultured human bronchial epithelial cells. Eur Respir J 1994;7:2109-16.
20. Ball P, Harris JM, Lowson D, et al. Acute infective exacerbations of chronic bronchitis. Q J Med 1995;88:61-8.
21. Ketelaars CAJ, Schlosser MAG, Mostert RT, et al. Determinants of health-related quality of life in patients with chronic obstructive pulmonary disease. Thorax 1996;51: 39-43.
22. Okubadejo AA, Jones PW, Wedzicha JA. Quality of life in patients with chronic obstructive pulmonary disease and severe hypoxaemia. Thorax 1996;51:44-7.
23. Pizzichini MMM, Pizzichini E, Efthimiadis A, et al. Asthma and natural colds: Inflammatory indices in induced sputum: A feasibility study. Am J Respir Crit Care Med 1998;158:1178-84.
24. Denny FW. The clinical impact of human respiratory virus infections. Am J Respir Crit Care Med 1995;152:S4-12.
25. Pizzichini MMM, Pizzichini E, Clelland L, et al. Sputum in severe exacerbations of asthma: Kinetics of inflammatory indices after prednisone treatment. Am J Respir Crit Care Med 1997;155:1501-8.
26. Thompson WH, Nielson CP, Carvalho P, et al. Controlled trial of oral prednisolone in outpatients with acute COPD exacerbation. Am J Respir Crit Care Med 1996;154: 407-12.
27. Albert RK, Martin TR, Lewis SW. Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med 1980;92:753-8.
28. Pizzichini E, Pizzichini MMM, Gibson P, et al. Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. Am J Respir Crit Care Med 1998;158:1511-7.
29. Fletcher C, Peto R, Tinker C, et al. The Natural History of Chronic Bronchitis and Emphysema. Oxford: Oxford University Press, 1976.
30. Kanner RE, Renzetti AD Jr, Klauber MR, et al. Variables associated with changes in spirometry in patients with obstructive lung diseases. Am J Med 1976;67:44-50.