Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 1 24-1, 2001, Pages

  Fujita, Masaki ^a   Shannon, John M ^a   Irvin, Charles G ^a   Fagan, Karen A ^b   Cool, Carlyne ^a   Augustin, Andrei ^a   Mason, Robert J ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Emphysema; Pulmonary fibrosis; Pulmonary hypertension

Indexed keywords

GELATINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOPATHOLOGY; LUNG ALVEOLUS CELL TYPE 2; LUNG EMPHYSEMA; LUNG FIBROSIS; LUNG VOLUME; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

EID: 0034997949     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.1.l39     Document Type: Article

References (48)

1. Akdis CA, Blesken T, Akdis M, Wuthrich B, and Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest 102: 98-106, 1998.
2. Amy RW, Bowes D, Burri PH, Haines J, and Thurlbeck WM. Postnatal growth of the mouse lung. J Anat 124: 131-151, 1977.
3. Bazzoni F and Beutler B. The tumor necrosis factor ligand and receptor families. N Engl J Med 334: 1717-1725, 1996.
4. Blackwood RA, Moret J, Mandl I, and Turino GM. Emphysema induced by intravenously administered endotoxin in an alpha 1-antitrypsin-deficient rat model. Am Rev Respir Dis 130: 231-236, 1984.
5. Burnett D, Chamba A, Hill SL, and Stockley RA. Effects of plasma, tumor necrosis factor, endotoxin and dexamethasone on extracellular proteolysis by neutrophils from healthy subjects and patients with emphysema. Clin Sci (Colch) 77: 35-41, 1989.
6. Cardoso WV, Sekhon HS, Hyde DM, and Thurlbeck WM. Collagen and elastin in human pulmonary emphysema. Am Rev Respir Dis 147: 975-981, 1993.
7. D'Armiento J, Dalal SS, Okada Y, Berg RA, and Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 71: 955-961, 1992.
8. De Godoy I, Donahoe M, Calhoun WJ, Mancino J, and Rogers RM. Elevated TNF-α production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 153: 633-637, 1996.
9. Di Francia M, Barbier D, Mege JL, and Orehek J. Tumor necrosis factor-α levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 150: 1453-1455, 1994.
10. Dunnill MS. Quantitative methods in the study of pulmonary pathology. Thorax 17: 320-328, 1962.
11. Fagan KA, Fouty BW, Tyler RC, Morris JKG, Hepler LK, Sato K, Le Cras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, and Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
12. Finkelstein R, Fraser RS, Ghezzo H, and Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 152: 1666-1672, 1995.
13. Finlay GA, O'Driscoll LR, Russell KJ, D'Arcy EM, Masterson JB, FitzGerald MX, and O'Connor CM. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am J Respir Crit Care Med 156: 240-247, 1997.
14. Finlay GA, Russell KJ, McMahon KJ, D'Arcy EM, Masterson JB, FitzGerald MX, and O'Connor CM. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 52: 502-506, 1997.
15. Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BMJ, and Brennan FM. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 160: 920-928, 1998.
16. French BT, Lee WH, and Maul GG. Nucleotide sequence of a cDNA clone for mouse pro alpha 1(I) collagen protein. Gene 39: 311-312, 1985.
17. Furuie H, Yamasaki H, Suga M, and Ando M. Altered accessory cell function of alveolar macrophages: a possible mechanism for induction of Th2 secretory profile in idiopathic pulmonary fibrosis. Eur Respir J 1997: 787-794, 1997.
18. Guenter CA, Coalson JJ, and Jacques J. Emphysema associated with intravascular leukocyte sequestration. Am Rev Respir Dis 123: 79-84, 1981.
19. Hardie WD, Bruno MD, Huelsman KM, Iwamoto HS, Carrigan PE, Leikauf GD, Whitsett JA, and Korfhagen TR. Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-α. Am J Pathol 151: 1075-1083, 1997.
20. Hautamaki RD, Kobayashi DK, Senior RM, and Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 2002-2004, 1997.
21. Irvin CG, Tu Y-P, Sheller JR, and Funk CD. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice. Am J Physiol Lung Cell Mol Physiol 272: L1053-L1058, 1997.
22. Janoff A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 132: 417-433, 1985.
23. Johnson J, Brigham KL, Jesmok G, and Meyrick B. Morphologic changes in lungs of anesthetized sheep following intravenous infusion of recombinant tumor necrosis factor α. Am Rev Respir Dis 144: 179-186, 1991.
24. Keatings VM, Collins PD, Scott DM, and Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 153: 530-534, 1996.
25. Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, and Senior RM. Gelatinase B-dencient mice are resistant to experimental bullous pemphigoid. J Exp Med 188: 475-482, 1998.
26. Martinez JA, King TE Jr, Brown K, Jennings CA, Borish L, Mortenson RL, Khan TZ, Bost TW, and Riches DW. Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease. Am J Physiol Lung Cell Mol Physiol 273: L676-L683, 1997.
27. Mauviel A, Daireaux M, Redini F, Galera P, Loyau G, and Pujol JP. Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts. FEBS Lett 236: 47-52, 1988.
28. Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol Regulatory Integrative Comp Physiol 274: R577-R595, 1998.
29. Miyazaki Y, Araki K, Vesin C, Garcia I, Kapanci Y, Whitsett JA, Piguet PF, and Vassalli P. Expression of a tumor necrosis factor-α transgene in murine lung causes lymphocytic and flbrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 96: 250-259, 1995.
30. Mosmann TR and Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17: 138-146, 1996.
31. Mueller R, Chanez P, Campbell AM, Bousquet J, Heusser C, and Bullock GR. Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis. Respir Med 90: 79-85, 1996.
32. Nelson S, Bagby GJ, Bainton BG, Wilson LA, Thompson JJ, and Summer WR. Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response. J Infect Dis 159: 189-194, 1989.
33. O'Connor CM and FitzGerald MX. Matrix metalloproteases and lung disease. Thorax 49: 602-609, 1994.
34. Ohnishi K, Takagi M, Kurokawa Y, Satomi S, and Konttinen YT. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 78: 1077-1087, 1998.
35. Piguet PF, Collart MA, Grau GE, Kapanci Y, and Vassalli P. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170: 655-663, 1989.
36. Piguet PF, Collart MA, Grau GE, Sappino A-P, and Vassalli P. Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature 344: 245-247, 1990.
37. Piguet PF, Ribaux C, Karpuz V, Grau GE, and Kapanci Y. Expression and localization of tumor necrosis factor-α and its mRNA in idiopathic pulmonary fibrosis. Am J Pathol 143: 651-655, 1993.
38. Piguet PF and Vesin C. Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 7: 515-518, 1994.
39. Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, Gately MK, and Gubler U. Cloning and expression of murine IL-12. J Immunol 148: 3433-3440, 1992.
40. Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, and Welgus HG. Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem 266: 7870-7875, 1991.
41. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, and Gauldie J. Transfer of tumor necrosis factor-α to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-β1 and myoblasts. Am J Pathol 153: 825-832, 1998.
42. Sueoka N, Sueoka E, Miyazaki Y, Okabe S, Kurosumi M, Takayama S, and Fujiki H. Molecular pathogenesis of interstitial pneumonitis with TNF-α transgenic mice. Cytokine 10: 124-131, 1998.
43. Sulkowska M, Sulkowski S, Terlikowski S, and Nowak HF. Tumor necrosis factor-α induces emphysema-like pulmonary tissue rebuilding. Changes in type II alveolar epithelial cells. Pol J Pathol 48: 179-188, 1997.
44. Tanaka H, Hojo K, Yoshida H, Yoshioka T, and Sugita K. Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun 190: 732-740, 1993.
45. Thrall RS, Vogel SN, Evans R, and Shultz LD. Role of tumor necrosis factor-α in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice. Am J Pathol 151: 1303-1310, 1997.
46. Wang Z, Zhu Z, Homer RJ, and Elias JA. Inducible overexpression of interferon gamma in the lung induction of tissue inflammation and alveolar enlargement (Abstract). Am J Respir Crit Care Med 159: A213, 1999.
47. Wilmott RW, Kitzmiller JA, Fiedler MA, and Stark JM. Generation of a transgenic mouse with lung-specific overexpression of the human interleukin-1 receptor antagonist protein. Am J Respir Cell Mol Biol 18: 429-434, 1998.
48. Zhang K, Gharaee-Kermani M, McGarry B, Remick D, and Phan SH. TNF-α-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J Immunol 158: 954-959, 1997.