메뉴 건너뛰기




Volumn 10, Issue 6, 2013, Pages 618-630

On the interaction of β-Amyloid peptides and α7-Nicotinic acetylcholine receptors in Alzheimer's disease

Author keywords

Acetylcholinesterase; Alzheimer's Disease; Amyloid; Cholinergic; Hippocampus; Neuroprotection; Nicotinic acetylcholine receptor; Review; Tau phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN; BUNGAROTOXIN RECEPTOR; MONOMER; OLIGOMER; TAU PROTEIN;

EID: 84882778234     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/15672050113109990132     Document Type: Review
Times cited : (60)

References (170)
  • 1
    • 0000293742 scopus 로고
    • Über eine eigenartige Erkrankung der Hirnrinde
    • Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Zeitschrift für Psychiatrie 64: 146-148 (1907).
    • (1907) Zeitschrift Für Psychiatrie , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 2
    • 0031720801 scopus 로고    scopus 로고
    • The incidence of dementia: A meta-analysis
    • Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology 51: 728-33 (1998).
    • (1998) Neurology , vol.51 , pp. 728-733
    • Jorm, A.F.1    Jolley, D.2
  • 3
    • 33750361022 scopus 로고    scopus 로고
    • Aging of the brain, entropy, and Alzheimer disease
    • Drachman DA. Aging of the brain, entropy, and Alzheimer disease. Neurology 67: 1340-52 (2006).
    • (2006) Neurology , vol.67 , pp. 1340-1352
    • Drachman, D.A.1
  • 4
    • 72849142054 scopus 로고    scopus 로고
    • Alzheimer's disease: Synaptic dysfunction and Abeta
    • Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener 4: 48 (2009).
    • (2009) Mol Neurodegener , vol.4 , pp. 48
    • Shankar, G.M.1    Walsh, D.M.2
  • 5
    • 33847135229 scopus 로고    scopus 로고
    • Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    • Lorke DE, Lu G, Cho E, Yew DT. Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC Neurosci 7: 36 (2006).
    • (2006) BMC Neurosci , vol.7 , pp. 36
    • Lorke, D.E.1    Lu, G.2    Cho, E.3    Yew, D.T.4
  • 6
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41: 17-24 (1997).
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3    Mui, S.4    Growdon, J.H.5    Petersen, R.C.6
  • 7
    • 33749177143 scopus 로고    scopus 로고
    • A hundred years of Alzheimer's disease research
    • Hardy J. A hundred years of Alzheimer's disease research. Neuron 52: 3-13 (2006).
    • (2006) Neuron , vol.52 , pp. 3-13
    • Hardy, J.1
  • 8
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimerrelated changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimerrelated changes. Acta Neuropathol 82: 239-59 (1991).
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 77951753692 scopus 로고    scopus 로고
    • TUNEL and growth factor expression in the prefrontal cortex of Alzheimer patients over 80 years old
    • Lorke DE, Wai MS, Liang Y, Yew DT. TUNEL and growth factor expression in the prefrontal cortex of Alzheimer patients over 80 years old. Int J Immunopathol Pharmacol 23: 13-23 (2010).
    • (2010) Int J Immunopathol Pharmacol , vol.23 , pp. 13-23
    • Lorke, D.E.1    Wai, M.S.2    Liang, Y.3    Yew, D.T.4
  • 11
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43: 545-84 (2003).
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 12
    • 84877968410 scopus 로고    scopus 로고
    • Amyloid-beta Peptide: Dr. Jekyll or Mr. Hyde?
    • Puzzo D, Arancio O. Amyloid-beta Peptide: Dr. Jekyll or Mr. Hyde? J Alzheimers Dis (2012).
    • (2012) J Alzheimers Dis
    • Puzzo, D.1    Arancio, O.2
  • 13
    • 0032814135 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?
    • Small DH, McLean CA. Alzheimer's disease and the amyloid beta protein: What is the role of amyloid? J Neurochem 73: 443-9 (1999).
    • (1999) J Neurochem , vol.73 , pp. 443-449
    • Small, D.H.1    McLean, C.A.2
  • 14
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • Turner PR, O'Connor K, Tate WP, Abraham WC. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70: 1-32 (2003).
    • (2003) Prog Neurobiol , vol.70 , pp. 1-32
    • Turner, P.R.1    O'Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 15
    • 33745700370 scopus 로고    scopus 로고
    • Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40
    • Kumar-Singh S, Theuns J, Van Broeck B, Pirici D, Vennekens K, Corsmit E, et al. Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat 27: 686-95 (2006).
    • (2006) Hum Mutat , vol.27 , pp. 686-695
    • Kumar-Singh, S.1    Theuns, J.2    Van Broeck, B.3    Pirici, D.4    Vennekens, K.5    Corsmit, E.6
  • 17
    • 58149497521 scopus 로고    scopus 로고
    • Biochemistry and molecular biology of amyloid betaprotein and the mechanism of Alzheimer's disease
    • Selkoe DJ. Biochemistry and molecular biology of amyloid betaprotein and the mechanism of Alzheimer's disease. Handb Clin Neurol 89: 245-60 (2008).
    • (2008) Handb Clin Neurol , vol.89 , pp. 245-260
    • Selkoe, D.J.1
  • 18
    • 0034728596 scopus 로고    scopus 로고
    • Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients
    • Burghaus L, Schutz U, Krempel U, de Vos RA, Jansen Steur EN, Wevers A, et al. Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients. Brain Res Mol Brain Res 76: 385-8 (2000).
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 385-388
    • Burghaus, L.1    Schutz, U.2    Krempel, U.3    de Vos, R.A.4    Jansen Steur, E.N.5    Wevers, A.6
  • 20
    • 0033841591 scopus 로고    scopus 로고
    • Expression of nicotinic acetylcholine receptors in Alzheimer's disease: Postmortem investigations and experimental approaches
    • Wevers A, Burghaus L, Moser N, Witter B, Steinlein OK, Schutz U, et al. Expression of nicotinic acetylcholine receptors in Alzheimer's disease: postmortem investigations and experimental approaches. Behav Brain Res 113: 207-15 (2000).
    • (2000) Behav Brain Res , vol.113 , pp. 207-215
    • Wevers, A.1    Burghaus, L.2    Moser, N.3    Witter, B.4    Steinlein, O.K.5    Schutz, U.6
  • 21
    • 0032589299 scopus 로고    scopus 로고
    • Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease
    • Martin-Ruiz CM, Court JA, Molnar E, Lee M, Gotti C, Mamalaki A, et al. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J Neurochem 73: 1635-40 (1999).
    • (1999) J Neurochem , vol.73 , pp. 1635-1640
    • Martin-Ruiz, C.M.1    Court, J.A.2    Molnar, E.3    Lee, M.4    Gotti, C.5    Mamalaki, A.6
  • 22
    • 0035232357 scopus 로고    scopus 로고
    • Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease
    • Engidawork E, Gulesserian T, Balic N, Cairns N, Lubec G. Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. J Neural Transm Suppl 211-22 (2001).
    • (2001) J Neural Transm Suppl , pp. 211-222
    • Engidawork, E.1    Gulesserian, T.2    Balic, N.3    Cairns, N.4    Lubec, G.5
  • 23
    • 0033983966 scopus 로고    scopus 로고
    • Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease
    • Guan ZZ, Zhang X, Ravid R, Nordberg A. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem 74: 237-43 (2000).
    • (2000) J Neurochem , vol.74 , pp. 237-243
    • Guan, Z.Z.1    Zhang, X.2    Ravid, R.3    Nordberg, A.4
  • 24
    • 0019521132 scopus 로고
    • Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain
    • Davies P, Feisullin S. Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain. Brain Res 216: 449-54 (1981).
    • (1981) Brain Res , vol.216 , pp. 449-454
    • Davies, P.1    Feisullin, S.2
  • 25
    • 33847029091 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    • Dani JA, Bertrand D. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol 47: 699-729 (2007).
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 699-729
    • Dani, J.A.1    Bertrand, D.2
  • 26
    • 0141748121 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors of muscles and nerves: Comparison of their structures, functional roles, and vulnerability to pathology
    • Lindstrom JM. Nicotinic acetylcholine receptors of muscles and nerves: comparison of their structures, functional roles, and vulnerability to pathology. Ann N Y Acad Sci 998: 41-52 (2003).
    • (2003) Ann N Y Acad Sci , vol.998 , pp. 41-52
    • Lindstrom, J.M.1
  • 27
    • 58249113980 scopus 로고    scopus 로고
    • Mammalian nicotinic acetylcholine receptors: From structure to function
    • Albuquerque EX, Pereira EF, Alkondon M, Rogers SW. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89: 73-120 (2009).
    • (2009) Physiol Rev , vol.89 , pp. 73-120
    • Albuquerque, E.X.1    Pereira, E.F.2    Alkondon, M.3    Rogers, S.W.4
  • 28
    • 33846029827 scopus 로고    scopus 로고
    • Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model
    • Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J 21: 61-73 (2007).
    • (2007) FASEB J , vol.21 , pp. 61-73
    • Liu, Q.1    Zhang, J.2    Zhu, H.3    Qin, C.4    Chen, Q.5    Zhao, B.6
  • 29
    • 0025605864 scopus 로고
    • A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homooligomeric channel blocked by alpha-BTX
    • Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, et al. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homooligomeric channel blocked by alpha-BTX. Neuron 5: 847-56 (1990).
    • (1990) Neuron , vol.5 , pp. 847-856
    • Couturier, S.1    Bertrand, D.2    Matter, J.M.3    Hernandez, M.C.4    Bertrand, S.5    Millar, N.6
  • 30
    • 0027518923 scopus 로고
    • Molecular cloning, functional properties, and distribution of rat brain alpha 7: A nicotinic cation channel highly permeable to calcium
    • Seguela P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J Neurosci 13: 596-604 (1993).
    • (1993) J Neurosci , vol.13 , pp. 596-604
    • Seguela, P.1    Wadiche, J.2    Dineley-Miller, K.3    Dani, J.A.4    Patrick, J.W.5
  • 31
    • 77449137869 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic ligand-gated ion channels
    • Schicker KW, Dorostkar MM, Boehm S. Modulation of transmitter release via presynaptic ligand-gated ion channels. Curr Mol Pharmacol 1: 106-29 (2008).
    • (2008) Curr Mol Pharmacol , vol.1 , pp. 106-129
    • Schicker, K.W.1    Dorostkar, M.M.2    Boehm, S.3
  • 32
    • 0034468856 scopus 로고    scopus 로고
    • Nicotinic receptors in human brain: Topography and pathology
    • Court JA, Martin-Ruiz C, Graham A, Perry E. Nicotinic receptors in human brain: topography and pathology. J Chem Neuroanat 20: 281-98 (2000).
    • (2000) J Chem Neuroanat , vol.20 , pp. 281-298
    • Court, J.A.1    Martin-Ruiz, C.2    Graham, A.3    Perry, E.4
  • 33
    • 0027257837 scopus 로고
    • Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus
    • Perry EK, Court JA, Johnson M, Smith CJ, James V, Cheng AV, et al. Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus. Hippocampus 3: 307-15 (1993).
    • (1993) Hippocampus , vol.3 , pp. 307-315
    • Perry, E.K.1    Court, J.A.2    Johnson, M.3    Smith, C.J.4    James, V.5    Cheng, A.V.6
  • 34
    • 0029805769 scopus 로고    scopus 로고
    • Hippocampal synaptic transmission enhanced by low concentrations of nicotine
    • Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383: 713-6 (1996).
    • (1996) Nature , vol.383 , pp. 713-716
    • Gray, R.1    Rajan, A.S.2    Radcliffe, K.A.3    Yakehiro, M.4    Dani, J.A.5
  • 35
    • 0032520135 scopus 로고    scopus 로고
    • Acetylcholine activates an alpha-bungarotoxinsensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells
    • Frazier CJ, Rollins YD, Breese CR, Leonard S, Freedman R, Dunwiddie TV. Acetylcholine activates an alpha-bungarotoxinsensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J Neurosci 18: 1187-95 (1998).
    • (1998) J Neurosci , vol.18 , pp. 1187-1195
    • Frazier, C.J.1    Rollins, Y.D.2    Breese, C.R.3    Leonard, S.4    Freedman, R.5    Dunwiddie, T.V.6
  • 36
    • 65249151342 scopus 로고    scopus 로고
    • Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
    • Carson R, Craig D, Hart D, Todd S, McGuinness B, Johnston JA, et al. Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease. Neuromolecular Med 10: 377-84 (2008).
    • (2008) Neuromolecular Med , vol.10 , pp. 377-384
    • Carson, R.1    Craig, D.2    Hart, D.3    Todd, S.4    McGuinness, B.5    Johnston, J.A.6
  • 37
    • 0035251677 scopus 로고    scopus 로고
    • Nicotinic receptor abnormalities of Alzheimer's disease: Therapeutic implications
    • Nordberg A. Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol Psychiatry 49: 200-10 (2001).
    • (2001) Biol Psychiatry , vol.49 , pp. 200-210
    • Nordberg, A.1
  • 38
    • 0032971370 scopus 로고    scopus 로고
    • Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: Histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein
    • Wevers A, Monteggia L, Nowacki S, Bloch W, Schutz U, Lindstrom J, et al. Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein. Eur J Neurosci 11: 2551-65 (1999).
    • (1999) Eur J Neurosci , vol.11 , pp. 2551-2565
    • Wevers, A.1    Monteggia, L.2    Nowacki, S.3    Bloch, W.4    Schutz, U.5    Lindstrom, J.6
  • 39
    • 37149055806 scopus 로고    scopus 로고
    • Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
    • Counts SE, He B, Che S, Ikonomovic MD, DeKosky ST, Ginsberg SD, et al. Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease. Arch Neurol 64: 1771-6 (2007).
    • (2007) Arch Neurol , vol.64 , pp. 1771-1776
    • Counts, S.E.1    He, B.2    Che, S.3    Ikonomovic, M.D.4    Dekosky, S.T.5    Ginsberg, S.D.6
  • 40
    • 33645319504 scopus 로고    scopus 로고
    • Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons
    • D'Andrea MR, Nagele RG. Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons. Curr Pharm Des 12: 677-84 (2006).
    • (2006) Curr Pharm Des , vol.12 , pp. 677-684
    • D'Andrea, M.R.1    Nagele, R.G.2
  • 41
    • 33746267516 scopus 로고    scopus 로고
    • Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    • Gotti C, Moretti M, Bohr I, Ziabreva I, Vailati S, Longhi R, et al. Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation. Neurobiol Dis 23: 481-9 (2006).
    • (2006) Neurobiol Dis , vol.23 , pp. 481-489
    • Gotti, C.1    Moretti, M.2    Bohr, I.3    Ziabreva, I.4    Vailati, S.5    Longhi, R.6
  • 42
    • 33845535334 scopus 로고    scopus 로고
    • Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging
    • Sabbagh MN, Shah F, Reid RT, Sue L, Connor DJ, Peterson LK, et al. Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging. Arch Neurol 63: 1771-6 (2006).
    • (2006) Arch Neurol , vol.63 , pp. 1771-1776
    • Sabbagh, M.N.1    Shah, F.2    Reid, R.T.3    Sue, L.4    Connor, D.J.5    Peterson, L.K.6
  • 43
    • 0034006944 scopus 로고    scopus 로고
    • beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
    • Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB. beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 275: 5626-32 (2000).
    • (2000) J Biol Chem , vol.275 , pp. 5626-5632
    • Wang, H.Y.1    Lee, D.H.2    D'Andrea, M.R.3    Peterson, P.A.4    Shank, R.P.5    Reitz, A.B.6
  • 44
    • 0033624509 scopus 로고    scopus 로고
    • Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors
    • Wang HY, Lee DH, Davis CB, Shank RP. Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem 75: 1155-61 (2000).
    • (2000) J Neurochem , vol.75 , pp. 1155-1161
    • Wang, H.Y.1    Lee, D.H.2    Davis, C.B.3    Shank, R.P.4
  • 45
    • 0037066072 scopus 로고    scopus 로고
    • Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease
    • Nagele RG, D'Andrea MR, Anderson WJ, Wang HY. Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110: 199-211 (2002).
    • (2002) Neuroscience , vol.110 , pp. 199-211
    • Nagele, R.G.1    D'Andrea, M.R.2    Anderson, W.J.3    Wang, H.Y.4
  • 46
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43: 321-32 (2004).
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    Laferla, F.M.5
  • 47
    • 0027461090 scopus 로고
    • An amyloid peptide, beta A4 25-35, mimics the function of substance P on modulation of nicotine-evoked secretion and desensitization in cultured bovine adrenal chromaffin cells
    • Cheung NS, Small DH, Livett BG. An amyloid peptide, beta A4 25-35, mimics the function of substance P on modulation of nicotine-evoked secretion and desensitization in cultured bovine adrenal chromaffin cells. J Neurochem 60: 1163-6 (1993).
    • (1993) J Neurochem , vol.60 , pp. 1163-1166
    • Cheung, N.S.1    Small, D.H.2    Livett, B.G.3
  • 48
    • 0042357192 scopus 로고    scopus 로고
    • Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation
    • Wang HY, Li W, Benedetti NJ, Lee DH. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J Biol Chem 278: 31547-53 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 31547-31553
    • Wang, H.Y.1    Li, W.2    Benedetti, N.J.3    Lee, D.H.4
  • 49
    • 34249823327 scopus 로고    scopus 로고
    • The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor
    • Small DH, Maksel D, Kerr ML, Ng J, Hou X, Chu C, et al. The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem 101: 1527-38 (2007).
    • (2007) J Neurochem , vol.101 , pp. 1527-1538
    • Small, D.H.1    Maksel, D.2    Kerr, M.L.3    Ng, J.4    Hou, X.5    Chu, C.6
  • 50
    • 5444257609 scopus 로고    scopus 로고
    • MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time
    • Bell KA, O'Riordan KJ, Sweatt JD, Dineley KT. MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. J Neurochem 91: 349-61 (2004).
    • (2004) J Neurochem , vol.91 , pp. 349-361
    • Bell, K.A.1    O'Riordan, K.J.2    Sweatt, J.D.3    Dineley, K.T.4
  • 52
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-9 (2002).
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6
  • 53
    • 80053215529 scopus 로고    scopus 로고
    • Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid
    • Tong M, Arora K, White MM, Nichols RA. Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid. J Biol Chem 286: 34373-81 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 34373-34381
    • Tong, M.1    Arora, K.2    White, M.M.3    Nichols, R.A.4
  • 54
    • 0027772476 scopus 로고
    • Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities
    • Eisele JL, Bertrand S, Galzi JL, Devillers-Thiery A, Changeux JP, Bertrand D. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature 366: 479-83 (1993).
    • (1993) Nature , vol.366 , pp. 479-483
    • Eisele, J.L.1    Bertrand, S.2    Galzi, J.L.3    Devillers-Thiery, A.4    Changeux, J.P.5    Bertrand, D.6
  • 55
    • 35348820536 scopus 로고    scopus 로고
    • Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras
    • Gee VJ, Kracun S, Cooper ST, Gibb AJ, Millar NS. Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras. Br J Pharmacol 152: 501-12 (2007).
    • (2007) Br J Pharmacol , vol.152 , pp. 501-512
    • Gee, V.J.1    Kracun, S.2    Cooper, S.T.3    Gibb, A.J.4    Millar, N.S.5
  • 56
    • 0035836747 scopus 로고    scopus 로고
    • beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
    • Liu Q, Kawai H, Berg DK. beta-Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 98: 4734-9 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4734-4739
    • Liu, Q.1    Kawai, H.2    Berg, D.K.3
  • 57
    • 0031025811 scopus 로고    scopus 로고
    • Volatile general anaesthetic actions on recombinant nACh alpha 7, 5-HT3 and chimeric nACh alpha 7-5-HT3 receptors expressed in Xenopus oocytes
    • Zhang L, Oz M, Stewart RR, Peoples RW, Weight FF. Volatile general anaesthetic actions on recombinant nACh alpha 7, 5-HT3 and chimeric nACh alpha 7-5-HT3 receptors expressed in Xenopus oocytes. Br J Pharmacol 120: 353-5 (1997).
    • (1997) Br J Pharmacol , vol.120 , pp. 353-355
    • Zhang, L.1    Oz, M.2    Stewart, R.R.3    Peoples, R.W.4    Weight, F.F.5
  • 58
    • 0043135255 scopus 로고    scopus 로고
    • Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex
    • Dougherty JJ, Wu J, Nichols RA. Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex. J Neurosci 23: 6740-7 (2003).
    • (2003) J Neurosci , vol.23 , pp. 6740-6747
    • Dougherty, J.J.1    Wu, J.2    Nichols, R.A.3
  • 59
    • 0026758178 scopus 로고
    • Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor
    • O'Leary ME, White MM. Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor. J Biol Chem 267: 8360-5 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 8360-8365
    • O'Leary, M.E.1    White, M.M.2
  • 61
    • 79955051063 scopus 로고    scopus 로고
    • Linking lipids to Alzheimer's disease: Cholesterol and beyond
    • Di Paolo G, Kim TW. Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat Rev Neurosci 12: 284-96 (2011).
    • (2011) Nat Rev Neurosci , vol.12 , pp. 284-296
    • Di Paolo, G.1    Kim, T.W.2
  • 62
    • 77649211967 scopus 로고    scopus 로고
    • beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: Involvement of lipid rafts
    • Khan GM, Tong M, Jhun M, Arora K, Nichols RA. beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts. Eur J Neurosci 31: 788-96 (2010).
    • (2010) Eur J Neurosci , vol.31 , pp. 788-796
    • Khan, G.M.1    Tong, M.2    Jhun, M.3    Arora, K.4    Nichols, R.A.5
  • 63
    • 0035875962 scopus 로고    scopus 로고
    • Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    • Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 21: 4125-33 (2001).
    • (2001) J Neurosci , vol.21 , pp. 4125-4133
    • Dineley, K.T.1    Westerman, M.2    Bui, D.3    Bell, K.4    Ashe, K.H.5    Sweatt, J.D.6
  • 64
    • 0035219699 scopus 로고    scopus 로고
    • beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice
    • Pettit DL, Shao Z, Yakel JL. beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice. J Neurosci 21: RC120 (2001).
    • (2001) J Neurosci , vol.21
    • Pettit, D.L.1    Shao, Z.2    Yakel, J.L.3
  • 65
    • 0037067717 scopus 로고    scopus 로고
    • beta-Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
    • Dineley KT, Bell KA, Bui D, Sweatt JD. beta-Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem 277: 25056-61 (2002).
    • (2002) J Biol Chem , vol.277 , pp. 25056-25061
    • Dineley, K.T.1    Bell, K.A.2    Bui, D.3    Sweatt, J.D.4
  • 66
    • 0038496743 scopus 로고    scopus 로고
    • Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing
    • Sharma G, Vijayaraghavan S. Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing. Neuron 38: 929-39 (2003).
    • (2003) Neuron , vol.38 , pp. 929-939
    • Sharma, G.1    Vijayaraghavan, S.2
  • 67
    • 53749087290 scopus 로고    scopus 로고
    • Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine
    • Kenney JW, Gould TJ. Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine. Mol Neurobiol 38: 101-21 (2008).
    • (2008) Mol Neurobiol , vol.38 , pp. 101-121
    • Kenney, J.W.1    Gould, T.J.2
  • 68
    • 65549084830 scopus 로고    scopus 로고
    • Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants
    • Mehta TK, Dougherty JJ, Wu J, Choi CH, Khan GM, Nichols RA. Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants. J Neurochem 109: 1452-8 (2009).
    • (2009) J Neurochem , vol.109 , pp. 1452-1458
    • Mehta, T.K.1    Dougherty, J.J.2    Wu, J.3    Choi, C.H.4    Khan, G.M.5    Nichols, R.A.6
  • 69
    • 36049007514 scopus 로고    scopus 로고
    • Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors
    • Wu J, Khan GM, Nichols RA. Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors. Brain Res 1182: 82-9 (2007).
    • (2007) Brain Res , vol.1182 , pp. 82-89
    • Wu, J.1    Khan, G.M.2    Nichols, R.A.3
  • 70
    • 58149385218 scopus 로고    scopus 로고
    • Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    • Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, et al. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 28: 14537-45 (2008).
    • (2008) J Neurosci , vol.28 , pp. 14537-14545
    • Puzzo, D.1    Privitera, L.2    Leznik, E.3    Fa, M.4    Staniszewski, A.5    Palmeri, A.6
  • 71
    • 0029096914 scopus 로고
    • Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
    • McGehee DS, Heath MJ, Gelber S, Devay P, Role LW. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269: 1692-6 (1995).
    • (1995) Science , vol.269 , pp. 1692-1696
    • McGehee, D.S.1    Heath, M.J.2    Gelber, S.3    Devay, P.4    Role, L.W.5
  • 72
    • 0035107610 scopus 로고    scopus 로고
    • Ca(2+) changes induced by different presynaptic nicotinic receptors in separate populations of individual striatal nerve terminals
    • Nayak SV, Dougherty JJ, McIntosh JM, Nichols RA. Ca(2+) changes induced by different presynaptic nicotinic receptors in separate populations of individual striatal nerve terminals. J Neurochem 76: 1860-70 (2001).
    • (2001) J Neurochem , vol.76 , pp. 1860-1870
    • Nayak, S.V.1    Dougherty, J.J.2    McIntosh, J.M.3    Nichols, R.A.4
  • 73
    • 84856299171 scopus 로고    scopus 로고
    • Activation of alpha7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Ass-mediated inhibition of LTP in the rat hippocampus
    • Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, et al. Activation of alpha7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Ass-mediated inhibition of LTP in the rat hippocampus. Eur J Pharmacol 677: 63-70 (2012).
    • (2012) Eur J Pharmacol , vol.677 , pp. 63-70
    • Ondrejcak, T.1    Wang, Q.2    Kew, J.N.3    Virley, D.J.4    Upton, N.5    Anwyl, R.6
  • 74
    • 21044453723 scopus 로고    scopus 로고
    • Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
    • Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11: 556-61 (2005).
    • (2005) Nat Med , vol.11 , pp. 556-561
    • Klyubin, I.1    Walsh, D.M.2    Lemere, C.A.3    Cullen, W.K.4    Shankar, G.M.5    Betts, V.6
  • 75
    • 80052366846 scopus 로고    scopus 로고
    • Requirement of alpha7 nicotinic acetylcholine receptors for amyloid beta protein-induced depression of hippocampal long-term potentiation in CA1 region of rats in vivo
    • Li SF, Wu MN, Wang XH, Yuan L, Yang D, Qi JS. Requirement of alpha7 nicotinic acetylcholine receptors for amyloid beta protein-induced depression of hippocampal long-term potentiation in CA1 region of rats in vivo. Synapse 65: 1136-43 (2011).
    • (2011) Synapse , vol.65 , pp. 1136-1143
    • Li, S.F.1    Wu, M.N.2    Wang, X.H.3    Yuan, L.4    Yang, D.5    Qi, J.S.6
  • 76
    • 75049085215 scopus 로고    scopus 로고
    • Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: Role of alpha4 and alpha7 receptors in neuroprotection
    • Akaike A, Takada-Takatori Y, Kume T, Izumi Y. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci 40: 211-6 (2010).
    • (2010) J Mol Neurosci , vol.40 , pp. 211-216
    • Akaike, A.1    Takada-Takatori, Y.2    Kume, T.3    Izumi, Y.4
  • 77
    • 84863534359 scopus 로고    scopus 로고
    • Cotinine: A potential new therapeutic agent against Alzheimer's disease
    • Echeverria V, Zeitlin R. Cotinine: a potential new therapeutic agent against Alzheimer's disease. CNS Neurosci Ther 18: 517-23 (2012).
    • (2012) CNS Neurosci Ther , vol.18 , pp. 517-523
    • Echeverria, V.1    Zeitlin, R.2
  • 78
    • 84860468079 scopus 로고    scopus 로고
    • alpha7 nicotinic acetylcholine receptors in Alzheimer's disease: Neuroprotective, neurotrophic or both?
    • Hernandez CM, Dineley KT. alpha7 nicotinic acetylcholine receptors in Alzheimer's disease: neuroprotective, neurotrophic or both? Curr Drug Targets 13: 613-22 (2012).
    • (2012) Curr Drug Targets , vol.13 , pp. 613-622
    • Hernandez, C.M.1    Dineley, K.T.2
  • 79
    • 0035957946 scopus 로고    scopus 로고
    • alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
    • Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, et al. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276: 13541-6 (2001).
    • (2001) J Biol Chem , vol.276 , pp. 13541-13546
    • Kihara, T.1    Shimohama, S.2    Sawada, H.3    Honda, K.4    Nakamizo, T.5    Shibasaki, H.6
  • 80
    • 84861074503 scopus 로고    scopus 로고
    • Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase--Akt pathways
    • Huang X, Cheng Z, Su Q, Zhu X, Wang Q, Chen R, et al. Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase--Akt pathways. Int J Neurosci 122: 324-32 (2012).
    • (2012) Int J Neurosci , vol.122 , pp. 324-332
    • Huang, X.1    Cheng, Z.2    Su, Q.3    Zhu, X.4    Wang, Q.5    Chen, R.6
  • 81
    • 80054811612 scopus 로고    scopus 로고
    • alpha7 Nicotinic receptor activation reduces beta-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling
    • Yu W, Mechawar N, Krantic S, Quirion R. alpha7 Nicotinic receptor activation reduces beta-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling. J Neurochem 119: 848-58 (2011).
    • (2011) J Neurochem , vol.119 , pp. 848-858
    • Yu, W.1    Mechawar, N.2    Krantic, S.3    Quirion, R.4
  • 82
    • 4444222410 scopus 로고    scopus 로고
    • The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures
    • Martin SE, de Fiebre NE, de Fiebre CM. The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures. Brain Res 1022: 254-6 (2004).
    • (2004) Brain Res , vol.1022 , pp. 254-256
    • Martin, S.E.1    de Fiebre, N.E.2    de Fiebre, C.M.3
  • 83
    • 0035889406 scopus 로고    scopus 로고
    • Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists
    • Jonnala RR, Buccafusco JJ. Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists. J Neurosci Res 66: 565-72 (2001).
    • (2001) J Neurosci Res , vol.66 , pp. 565-572
    • Jonnala, R.R.1    Buccafusco, J.J.2
  • 84
    • 77953287701 scopus 로고    scopus 로고
    • Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats
    • Deng J, Shen C, Wang YJ, Zhang M, Li J, Xu ZQ, et al. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. Eur J Pharmacol 637: 83-8 (2010).
    • (2010) Eur J Pharmacol , vol.637 , pp. 83-88
    • Deng, J.1    Shen, C.2    Wang, Y.J.3    Zhang, M.4    Li, J.5    Xu, Z.Q.6
  • 85
    • 14544304591 scopus 로고    scopus 로고
    • Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease
    • Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A 102: 3046-51 (2005).
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3046-3051
    • Oddo, S.1    Caccamo, A.2    Green, K.N.3    Liang, K.4    Tran, L.5    Chen, Y.6
  • 86
    • 0037381479 scopus 로고    scopus 로고
    • Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and betaamyloid1-42
    • Lee DH, Wang HY. Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and betaamyloid1-42. J Neurobiol 55: 25-30 (2003).
    • (2003) J Neurobiol , vol.55 , pp. 25-30
    • Lee, D.H.1    Wang, H.Y.2
  • 87
    • 69749119522 scopus 로고    scopus 로고
    • Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain
    • Wang HY, Stucky A, Liu J, Shen C, Trocme-Thibierge C, Morain P. Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J Neurosci 29: 10961-73 (2009).
    • (2009) J Neurosci , vol.29 , pp. 10961-10973
    • Wang, H.Y.1    Stucky, A.2    Liu, J.3    Shen, C.4    Trocme-Thibierge, C.5    Morain, P.6
  • 88
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440: 352-7 (2006).
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3    Kayed, R.4    Glabe, C.G.5    Yang, A.6
  • 90
    • 1842375103 scopus 로고    scopus 로고
    • The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells
    • Sberna G, Saez-Valero J, Beyreuther K, Masters CL, Small DH. The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. J Neurochem 69: 1177-84 (1997).
    • (1997) J Neurochem , vol.69 , pp. 1177-1184
    • Sberna, G.1    Saez-Valero, J.2    Beyreuther, K.3    Masters, C.L.4    Small, D.H.5
  • 91
    • 1442348421 scopus 로고    scopus 로고
    • Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones
    • Fodero LR, Mok SS, Losic D, Martin LL, Aguilar MI, Barrow CJ, et al. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. J Neurochem 88: 1186-93 (2004).
    • (2004) J Neurochem , vol.88 , pp. 1186-1193
    • Fodero, L.R.1    Mok, S.S.2    Losic, D.3    Martin, L.L.4    Aguilar, M.I.5    Barrow, C.J.6
  • 92
    • 34848913464 scopus 로고    scopus 로고
    • The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease
    • Qi XL, Nordberg A, Xiu J, Guan ZZ. The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease. Neurochem Int 51: 377-83 (2007).
    • (2007) Neurochem Int , vol.51 , pp. 377-383
    • Qi, X.L.1    Nordberg, A.2    Xiu, J.3    Guan, Z.Z.4
  • 93
    • 77249153190 scopus 로고    scopus 로고
    • Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
    • Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci 30: 2442-53 (2010).
    • (2010) J Neurosci , vol.30 , pp. 2442-2453
    • Hernandez, C.M.1    Kayed, R.2    Zheng, H.3    Sweatt, J.D.4    Dineley, K.T.5
  • 94
    • 62949084265 scopus 로고    scopus 로고
    • Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo
    • Bitner RS, Nikkel AL, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M. Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. Brain Res 1265: 65-74 (2009).
    • (2009) Brain Res , vol.1265 , pp. 65-74
    • Bitner, R.S.1    Nikkel, A.L.2    Markosyan, S.3    Otte, S.4    Puttfarcken, P.5    Gopalakrishnan, M.6
  • 95
    • 0345434817 scopus 로고    scopus 로고
    • Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
    • Hellstrom-Lindahl E, Mousavi M, Zhang X, Ravid R, Nordberg A. Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain. Brain Res Mol Brain Res 66: 94-103 (1999).
    • (1999) Brain Res Mol Brain Res , vol.66 , pp. 94-103
    • Hellstrom-Lindahl, E.1    Mousavi, M.2    Zhang, X.3    Ravid, R.4    Nordberg, A.5
  • 96
    • 20644443926 scopus 로고    scopus 로고
    • Increased alpha 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients
    • Chu LW, Ma ES, Lam KK, Chan MF, Lee DH. Increased alpha 7 nicotinic acetylcholine receptor protein levels in Alzheimer's disease patients. Dement Geriatr Cogn Disord 19: 106-12 (2005).
    • (2005) Dement Geriatr Cogn Disord , vol.19 , pp. 106-112
    • Chu, L.W.1    Ma, E.S.2    Lam, K.K.3    Chan, M.F.4    Lee, D.H.5
  • 98
    • 2542481651 scopus 로고    scopus 로고
    • Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    • Nagele RG, Wegiel J, Venkataraman V, Imaki H, Wang KC. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging 25: 663-74 (2004).
    • (2004) Neurobiol Aging , vol.25 , pp. 663-674
    • Nagele, R.G.1    Wegiel, J.2    Venkataraman, V.3    Imaki, H.4    Wang, K.C.5
  • 99
    • 66249133352 scopus 로고    scopus 로고
    • Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease
    • Ikonomovic MD, Wecker L, Abrahamson EE, Wuu J, Counts SE, Ginsberg SD, et al. Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease. Arch Neurol 66: 646-51 (2009).
    • (2009) Arch Neurol , vol.66 , pp. 646-651
    • Ikonomovic, M.D.1    Wecker, L.2    Abrahamson, E.E.3    Wuu, J.4    Counts, S.E.5    Ginsberg, S.D.6
  • 100
    • 0036178441 scopus 로고    scopus 로고
    • Molecular psychology: Roles for the ERK MAP kinase cascade in memory
    • Adams JP, Sweatt JD. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42: 135-63 (2002).
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , pp. 135-163
    • Adams, J.P.1    Sweatt, J.D.2
  • 101
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signalling and synaptic plasticity
    • Thomas GM, Huganir RL. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5: 173-83 (2004).
    • (2004) Nat Rev Neurosci , vol.5 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 102
    • 70349952431 scopus 로고    scopus 로고
    • Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor
    • Young KF, Pasternak SH, Rylett RJ. Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor. Neurochem Int 55: 796-801 (2009).
    • (2009) Neurochem Int , vol.55 , pp. 796-801
    • Young, K.F.1    Pasternak, S.H.2    Rylett, R.J.3
  • 103
    • 43849088152 scopus 로고    scopus 로고
    • Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors
    • Abbott JJ, Howlett DR, Francis PT, Williams RJ. Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors. Neurobiol Aging 29: 992-1001 (2008).
    • (2008) Neurobiol Aging , vol.29 , pp. 992-1001
    • Abbott, J.J.1    Howlett, D.R.2    Francis, P.T.3    Williams, R.J.4
  • 105
    • 2542509442 scopus 로고    scopus 로고
    • Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
    • Hellstrom-Lindahl E, Moore H, Nordberg A. Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists. J Neurochem 74: 777-84 (2000).
    • (2000) J Neurochem , vol.74 , pp. 777-784
    • Hellstrom-Lindahl, E.1    Moore, H.2    Nordberg, A.3
  • 106
    • 84863963797 scopus 로고    scopus 로고
    • Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A
    • Wang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci 32: 9773-84 (2012).
    • (2012) J Neurosci , vol.32 , pp. 9773-9784
    • Wang, H.Y.1    Bakshi, K.2    Frankfurt, M.3    Stucky, A.4    Goberdhan, M.5    Shah, S.M.6
  • 107
    • 0343570105 scopus 로고    scopus 로고
    • Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors
    • Hellstrom-Lindahl E. Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors. Eur J Pharmacol 393: 255-63 (2000).
    • (2000) Eur J Pharmacol , vol.393 , pp. 255-263
    • Hellstrom-Lindahl, E.1
  • 108
    • 0030773730 scopus 로고    scopus 로고
    • Does smoking protect from Alzheimer's disease? Alzheimer-type changes in 301 unselected brains from patients with known smoking history
    • Ulrich J, Johannson-Locher G, Seiler WO, Stahelin HB. Does smoking protect from Alzheimer's disease? Alzheimer-type changes in 301 unselected brains from patients with known smoking history. Acta Neuropathol 94: 450-4 (1997).
    • (1997) Acta Neuropathol , vol.94 , pp. 450-454
    • Ulrich, J.1    Johannson-Locher, G.2    Seiler, W.O.3    Stahelin, H.B.4
  • 109
    • 84859557082 scopus 로고    scopus 로고
    • Smoking, nicotine and dementia
    • Grayson L, Thomas AJ. Smoking, nicotine and dementia. Maturitas 72: 4-5 (2012).
    • (2012) Maturitas , vol.72 , pp. 4-5
    • Grayson, L.1    Thomas, A.J.2
  • 110
    • 0028986916 scopus 로고
    • beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
    • Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14: 879-88 (1995).
    • (1995) Neuron , vol.14 , pp. 879-888
    • Busciglio, J.1    Lorenzo, A.2    Yeh, J.3    Yankner, B.A.4
  • 111
    • 40649095625 scopus 로고    scopus 로고
    • Network dysfunction in Alzheimer's disease: Does synaptic scaling drive disease progression?
    • Small DH. Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression? Trends Mol Med 14: 103-8 (2008).
    • (2008) Trends Mol Med , vol.14 , pp. 103-108
    • Small, D.H.1
  • 112
    • 0034535535 scopus 로고    scopus 로고
    • Cell death or synaptic loss in Alzheimer disease
    • Terry RD. Cell death or synaptic loss in Alzheimer disease. J Neuropathol Exp Neurol 59: 1118-9 (2000).
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 1118-1119
    • Terry, R.D.1
  • 113
    • 0742323527 scopus 로고    scopus 로고
    • Homeostatic plasticity in the developing nervous system
    • Turrigiano GG, Nelson SB. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5: 97-107 (2004).
    • (2004) Nat Rev Neurosci , vol.5 , pp. 97-107
    • Turrigiano, G.G.1    Nelson, S.B.2
  • 114
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55: 697-711 (2007).
    • (2007) Neuron , vol.55 , pp. 697-711
    • Palop, J.J.1    Chin, J.2    Roberson, E.D.3    Wang, J.4    Thwin, M.T.5    Bien-Ly, N.6
  • 115
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: From synapses toward neural networks
    • Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13: 812-8 (2010).
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 116
    • 1942436820 scopus 로고    scopus 로고
    • Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?
    • Small DH. Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends Neurosci 27: 245-9 (2004).
    • (2004) Trends Neurosci , vol.27 , pp. 245-249
    • Small, D.H.1
  • 117
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky ST, Ikonomovic MD, Styren SD, Beckett L, Wisniewski S, Bennett DA, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 51: 145-55 (2002).
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • Dekosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3    Beckett, L.4    Wisniewski, S.5    Bennett, D.A.6
  • 118
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and upregulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H. Accelerated plaque accumulation, associative learning deficits, and upregulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem 277: 22768-80 (2002).
    • (2002) J Biol Chem , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 119
    • 0036312401 scopus 로고    scopus 로고
    • Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition
    • Fodero LR, Saez-Valero J, McLean CA, Martins RN, Beyreuther K, Masters CL, et al. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. J Neurochem 81: 441-8 (2002).
    • (2002) J Neurochem , vol.81 , pp. 441-448
    • Fodero, L.R.1    Saez-Valero, J.2    McLean, C.A.3    Martins, R.N.4    Beyreuther, K.5    Masters, C.L.6
  • 120
    • 34547653708 scopus 로고    scopus 로고
    • Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
    • Dineley KT, Hogan D, Zhang WR, Taglialatela G. Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol Learn Mem 88: 217-24 (2007).
    • (2007) Neurobiol Learn Mem , vol.88 , pp. 217-224
    • Dineley, K.T.1    Hogan, D.2    Zhang, W.R.3    Taglialatela, G.4
  • 121
    • 67650484613 scopus 로고    scopus 로고
    • Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
    • Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J Neurosci 29: 8805-15 (2009).
    • (2009) J Neurosci , vol.29 , pp. 8805-8815
    • Dziewczapolski, G.1    Glogowski, C.M.2    Masliah, E.3    Heinemann, S.F.4
  • 122
    • 62649147319 scopus 로고    scopus 로고
    • Intermediateand long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
    • Taglialatela G, Hogan D, Zhang WR, Dineley KT. Intermediateand long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res 200: 95-9 (2009).
    • (2009) Behav Brain Res , vol.200 , pp. 95-99
    • Taglialatela, G.1    Hogan, D.2    Zhang, W.R.3    Dineley, K.T.4
  • 123
    • 0028172886 scopus 로고
    • Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
    • Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A 91: 12243-7 (1994).
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12243-12247
    • Lorenzo, A.1    Yankner, B.A.2
  • 125
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers-a decade of discovery
    • Walsh DM, Selkoe DJ. A beta oligomers-a decade of discovery. J Neurochem 101: 1172-84 (2007).
    • (2007) J Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 127
    • 33645220400 scopus 로고    scopus 로고
    • Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    • Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, et al. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem 281: 4292-9 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 4292-4299
    • Lee, E.B.1    Leng, L.Z.2    Zhang, B.3    Kwong, L.4    Trojanowski, J.Q.5    Abel, T.6
  • 128
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 100: 10417-22 (2003).
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6
  • 129
    • 78149361157 scopus 로고    scopus 로고
    • How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity?
    • Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Front Cell Neurosci 4: 5 (2010).
    • (2010) Front Cell Neurosci , vol.4 , pp. 5
    • Li, S.1    Shankar, G.M.2    Selkoe, D.J.3
  • 130
    • 79951567728 scopus 로고    scopus 로고
    • Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease
    • Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A. Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease. J Alzheimers Dis 23: 335-47 (2011).
    • (2011) J Alzheimers Dis , vol.23 , pp. 335-347
    • Lilja, A.M.1    Porras, O.2    Storelli, E.3    Nordberg, A.4    Marutle, A.5
  • 131
    • 80052033738 scopus 로고    scopus 로고
    • Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease
    • Parri HR, Hernandez CM, Dineley KT. Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochem Pharmacol 82: 931-42 (2011).
    • (2011) Biochem Pharmacol , vol.82 , pp. 931-942
    • Parri, H.R.1    Hernandez, C.M.2    Dineley, K.T.3
  • 132
    • 30744443800 scopus 로고    scopus 로고
    • alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats
    • Chen L, Yamada K, Nabeshima T, Sokabe M. alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats. Neuropharmacology 50: 254-68 (2006).
    • (2006) Neuropharmacology , vol.50 , pp. 254-268
    • Chen, L.1    Yamada, K.2    Nabeshima, T.3    Sokabe, M.4
  • 133
    • 79955474315 scopus 로고    scopus 로고
    • Endogenous amyloid-beta is necessary for hippocampal synaptic plasticity and memory
    • Puzzo D, Privitera L, Fa M, Staniszewski A, Hashimoto G, Aziz F, et al. Endogenous amyloid-beta is necessary for hippocampal synaptic plasticity and memory. Ann Neurol 69: 819-30 (2011).
    • (2011) Ann Neurol , vol.69 , pp. 819-830
    • Puzzo, D.1    Privitera, L.2    Fa, M.3    Staniszewski, A.4    Hashimoto, G.5    Aziz, F.6
  • 134
    • 0031410384 scopus 로고    scopus 로고
    • Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons
    • Alkondon M, Pereira EF, Cortes WS, Maelicke A, Albuquerque EX. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. Eur J Neurosci 9: 2734-42 (1997).
    • (1997) Eur J Neurosci , vol.9 , pp. 2734-2742
    • Alkondon, M.1    Pereira, E.F.2    Cortes, W.S.3    Maelicke, A.4    Albuquerque, E.X.5
  • 135
    • 0030576581 scopus 로고    scopus 로고
    • An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype
    • Papke RL, Bencherif M, Lippiello P. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. Neurosci Lett 213: 201-4 (1996).
    • (1996) Neurosci Lett , vol.213 , pp. 201-204
    • Papke, R.L.1    Bencherif, M.2    Lippiello, P.3
  • 136
    • 27744573850 scopus 로고    scopus 로고
    • Chronic treatment with amyloid beta(1-42) inhibits non-cholinergic highaffinity choline transport in NG108-15 cells through protein kinase C signaling
    • Novakova J, Mikasova L, Machova E, Lisa V, Dolezal V. Chronic treatment with amyloid beta(1-42) inhibits non-cholinergic highaffinity choline transport in NG108-15 cells through protein kinase C signaling. Brain Res 1062: 101-10 (2005).
    • (2005) Brain Res , vol.1062 , pp. 101-110
    • Novakova, J.1    Mikasova, L.2    Machova, E.3    Lisa, V.4    Dolezal, V.5
  • 137
    • 35348889638 scopus 로고    scopus 로고
    • Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
    • Wang B, Yang L, Wang Z, Zheng H. Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc Natl Acad Sci U S A 104: 14140-5 (2007).
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14140-14145
    • Wang, B.1    Yang, L.2    Wang, Z.3    Zheng, H.4
  • 138
    • 52049104649 scopus 로고    scopus 로고
    • Alpha7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Abeta peptides and promotes cerebrovascular amyloid angiopathy
    • Clifford PM, Siu G, Kosciuk M, Levin EC, Venkataraman V, D'Andrea MR, et al. Alpha7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Abeta peptides and promotes cerebrovascular amyloid angiopathy. Brain Res 1234: 158-71 (2008).
    • (2008) Brain Res , vol.1234 , pp. 158-171
    • Clifford, P.M.1    Siu, G.2    Kosciuk, M.3    Levin, E.C.4    Venkataraman, V.5    D'Andrea, M.R.6
  • 139
    • 0037440372 scopus 로고    scopus 로고
    • Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
    • Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, et al. Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia 41: 207-11 (2003).
    • (2003) Glia , vol.41 , pp. 207-211
    • Teaktong, T.1    Graham, A.2    Court, J.3    Perry, R.4    Jaros, E.5    Johnson, M.6
  • 140
    • 4744354513 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: Differential neuronal and astroglial pathology
    • Teaktong T, Graham AJ, Court JA, Perry RH, Jaros E, Johnson M, et al. Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology. J Neurol Sci 225: 39-49 (2004).
    • (2004) J Neurol Sci , vol.225 , pp. 39-49
    • Teaktong, T.1    Graham, A.J.2    Court, J.A.3    Perry, R.H.4    Jaros, E.5    Johnson, M.6
  • 141
    • 13444280311 scopus 로고    scopus 로고
    • High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: A possible association with neuritic plaques
    • Yu WF, Guan ZZ, Bogdanovic N, Nordberg A. High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques. Exp Neurol 192: 215-25 (2005).
    • (2005) Exp Neurol , vol.192 , pp. 215-225
    • Yu, W.F.1    Guan, Z.Z.2    Bogdanovic, N.3    Nordberg, A.4
  • 142
    • 21744455896 scopus 로고    scopus 로고
    • Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42)
    • Xiu J, Nordberg A, Zhang JT, Guan ZZ. Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42). Neurochem Int 47: 281-90 (2005).
    • (2005) Neurochem Int , vol.47 , pp. 281-290
    • Xiu, J.1    Nordberg, A.2    Zhang, J.T.3    Guan, Z.Z.4
  • 143
    • 0037427384 scopus 로고    scopus 로고
    • Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    • Nagele RG, D'Andrea MR, Lee H, Venkataraman V, Wang HY. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 971: 197-209 (2003).
    • (2003) Brain Res , vol.971 , pp. 197-209
    • Nagele, R.G.1    D'Andrea, M.R.2    Lee, H.3    Venkataraman, V.4    Wang, H.Y.5
  • 144
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • Schliebs R, Arendt T. The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221: 555-63 (2011).
    • (2011) Behav Brain Res , vol.221 , pp. 555-563
    • Schliebs, R.1    Arendt, T.2
  • 145
    • 34548677767 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors
    • Bertrand D, Gopalakrishnan M. Allosteric modulation of nicotinic acetylcholine receptors. Biochem Pharmacol 74: 1155-63 (2007).
    • (2007) Biochem Pharmacol , vol.74 , pp. 1155-1163
    • Bertrand, D.1    Gopalakrishnan, M.2
  • 146
    • 80052026910 scopus 로고    scopus 로고
    • Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations
    • Williams DK, Wang J, Papke RL. Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations. Biochem Pharmacol 82: 915-30 (2011).
    • (2011) Biochem Pharmacol , vol.82 , pp. 915-930
    • Williams, D.K.1    Wang, J.2    Papke, R.L.3
  • 147
    • 63849213473 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor signalling: Roles in Alzheimer's disease and amyloid neuroprotection
    • Buckingham SD, Jones AK, Brown LA, Sattelle DB. Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev 61: 39-61 (2009).
    • (2009) Pharmacol Rev , vol.61 , pp. 39-61
    • Buckingham, S.D.1    Jones, A.K.2    Brown, L.A.3    Sattelle, D.B.4
  • 148
    • 59649098711 scopus 로고    scopus 로고
    • Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
    • Buccafusco JJ, Beach JW, Terry AV, Jr. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther 328: 364-70 (2009).
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 364-370
    • Buccafusco, J.J.1    Beach, J.W.2    Terry Jr., A.V.3
  • 149
    • 0038814240 scopus 로고    scopus 로고
    • Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    • Ferchmin PA, Perez D, Eterovic VA, de Vellis J. Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices. J Pharmacol Exp Ther 305: 1071-8 (2003).
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 1071-1078
    • Ferchmin, P.A.1    Perez, D.2    Eterovic, V.A.3    de Vellis, J.4
  • 150
    • 0034595443 scopus 로고    scopus 로고
    • Inactivation of alpha7 ACh receptors and activation of non-alpha7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region
    • Fujii S, Ji Z, Sumikawa K. Inactivation of alpha7 ACh receptors and activation of non-alpha7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region. Neurosci Lett 286: 134-8 (2000).
    • (2000) Neurosci Lett , vol.286 , pp. 134-138
    • Fujii, S.1    Ji, Z.2    Sumikawa, K.3
  • 151
    • 34248177330 scopus 로고    scopus 로고
    • High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands
    • Hu M, Schurdak ME, Puttfarcken PS, El Kouhen R, Gopalakrishnan M, Li J. High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands. Brain Res 1151: 227-35 (2007).
    • (2007) Brain Res , vol.1151 , pp. 227-235
    • Hu, M.1    Schurdak, M.E.2    Puttfarcken, P.S.3    El Kouhen, R.4    Gopalakrishnan, M.5    Li, J.6
  • 152
    • 60949111629 scopus 로고    scopus 로고
    • Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
    • Mousavi M, Hellstrom-Lindahl E. Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro. Neurochem Int 54: 237-44 (2009).
    • (2009) Neurochem Int , vol.54 , pp. 237-244
    • Mousavi, M.1    Hellstrom-Lindahl, E.2
  • 153
    • 0036891571 scopus 로고    scopus 로고
    • Desensitization of neuronal nicotinic receptors
    • Quick MW, Lester RA. Desensitization of neuronal nicotinic receptors. J Neurobiol 53: 457-78 (2002).
    • (2002) J Neurobiol , vol.53 , pp. 457-478
    • Quick, M.W.1    Lester, R.A.2
  • 154
    • 76849083911 scopus 로고    scopus 로고
    • S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies
    • Wang HY, Bakshi K, Shen C, Frankfurt M, Trocme-Thibierge C, Morain P. S 24795 limits beta-amyloid-alpha7 nicotinic receptor interaction and reduces Alzheimer's disease-like pathologies. Biol Psychiatry 67: 522-30 (2010).
    • (2010) Biol Psychiatry , vol.67 , pp. 522-530
    • Wang, H.Y.1    Bakshi, K.2    Shen, C.3    Frankfurt, M.4    Trocme-Thibierge, C.5    Morain, P.6
  • 156
    • 33751309819 scopus 로고    scopus 로고
    • Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation
    • Mozayan M, Chen MF, Si M, Chen PY, Premkumar LS, Lee TJ. Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. J Cereb Blood Flow Metab 26: 1562-76 (2006).
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1562-1576
    • Mozayan, M.1    Chen, M.F.2    Si, M.3    Chen, P.Y.4    Premkumar, L.S.5    Lee, T.J.6
  • 157
    • 34548396785 scopus 로고    scopus 로고
    • Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons
    • Mozayan M, Lee TJ. Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons. Am J Physiol Heart Circ Physiol 293: H1737-44 (2007).
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Mozayan, M.1    Lee, T.J.2
  • 159
    • 0027432528 scopus 로고
    • Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons
    • Pereira EF, Reinhardt-Maelicke S, Schrattenholz A, Maelicke A, Albuquerque EX. Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J Pharmacol Exp Ther 265: 1474-91 (1993).
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 1474-1491
    • Pereira, E.F.1    Reinhardt-Maelicke, S.2    Schrattenholz, A.3    Maelicke, A.4    Albuquerque, E.X.5
  • 160
    • 10744232323 scopus 로고    scopus 로고
    • Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
    • Samochocki M, Hoffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther 305: 1024-36 (2003).
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 1024-1036
    • Samochocki, M.1    Hoffle, A.2    Fehrenbacher, A.3    Jostock, R.4    Ludwig, J.5    Christner, C.6
  • 161
    • 14344253935 scopus 로고    scopus 로고
    • Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons
    • Aracava Y, Pereira EF, Maelicke A, Albuquerque EX. Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons. J Pharmacol Exp Ther 312: 1195-205 (2005).
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 1195-1205
    • Aracava, Y.1    Pereira, E.F.2    Maelicke, A.3    Albuquerque, E.X.4
  • 162
    • 1642422286 scopus 로고    scopus 로고
    • Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors
    • Maskell PD, Speder P, Newberry NR, Bermudez I. Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors. Br J Pharmacol 140: 1313-9 (2003).
    • (2003) Br J Pharmacol , vol.140 , pp. 1313-1319
    • Maskell, P.D.1    Speder, P.2    Newberry, N.R.3    Bermudez, I.4
  • 163
    • 0034959817 scopus 로고    scopus 로고
    • Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells
    • Oliver D, Ludwig J, Reisinger E, Zoellner W, Ruppersberg JP, Fakler B. Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Mol Pharmacol 60: 183-9 (2001).
    • (2001) Mol Pharmacol , vol.60 , pp. 183-189
    • Oliver, D.1    Ludwig, J.2    Reisinger, E.3    Zoellner, W.4    Ruppersberg, J.P.5    Fakler, B.6
  • 164
    • 34249046017 scopus 로고    scopus 로고
    • Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-Daspartate receptors
    • Plazas PV, Savino J, Kracun S, Gomez-Casati ME, Katz E, Parsons CG, et al. Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-Daspartate receptors. Eur J Pharmacol 566: 11-9 (2007).
    • (2007) Eur J Pharmacol , vol.566 , pp. 11-19
    • Plazas, P.V.1    Savino, J.2    Kracun, S.3    Gomez-Casati, M.E.4    Katz, E.5    Parsons, C.G.6
  • 165
    • 0031977071 scopus 로고    scopus 로고
    • Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor
    • Buisson B, Bertrand D. Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 53: 555-63 (1998).
    • (1998) Mol Pharmacol , vol.53 , pp. 555-563
    • Buisson, B.1    Bertrand, D.2
  • 168
    • 25644432066 scopus 로고    scopus 로고
    • Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons
    • Moriguchi S, Zhao X, Marszalec W, Yeh JZ, Narahashi T. Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons. J Pharmacol Exp Ther 315: 125-35 (2005).
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 125-135
    • Moriguchi, S.1    Zhao, X.2    Marszalec, W.3    Yeh, J.Z.4    Narahashi, T.5
  • 170
    • 84874617868 scopus 로고    scopus 로고
    • Improvement of attentional function with antagonism of nicotinic receptors in female rats
    • Levin ED, Cauley M, Rezvani AH. Improvement of attentional function with antagonism of nicotinic receptors in female rats. Eur J Pharmacol 702: 269-274 (2013).
    • (2013) Eur J Pharmacol , vol.702 , pp. 269-274
    • Levin, E.D.1    Cauley, M.2    Rezvani, A.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.