The consequences of reducing expression of the α7 nicotinic receptor by RNA interference and of stimulating its activity with an α7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease

Neurochemistry International

Volumn 51, Issue 6-7, 2007, Pages 377-383

  Qi, Xiao Lan ^a   Nordberg, Agneta ^b   Xiu, Jin ^a   Guan, Zhi Zhong ^a,b  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b Care Medicine and Society ^*  (Sweden)

Author keywords

7 nicotinic receptor; Amyloid precursor protein; Extracellular signal regulated kinase; RNA interference; SH SY5Y cells

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; AMYLOID PRECURSOR PROTEIN; BUNGAROTOXIN RECEPTOR; CYCLOPHILIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC AGENT; SMALL INTERFERING RNA; TETRAZOLIUM;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIPID PEROXIDATION; NEUROBLASTOMA CELL; NEUROPROTECTION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ACETYLCHOLINE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; BENZYLIDENE COMPOUNDS; BRAIN; CELL LINE, TUMOR; CYTOPROTECTION; DOWN-REGULATION; HUMANS; INDICATORS AND REAGENTS; LIPID PEROXIDATION; MITOGEN-ACTIVATED PROTEIN KINASE 3; NERVE DEGENERATION; NEURONS; NICOTINIC AGONISTS; OXIDATIVE STRESS; PYRIDINES; RECEPTORS, NICOTINIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SYNAPTIC TRANSMISSION; TETRAZOLIUM SALTS;

EID: 34848913464     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.04.002     Document Type: Article

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