Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 35, 2010, Pages 15595-15600

  Sandberg, Anders ^a   Luheshi, Leila M ^b   Söllvander, Sofia ^c   De Barros, Teresa Pereira ^b   Macao, Bertil ^a   Knowles, Tuomas P J ^b   Biverstål, Henrik ^d   Lendel, Christofer ^d   Ekholm Petterson, Frida ^c   Dubnovitsky, Anatoly ^d   Lannfelt, Lars ^c   Dobson, Christopher M ^b   Härd, Torleif ^d  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

hairpin conformation; Amyloid peptide; Protein aggregation; Protein structure; Protofibril

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BETA SHEET; DISULFIDE BOND; MOLECULAR WEIGHT; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HUMANS; KINETICS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 77957257176     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001740107     Document Type: Article

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