Development of an in vivo ovine dry powder inhalation model for the evaluation of conventional and controlled release microparticles

AAPS Journal

Volumn 11, Issue 3, 2009, Pages 465-468

  Salama, Rania O ^a   Ladd, Leigh ^b   Chan, Hak Kim ^a   Traini, Daniela ^a   Young, Paul M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Controlled release; Dry powder inhalation; In vivo; Ovine model; Pharmacokinetics

Indexed keywords

CROMOGLYCATE DISODIUM; POLYVINYL ALCOHOL;

AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTROLLED RELEASE FORMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRY POWDER; ENDOTRACHEAL TUBE; GASTROINTESTINAL ABSORPTION; LUNG DISEASE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; SHEEP; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION;

ADMINISTRATION, INHALATION; ANIMALS; AREA UNDER CURVE; DELAYED-ACTION PREPARATIONS; FEMALE; MODELS, BIOLOGICAL; PARTICLE SIZE; POWDERS; SHEEP;

EID: 73349132967     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-009-9125-0     Document Type: Article

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