-
1
-
-
66449114033
-
p62 at the crossroads of autophagy, apoptosis, and cancer
-
Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 2009;137:1001-4.
-
(2009)
Cell
, vol.137
, pp. 1001-1004
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
4
-
-
77950495123
-
Physiological significance of selective degradation of p62 by autophagy
-
Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 2010;584:1374-8.
-
(2010)
FEBS Lett
, vol.584
, pp. 1374-1378
-
-
Komatsu, M.1
Ichimura, Y.2
-
6
-
-
0442325388
-
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
-
Duran A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, Diaz-Meco MT. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell 2004;6:303-9.
-
(2004)
Dev Cell
, vol.6
, pp. 303-309
-
-
Duran, A.1
Serrano, M.2
Leitges, M.3
Flores, J.M.4
Picard, S.5
Brown, J.P.6
Moscat, J.7
Diaz-Meco, M.T.8
-
7
-
-
84873842067
-
p62 links beta-adrenergic input to mitochondrial function and thermogenesis
-
Muller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Kuchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschop MH. p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest 2013;123:469-78.
-
(2013)
J Clin Invest
, vol.123
, pp. 469-478
-
-
Muller, T.D.1
Lee, S.J.2
Jastroch, M.3
Kabra, D.4
Stemmer, K.5
Aichler, M.6
Abplanalp, B.7
Ananthakrishnan, G.8
Bhardwaj, N.9
Collins, S.10
Divanovic, S.11
Endele, M.12
Finan, B.13
Gao, Y.14
Habegger, K.M.15
Hembree, J.16
Heppner, K.M.17
Hofmann, S.18
Holland, J.19
Kuchler, D.20
Kutschke, M.21
Krishna, R.22
Lehti, M.23
Oelkrug, R.24
Ottaway, N.25
Perez-Tilve, D.26
Raver, C.27
Walch, A.K.28
Schriever, S.C.29
Speakman, J.30
Tseng, Y.H.31
Diaz-Meco, M.32
Pfluger, P.T.33
Moscat, J.34
Tschop, M.H.35
more..
-
8
-
-
77749301510
-
Recent advances in understanding the molecular basis of Paget disease of bone
-
Goode A, Layfield R. Recent advances in understanding the molecular basis of Paget disease of bone. J Clin Pathol 2010;63:199-203.
-
(2010)
J Clin Pathol
, vol.63
, pp. 199-203
-
-
Goode, A.1
Layfield, R.2
-
9
-
-
79952355107
-
Selective autophagy mediated by autophagic adapter proteins
-
Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011;7:279-96.
-
(2011)
Autophagy
, vol.7
, pp. 279-296
-
-
Johansen, T.1
Lamark, T.2
-
10
-
-
77956410115
-
Selective autophagy: Ubiquitin-mediated recognition and beyond
-
Kraft C, Peter M, Hofmann K. Selective autophagy: ubiquitin-mediated recognition and beyond. Nat Cell Biol 2010;12:836-41.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 836-841
-
-
Kraft, C.1
Peter, M.2
Hofmann, K.3
-
11
-
-
81055140893
-
Feedback on fat: P62-mTORC1-autophagy connections
-
Moscat J, Diaz-Meco MT. Feedback on fat: p62-mTORC1-autophagy connections. Cell 2011;147:724-7.
-
(2011)
Cell
, vol.147
, pp. 724-727
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
12
-
-
0029616212
-
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
-
Park I, Chung J, Walsh CT, Yun Y, Strominger JL, Shin J. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc Natl Acad Sci U S A 1995;92:12338-42.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 12338-12342
-
-
Park, I.1
Chung, J.2
Walsh, C.T.3
Yun, Y.4
Strominger, J.L.5
Shin, J.6
-
13
-
-
0029894586
-
Molecular cloning of a phosphotyrosineindependent ligand of the p56lck SH2 domain
-
Joung I, Strominger JL, Shin J. Molecular cloning of a phosphotyrosineindependent ligand of the p56lck SH2 domain. Proc Natl Acad Sci U S A 1996;93:5991-5.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 5991-5995
-
-
Joung, I.1
Strominger, J.L.2
Shin, J.3
-
14
-
-
0032253214
-
P62 and the sequestosome, a novel mechanism for protein metabolism
-
Shin J. P62 and the sequestosome, a novel mechanism for protein metabolism. Arch Pharm Res 1998;21:629-33.
-
(1998)
Arch Pharm Res
, vol.21
, pp. 629-633
-
-
Shin, J.1
-
15
-
-
0030582370
-
Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress
-
Ishii T, Yanagawa T, Kawane T, Yuki K, Seita J, Yoshida H, Bannai S. Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun 1996;226:456-60.
-
(1996)
Biochem Biophys Res Commun
, vol.226
, pp. 456-460
-
-
Ishii, T.1
Yanagawa, T.2
Kawane, T.3
Yuki, K.4
Seita, J.5
Yoshida, H.6
Bannai, S.7
-
16
-
-
0031946369
-
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
-
Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT. Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol 1998;18:3069-80.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3069-3080
-
-
Sanchez, P.1
de Carcer, G.2
Sandoval, I.V.3
Moscat, J.4
Diaz-Meco, M.T.5
-
17
-
-
0030911597
-
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein
-
Puls A, Schmidt S, Grawe F, Stabel S. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A 1997;94:6191-6.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6191-6196
-
-
Puls, A.1
Schmidt, S.2
Grawe, F.3
Stabel, S.4
-
18
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death
-
Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtininduced cell death. J Cell Biol 2005;171:603-14.
-
(2005)
J Cell Biol
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
19
-
-
53049103308
-
Structural basis for sorting mechanism of p62 in selective autophagy
-
Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 2008;283:22847-57.
-
(2008)
J Biol Chem
, vol.283
, pp. 22847-22857
-
-
Ichimura, Y.1
Kumanomidou, T.2
Sou, Y.S.3
Mizushima, T.4
Ezaki, J.5
Ueno, T.6
Kominami, E.7
Yamane, T.8
Tanaka, K.9
Komatsu, M.10
-
20
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007;282:24131-45.
-
(2007)
J Biol Chem
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
21
-
-
36849089101
-
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy- deficient mice
-
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy- deficient mice. Cell 2007;131:1149-63.
-
(2007)
Cell
, vol.131
, pp. 1149-1163
-
-
Komatsu, M.1
Waguri, S.2
Koike, M.3
Sou, Y.S.4
Ueno, T.5
Hara, T.6
Mizushima, N.7
Iwata, J.8
Ezaki, J.9
Murata, S.10
Hamazaki, J.11
Nishito, Y.12
Iemura, S.13
Natsume, T.14
Yanagawa, T.15
Uwayama, J.16
Warabi, E.17
Yoshida, H.18
Ishii, T.19
Kobayashi, A.20
Yamamoto, M.21
Yue, Z.22
Uchiyama, Y.23
Kominami, E.24
Tanaka, K.25
more..
-
22
-
-
0033058534
-
Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent
-
Stumptner C, Heid H, Fuchsbichler A, Hauser H, Mischinger HJ, Zatloukal K, Denk H. Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent. Am J Pathol 1999;154:1701-10.
-
(1999)
Am J Pathol
, vol.154
, pp. 1701-1710
-
-
Stumptner, C.1
Heid, H.2
Fuchsbichler, A.3
Hauser, H.4
Mischinger, H.J.5
Zatloukal, K.6
Denk, H.7
-
23
-
-
34249697629
-
From Mallory to Mallory-Denk bodies: What, how and why?
-
Zatloukal K, French SW, Stumptner C, Strnad P, Harada M, Toivola DM, Cadrin M, Omary MB. From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res 2007;313:2033-49.
-
(2007)
Exp Cell Res
, vol.313
, pp. 2033-2049
-
-
Zatloukal, K.1
French, S.W.2
Stumptner, C.3
Strnad, P.4
Harada, M.5
Toivola, D.M.6
Cadrin, M.7
Omary, M.B.8
-
24
-
-
0036144410
-
p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
-
Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, Kleinert R, Prinz M, Aguzzi A, Denk H. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol 2002;160:255-63.
-
(2002)
Am J Pathol
, vol.160
, pp. 255-263
-
-
Zatloukal, K.1
Stumptner, C.2
Fuchsbichler, A.3
Heid, H.4
Schnoelzer, M.5
Kenner, L.6
Kleinert, R.7
Prinz, M.8
Aguzzi, A.9
Denk, H.10
-
25
-
-
33846240526
-
Sequestosome 1/p62 - more than just a scaffold
-
Seibenhener ML, Geetha T, Wooten MW. Sequestosome 1/p62 - more than just a scaffold. FEBS Lett 2007;581:175-9.
-
(2007)
FEBS Lett
, vol.581
, pp. 175-179
-
-
Seibenhener, M.L.1
Geetha, T.2
Wooten, M.W.3
-
26
-
-
46349098516
-
Specific regulation of cytokinedependent p38 MAP kinase activation by p62/SQSTM1
-
Kawai K, Saito A, Sudo T, Osada H. Specific regulation of cytokinedependent p38 MAP kinase activation by p62/SQSTM1. J Biochem 2008;143:765-72.
-
(2008)
J Biochem
, vol.143
, pp. 765-772
-
-
Kawai, K.1
Saito, A.2
Sudo, T.3
Osada, H.4
-
27
-
-
54849417613
-
Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase
-
Saito A, Kawai K, Takayama H, Sudo T, Osada H. Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase. Chem Asian J 2008;3:1607-12.
-
(2008)
Chem Asian J
, vol.3
, pp. 1607-1612
-
-
Saito, A.1
Kawai, K.2
Takayama, H.3
Sudo, T.4
Osada, H.5
-
28
-
-
77949324195
-
Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies
-
Pankiv S, Lamark T, Bruun JA, Overvatn A, Bjorkoy G, Johansen T. Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J Biol Chem 2010;285:5941-53.
-
(2010)
J Biol Chem
, vol.285
, pp. 5941-5953
-
-
Pankiv, S.1
Lamark, T.2
Bruun, J.A.3
Overvatn, A.4
Bjorkoy, G.5
Johansen, T.6
-
29
-
-
0034599476
-
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
-
Sanz L, Diaz-Meco MT, Nakano H, Moscat J. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 2000;19:1576-86.
-
(2000)
EMBO J
, vol.19
, pp. 1576-1586
-
-
Sanz, L.1
Diaz-Meco, M.T.2
Nakano, H.3
Moscat, J.4
-
30
-
-
84863425313
-
p62 at the interface of autophagy, oxidative stress signaling, and cancer
-
Nezis IP, Stenmark H. p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxidants Redox Signal 2012;17:786-93.
-
(2012)
Antioxidants Redox Signal
, vol.17
, pp. 786-793
-
-
Nezis, I.P.1
Stenmark, H.2
-
31
-
-
70350037529
-
Of the atypical PKCs, Par-4 and p62: Recent understandings of the biology and pathology of a PB1- dominated complex
-
Moscat J, Diaz-Meco MT, Wooten MW. Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1- dominated complex. Cell Death Diff 2009;16:1426-37.
-
(2009)
Cell Death Diff
, vol.16
, pp. 1426-1437
-
-
Moscat, J.1
Diaz-Meco, M.T.2
Wooten, M.W.3
-
32
-
-
78651282673
-
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
-
Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 2011;192:17-27.
-
(2011)
J Cell Biol
, vol.192
, pp. 17-27
-
-
Itakura, E.1
Mizushima, N.2
-
33
-
-
0033153320
-
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
-
Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J 1999;18:3044-53.
-
(1999)
EMBO J
, vol.18
, pp. 3044-3053
-
-
Sanz, L.1
Sanchez, P.2
Lallena, M.J.3
Diaz-Meco, M.T.4
Moscat, J.5
-
34
-
-
33846692198
-
Signal integration and diversification through the p62 scaffold protein
-
Moscat J, Diaz-Meco MT, Wooten MW. Signal integration and diversification through the p62 scaffold protein. Trends Biochem Sci 2007;32:95-100.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 95-100
-
-
Moscat, J.1
Diaz-Meco, M.T.2
Wooten, M.W.3
-
35
-
-
77954599053
-
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A, McMahon M, Hayes JD, Johansen T. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 2010;285:22576-91.
-
(2010)
J Biol Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
Overvatn, A.6
McMahon, M.7
Hayes, J.D.8
Johansen, T.9
-
36
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
-
Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 2010;30:3275-85.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
Jiang, T.6
Sun, Z.7
White, E.8
Zhang, D.D.9
-
37
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 2006;38:769-89.
-
(2006)
Drug Metab Rev
, vol.38
, pp. 769-789
-
-
Zhang, D.D.1
-
38
-
-
0032544438
-
Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein
-
Vadlamudi RK, Shin J. Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein. FEBS Lett 1998;435:138-42.
-
(1998)
FEBS Lett
, vol.435
, pp. 138-142
-
-
Vadlamudi, R.K.1
Shin, J.2
-
39
-
-
84855279854
-
The adaptor protein p62/SQSTM1 in osteoclast signaling pathways
-
McManus S, Roux S. The adaptor protein p62/SQSTM1 in osteoclast signaling pathways. J Mol Signal 2012;7:1.
-
(2012)
J Mol Signal
, vol.7
, pp. 1
-
-
McManus, S.1
Roux, S.2
-
40
-
-
0036094026
-
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone
-
Laurin N, Brown JP, Morissette J, Raymond V. Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am J Hum Genet 2002;70:1582-8.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 1582-1588
-
-
Laurin, N.1
Brown, J.P.2
Morissette, J.3
Raymond, V.4
-
41
-
-
0037108914
-
Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease
-
Hocking LJ, Lucas GJ, Daroszewska A, Mangion J, Olavesen M, Cundy T, Nicholson GC, Ward L, Bennett ST, Wuyts W, Van Hul W, Ralston SH. Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease. Hum Mol Genet 2002;11:2735-9.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2735-2739
-
-
Hocking, L.J.1
Lucas, G.J.2
Daroszewska, A.3
Mangion, J.4
Olavesen, M.5
Cundy, T.6
Nicholson, G.C.7
Ward, L.8
Bennett, S.T.9
Wuyts, W.10
van Hul, W.11
Ralston, S.H.12
-
42
-
-
41249084239
-
The signaling adaptor p62 is an important NFkappaB mediator in tumorigenesis
-
Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz- Meco MT, Moscat J. The signaling adaptor p62 is an important NFkappaB mediator in tumorigenesis. Cancer Cell 2008;13:343-54.
-
(2008)
Cancer Cell
, vol.13
, pp. 343-354
-
-
Duran, A.1
Linares, J.F.2
Galvez, A.S.3
Wikenheiser, K.4
Flores, J.M.5
Diaz-Meco, M.T.6
Moscat, J.7
-
43
-
-
27444433045
-
The p62 scaffold regulates nerve growth factor-induced NFkappaB activation by influencing TRAF6 polyubiquitination
-
Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J. The p62 scaffold regulates nerve growth factor-induced NFkappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem 2005;280:35625-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 35625-35629
-
-
Wooten, M.W.1
Geetha, T.2
Seibenhener, M.L.3
Babu, J.R.4
Diaz-Meco, M.T.5
Moscat, J.6
-
44
-
-
85172064780
-
Involvement of kinase PKC-zeta in the p62/p62(P392L)-driven activation of NFkappaB in human osteoclasts
-
Chamoux E, McManus S, Laberge G, Bisson M, Roux S. Involvement of kinase PKC-zeta in the p62/p62(P392L)-driven activation of NFkappaB in human osteoclasts. Biochim Biophys Acta 2013;1832:475-84.
-
(1832)
Biochim Biophys Acta
, vol.2013
, pp. 475-484
-
-
Chamoux, E.1
McManus, S.2
Laberge, G.3
Bisson, M.4
Roux, S.5
-
45
-
-
79952139698
-
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
-
Fujita K, Maeda D, Xiao Q, Srinivasula SM. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A 2011;108:1427-32.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 1427-1432
-
-
Fujita, K.1
Maeda, D.2
Xiao, Q.3
Srinivasula, S.M.4
-
46
-
-
84865439276
-
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor
-
Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL. Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PloS one 2012;7:e43961.
-
(2012)
PloS One
, vol.7
-
-
Williams, J.A.1
Thomas, A.M.2
Li, G.3
Kong, B.4
Zhan, L.5
Inaba, Y.6
Xie, W.7
Ding, W.X.8
Guo, G.L.9
-
47
-
-
0344564144
-
Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene
-
Okazaki M, Ito S, Kawakita K, Takeshita S, Kawai S, Makishima F, Oda H, Kakinuma A. Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. Genomics 1999;60:87-95.
-
(1999)
Genomics
, vol.60
, pp. 87-95
-
-
Okazaki, M.1
Ito, S.2
Kawakita, K.3
Takeshita, S.4
Kawai, S.5
Makishima, F.6
Oda, H.7
Kakinuma, A.8
-
48
-
-
0034805395
-
Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells
-
Kuusisto E, Suuronen T, Salminen A. Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. Biochem Biophys Res Commun 2001;280:223-8.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 223-228
-
-
Kuusisto, E.1
Suuronen, T.2
Salminen, A.3
-
49
-
-
0031555892
-
Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages
-
Ishii T, Yanagawa T, Yuki K, Kawane T, Yoshida H, Bannai S. Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. Biochem Biophys Res Commun 1997;232:33-7.
-
(1997)
Biochem Biophys Res Commun
, vol.232
, pp. 33-37
-
-
Ishii, T.1
Yanagawa, T.2
Yuki, K.3
Kawane, T.4
Yoshida, H.5
Bannai, S.6
-
50
-
-
76249124608
-
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation
-
Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res 2010;70:1042-52.
-
(2010)
Cancer Res
, vol.70
, pp. 1042-1052
-
-
Puissant, A.1
Robert, G.2
Fenouille, N.3
Luciano, F.4
Cassuto, J.P.5
Raynaud, S.6
Auberger, P.7
-
51
-
-
82455172117
-
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins
-
Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell 2011;44:279-89.
-
(2011)
Mol Cell
, vol.44
, pp. 279-289
-
-
Matsumoto, G.1
Wada, K.2
Okuno, M.3
Kurosawa, M.4
Nukina, N.5
-
52
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011;25:795-800.
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
Eishi, Y.7
Hino, O.8
Tanaka, K.9
Mizushima, N.10
-
53
-
-
84861466718
-
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
-
Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci 2012;127:438-50.
-
(2012)
Toxicol Sci
, vol.127
, pp. 438-450
-
-
Ni, H.M.1
Boggess, N.2
McGill, M.R.3
Lebofsky, M.4
Borude, P.5
Apte, U.6
Jaeschke, H.7
Ding, W.X.8
-
54
-
-
4444220680
-
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
-
Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 2004;24:8055-68.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8055-8068
-
-
Seibenhener, M.L.1
Babu, J.R.2
Geetha, T.3
Wong, H.C.4
Krishna, N.R.5
Wooten, M.W.6
-
55
-
-
84871279726
-
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation
-
Ding WX, Guo F, Ni HM, Bockus A, Manley S, Stolz DB, Eskelinen EL, Jaeschke H, Yin XM. Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation. J Biol Chem 2012;287:42379-88.
-
(2012)
J Biol Chem
, vol.287
, pp. 42379-42388
-
-
Ding, W.X.1
Guo, F.2
Ni, H.M.3
Bockus, A.4
Manley, S.5
Stolz, D.B.6
Eskelinen, E.L.7
Jaeschke, H.8
Yin, X.M.9
-
57
-
-
77949997805
-
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
-
Ponpuak M, Davis AS, Roberts EA, Delgado MA, Dinkins C, Zhao Z, Virgin HW, Kyei GB, Johansen T, Vergne I, Deretic V. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 2010;32:329-41.
-
(2010)
Immunity
, vol.32
, pp. 329-341
-
-
Ponpuak, M.1
Davis, A.S.2
Roberts, E.A.3
Delgado, M.A.4
Dinkins, C.5
Zhao, Z.6
Virgin, H.W.7
Kyei, G.B.8
Johansen, T.9
Vergne, I.10
Deretic, V.11
-
58
-
-
77950903972
-
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
-
Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell 2010;38:265-79.
-
(2010)
Mol Cell
, vol.38
, pp. 265-279
-
-
Filimonenko, M.1
Isakson, P.2
Finley, K.D.3
Anderson, M.4
Jeong, H.5
Melia, T.J.6
Bartlett, B.J.7
Myers, K.M.8
Birkeland, H.C.9
Lamark, T.10
Krainc, D.11
Brech, A.12
Stenmark, H.13
Simonsen, A.14
Yamamoto, A.15
-
59
-
-
60849099049
-
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
-
Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Overvatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009;33:505-16.
-
(2009)
Mol Cell
, vol.33
, pp. 505-516
-
-
Kirkin, V.1
Lamark, T.2
Sou, Y.S.3
Bjorkoy, G.4
Nunn, J.L.5
Bruun, J.A.6
Shvets, E.7
McEwan, D.G.8
Clausen, T.H.9
Wild, P.10
Bilusic, I.11
Theurillat, J.P.12
Overvatn, A.13
Ishii, T.14
Elazar, Z.15
Komatsu, M.16
Dikic, I.17
Johansen, T.18
-
60
-
-
4944247868
-
Alfy, a novel FYVEdomain- containing protein associated with protein granules and autophagic membranes
-
Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H. Alfy, a novel FYVEdomain- containing protein associated with protein granules and autophagic membranes. J Cell Sci 2004;117:4239-51.
-
(2004)
J Cell Sci
, vol.117
, pp. 4239-4251
-
-
Simonsen, A.1
Birkeland, H.C.2
Gillooly, D.J.3
Mizushima, N.4
Kuma, A.5
Yoshimori, T.6
Slagsvold, T.7
Brech, A.8
Stenmark, H.9
-
61
-
-
77952914565
-
p62/ SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ ALIS and their degradation by autophagy
-
Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Overvatn A, Stenmark H, Bjorkoy G, Simonsen A, Johansen T. p62/ SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ ALIS and their degradation by autophagy. Autophagy 2010;6:330-44.
-
(2010)
Autophagy
, vol.6
, pp. 330-344
-
-
Clausen, T.H.1
Lamark, T.2
Isakson, P.3
Finley, K.4
Larsen, K.B.5
Brech, A.6
Overvatn, A.7
Stenmark, H.8
Bjorkoy, G.9
Simonsen, A.10
Johansen, T.11
-
62
-
-
28844475400
-
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
-
Iwata A, Riley BE, Johnston JA, Kopito RR. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem 2005;280:40282-92.
-
(2005)
J Biol Chem
, vol.280
, pp. 40282-40292
-
-
Iwata, A.1
Riley, B.E.2
Johnston, J.A.3
Kopito, R.R.4
-
63
-
-
77649337122
-
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality- control autophagy
-
Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J, Taylor JP, Cuervo AM, Yao TP. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality- control autophagy. EMBO J 2010;29:969-80.
-
(2010)
EMBO J
, vol.29
, pp. 969-980
-
-
Lee, J.Y.1
Koga, H.2
Kawaguchi, Y.3
Tang, W.4
Wong, E.5
Gao, Y.S.6
Pandey, U.B.7
Kaushik, S.8
Tresse, E.9
Lu, J.10
Taylor, J.P.11
Cuervo, A.M.12
Yao, T.P.13
-
64
-
-
79952843826
-
The role of ubiquitin in autophagy-dependent protein aggregate processing
-
Yao TP. The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes Cancer 2010;1:779-86.
-
(2010)
Genes Cancer
, vol.1
, pp. 779-786
-
-
Yao, T.P.1
-
65
-
-
38949096081
-
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
-
Ding WX, Yin XM. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 2008;4:141-50.
-
(2008)
Autophagy
, vol.4
, pp. 141-150
-
-
Ding, W.X.1
Yin, X.M.2
-
66
-
-
77956252454
-
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitinp62- mediated mitochondrial priming
-
Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitinp62- mediated mitochondrial priming. J Biol Chem 2010;285:27879-90.
-
(2010)
J Biol Chem
, vol.285
, pp. 27879-27890
-
-
Ding, W.X.1
Ni, H.M.2
Li, M.3
Liao, Y.4
Chen, X.5
Stolz, D.B.6
Dorn 2nd, G.W.7
Yin, X.M.8
-
67
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010;12:119-31.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmstrom, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
68
-
-
58149344946
-
Midbody ring disposal by autophagy is a postabscission event of cytokinesis
-
Pohl C, Jentsch S. Midbody ring disposal by autophagy is a postabscission event of cytokinesis. Nat Cell Biol 2009;11:65-70.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 65-70
-
-
Pohl, C.1
Jentsch, S.2
-
69
-
-
79952348751
-
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteriaassociated microdomains to target Salmonella to the autophagy pathway
-
Cemma M, Kim PK, Brumell JH. The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteriaassociated microdomains to target Salmonella to the autophagy pathway. Autophagy 2011;7:341-5.
-
(2011)
Autophagy
, vol.7
, pp. 341-345
-
-
Cemma, M.1
Kim, P.K.2
Brumell, J.H.3
-
70
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008;183:795-803.
-
(2008)
J Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
71
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010;8:e1000298.
-
(2010)
PLoS Biol
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.F.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
72
-
-
75949098487
-
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
-
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrane J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2010;107:378-83.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 378-383
-
-
Vives-Bauza, C.1
Zhou, C.2
Huang, Y.3
Cui, M.4
de Vries, R.L.5
Kim, J.6
May, J.7
Tocilescu, M.A.8
Liu, W.9
Ko, H.S.10
Magrane, J.11
Moore, D.J.12
Dawson, V.L.13
Grailhe, R.14
Dawson, T.M.15
Li, C.16
Tieu, K.17
Przedborski, S.18
-
73
-
-
78649685455
-
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
-
Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 2010;191:933-42.
-
(2010)
J Cell Biol
, vol.191
, pp. 933-942
-
-
Jin, S.M.1
Lazarou, M.2
Wang, C.3
Kane, L.A.4
Narendra, D.P.5
Youle, R.J.6
-
74
-
-
84873045973
-
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
-
Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ. PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol 2013;200:163-72.
-
(2013)
J Cell Biol
, vol.200
, pp. 163-172
-
-
Lazarou, M.1
Narendra, D.P.2
Jin, S.M.3
Tekle, E.4
Banerjee, S.5
Youle, R.J.6
-
75
-
-
84871891737
-
PINK1-mediated phosphorylation of the Parkin ubiquitinlike domain primes mitochondrial translocation of Parkin and regulates mitophagy
-
Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N. PINK1-mediated phosphorylation of the Parkin ubiquitinlike domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep 2012;2:1002.
-
(2012)
Sci Rep
, vol.2
, pp. 1002
-
-
Shiba-Fukushima, K.1
Imai, Y.2
Yoshida, S.3
Ishihama, Y.4
Kanao, T.5
Sato, S.6
Hattori, N.7
-
76
-
-
79954520907
-
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
-
Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 2011;20:1726-37.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 1726-1737
-
-
Chan, N.C.1
Salazar, A.M.2
Pham, A.H.3
Sweredoski, M.J.4
Kolawa, N.J.5
Graham, R.L.6
Hess, S.7
Chan, D.C.8
-
77
-
-
79957472437
-
Parkin mediates proteasome- dependent protein degradation and rupture of the outer mitochondrial membrane
-
Yoshii SR, Kishi C, Ishihara N, Mizushima N. Parkin mediates proteasome- dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem 2011;286:19630-40.
-
(2011)
J Biol Chem
, vol.286
, pp. 19630-19640
-
-
Yoshii, S.R.1
Kishi, C.2
Ishihara, N.3
Mizushima, N.4
-
78
-
-
78649300971
-
p62/ SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/ SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010;6:1090-106.
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.A.2
Hauser, D.N.3
Fearnley, I.M.4
Youle, R.J.5
-
79
-
-
34548817868
-
In vitro production of Mallory bodies and intracellular hyaline bodies: The central role of sequestosome 1/p62
-
Stumptner C, Fuchsbichler A, Zatloukal K, Denk H. In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62. Hepatology 2007;46:851-60.
-
(2007)
Hepatology
, vol.46
, pp. 851-860
-
-
Stumptner, C.1
Fuchsbichler, A.2
Zatloukal, K.3
Denk, H.4
-
80
-
-
56449086372
-
Mallory- Denk-bodies: Lessons from keratin-containing hepatic inclusion bodies
-
Strnad P, Zatloukal K, Stumptner C, Kulaksiz H, Denk H. Mallory- Denk-bodies: lessons from keratin-containing hepatic inclusion bodies. Biochim Biophys Acta 2008;1782:764-74.
-
(2008)
Biochim Biophys Acta
, vol.1782
, pp. 764-774
-
-
Strnad, P.1
Zatloukal, K.2
Stumptner, C.3
Kulaksiz, H.4
Denk, H.5
-
81
-
-
12144290092
-
Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis
-
Muller T, Langner C, Fuchsbichler A, Heinz-Erian P, Ellemunter H, Schlenck B, Bavdekar AR, Pradhan AM, Pandit A, Muller-Hocker J, Melter M, Kobayashi K, Nagasaka H, Kikuta H, Muller W, Tanner MS, Sternlieb I, Zatloukal K, Denk H. Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis. Hepatology 2004;39:963-9.
-
(2004)
Hepatology
, vol.39
, pp. 963-969
-
-
Muller, T.1
Langner, C.2
Fuchsbichler, A.3
Heinz-Erian, P.4
Ellemunter, H.5
Schlenck, B.6
Bavdekar, A.R.7
Pradhan, A.M.8
Pandit, A.9
Muller-Hocker, J.10
Melter, M.11
Kobayashi, K.12
Nagasaka, H.13
Kikuta, H.14
Muller, W.15
Tanner, M.S.16
Sternlieb, I.17
Zatloukal, K.18
Denk, H.19
-
82
-
-
0347301683
-
The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation
-
Bardag-Gorce F, Riley NE, Nan L, Montgomery RO, Li J, French BA, Lue YH, French SW. The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation. Exp Mol Pathol 2004;76:9-16.
-
(2004)
Exp Mol Pathol
, vol.76
, pp. 9-16
-
-
Bardag-Gorce, F.1
Riley, N.E.2
Nan, L.3
Montgomery, R.O.4
Li, J.5
French, B.A.6
Lue, Y.H.7
French, S.W.8
-
83
-
-
46249115957
-
Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation
-
Harada M, Hanada S, Toivola DM, Ghori N, Omary MB. Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation. Hepatology 2008;47:2026-35.
-
(2008)
Hepatology
, vol.47
, pp. 2026-2035
-
-
Harada, M.1
Hanada, S.2
Toivola, D.M.3
Ghori, N.4
Omary, M.B.5
-
84
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003;115:727-38.
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
85
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010;12:213-23.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
Sou, Y.S.7
Ueno, I.8
Sakamoto, A.9
Tong, K.I.10
Kim, M.11
Nishito, Y.12
Iemura, S.13
Natsume, T.14
Ueno, T.15
Kominami, E.16
Motohashi, H.17
Tanaka, K.18
Yamamoto, M.19
-
86
-
-
84856634376
-
A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis
-
Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. Liver Int 2012;32:487-99.
-
(2012)
Liver Int
, vol.32
, pp. 487-499
-
-
Sasaki, M.1
Miyakoshi, M.2
Sato, Y.3
Nakanuma, Y.4
-
87
-
-
84859502562
-
Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis
-
Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis. Dig Dis Sci 2012;57:660-6.
-
(2012)
Dig Dis Sci
, vol.57
, pp. 660-666
-
-
Sasaki, M.1
Miyakoshi, M.2
Sato, Y.3
Nakanuma, Y.4
-
88
-
-
0036900927
-
Bile acid-induced Mallory body formation in drug-primed mouse liver
-
Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H. Bile acid-induced Mallory body formation in drug-primed mouse liver. Am J Pathol 2002;161:2019-26.
-
(2002)
Am J Pathol
, vol.161
, pp. 2019-2026
-
-
Fickert, P.1
Trauner, M.2
Fuchsbichler, A.3
Stumptner, C.4
Zatloukal, K.5
Denk, H.6
-
89
-
-
0015534944
-
Hepatocellular hyalin in cholestasis and cirrhosis: Its diagnostic significance
-
Gerber MA, Orr W, Denk H, Schaffner F, Popper H. Hepatocellular hyalin in cholestasis and cirrhosis: its diagnostic significance. Gastroenterology 1973;64:89-98.
-
(1973)
Gastroenterology
, vol.64
, pp. 89-98
-
-
Gerber, M.A.1
Orr, W.2
Denk, H.3
Schaffner, F.4
Popper, H.5
-
91
-
-
0032874718
-
Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria
-
Meerman L, Koopen NR, Bloks V, Van Goor H, Havinga R, Wolthers BG, Kramer W, Stengelin S, Muller M, Kuipers F, Jansen PL. Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. Gastroenterology 1999;117:696-705.
-
(1999)
Gastroenterology
, vol.117
, pp. 696-705
-
-
Meerman, L.1
Koopen, N.R.2
Bloks, V.3
van Goor, H.4
Havinga, R.5
Wolthers, B.G.6
Kramer, W.7
Stengelin, S.8
Muller, M.9
Kuipers, F.10
Jansen, P.L.11
-
94
-
-
33644629034
-
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
-
Rodriguez A, Duran A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab 2006;3:211-22.
-
(2006)
Cell Metab
, vol.3
, pp. 211-222
-
-
Rodriguez, A.1
Duran, A.2
Selloum, M.3
Champy, M.F.4
Diez-Guerra, F.J.5
Flores, J.M.6
Serrano, M.7
Auwerx, J.8
Diaz-Meco, M.T.9
Moscat, J.10
-
95
-
-
19944433322
-
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
Bost F, Aouadi M, Caron L, Even P, Belmonte N, Prot M, Dani C, Hofman P, Pages G, Pouyssegur J, Le Marchand-Brustel Y, Binetruy B. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 2005;54:402-11.
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
Aouadi, M.2
Caron, L.3
Even, P.4
Belmonte, N.5
Prot, M.6
Dani, C.7
Hofman, P.8
Pages, G.9
Pouyssegur, J.10
Le Marchand-Brustel, Y.11
Binetruy, B.12
-
96
-
-
14544298335
-
The role of MAPKs in adipocyte differentiation and obesity
-
Bost F, Aouadi M, Caron L, Binetruy B. The role of MAPKs in adipocyte differentiation and obesity. Biochimie 2005;87:51-6.
-
(2005)
Biochimie
, vol.87
, pp. 51-56
-
-
Bost, F.1
Aouadi, M.2
Caron, L.3
Binetruy, B.4
-
97
-
-
77649265416
-
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis
-
Lee SJ, Pfluger PT, Kim JY, Nogueiras R, Duran A, Pages G, Pouyssegur J, Tschop MH, Diaz-Meco MT, Moscat J. A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep 2010;11:226-32.
-
(2010)
EMBO Rep
, vol.11
, pp. 226-232
-
-
Lee, S.J.1
Pfluger, P.T.2
Kim, J.Y.3
Nogueiras, R.4
Duran, A.5
Pages, G.6
Pouyssegur, J.7
Tschop, M.H.8
Diaz-Meco, M.T.9
Moscat, J.10
-
98
-
-
84873842067
-
Tschop MH. p62 Links beta-adrenergic input to mitochondrial function and thermogenesis
-
Muller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Kuchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschop MH. p62 Links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Investig 2013;123:469-78.
-
(2013)
J Clin Investig
, vol.123
, pp. 469-478
-
-
Muller, T.D.1
Lee, S.J.2
Jastroch, M.3
Kabra, D.4
Stemmer, K.5
Aichler, M.6
Abplanalp, B.7
Ananthakrishnan, G.8
Bhardwaj, N.9
Collins, S.10
Divanovic, S.11
Endele, M.12
Finan, B.13
Gao, Y.14
Habegger, K.M.15
Hembree, J.16
Heppner, K.M.17
Hofmann, S.18
Holland, J.19
Kuchler, D.20
Kutschke, M.21
Krishna, R.22
Lehti, M.23
Oelkrug, R.24
Ottaway, N.25
Perez-Tilve, D.26
Raver, C.27
Walch, A.K.28
Schriever, S.C.29
Speakman, J.30
Tseng, Y.H.31
Diaz-Meco, M.32
Pfluger, P.T.33
Moscat, J.34
more..
-
99
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-6.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
100
-
-
33750823407
-
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
-
Solinas G, Naugler W, Galimi F, Lee MS, Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 2006;103:16454-9.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16454-16459
-
-
Solinas, G.1
Naugler, W.2
Galimi, F.3
Lee, M.S.4
Karin, M.5
-
101
-
-
84864198388
-
A liver full of JNK: Signaling in regulation of cell function and disease pathogenesis, and clinical approaches
-
Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012;143:307-20.
-
(2012)
Gastroenterology
, vol.143
, pp. 307-320
-
-
Seki, E.1
Brenner, D.A.2
Karin, M.3
-
102
-
-
58949093454
-
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
-
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 2009;49:87-96.
-
(2009)
Hepatology
, vol.49
, pp. 87-96
-
-
Singh, R.1
Wang, Y.2
Xiang, Y.3
Tanaka, K.E.4
Gaarde, W.A.5
Czaja, M.J.6
-
103
-
-
34548299555
-
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
-
Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 2007;171:513-24.
-
(2007)
Am J Pathol
, vol.171
, pp. 513-524
-
-
Ding, W.X.1
Ni, H.M.2
Gao, W.3
Yoshimori, T.4
Stolz, D.B.5
Ron, D.6
Yin, X.M.7
-
104
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008;30:678-88.
-
(2008)
Mol Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
105
-
-
60149098492
-
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells
-
Li DD, Wang LL, Deng R, Tang J, Shen Y, Guo JF, Wang Y, Xia LP, Feng GK, Liu QQ, Huang WL, Zeng YX, Zhu XF. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 2009;28:886-98.
-
(2009)
Oncogene
, vol.28
, pp. 886-898
-
-
Li, D.D.1
Wang, L.L.2
Deng, R.3
Tang, J.4
Shen, Y.5
Guo, J.F.6
Wang, Y.7
Xia, L.P.8
Feng, G.K.9
Liu, Q.Q.10
Huang, W.L.11
Zeng, Y.X.12
Zhu, X.F.13
-
106
-
-
84865467434
-
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein
-
Geetha T, Zheng C, Vishwaprakash N, Broderick TL, Babu JR. Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein. J Biol Chem 2012;287:29672-8.
-
(2012)
J Biol Chem
, vol.287
, pp. 29672-29678
-
-
Geetha, T.1
Zheng, C.2
Vishwaprakash, N.3
Broderick, T.L.4
Babu, J.R.5
-
107
-
-
79955492012
-
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
-
Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 2011;193:275-84.
-
(2011)
J Cell Biol
, vol.193
, pp. 275-284
-
-
Inami, Y.1
Waguri, S.2
Sakamoto, A.3
Kouno, T.4
Nakada, K.5
Hino, O.6
Watanabe, S.7
Ando, J.8
Iwadate, M.9
Yamamoto, M.10
Lee, M.S.11
Tanaka, K.12
Komatsu, M.13
-
108
-
-
0037994340
-
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells
-
Thompson HG, Harris JW, Wold BJ, Lin F, Brody JP. p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. Oncogene 2003;22:2322-33.
-
(2003)
Oncogene
, vol.22
, pp. 2322-2333
-
-
Thompson, H.G.1
Harris, J.W.2
Wold, B.J.3
Lin, F.4
Brody, J.P.5
-
109
-
-
84862811895
-
Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
-
Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M. Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. Cancer Sci 2012;103:760-6.
-
(2012)
Cancer Sci
, vol.103
, pp. 760-766
-
-
Inoue, D.1
Suzuki, T.2
Mitsuishi, Y.3
Miki, Y.4
Suzuki, S.5
Sugawara, S.6
Watanabe, M.7
Sakurada, A.8
Endo, C.9
Uruno, A.10
Sasano, H.11
Nakagawa, T.12
Satoh, K.13
Tanaka, N.14
Kubo, H.15
Motohashi, H.16
Yamamoto, M.17
-
110
-
-
84873442017
-
Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy
-
Myung Park J, Huang S, Wu TT, Foster NR, Sinicrope FA. Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther 2013;14:100-7.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 100-107
-
-
Myung, P.J.1
Huang, S.2
Wu, T.T.3
Foster, N.R.4
Sinicrope, F.A.5
-
111
-
-
84861939463
-
p62: A versatile multitasker takes on cancer
-
Moscat J, Diaz-Meco MT. p62: a versatile multitasker takes on cancer. Trends Biochem Sci 2012;37:230-6.
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 230-236
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
112
-
-
76249090326
-
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation
-
Nakamura K, Kimple AJ, Siderovski DP, Johnson GL. PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem 2010;285:2077-89.
-
(2010)
J Biol Chem
, vol.285
, pp. 2077-2089
-
-
Nakamura, K.1
Kimple, A.J.2
Siderovski, D.P.3
Johnson, G.L.4
-
113
-
-
43049124129
-
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
-
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 2008;118:1858-66.
-
(2008)
J Clin Invest
, vol.118
, pp. 1858-1866
-
-
Jin, W.1
Chang, M.2
Paul, E.M.3
Babu, G.4
Lee, A.J.5
Reiley, W.6
Wright, A.7
Zhang, M.8
You, J.9
Sun, S.C.10
-
114
-
-
78650859531
-
NF-kappaB and STAT3 - key players in liver inflammation and cancer
-
He G, Karin M. NF-kappaB and STAT3 - key players in liver inflammation and cancer. Cell Res 2011;21:159-68.
-
(2011)
Cell Res
, vol.21
, pp. 159-168
-
-
He, G.1
Karin, M.2
-
115
-
-
4644324186
-
NFkappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y. NFkappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-6.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
Gutkovich-Pyest, E.7
Urieli-Shoval, S.8
Galun, E.9
Ben-Neriah, Y.10
-
116
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90.
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
117
-
-
33846839443
-
Deletion of NEMO/ IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
-
Luedde T, Beraza N, Kotsikoris V, Van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M. Deletion of NEMO/ IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007;11:119-32.
-
(2007)
Cancer Cell
, vol.11
, pp. 119-132
-
-
Luedde, T.1
Beraza, N.2
Kotsikoris, V.3
van Loo, G.4
Nenci, A.5
de Vos, R.6
Roskams, T.7
Trautwein, C.8
Pasparakis, M.9
-
118
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009;137:1062-75.
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
Vuong, N.4
Chen, G.5
Chen, H.Y.6
Bray, K.7
Reddy, A.8
Bhanot, G.9
Gelinas, C.10
Dipaola, R.S.11
Karantza-Wadsworth, V.12
White, E.13
-
119
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008;29:1235-43.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
Chen, W.7
Yi, X.8
Zheng, W.9
Wondrak, G.T.10
Wong, P.K.11
Zhang, D.D.12
-
120
-
-
0035260034
-
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione
-
Kwak MK, Itoh K, Yamamoto M, Sutter TR, Kensler TW. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med 2001;7:135-45.
-
(2001)
Mol Med
, vol.7
, pp. 135-145
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
Sutter, T.R.4
Kensler, T.W.5
-
121
-
-
54149084936
-
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
-
Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect 2008;116:1154-61.
-
(2008)
Environ Health Perspect
, vol.116
, pp. 1154-1161
-
-
Du, Y.1
Villeneuve, N.F.2
Wang, X.J.3
Sun, Z.4
Chen, W.5
Li, J.6
Lou, H.7
Wong, P.K.8
Zhang, D.D.9
-
122
-
-
84865287281
-
Keap1 degradation by autophagy for the maintenance of redox homeostasis
-
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A 2012;109:13561-6.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13561-13566
-
-
Taguchi, K.1
Fujikawa, N.2
Komatsu, M.3
Ishii, T.4
Unno, M.5
Akaike, T.6
Motohashi, H.7
Yamamoto, M.8
-
123
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, Ashkenazi A. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009;137:721-35.
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
Lawrence, D.4
Pham, V.C.5
Lill, J.R.6
Ashkenazi, A.7
-
124
-
-
79960325950
-
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes
-
Pan JA, Ullman E, Dou Z, Zong WX. Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol 2011;31:3158-70.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3158-3170
-
-
Pan, J.A.1
Ullman, E.2
Dou, Z.3
Zong, W.X.4
-
125
-
-
79960324454
-
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury
-
Ullman E, Pan JA, Zong WX. Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol 2011;31:2902-19.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2902-2919
-
-
Ullman, E.1
Pan, J.A.2
Zong, W.X.3
-
126
-
-
84859480341
-
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
-
Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, Sharma AK, Amin S, Hu CD, Zhang J, Kester M, Wang HG. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem 2012;287:12455-68.
-
(2012)
J Biol Chem
, vol.287
, pp. 12455-12468
-
-
Young, M.M.1
Takahashi, Y.2
Khan, O.3
Park, S.4
Hori, T.5
Yun, J.6
Sharma, A.K.7
Amin, S.8
Hu, C.D.9
Zhang, J.10
Kester, M.11
Wang, H.G.12
-
127
-
-
78049495046
-
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: A potential role for protein aggregation in autophagic substrate selection
-
Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010;191:537-52.
-
(2010)
J Cell Biol
, vol.191
, pp. 537-552
-
-
Riley, B.E.1
Kaiser, S.E.2
Shaler, T.A.3
Ng, A.C.4
Hara, T.5
Hipp, M.S.6
Lage, K.7
Xavier, R.J.8
Ryu, K.Y.9
Taguchi, K.10
Yamamoto, M.11
Tanaka, K.12
Mizushima, N.13
Komatsu, M.14
Kopito, R.R.15
-
128
-
-
84872137966
-
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
-
Bae SH, Sung SH, Oh SY, Lim JM, Lee SK, Park YN, Lee HE, Kang D, Rhee SG. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab 2013;17:73-84.
-
(2013)
Cell Metab
, vol.17
, pp. 73-84
-
-
Bae, S.H.1
Sung, S.H.2
Oh, S.Y.3
Lim, J.M.4
Lee, S.K.5
Park, Y.N.6
Lee, H.E.7
Kang, D.8
Rhee, S.G.9
-
129
-
-
29544448331
-
Intracellular signaling mechanisms of acetaminophen- induced liver cell death
-
Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen- induced liver cell death. Toxicol Sci 2006;89:31-41.
-
(2006)
Toxicol Sci
, vol.89
, pp. 31-41
-
-
Jaeschke, H.1
Bajt, M.L.2
-
130
-
-
84155194923
-
Activation of autophagy protects against acetaminophen-induced hepatotoxicity
-
Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 2012;55:222-32.
-
(2012)
Hepatology
, vol.55
, pp. 222-232
-
-
Ni, H.M.1
Bockus, A.2
Boggess, N.3
Jaeschke, H.4
Ding, W.X.5
-
131
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res 2008;58:262-70.
-
(2008)
Pharmacol Res
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
132
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 2001;98:3410-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
133
-
-
4644328941
-
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
-
Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 2004;64:6424-31.
-
(2004)
Cancer Res
, vol.64
, pp. 6424-6431
-
-
Iida, K.1
Itoh, K.2
Kumagai, Y.3
Oyasu, R.4
Hattori, K.5
Kawai, K.6
Shimazui, T.7
Akaza, H.8
Yamamoto, M.9
-
134
-
-
63549121490
-
NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
-
Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009;34:176-88.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
135
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011;16:123-40.
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
136
-
-
77951214016
-
Mammalian autophagy: Core molecular machinery and signaling regulation
-
Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010;22:124-31.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
138
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart EF, Luiken JJ, Blommaart PJ, vanWoerkom GM, Meijer AJ. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995;270:2320-6.
-
(1995)
J Biol Chem
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
Vanwoerkom, G.M.4
Meijer, A.J.5
-
139
-
-
77951221542
-
The role of the Atg1/ULK1 complex in autophagy regulation
-
Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010;22:132-9.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 132-139
-
-
Mizushima, N.1
-
140
-
-
77949357437
-
Cardioprotection by resveratrol: A novel mechanism via autophagy involving the mTORC2 pathway
-
Gurusamy N, Lekli I, Mukherjee S, Ray D, Ahsan MK, Gherghiceanu M, Popescu LM, Das DK. Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res 2010;86:103-12.
-
(2010)
Cardiovasc Res
, vol.86
, pp. 103-112
-
-
Gurusamy, N.1
Lekli, I.2
Mukherjee, S.3
Ray, D.4
Ahsan, M.K.5
Gherghiceanu, M.6
Popescu, L.M.7
Das, D.K.8
-
141
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del P, iccolo P, Burden SJ, Di L, isi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007;6:458-71.
-
(2007)
Cell Metab
, vol.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
Masiero, E.4
Rudolf, R.5
Del, P.6
Iccolo, P.7
Burden, S.J.8
Di, L.9
Isi, R.10
Sandri, C.11
Zhao, J.12
Goldberg, A.L.13
Schiaffino, S.14
Sandri, M.15
-
142
-
-
84865592978
-
Amino acids and mTORC1: From lysosomes to disease
-
Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med 2012;18:524-33.
-
(2012)
Trends Mol Med
, vol.18
, pp. 524-533
-
-
Efeyan, A.1
Zoncu, R.2
Sabatini, D.M.3
-
143
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
144
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
145
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009;19:R1046-52.
-
(2009)
Curr Biol
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
146
-
-
84874655800
-
The multifaceted role of mTORC1 in the control of lipid metabolism
-
Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep 2013;14:242-51.
-
(2013)
EMBO Rep
, vol.14
, pp. 242-251
-
-
Ricoult, S.J.1
Manning, B.D.2
-
147
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010;141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
148
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010;465:942-6.
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
Peng, J.6
Mi, N.7
Zhao, Y.8
Liu, Z.9
Wan, F.10
Hailey, D.W.11
Oorschot, V.12
Klumperman, J.13
Baehrecke, E.H.14
Lenardo, M.J.15
-
149
-
-
80053586265
-
p62 is a key regulator of nutrient sensing in the mTORC1 pathway
-
Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell 2011;44:134-46.
-
(2011)
Mol Cell
, vol.44
, pp. 134-146
-
-
Duran, A.1
Amanchy, R.2
Linares, J.F.3
Joshi, J.4
Abu-Baker, S.5
Porollo, A.6
Hansen, M.7
Moscat, J.8
Diaz-Meco, M.T.9
-
150
-
-
84859090262
-
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice
-
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal 2012;5:ra24.
-
(2012)
Sci Signal
, vol.5
-
-
Menon, S.1
Yecies, J.L.2
Zhang, H.H.3
Howell, J.J.4
Nicholatos, J.5
Harputlugil, E.6
Bronson, R.T.7
Kwiatkowski, D.J.8
Manning, B.D.9
|