Immunohistochemical Analysis of Mallory Bodies in Wilsonian and Non-Wilsonian Hepatic Copper Toxicosis

Hepatology

Volumn 39, Issue 4, 2004, Pages 963-969

  Müller, Thomas ^a   Langner, Cord ^b   Fuchsbichler, Andrea ^b   Heinz Erian, Peter ^a   Ellemunter, Helmut ^a   Schlenck, Barbara ^a   Bavdekar, Ashish R ^c   Pradhan, Avinash M ^c   Pandit, Anand ^c   Müller Höcker, Josef ^d   Melter, Michael ^e   Kobayashi, Kunihiko ^f   Nagasaka, Hironori ^f   Kikuta, Hideaki ^f   Müller, Wilfried ^g   Tanner, M Stuart ^h   Sternlieb, Irmin ⁱ   Zatloukal, Kurt ^b   Denk, Helmut ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c KEM HOSPITAL   (India)

^d UNIVERSITY OF MUNICH   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f HOKKAIDO UNIVERSITY   (Japan)

^g Hospital Reutte   (Austria)

^h UNIVERSITY OF SHEFFIELD   (United Kingdom)

ⁱ Natl Ctr Stud of Wilson's Dis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; COPPER; KERATIN; PROTEIN KINASE C; PROTEIN P62; PROTEIN RIP; UBIQUITIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALCOHOLIC FATTY LIVER; ARTICLE; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDIAN CHILDHOOD CIRRHOSIS; INFANT; LIVER BIOPSY; LIVER TOXICITY; MALE; MALLORY BODY; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; WILSON DISEASE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; COPPER; FEMALE; HEPATOLENTICULAR DEGENERATION; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; INFANT; LIVER; LIVER CIRRHOSIS; MALE; NERVE DEGENERATION;

EID: 12144290092     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20108     Document Type: Article

References (42)

1. Wilson SAK. Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver. Brain 1912;34:295-509.
2. Tanner MS. Role of copper in Indian childhood cirrhosis. Am J Clin Nutr 1998;67(Suppl):1074S-1081S.
3. Scheinberg IH, Sternlieb I. Wilson disease and idiopathic copper toxicosis. Am J Clin Nutr 1996;63:842S-845S.
4. Müller T, Müller W, Feichtinger H. Idiopathic copper toxicosis. Am J Clin Nutr 1998;67(Suppl):1082S-1086S.
5. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 1993;5:327-337.
6. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 1993;5: 344-350.
7. Tanner MS, Kantarjian AH, Bhave SA, Pandit AN. Early introduction of copper-contaminated animal milk feeds as a possible cause of Indian childhood cirrhosis. Lancet 1983;ii:992-995.
8. Müller T, Feichtinger H, Berger H, Müller W. Endemic Tyrolean infantile cirrhosis: an ecogenetic disorder. Lancet 1996;347:877-880.
9. Müller T, van de Sluis B, Zhernakova A, van Binsbergen E, Janecke AR, Bavdekar A, Pandit A, et al. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. J Hepatol 2003;38: 164-168.
10. Popper H, Goldfischer S, Sternlieb I, Nayak NC, Madhavan TV. Cytoplasmic copper and its toxic effects. Studies in Indian childhood cirrhosis. Lancet 1979;i:1205-1208.
11. Müller-Höcker J, Summer KH, Schramel P, Rodeck B. Different pathomorphologic patterns in exogenic infantile copper intoxication of the liver. Pathol Res Pract 1998;194:377-384.
12. Müller T, Schafer H, Rodeck B, Haupt G, Koch H, Bosse H, Welling P, et al. Familial clustering of infantile cirrhosis in Northern Germany: a clue to the etiology of idiopathic copper toxicosis. J Pediatr 1999;135:189-196.
13. Denk H, Stumptner C, Zatloukal K. Mallory bodies revisited. J Hepatol 2000;32:689-702.
14. Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H. Mallory body - a disease-associated type of sequestosome. HEPATOLOGY 2002;35: 1053-1062.
15. Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, Kleinert R, et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol 2002;160:255-263.
16. Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, et al. Cu(II) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999;274:37111-37116.
17. Bush AI. Metals and neuroscience. Curr Opin Chem Biol 2000;4:184-191.
18. Hutter H, Zatloukal K, Winter G, Stumptner C, Denk H. Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver. Lab Invest 1993;69:576-582.
19. Preisegger KH, Zatloukal K, Spurej G, Riegelnegg D, Denk H. Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody. Lab Invest 1992;66:193-199.
20. Stumptner C, Heid H, Fuchsbichler A, Hauser H, Mischinger HJ, Zatloukal K, Denk H. Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major Constituent. Am J Pathol 1999;154:1701-1710.
21. Westendorf JM, Rao PN, Gerace L. Cloning of cDNAs for M-phase Phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc Natl Acad Sci U S A 1994;91: 714-718.
22. Stromeyer FW, Ishak KG. Histology of the liver in Wilson's disease: a study of 34 cases. Am J Clin Pathol 1980;73:12-24.
23. Adamson M, Reiner B, Olson JL, Goodman Z, Plotnick L, Bernardini I, Gahl WA. Indian childhood cirrhosis in an American child. Gastroenterology 1992;102:1771-1777.
24. Nayak NC, Roy S. Morphological types of hepatocellular hyalin in Indian childhood cirrhosis: an ultrastructural study. Gut 1976;17:791-796.
25. Ishii T, Yanagawa T, Kawane T, Yuki K, Seita J, Yoshida H, Bannai S. Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p561ck-associated protein in response to oxidative stress. Biochem Biophys Res Commun 1996;226:456-460.
26. Sokol RJ, Twedt D, McKim JM Jr, Devereaux MW, Karrer FM, Kam I, von Steigman G, et al. Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 1994;107:1788-1798.
27. Mansouri A, Gaou I, Fromenty B, Berson A, Letteron P, Degott C, Erlinger S, et al. Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease. Gastroenterology 1997; 113:599-605.
28. Moscat J, Diaz-Meco MT. The atypical protein kinase C. Functional specificity mediated by specific protein adapters. EMBO Rep 2000;1:399-403.
29. Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J. The interaction of p62 with RIP links the atypical PKC to NF-kappaB activation. EMBO J 1999;18:3044-3053.
30. Taub R. Blocking NF-kappaB in the liver: the good and bad news. HEPATOLOGY 1998;27:1445-1446.
31. Miyoshi H, Rust C, Guicciardi ME, Gores GJ. NF-kappaB is activated in cholestasis and functions to reduce liver injury. Am J Pathol 2001;158: 967-975.
32. Strand S, Hofmann WJ, Grambihler A, Hug H, Volkmann M, Otto G, Wesch H, et al. Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat Med 1998;4: 588-593.
33. Yamate J, Kumagai D, Tsujino K, Nakatsuji S, Kuwamura M, Kotani T, Sakuma S, et al. Macrophage populations and apoptotic cells in the liver before spontaneous hepatitis in Long-Evans Cinnamon (LEC) rats. J Comp Pathol 1999; 120:333-346.
34. Kuusisto E, Suuronen T, Salminen A. Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. Biochem Biophys Res Commun 2001;280:223-228.
35. Johnston JA, Ward CL, Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 1998;143:1883-1898.
36. Wickner S, Maurizi MR, Gottesman S. Posttranslational quality control: folding, refolding, and degrading proteins. Science 1999;286:1888-1893.
37. Kopito RR. Aggresomes, inclusion bodies andprotein aggregation. Trends Cell Biol 2000;10(12):524-30.
38. Harada M, Sakisaka S, Terada K, Kimura R, Kawaguchi T, Koga H, Kim M, et al. A mutation of the Wilson disease protein, ATPTB, is degraded in the ptoteasomes and forms protein aggregates. Gastroenterology 2001; 120:967-974.
39. Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002;295:1852-1858.
40. Bence NF, Sampat RM, Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001;292:1552-1555.
41. Fataccioli V, Andraud E, Gentii M, French SW, Rouach H. Effects of chronic ethanol administration on rat liver proteasome activities: relationship with oxidative stress. HEPATOLOGY 1999;29:14-20.
42. Pradhan AM, Bhave SA, Joshi VV, Bavdekar AR, Pandit AN, Tanner MS. Reversal of Indian childhood cirrhosis by D-penicillamine therapy. J Pediatr Gastroenterol Nutr 1995;20:28-35.