-
1
-
-
33846692198
-
Signal integration and diversification through the p62 scaffold protein
-
Moscat J, Diaz-Meco MT, Wooten MW, (2007) Signal integration and diversification through the p62 scaffold protein. Trends Biochem Sci 32: 95-100.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 95-100
-
-
Moscat, J.1
Diaz-Meco, M.T.2
Wooten, M.W.3
-
2
-
-
77956252454
-
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
-
Ding WX, Ni HM, Li M, Liao Y, Chen X, et al. (2010) Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem 285: 27879-27890.
-
(2010)
J Biol Chem
, vol.285
, pp. 27879-27890
-
-
Ding, W.X.1
Ni, H.M.2
Li, M.3
Liao, Y.4
Chen, X.5
-
3
-
-
78649300971
-
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ, (2010) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6: 1090-1106.
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.A.2
Hauser, D.N.3
Fearnley, I.M.4
Youle, R.J.5
-
4
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, et al. (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137: 721-735.
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
Lawrence, D.4
Pham, V.C.5
-
5
-
-
0034599476
-
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
-
Sanz L, Diaz-Meco MT, Nakano H, Moscat J, (2000) The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 19: 1576-1586.
-
(2000)
EMBO J
, vol.19
, pp. 1576-1586
-
-
Sanz, L.1
Diaz-Meco, M.T.2
Nakano, H.3
Moscat, J.4
-
6
-
-
41249084239
-
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis
-
Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, et al. (2008) The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell 13: 343-354.
-
(2008)
Cancer Cell
, vol.13
, pp. 343-354
-
-
Duran, A.1
Linares, J.F.2
Galvez, A.S.3
Wikenheiser, K.4
Flores, J.M.5
-
7
-
-
0033153320
-
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
-
Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J, (1999) The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J 18: 3044-3053.
-
(1999)
EMBO J
, vol.18
, pp. 3044-3053
-
-
Sanz, L.1
Sanchez, P.2
Lallena, M.J.3
Diaz-Meco, M.T.4
Moscat, J.5
-
8
-
-
0034283837
-
The Rel/NF-kappa B family: friend and foe
-
Perkins ND, (2000) The Rel/NF-kappa B family: friend and foe. Trends Biochem Sci 25: 434-440.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 434-440
-
-
Perkins, N.D.1
-
9
-
-
77954599053
-
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, et al. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285: 22576-22591.
-
(2010)
J Biol Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
-
10
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213-223.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
-
11
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
-
Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, et al. (2010) A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 30: 3275-3285.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
-
12
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, et al. (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81: 687-693.
-
(1995)
Cell
, vol.81
, pp. 687-693
-
-
Forman, B.M.1
Goode, E.2
Chen, J.3
Oro, A.E.4
Bradley, D.J.5
-
13
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, et al. (1999) Identification of a nuclear receptor for bile acids. Science 284: 1362-1365.
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
-
14
-
-
0033591387
-
Bile acids: natural ligands for an orphan nuclear receptor
-
Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, et al. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284: 1365-1368.
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
Chandra, G.4
Consler, T.G.5
-
15
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H, Chen J, Hollister K, Sowers LC, Forman BM, (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3: 543-553.
-
(1999)
Mol Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
16
-
-
0034632762
-
Identification of a chemical tool for the orphan nuclear receptor FXR
-
Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, et al. (2000) Identification of a chemical tool for the orphan nuclear receptor FXR. J Med Chem 43: 2971-2974.
-
(2000)
J Med Chem
, vol.43
, pp. 2971-2974
-
-
Maloney, P.R.1
Parks, D.J.2
Haffner, C.D.3
Fivush, A.M.4
Chandra, G.5
-
17
-
-
79951814502
-
Tissue-specific function of farnesoid X receptor in liver and intestine
-
Zhu Y, Li F, Guo GL, (2011) Tissue-specific function of farnesoid X receptor in liver and intestine. Pharmacol Res 63: 259-265.
-
(2011)
Pharmacol Res
, vol.63
, pp. 259-265
-
-
Zhu, Y.1
Li, F.2
Guo, G.L.3
-
18
-
-
0042666932
-
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
-
Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, et al. (2003) Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology 125: 544-555.
-
(2003)
Gastroenterology
, vol.125
, pp. 544-555
-
-
Claudel, T.1
Inoue, Y.2
Barbier, O.3
Duran-Sandoval, D.4
Kosykh, V.5
-
19
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, et al. (2004) Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113: 1408-1418.
-
(2004)
J Clin Invest
, vol.113
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
Moschetta, A.4
Mangelsdorf, D.J.5
-
20
-
-
33645983221
-
LXRS and FXR: the yin and yang of cholesterol and fat metabolism
-
Kalaany NY, Mangelsdorf DJ, (2006) LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 68: 159-191.
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 159-191
-
-
Kalaany, N.Y.1
Mangelsdorf, D.J.2
-
21
-
-
0037462815
-
The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
-
Lambert G, Amar MJ, Guo G, Brewer HB Jr, Gonzalez FJ, et al. (2003) The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J Biol Chem 278: 2563-2570.
-
(2003)
J Biol Chem
, vol.278
, pp. 2563-2570
-
-
Lambert, G.1
Amar, M.J.2
Guo, G.3
Brewer Jr., H.B.4
Gonzalez, F.J.5
-
22
-
-
33645821043
-
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
-
Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, et al. (2006) Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312: 233-236.
-
(2006)
Science
, vol.312
, pp. 233-236
-
-
Huang, W.1
Ma, K.2
Zhang, J.3
Qatanani, M.4
Cuvillier, J.5
-
23
-
-
1842527650
-
Glucose regulates the expression of the farnesoid X receptor in liver
-
Duran-Sandoval D, Mautino G, Martin G, Percevault F, Barbier O, et al. (2004) Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes 53: 890-898.
-
(2004)
Diabetes
, vol.53
, pp. 890-898
-
-
Duran-Sandoval, D.1
Mautino, G.2
Martin, G.3
Percevault, F.4
Barbier, O.5
-
24
-
-
79952535597
-
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
-
Gadaleta RM, van Erpecum KJ, Oldenburg B, Willemsen EC, Renooij W, et al. (2011) Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60: 463-472.
-
(2011)
Gut
, vol.60
, pp. 463-472
-
-
Gadaleta, R.M.1
van Erpecum, K.J.2
Oldenburg, B.3
Willemsen, E.C.4
Renooij, W.5
-
25
-
-
0037646504
-
Repression of farnesoid X receptor during the acute phase response
-
Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C, (2003) Repression of farnesoid X receptor during the acute phase response. J Biol Chem 278: 8988-8995.
-
(2003)
J Biol Chem
, vol.278
, pp. 8988-8995
-
-
Kim, M.S.1
Shigenaga, J.2
Moser, A.3
Feingold, K.4
Grunfeld, C.5
-
26
-
-
77149159568
-
The bile acid receptor FXR is a modulator of intestinal innate immunity
-
Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S, (2009) The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 183: 6251-6261.
-
(2009)
J Immunol
, vol.183
, pp. 6251-6261
-
-
Vavassori, P.1
Mencarelli, A.2
Renga, B.3
Distrutti, E.4
Fiorucci, S.5
-
27
-
-
56149085041
-
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
-
Wang YD, Chen WD, Wang M, Yu D, Forman BM, et al. (2008) Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48: 1632-1643.
-
(2008)
Hepatology
, vol.48
, pp. 1632-1643
-
-
Wang, Y.D.1
Chen, W.D.2
Wang, M.3
Yu, D.4
Forman, B.M.5
-
28
-
-
34447098081
-
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
-
Kim I, Morimura K, Shah Y, Yang Q, Ward JM, et al. (2007) Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28: 940-946.
-
(2007)
Carcinogenesis
, vol.28
, pp. 940-946
-
-
Kim, I.1
Morimura, K.2
Shah, Y.3
Yang, Q.4
Ward, J.M.5
-
29
-
-
33847044019
-
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
-
Yang F, Huang X, Yi T, Yen Y, Moore DD, et al. (2007) Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 67: 863-867.
-
(2007)
Cancer Res
, vol.67
, pp. 863-867
-
-
Yang, F.1
Huang, X.2
Yi, T.3
Yen, Y.4
Moore, D.D.5
-
30
-
-
3543031024
-
The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer
-
De Gottardi A, Touri F, Maurer CA, Perez A, Maurhofer O, et al. (2004) The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. Dig Dis Sci 49: 982-989.
-
(2004)
Dig Dis Sci
, vol.49
, pp. 982-989
-
-
de Gottardi, A.1
Touri, F.2
Maurer, C.A.3
Perez, A.4
Maurhofer, O.5
-
31
-
-
59649084903
-
Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development
-
Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, et al. (2009) Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther 328: 469-477.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 469-477
-
-
Maran, R.R.1
Thomas, A.2
Roth, M.3
Sheng, Z.4
Esterly, N.5
-
32
-
-
57149118460
-
Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
-
Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A, (2008) Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res 68: 9589-9594.
-
(2008)
Cancer Res
, vol.68
, pp. 9589-9594
-
-
Modica, S.1
Murzilli, S.2
Salvatore, L.3
Schmidt, D.R.4
Moschetta, A.5
-
33
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, et al. (2006) Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 103: 3920-3925.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3920-3925
-
-
Inagaki, T.1
Moschetta, A.2
Lee, Y.K.3
Peng, L.4
Zhao, G.5
-
34
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, et al. (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102: 731-744.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
-
35
-
-
59149106502
-
Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
-
Kong B, Luyendyk JP, Tawfik O, Guo GL, (2009) Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther 328: 116-122.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 116-122
-
-
Kong, B.1
Luyendyk, J.P.2
Tawfik, O.3
Guo, G.L.4
-
36
-
-
11144318237
-
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
-
Moschetta A, Bookout AL, Mangelsdorf DJ, (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 10: 1352-1358.
-
(2004)
Nat Med
, vol.10
, pp. 1352-1358
-
-
Moschetta, A.1
Bookout, A.L.2
Mangelsdorf, D.J.3
-
37
-
-
77950605769
-
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
-
Thomas AM, Hart SN, Kong B, Fang J, Zhong XB, et al. (2010) Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology 51: 1410-1419.
-
(2010)
Hepatology
, vol.51
, pp. 1410-1419
-
-
Thomas, A.M.1
Hart, S.N.2
Kong, B.3
Fang, J.4
Zhong, X.B.5
-
38
-
-
84859986063
-
Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding
-
Li G, Thomas AM, Williams JA, Kong B, Liu J, et al. (2012) Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One 7: e35895.
-
(2012)
PLoS One
, vol.7
-
-
Li, G.1
Thomas, A.M.2
Williams, J.A.3
Kong, B.4
Liu, J.5
-
39
-
-
70349739736
-
The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets
-
Nicol JW, Helt GA, Blanchard SG Jr, Raja A, Loraine AE, (2009) The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets. Bioinformatics 25: 2730-2731.
-
(2009)
Bioinformatics
, vol.25
, pp. 2730-2731
-
-
Nicol, J.W.1
Helt, G.A.2
Blanchard Jr., S.G.3
Raja, A.4
Loraine, A.E.5
-
40
-
-
77954821918
-
Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner
-
Li G, Thomas AM, Hart SN, Zhong X, Wu D, et al. (2010) Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endocrinol 24: 1404-1412.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1404-1412
-
-
Li, G.1
Thomas, A.M.2
Hart, S.N.3
Zhong, X.4
Wu, D.5
-
41
-
-
85047682066
-
NUBIScan, an in silico approach for prediction of nuclear receptor response elements
-
Podvinec M, Kaufmann MR, Handschin C, Meyer UA, (2002) NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol 16: 1269-1279.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1269-1279
-
-
Podvinec, M.1
Kaufmann, M.R.2
Handschin, C.3
Meyer, U.A.4
-
42
-
-
77956998767
-
Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis
-
Maynard AA, Dvorak K, Khailova L, Dobrenen H, Arganbright KM, et al. (2010) Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 299: G614-622.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.299
-
-
Maynard, A.A.1
Dvorak, K.2
Khailova, L.3
Dobrenen, H.4
Arganbright, K.M.5
|