SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 17, 2013, Pages 5130-5138

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: Solution and X-ray crystallographic studies

(7) Leitans, Janis a Sprudza, Agnese b Tanc, Muhammet c Vozny, Igor b Zalubovskis, Raivis b Tars, Kaspars a Supuran, Claudiu T c

a LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE (Latvia)

b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (Latvia)

c UNIVERSITY OF FLORENCE (Italy)

Author keywords

Carbonic anhydrase; Click chemistry; Enzyme inhibitor; Sulfonamide; Thiophene 2 sulfonamide; X ray crystallography

Indexed keywords

5 (1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)THIOPHENE 2 SULFONAMIDE; 5 [1 (3 BROMOPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (3 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (3 CHLORO 4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (3 CYANOPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (3 METHYLPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (3,4 DICHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (4 IODOPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (4 METHYLPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (4 TERT BUTYLPHENYL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 (NAPHTHALEN 1 YL) 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 [2 FLUORO 4 (METHYLSULFONYL)PHENYL] 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 [4 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 [1 [4 CYANO 3 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 4 YL]THIOPHENE 2 SULFONAMIDE; 5 SUBSTITUTED (1,2,3 TRIAZOL 4 YL)THIOPHENE 2 SULFONAMIDE DERIVATIVE; ACETAZOLAMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CLICK CHEMISTRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROPHOBICITY; X RAY CRYSTALLOGRAPHY;

CARBONIC ANHYDRASE; CLICK CHEMISTRY; ENZYME INHIBITOR; SULFONAMIDE; THIOPHENE-2-SULFONAMIDE; X-RAY CRYSTALLOGRAPHY;

ANTIGENS, NEOPLASM; BINDING SITES; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; SULFONAMIDES;

EID: 84881376179 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.06.041 Document Type: Article

Times cited : (31)

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