Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3732-3738

  Biswas, Shyamasri ^a   Aggarwal, Mayank ^a   Güzel, Özlen ^b,c   Scozzafava, Andrea ^c   McKenna, Robert ^a   Supuran, Claudiu T ^c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b ISTANBUL UNIVERSITY   (Turkey)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

2 Thienylacetamido tail; Carbonic anhydrase; Cytosolic isoforms; Isoform selective inhibitor; Sulfonamide; X ray crystallography

Indexed keywords

2 THIENYLACETAMIDO BENZENESULFONAMIDE DERIVATIVE; ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE 13; CARBONATE DEHYDRATASE 7; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; DICLOFENAMIDE; DORZOLAMIDE; ETHOXZOLAMIDE; METHAZOLAMIDE; SULFANILAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; MOLECULAR DOCKING; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; ENZYME ACTIVATION; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 79958247146     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.006     Document Type: Article

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