Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding

Journal of the American Chemical Society

Volumn 134, Issue 36, 2012, Pages 14726-14729

  Fisher, S Zoë ^a   Aggarwal, Mayank ^b   Kovalevsky, Andrey Y ^a   Silverman, David N ^b   McKenna, Robert ^b  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGED STATE; CLINICAL TARGETS; DRUG BINDING; DRUG DESIGN; H-BONDING NETWORKS; HIGH AFFINITY; HUMAN CARBONIC ANHYDRASE II; HYDROGEN ATOMS; ISOFORMS; PH REGULATION; PHYSIOLOGICAL PROCESS; X-RAY STRUCTURE;

ATOMS; CARBON DIOXIDE; CARBONIC ANHYDRASE; HYDROGEN; NEUTRON DIFFRACTION; PHYSIOLOGY; SULFUR COMPOUNDS;

CRYSTAL ATOMIC STRUCTURE;

ACETAZOLAMIDE; CARBONATE DEHYDRATASE II; HYDROGEN;

ARTICLE; DRUG DESIGN; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; HYDROGEN BOND; NEUTRON DIFFRACTION;

ACETAZOLAMIDE; BINDING SITES; CARBONIC ANHYDRASE II; HUMANS; HYDROGEN; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUTRON DIFFRACTION; PHARMACEUTICAL PREPARATIONS;

EID: 84866414247     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3068098     Document Type: Article

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