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Volumn 45, Issue 7, 2013, Pages 543-551

Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies

Author keywords

Gut microbiome; Liver fibrosis; NAFLD; NASH

Indexed keywords

CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; MESSENGER RNA; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 84881222178     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2012.11.010     Document Type: Review
Times cited : (82)

References (109)
  • 1
    • 79958169116 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: a massive problem
    • Day C.P. Non-alcoholic fatty liver disease: a massive problem. Clinical Medicine 2011, 11:176-178.
    • (2011) Clinical Medicine , vol.11 , pp. 176-178
    • Day, C.P.1
  • 3
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen J.C., Horton J.D., Hobbs H.H. Human fatty liver disease: old questions and new insights. Science 2011, 332:1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 4
    • 77952563587 scopus 로고    scopus 로고
    • Genetic and environmental susceptibility to non-alcoholic fatty liver disease
    • Day C.P. Genetic and environmental susceptibility to non-alcoholic fatty liver disease. Digestive Diseases 2010, 28:255-260.
    • (2010) Digestive Diseases , vol.28 , pp. 255-260
    • Day, C.P.1
  • 5
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52:1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 8
    • 84856350648 scopus 로고    scopus 로고
    • Role of innate immunity and the microbiota in liver fibrossis: crosstalk between the liver and the gut
    • Seki E., Schnabl B. Role of innate immunity and the microbiota in liver fibrossis: crosstalk between the liver and the gut. Journal of Physiology 2012, 590:447-458.
    • (2012) Journal of Physiology , vol.590 , pp. 447-458
    • Seki, E.1    Schnabl, B.2
  • 9
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signalling and hepatic fibrosis
    • Seki E., De Minicis S., Osterreicher C.H., et al. TLR4 enhances TGF-beta signalling and hepatic fibrosis. Nature Medicine 2007, 13:1324-1332.
    • (2007) Nature Medicine , vol.13 , pp. 1324-1332
    • Seki, E.1    De Minicis, S.2    Osterreicher, C.H.3
  • 10
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
    • Miura K., Kodama Y., Inokuchi S., et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010, 139:323-334.
    • (2010) Gastroenterology , vol.139 , pp. 323-334
    • Miura, K.1    Kodama, Y.2    Inokuchi, S.3
  • 11
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • Gill S.R., Pop M., Deboy R.T., et al. Metagenomic analysis of the human distal gut microbiome. Science 2006, 312:1355-1359.
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1    Pop, M.2    Deboy, R.T.3
  • 12
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg P.B., Bik E.M., Bernstein C.N., et al. Diversity of the human intestinal microbial flora. Science 2005, 308:1635-1638.
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3
  • 13
    • 77950843915 scopus 로고    scopus 로고
    • Medicine. The microbes made me eat it
    • Sandoval D.A., Seeley R.J. Medicine. The microbes made me eat it. Science 2010, 328:179-180.
    • (2010) Science , vol.328 , pp. 179-180
    • Sandoval, D.A.1    Seeley, R.J.2
  • 14
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003, 112:1821-1830.
    • (2003) Journal of Clinical Investigation , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 15
    • 84871643501 scopus 로고    scopus 로고
    • Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus
    • in press. doi:10.1111/j.1440-1746.2012.07264.x
    • Kasturiratne A, Weerasinghe S, Dassanayake AS, et al. Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus. Journal of Gastroenterology and Hepatology, , in press. doi:10.1111/j.1440-1746.2012.07264.x.
    • Journal of Gastroenterology and Hepatology
    • Kasturiratne, A.1    Weerasinghe, S.2    Dassanayake, A.S.3
  • 16
    • 40549088230 scopus 로고    scopus 로고
    • Early differences in fecal microbiota composition in children may predict overweight
    • Kalliomäki M., Collado M.C., Salminen S., et al. Early differences in fecal microbiota composition in children may predict overweight. American Journal of Clinical Nutrition 2008, 87:534-538.
    • (2008) American Journal of Clinical Nutrition , vol.87 , pp. 534-538
    • Kalliomäki, M.1    Collado, M.C.2    Salminen, S.3
  • 17
    • 79952316380 scopus 로고    scopus 로고
    • Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency
    • Spencer M.D., Hamp T., Reid R., et al. Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology 2011, 140:976-986.
    • (2011) Gastroenterology , vol.140 , pp. 976-986
    • Spencer, M.D.1    Hamp, T.2    Reid, R.3
  • 18
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani P.D., Amar J., Iglesias M.A., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 19
    • 59849107327 scopus 로고    scopus 로고
    • Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects
    • Larkin T.A., Astheimer L.B., Price W.E. Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects. European Journal of Clinical Nutrition 2009, 63:238-245.
    • (2009) European Journal of Clinical Nutrition , vol.63 , pp. 238-245
    • Larkin, T.A.1    Astheimer, L.B.2    Price, W.E.3
  • 20
    • 0141609047 scopus 로고    scopus 로고
    • Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers
    • Xiao J.Z., Kondo S., Takahashi N., et al. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. Journal of Dairy Science 2003, 86:2452-2461.
    • (2003) Journal of Dairy Science , vol.86 , pp. 2452-2461
    • Xiao, J.Z.1    Kondo, S.2    Takahashi, N.3
  • 22
    • 77649125721 scopus 로고    scopus 로고
    • Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders
    • Musso G., Gambino R., Cassader M. Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders. Current Opinion in Lipidology 2010, 21:76-83.
    • (2010) Current Opinion in Lipidology , vol.21 , pp. 76-83
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 23
    • 84862737088 scopus 로고    scopus 로고
    • Comparison of the gut microbe profiles and numbers between patients with liver cirrhosis and healthy individuals
    • Liu J., Wu D., Ahmed A., et al. Comparison of the gut microbe profiles and numbers between patients with liver cirrhosis and healthy individuals. Current Microbiology 2012, 65:7-13.
    • (2012) Current Microbiology , vol.65 , pp. 7-13
    • Liu, J.1    Wu, D.2    Ahmed, A.3
  • 24
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J., Elinav E., Jin C., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 25
    • 84857775690 scopus 로고    scopus 로고
    • Bile Acid signaling in liver metabolism and diseases
    • Li T., Chiang J.Y. Bile Acid signaling in liver metabolism and diseases. Journal of Lipids 2012, 2012:754067.
    • (2012) Journal of Lipids , vol.2012 , pp. 754067
    • Li, T.1    Chiang, J.Y.2
  • 26
    • 84863502669 scopus 로고    scopus 로고
    • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    • Tanaka N., Matsubara T., Krausz K.W., et al. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 2012, 56:118-129.
    • (2012) Hepatology , vol.56 , pp. 118-129
    • Tanaka, N.1    Matsubara, T.2    Krausz, K.W.3
  • 27
    • 84881253560 scopus 로고    scopus 로고
    • Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
    • Gut, in press.
    • Duboc H, Rajca S, Rainteau D, et al. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut, in press.
    • Duboc, H.1    Rajca, S.2    Rainteau, D.3
  • 28
    • 77649226704 scopus 로고    scopus 로고
    • Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps
    • Hwang S.T., Cho Y.K., Park J.H., et al. Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. Journal of Gastroenterology and Hepatology 2010, 25:562-567.
    • (2010) Journal of Gastroenterology and Hepatology , vol.25 , pp. 562-567
    • Hwang, S.T.1    Cho, Y.K.2    Park, J.H.3
  • 29
    • 79959344354 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia
    • Stadlmayr A., Aigner E., Steger B., et al. Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia. Journal of Internal Medicine 2011, 270:41-49.
    • (2011) Journal of Internal Medicine , vol.270 , pp. 41-49
    • Stadlmayr, A.1    Aigner, E.2    Steger, B.3
  • 30
    • 80052308377 scopus 로고    scopus 로고
    • Prevalence of colonic adenomas in patients with nonalcoholic fatty liver disease
    • Touzin N.T., Bush K.N., Williams C.D., et al. Prevalence of colonic adenomas in patients with nonalcoholic fatty liver disease. Therapeutic Advances in Gastroenterology 2011, 4:169-176.
    • (2011) Therapeutic Advances in Gastroenterology , vol.4 , pp. 169-176
    • Touzin, N.T.1    Bush, K.N.2    Williams, C.D.3
  • 31
    • 79955804203 scopus 로고    scopus 로고
    • High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis
    • Wong V.W., Wong G.L., Tsang S.W., et al. High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis. Gut 2011, 60:829-836.
    • (2011) Gut , vol.60 , pp. 829-836
    • Wong, V.W.1    Wong, G.L.2    Tsang, S.W.3
  • 32
    • 84863989936 scopus 로고    scopus 로고
    • A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects
    • Tjalsma H., Boleij A., Marchesi J.R., et al. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nature Reviews Microbiology 2012, 10:575-582.
    • (2012) Nature Reviews Microbiology , vol.10 , pp. 575-582
    • Tjalsma, H.1    Boleij, A.2    Marchesi, J.R.3
  • 33
    • 83555163743 scopus 로고    scopus 로고
    • Changing shape of disease: nonalcoholic fatty liver disease in Crohn's disease-a case series and review of the literature
    • McGowan C.E., Jones P., Long M.D., et al. Changing shape of disease: nonalcoholic fatty liver disease in Crohn's disease-a case series and review of the literature. Inflammatory Bowel Diseases 2012, 18:49-54.
    • (2012) Inflammatory Bowel Diseases , vol.18 , pp. 49-54
    • McGowan, C.E.1    Jones, P.2    Long, M.D.3
  • 34
    • 79959861780 scopus 로고    scopus 로고
    • Gut microbiota and inflammation
    • Hakansson A., Molin G. Gut microbiota and inflammation. Nutrients 2011, 3:637-682.
    • (2011) Nutrients , vol.3 , pp. 637-682
    • Hakansson, A.1    Molin, G.2
  • 36
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIRdomain-containing adaptors in Toll-like receptor signalling
    • O'Neill L.A., Bowie A.G. The family of five: TIRdomain-containing adaptors in Toll-like receptor signalling. Nature Reviews Immunology 2007, 7:353-364.
    • (2007) Nature Reviews Immunology , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 37
    • 80055057691 scopus 로고    scopus 로고
    • Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development
    • Alisi A., Carsetti R., Nobili V. Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. Hepatology 2011, 54:1500-1502.
    • (2011) Hepatology , vol.54 , pp. 1500-1502
    • Alisi, A.1    Carsetti, R.2    Nobili, V.3
  • 38
    • 33646347356 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the liver
    • Schwabe R.F., Seki E., Brenner D.A. Toll-like receptor signalling in the liver. Gastroenterology 2006, 130:1886-1900.
    • (2006) Gastroenterology , vol.130 , pp. 1886-1900
    • Schwabe, R.F.1    Seki, E.2    Brenner, D.A.3
  • 39
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 40
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: update
    • Seki E., Brenner D.A. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008, 48:322-335.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 42
    • 79954481268 scopus 로고    scopus 로고
    • Toll-like receptor 4 signalling in liver injury and hepatic fibrogenesis
    • Guo J., Friedman S.L. Toll-like receptor 4 signalling in liver injury and hepatic fibrogenesis. Fibrogenesis and Tissue Repair 2010, 3:21.
    • (2010) Fibrogenesis and Tissue Repair , vol.3 , pp. 21
    • Guo, J.1    Friedman, S.L.2
  • 43
    • 79551592245 scopus 로고    scopus 로고
    • Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease
    • Alisi A., Da Sacco L., Bruscalupi G., et al. Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Laboratory Investigation 2011, 91:283-293.
    • (2011) Laboratory Investigation , vol.91 , pp. 283-293
    • Alisi, A.1    Da Sacco, L.2    Bruscalupi, G.3
  • 44
    • 0033551235 scopus 로고    scopus 로고
    • A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning sequencingcharacterization chromosomal assignment
    • Myokai F., Takashiba S., Lebo R., Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning sequencingcharacterization chromosomal assignment. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:4518-4523.
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , pp. 4518-4523
    • Myokai, F.1    Takashiba, S.2    Lebo, R.3    Amar, S.4
  • 45
    • 33748797424 scopus 로고    scopus 로고
    • LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: evidence for LITAF-dependent LPS signalling pathways
    • Tang X., Metzger D., Leeman S., Amar S. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: evidence for LITAF-dependent LPS signalling pathways. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:13777-13782.
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , pp. 13777-13782
    • Tang, X.1    Metzger, D.2    Leeman, S.3    Amar, S.4
  • 46
    • 1642384019 scopus 로고    scopus 로고
    • Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2
    • Miyake K. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends in Microbiology 2004, 12:186-192.
    • (2004) Trends in Microbiology , vol.12 , pp. 186-192
    • Miyake, K.1
  • 47
    • 41649093814 scopus 로고    scopus 로고
    • Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity
    • Freudenberg M.A., Tchaptchet S., Keck S., et al. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity. Immunobiology 2008, 213:193-203.
    • (2008) Immunobiology , vol.213 , pp. 193-203
    • Freudenberg, M.A.1    Tchaptchet, S.2    Keck, S.3
  • 48
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
    • Kim H.M., Park B.S., Kim J.I., et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007, 130:906-917.
    • (2007) Cell , vol.130 , pp. 906-917
    • Kim, H.M.1    Park, B.S.2    Kim, J.I.3
  • 49
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease
    • Miura K., Seki E., Ohnishi H., et al. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease. Gastroenterology Research and Practice 2010, 362847.
    • (2010) Gastroenterology Research and Practice , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3
  • 50
    • 78649482865 scopus 로고    scopus 로고
    • The role of lipopolysaccharide/toll-like receptor 4 signalling in chronic liver diseases
    • Soares J.B., Pimentel-Nunes P., Roncon-Albuquerque R., et al. The role of lipopolysaccharide/toll-like receptor 4 signalling in chronic liver diseases. Hepatology International 2010, 4:659-672.
    • (2010) Hepatology International , vol.4 , pp. 659-672
    • Soares, J.B.1    Pimentel-Nunes, P.2    Roncon-Albuquerque, R.3
  • 52
    • 77649125721 scopus 로고    scopus 로고
    • Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanism and implication for metabolic disorders
    • Musso G., Gambino R., Cassader M. Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanism and implication for metabolic disorders. Current Opinion in Lipidology 2010, 21:76-83.
    • (2010) Current Opinion in Lipidology , vol.21 , pp. 76-83
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 54
    • 84862923545 scopus 로고    scopus 로고
    • Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis
    • Su L., Wang J.H., Cong X., et al. Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis. Chinese Medical Journal 2012, 125:306-311.
    • (2012) Chinese Medical Journal , vol.125 , pp. 306-311
    • Su, L.1    Wang, J.H.2    Cong, X.3
  • 55
    • 43049161319 scopus 로고    scopus 로고
    • Antibiotics protect against fructose induced hepatic lipid accumulation in mice: role of endotoxin
    • Bergheim I., Weber S., Vos M., et al. Antibiotics protect against fructose induced hepatic lipid accumulation in mice: role of endotoxin. Journal of Hepatology 2008, 48:983-992.
    • (2008) Journal of Hepatology , vol.48 , pp. 983-992
    • Bergheim, I.1    Weber, S.2    Vos, M.3
  • 56
    • 63349101854 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced non-alcoholic steatohepatitis model in mice
    • Velayudham A., Dolganiuc A., Ellis M., et al. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced non-alcoholic steatohepatitis model in mice. Hepatology 2009, 49:989-997.
    • (2009) Hepatology , vol.49 , pp. 989-997
    • Velayudham, A.1    Dolganiuc, A.2    Ellis, M.3
  • 58
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signalling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera C.A., Adegboyega P., van Rooijen N., et al. Toll-like receptor-4 signalling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. Journal of Hepatology 2007, 47:571-579.
    • (2007) Journal of Hepatology , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3
  • 59
    • 70350075402 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
    • Spruss A., Kanuri G., Wagnerberger S., et al. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 2009, 50:1094-1104.
    • (2009) Hepatology , vol.50 , pp. 1094-1104
    • Spruss, A.1    Kanuri, G.2    Wagnerberger, S.3
  • 60
    • 79954523464 scopus 로고    scopus 로고
    • Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    • Csak T., Velayudham A., Hritz I., et al. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. American Journal of Physiology Gastrointestinal and Liver Physiology 2011, 300:433-441.
    • (2011) American Journal of Physiology Gastrointestinal and Liver Physiology , vol.300 , pp. 433-441
    • Csak, T.1    Velayudham, A.2    Hritz, I.3
  • 61
    • 43349107591 scopus 로고    scopus 로고
    • High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis
    • Sabaté J.M., Jouët P., Harnois F., et al. High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obesity Surgery 2008, 18:371-377.
    • (2008) Obesity Surgery , vol.18 , pp. 371-377
    • Sabaté, J.M.1    Jouët, P.2    Harnois, F.3
  • 62
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L., Valenza V., La Torre G., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009, 49:1877-1887.
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 63
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg A.J., Roberts-Thomson I.C., Dymock R.B., et al. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001, 48:206-211.
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3
  • 64
    • 79955597671 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8
    • Shanab A.A., Scully P., Crosbie O., et al. Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8. Digestive Diseases and Sciences 2011, 56:1524-1534.
    • (2011) Digestive Diseases and Sciences , vol.56 , pp. 1524-1534
    • Shanab, A.A.1    Scully, P.2    Crosbie, O.3
  • 65
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • Thuy S., Ladurner R., Volynets V., et al. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. Journal of Nutrition 2008, 138:1452-1455.
    • (2008) Journal of Nutrition , vol.138 , pp. 1452-1455
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3
  • 66
    • 77953161601 scopus 로고    scopus 로고
    • Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children
    • Alisi A., Manco M., Devito R., et al. Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. Journal of Pediatric Gastroenterology and Nutrition 2010, 50:645-649.
    • (2010) Journal of Pediatric Gastroenterology and Nutrition , vol.50 , pp. 645-649
    • Alisi, A.1    Manco, M.2    Devito, R.3
  • 68
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 70
    • 33645757327 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides
    • Martin-Armas M., Simon-Santamaria J., Pettersen I., et al. Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides. Journal of Hepatology 2006, 44:939-946.
    • (2006) Journal of Hepatology , vol.44 , pp. 939-946
    • Martin-Armas, M.1    Simon-Santamaria, J.2    Pettersen, I.3
  • 71
    • 0034070414 scopus 로고    scopus 로고
    • Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4
    • Su G.L., Klein R.D., Aminlari A., et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 2000, 31:932-936.
    • (2000) Hepatology , vol.31 , pp. 932-936
    • Su, G.L.1    Klein, R.D.2    Aminlari, A.3
  • 72
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: the emerging view
    • Baffy G. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. Journal of Hepatology 2009, 51:212-223.
    • (2009) Journal of Hepatology , vol.51 , pp. 212-223
    • Baffy, G.1
  • 73
    • 77955655242 scopus 로고    scopus 로고
    • Pro- and anti-inflammatory cytokines in Steatosis and Steatohepatitis
    • Rabelo F., Oliveira C., Faintuch J., et al. Pro- and anti-inflammatory cytokines in Steatosis and Steatohepatitis. Obesity Surgery 2010, 20:906-912.
    • (2010) Obesity Surgery , vol.20 , pp. 906-912
    • Rabelo, F.1    Oliveira, C.2    Faintuch, J.3
  • 74
    • 33144463511 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice
    • Tomita K., Tamiya G., Ando S., et al. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice. Gut 2006, 55:415-424.
    • (2006) Gut , vol.55 , pp. 415-424
    • Tomita, K.1    Tamiya, G.2    Ando, S.3
  • 75
    • 33645233283 scopus 로고    scopus 로고
    • Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency
    • Kirsch R., Clarkson V., Verdonk R.C., et al. Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency. Journal of Gastroenterology and Hepatology 2006, 21:174-182.
    • (2006) Journal of Gastroenterology and Hepatology , vol.21 , pp. 174-182
    • Kirsch, R.1    Clarkson, V.2    Verdonk, R.C.3
  • 76
    • 84859907257 scopus 로고    scopus 로고
    • Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis
    • Wagnerberger S., Spruss A., Kanuri G., et al. Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis. British Journal of Nutrition 2011, 10:1-12.
    • (2011) British Journal of Nutrition , vol.10 , pp. 1-12
    • Wagnerberger, S.1    Spruss, A.2    Kanuri, G.3
  • 77
    • 80052477222 scopus 로고    scopus 로고
    • DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
    • Gäbele E., Dostert K., Hofmann C., et al. DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. Journal of Hepatology 2011, 55:1391-1399.
    • (2011) Journal of Hepatology , vol.55 , pp. 1391-1399
    • Gäbele, E.1    Dostert, K.2    Hofmann, C.3
  • 78
    • 38449120093 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of nonalcoholic steatohepatitis
    • Ruiz A.G., Casafont F., Crespo J., et al. Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of nonalcoholic steatohepatitis. Obesity Surgery 2007, 17:1374-1380.
    • (2007) Obesity Surgery , vol.17 , pp. 1374-1380
    • Ruiz, A.G.1    Casafont, F.2    Crespo, J.3
  • 79
    • 34250632770 scopus 로고    scopus 로고
    • Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
    • Manco M., Marcellini M., Giannone G., et al. Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. American Journal of Clinical Pathology 2007, 127:954-960.
    • (2007) American Journal of Clinical Pathology , vol.127 , pp. 954-960
    • Manco, M.1    Marcellini, M.2    Giannone, G.3
  • 80
    • 84863098121 scopus 로고    scopus 로고
    • Inflammation and fibrogenesis in steatohepatitis
    • Fujii H., Kawada N. Inflammation and fibrogenesis in steatohepatitis. Journal of Gastroenterology 2012, 47:215-225.
    • (2012) Journal of Gastroenterology , vol.47 , pp. 215-225
    • Fujii, H.1    Kawada, N.2
  • 82
    • 68349125150 scopus 로고    scopus 로고
    • Liver fibrosis and therapeutic strategies: the goal for improving metabolism
    • Balsano C., Alisi A., Nobili V. Liver fibrosis and therapeutic strategies: the goal for improving metabolism. Current Drug Targets 2009, 10:505-512.
    • (2009) Current Drug Targets , vol.10 , pp. 505-512
    • Balsano, C.1    Alisi, A.2    Nobili, V.3
  • 83
    • 0028934072 scopus 로고
    • Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation
    • Lin R.S., Lee F.Y., Lee S.D., et al. Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation. Journal of Hepatology 1995, 22:165-172.
    • (1995) Journal of Hepatology , vol.22 , pp. 165-172
    • Lin, R.S.1    Lee, F.Y.2    Lee, S.D.3
  • 84
    • 0030808419 scopus 로고    scopus 로고
    • Prognostic value of plasma endotoxin levels in patients with cirrhosis
    • Chan C.C., Hwang S.J., Lee F.Y., et al. Prognostic value of plasma endotoxin levels in patients with cirrhosis. Scandinavian Journal of Gastroenterology 1997, 32:942-946.
    • (1997) Scandinavian Journal of Gastroenterology , vol.32 , pp. 942-946
    • Chan, C.C.1    Hwang, S.J.2    Lee, F.Y.3
  • 85
    • 0029057032 scopus 로고
    • Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia
    • Grinko I., Geerts A., Wisse E. Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia. Journal of Hepatology 1995, 23:449-458.
    • (1995) Journal of Hepatology , vol.23 , pp. 449-458
    • Grinko, I.1    Geerts, A.2    Wisse, E.3
  • 89
    • 34250339733 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury
    • Hua J., Qiu de K., Li J.Q., et al. Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. Journal of Gastroenterology and Hepatology 2007, 22:862-869.
    • (2007) Journal of Gastroenterology and Hepatology , vol.22 , pp. 862-869
    • Hua, J.1    Qiu de, K.2    Li, J.Q.3
  • 90
    • 0033619255 scopus 로고    scopus 로고
    • Silencing of TGF-beta signalling by the pseudoreceptor BAMBI
    • Onichtchouk D., Chen Y.G., Dosch R., et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999, 401:480-485.
    • (1999) Nature , vol.401 , pp. 480-485
    • Onichtchouk, D.1    Chen, Y.G.2    Dosch, R.3
  • 91
    • 13944262590 scopus 로고    scopus 로고
    • Effect of Nma on growth inhibition by TGF-beta in human gastric carcinoma cell lines
    • Sasaki T., Sasahira T., Shimura H., et al. Effect of Nma on growth inhibition by TGF-beta in human gastric carcinoma cell lines. Oncology Reports 2004, 11:1219-1223.
    • (2004) Oncology Reports , vol.11 , pp. 1219-1223
    • Sasaki, T.1    Sasahira, T.2    Shimura, H.3
  • 92
    • 41349116553 scopus 로고    scopus 로고
    • A molecular link between inflammation and fibrogenesis: the bacterial microflora influences hepatic fibrosis via toll-like receptor 4-dependent modification of transforming growth factor-beta signalling in hepatic stellate cells
    • Luedde T., Trautwein C. A molecular link between inflammation and fibrogenesis: the bacterial microflora influences hepatic fibrosis via toll-like receptor 4-dependent modification of transforming growth factor-beta signalling in hepatic stellate cells. Hepatology 2008, 47:1089-1091.
    • (2008) Hepatology , vol.47 , pp. 1089-1091
    • Luedde, T.1    Trautwein, C.2
  • 93
    • 67349240835 scopus 로고    scopus 로고
    • Primary biliary cirrhosis is associated with altered hepatic microRNA expression
    • Padgett K.A., Lan R.Y., Leung P.C., et al. Primary biliary cirrhosis is associated with altered hepatic microRNA expression. Journal of Autoimmunity 2009, 32:246-253.
    • (2009) Journal of Autoimmunity , vol.32 , pp. 246-253
    • Padgett, K.A.1    Lan, R.Y.2    Leung, P.C.3
  • 95
    • 78751476297 scopus 로고    scopus 로고
    • Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
    • Roderburg C., Urban G.W., Bettermann K., et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 2011, 53:209-218.
    • (2011) Hepatology , vol.53 , pp. 209-218
    • Roderburg, C.1    Urban, G.W.2    Bettermann, K.3
  • 96
    • 40949083014 scopus 로고    scopus 로고
    • Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis
    • Frances R., Zapater P., Gonzalez-Navajas J.M., et al. Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis. Hepatology 2008, 47:978-985.
    • (2008) Hepatology , vol.47 , pp. 978-985
    • Frances, R.1    Zapater, P.2    Gonzalez-Navajas, J.M.3
  • 97
    • 80055043169 scopus 로고    scopus 로고
    • Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signalling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
    • Li L., Chen L., Hu L., et al. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signalling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 2011, 54:1620-1630.
    • (2011) Hepatology , vol.54 , pp. 1620-1630
    • Li, L.1    Chen, L.2    Hu, L.3
  • 98
    • 79960299110 scopus 로고    scopus 로고
    • Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms
    • Iacono A., Raso G.M., Canani R.B., et al. Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. Journal of Nutritional Biochemistry 2011, 22:699-711.
    • (2011) Journal of Nutritional Biochemistry , vol.22 , pp. 699-711
    • Iacono, A.1    Raso, G.M.2    Canani, R.B.3
  • 99
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z., Yang S., Lin H., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003, 37:343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 100
    • 53249101515 scopus 로고    scopus 로고
    • Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    • Ma X., Hua J., Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. Journal of Hepatology 2008, 49:821-830.
    • (2008) Journal of Hepatology , vol.49 , pp. 821-830
    • Ma, X.1    Hua, J.2    Li, Z.3
  • 101
    • 65349182352 scopus 로고    scopus 로고
    • Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats
    • Esposito E., Iacono A., Bianco G., et al. Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. Journal of Nutrition 2009, 139:905-911.
    • (2009) Journal of Nutrition , vol.139 , pp. 905-911
    • Esposito, E.1    Iacono, A.2    Bianco, G.3
  • 102
    • 84866700091 scopus 로고    scopus 로고
    • VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation
    • Mencarelli A., Cipriani S., Renga B., et al. VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation. PLoS One 2012, 7:e45425.
    • (2012) PLoS One , vol.7
    • Mencarelli, A.1    Cipriani, S.2    Renga, B.3
  • 103
    • 84855400121 scopus 로고    scopus 로고
    • Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model
    • Xu R.Y., Wan Y.P., Fang Q.Y., et al. Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model. Journal of Clinical Biochemistry and Nutrition 2012, 50:72-77.
    • (2012) Journal of Clinical Biochemistry and Nutrition , vol.50 , pp. 72-77
    • Xu, R.Y.1    Wan, Y.P.2    Fang, Q.Y.3
  • 105
    • 84858702708 scopus 로고    scopus 로고
    • Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice
    • Zhu Q., Zou L., Jagavelu K., et al. Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice. Journal of Hepatology 2011, 56:893-899.
    • (2011) Journal of Hepatology , vol.56 , pp. 893-899
    • Zhu, Q.1    Zou, L.2    Jagavelu, K.3
  • 106
    • 20844440555 scopus 로고    scopus 로고
    • Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    • Loguercio C., Federico A., Tuccillo C., et al. Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. Journal of Clinical Gastroenterology 2005, 39:540-543.
    • (2005) Journal of Clinical Gastroenterology , vol.39 , pp. 540-543
    • Loguercio, C.1    Federico, A.2    Tuccillo, C.3
  • 107
    • 84856763599 scopus 로고    scopus 로고
    • Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis
    • Malaguarnera M., Vacante M., Antic T., et al. Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis. Digestive Diseases and Sciences 2012, 57:545-553.
    • (2012) Digestive Diseases and Sciences , vol.57 , pp. 545-553
    • Malaguarnera, M.1    Vacante, M.2    Antic, T.3
  • 108
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N., Younossi Z., Lavine J.E., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012, 142:1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3


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