메뉴 건너뛰기




Volumn 7, Issue 9, 2012, Pages

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; FARNESOID X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; VITAMIN D RECEPTOR; VSL3;

EID: 84866700091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045425     Document Type: Article
Times cited : (88)

References (67)
  • 1
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5
  • 2
    • 33645062450 scopus 로고    scopus 로고
    • Association of the metabolic syndrome with early coronary disease in families with frequent myocardial infarction
    • Reinhard W, Holmer SR, Fischer M, Gloeckner C, Hubauer U, et al. (2006) Association of the metabolic syndrome with early coronary disease in families with frequent myocardial infarction. Am J Cardiol 97: 964-967.
    • (2006) Am J Cardiol , vol.97 , pp. 964-967
    • Reinhard, W.1    Holmer, S.R.2    Fischer, M.3    Gloeckner, C.4    Hubauer, U.5
  • 3
    • 20444467246 scopus 로고    scopus 로고
    • Should nonalcoholic fatty liver disease be renamed?
    • Loria P, Lonardo A, Carulli N, (2005) Should nonalcoholic fatty liver disease be renamed? Dig Dis 23: 72-82.
    • (2005) Dig Dis , vol.23 , pp. 72-82
    • Loria, P.1    Lonardo, A.2    Carulli, N.3
  • 5
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, et al. (2003) Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37: 917-923.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3    Cerrelli, F.4    Lenzi, M.5
  • 6
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, et al. (2005) The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 143: 722-728.
    • (2005) Ann Intern Med , vol.143 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3    Nakagawa, T.4    Taniguchi, H.5
  • 7
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease
    • Sanyal AJ, (2005) Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2: 46-53.
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 8
    • 34247647418 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease
    • Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, et al. (2007) Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 13: 1579-1584.
    • (2007) World J Gastroenterol , vol.13 , pp. 1579-1584
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3    Nagata, C.4    Takeda, J.5
  • 9
    • 33947169979 scopus 로고    scopus 로고
    • Alanine aminotransferase predicts coronary heart disease events: a 10 year follow-up of the Hoorn Study
    • Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, et al. (2007) Alanine aminotransferase predicts coronary heart disease events: a 10 year follow-up of the Hoorn Study. Atherosclerosis 191: 391-396.
    • (2007) Atherosclerosis , vol.191 , pp. 391-396
    • Schindhelm, R.K.1    Dekker, J.M.2    Nijpels, G.3    Bouter, L.M.4    Stehouwer, C.D.5
  • 10
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E, (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363: 1341-1350.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 11
    • 34547596738 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH
    • Yoneda M, Mawatari H, Fujita K, Iida H, Yonemitsu K, et al. (2007) High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH. J Gastroenterol 42: 573-582.
    • (2007) J Gastroenterol , vol.42 , pp. 573-582
    • Yoneda, M.1    Mawatari, H.2    Fujita, K.3    Iida, H.4    Yonemitsu, K.5
  • 12
    • 37549047145 scopus 로고    scopus 로고
    • Fatty liver: a novel component of the metabolic syndrome
    • Kotronen A, Yki-Jarvinen H, (2008) Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 28: 27-38.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 27-38
    • Kotronen, A.1    Yki-Jarvinen, H.2
  • 13
    • 44449129581 scopus 로고    scopus 로고
    • Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects
    • Musso G, Gambino R, Bo S, Uberti B, Biroli G, et al. (2008) Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects. Diabetes Care 31: 562-568.
    • (2008) Diabetes Care , vol.31 , pp. 562-568
    • Musso, G.1    Gambino, R.2    Bo, S.3    Uberti, B.4    Biroli, G.5
  • 14
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P, (2002) Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 15
    • 33749597707 scopus 로고    scopus 로고
    • Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease
    • Day CP, (2006) Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 26: 1021-1028.
    • (2006) Liver Int , vol.26 , pp. 1021-1028
    • Day, C.P.1
  • 16
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM, (1997) Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 94: 2557-2562.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 17
    • 79952760290 scopus 로고    scopus 로고
    • Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress
    • Sakaguchi S, Takahashi S, Sasaki T, Kumagai T, Nagata K, (2011) Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress. Drug Metab Pharmacokinet 26(1): 30-46.
    • (2011) Drug Metab Pharmacokinet , vol.26 , Issue.1 , pp. 30-46
    • Sakaguchi, S.1    Takahashi, S.2    Sasaki, T.3    Kumagai, T.4    Nagata, K.5
  • 18
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg AJ, Roberts-Thomson IC, Dymock RB, McCarthy PJ, Grose RH, et al. (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48: 206-211.
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3    McCarthy, P.J.4    Grose, R.H.5
  • 19
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, et al. (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49(6): 1877-1887.
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3    Montalto, M.4    Cammarota, G.5
  • 20
    • 0035045382 scopus 로고    scopus 로고
    • Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis
    • Nair S, Cope K, Risby TH, Diehl AM, (2001) Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Am J Gastroenterol 96: 1200-1204.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1200-1204
    • Nair, S.1    Cope, K.2    Risby, T.H.3    Diehl, A.M.4
  • 21
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, et al. (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 103: 12511-12516.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12511-12516
    • Dumas, M.E.1    Barton, R.H.2    Toye, A.3    Cloarec, O.4    Blancher, C.5
  • 23
    • 34247884376 scopus 로고    scopus 로고
    • C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
    • Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, et al. (2007) C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50(6): 1267-1276.
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1267-1276
    • Poggi, M.1    Bastelica, D.2    Gual, P.3    Iglesias, M.A.4    Gremeaux, T.5
  • 24
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al. (2007) Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56: 1986-1998.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3    Prada, P.O.4    Hirabara, S.M.5
  • 25
    • 0025964069 scopus 로고
    • Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline
    • Lichtman SN, Keku J, Schwab JH, Sartor RB, (1991) Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100: 513-519.
    • (1991) Gastroenterology , vol.100 , pp. 513-519
    • Lichtman, S.N.1    Keku, J.2    Schwab, J.H.3    Sartor, R.B.4
  • 26
    • 0025136962 scopus 로고
    • Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth
    • Lichtman SN, Sartor RB, Keku J, Schwab JH, (1990) Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth. Gastroenterology 98: 414-423.
    • (1990) Gastroenterology , vol.98 , pp. 414-423
    • Lichtman, S.N.1    Sartor, R.B.2    Keku, J.3    Schwab, J.H.4
  • 27
    • 53249101515 scopus 로고    scopus 로고
    • Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    • Ma X, Hua J, Li Z (2008) Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 49: 821-830.
    • (2008) J Hepatol , vol.49 , pp. 821-830
    • Ma, X.1    Hua, J.2    Li, Z.3
  • 28
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al. (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58(8): 1091-1103.
    • (2009) Gut , vol.58 , Issue.8 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    van de Wiele, T.3    Guiot, Y.4    Everard, A.5
  • 30
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, Bell K, Barocci N, et al. (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48: 1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barocci, N.5
  • 31
    • 34548757869 scopus 로고    scopus 로고
    • Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
    • Ewaschuk J, Endersby R, Thiel D, Diaz H, Backer J, et al. (2007) Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 46: 841-850.
    • (2007) Hepatology , vol.46 , pp. 841-850
    • Ewaschuk, J.1    Endersby, R.2    Thiel, D.3    Diaz, H.4    Backer, J.5
  • 35
    • 48849106640 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance
    • Cheng X, Chen Y, Xie JJ, Yao R, Yu X, et al. (2008) Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance. J Mol Cell Cardiol 45: 168-175.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 168-175
    • Cheng, X.1    Chen, Y.2    Xie, J.J.3    Yao, R.4    Yu, X.5
  • 36
    • 20444458026 scopus 로고    scopus 로고
    • Enhanced T helper-1 lymphocyte activation patterns in acute coronary syndromes
    • Methe H, Brunner S, Wiegand D, Nabauer M, Koglin J, et al. (2005) Enhanced T helper-1 lymphocyte activation patterns in acute coronary syndromes. J Am Coll Cardiol 45: 1939-1945.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1939-1945
    • Methe, H.1    Brunner, S.2    Wiegand, D.3    Nabauer, M.4    Koglin, J.5
  • 37
    • 73849097617 scopus 로고    scopus 로고
    • The Th17/Treg functional imbalance during atherogenesis in ApoE-/- mice
    • Xie JJ, Wang J, Tang TT, Chen J, Gao XL, et al. (2010) The Th17/Treg functional imbalance during atherogenesis in ApoE-/- mice. Cytokine 49(2): 185-193.
    • (2010) Cytokine , vol.49 , Issue.2 , pp. 185-193
    • Xie, J.J.1    Wang, J.2    Tang, T.T.3    Chen, J.4    Gao, X.L.5
  • 38
    • 47949094965 scopus 로고    scopus 로고
    • Integration of metabolism and inflammation by lipid-activated nuclear receptors
    • Bensinger SJ, Tontonoz P, (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454(7203): 470-477.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 470-477
    • Bensinger, S.J.1    Tontonoz, P.2
  • 39
    • 79960963699 scopus 로고    scopus 로고
    • Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation
    • Mencarelli A, Distrutti E, Renga B, D'Amore C, Cipriani S, et al. (2011) Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. PLoS One 6(7): e22978.
    • (2011) PLoS One , vol.6 , Issue.7
    • Mencarelli, A.1    Distrutti, E.2    Renga, B.3    D'Amore, C.4    Cipriani, S.5
  • 40
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly D, Campbell JI, King TP, Grant G, Jansson EA, et al. (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 5: 104-112.
    • (2004) Nat Immunol , vol.5 , pp. 104-112
    • Kelly, D.1    Campbell, J.I.2    King, T.P.3    Grant, G.4    Jansson, E.A.5
  • 41
    • 71949095393 scopus 로고    scopus 로고
    • Balancing inflammatory, lipid, and xenobiotic signaling pathways by VSL#3, a biotherapeutic agent, in the treatment of inflammatory bowel disease
    • Reiff C, Delday M, Rucklidge G, Reid M, Duncan G, et al. (2009) Balancing inflammatory, lipid, and xenobiotic signaling pathways by VSL#3, a biotherapeutic agent, in the treatment of inflammatory bowel disease. Inflamm Bowel Dis 15: 1721-1736.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1721-1736
    • Reiff, C.1    Delday, M.2    Rucklidge, G.3    Reid, M.4    Duncan, G.5
  • 42
    • 84857381354 scopus 로고    scopus 로고
    • Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis
    • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Carbo A, et al. (2012) Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. PLoS One 7(2): e31238.
    • (2012) PLoS One , vol.7 , Issue.2
    • Bassaganya-Riera, J.1    Viladomiu, M.2    Pedragosa, M.3    De Simone, C.4    Carbo, A.5
  • 43
    • 84864037467 scopus 로고    scopus 로고
    • Metabolic reconstruction for metagenomic data and its application to the human microbiome
    • Abubucker S, Segata N, Goll J, Schubert AM, Izard J, et al. (2012) Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol 8(6): e1002358.
    • (2012) PLoS Comput Biol , vol.8 , Issue.6
    • Abubucker, S.1    Segata, N.2    Goll, J.3    Schubert, A.M.4    Izard, J.5
  • 44
    • 80054722148 scopus 로고    scopus 로고
    • Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes
    • Brown CT, Davis-Richardson AG, Giongo A, Gano KA, Crabb DB, et al. (2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One 6(10): e25792.
    • (2011) PLoS One , vol.6 , Issue.10
    • Brown, C.T.1    Davis-Richardson, A.G.2    Giongo, A.3    Gano, K.A.4    Crabb, D.B.5
  • 45
    • 77958558890 scopus 로고    scopus 로고
    • Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-κB modulation in the human gut
    • pii
    • Lakhdari O, Cultrone A, Tap J, Gloux K, Bernard F, et al. (2010) Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-κB modulation in the human gut. PLoS One 5(9). pii: e13092.
    • (2010) PLoS One , vol.5 , Issue.9
    • Lakhdari, O.1    Cultrone, A.2    Tap, J.3    Gloux, K.4    Bernard, F.5
  • 46
    • 78649887273 scopus 로고    scopus 로고
    • Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
    • Murphy EF, Cotter PD, Healy S, Marques TM, O'Sullivan O, et al. (2010) Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut 59: 1635-1642.
    • (2010) Gut , vol.59 , pp. 1635-1642
    • Murphy, E.F.1    Cotter, P.D.2    Healy, S.3    Marques, T.M.4    O'Sullivan, O.5
  • 47
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5
  • 48
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, et al. (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331: 337-341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5
  • 49
    • 27644482670 scopus 로고    scopus 로고
    • Apolipoprotein E suppresses the type I inflammatory response in vivo
    • Ali K, Middleton M, Puré E, Rader DJ, (2005) Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res. 97: 922-927.
    • (2005) Circ Res , vol.97 , pp. 922-927
    • Ali, K.1    Middleton, M.2    Puré, E.3    Rader, D.J.4
  • 50
    • 63349101854 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    • Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, et al. (2009) VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology 49: 989-997.
    • (2009) Hepatology , vol.49 , pp. 989-997
    • Velayudham, A.1    Dolganiuc, A.2    Ellis, M.3    Petrasek, J.4    Kodys, K.5
  • 51
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z, Yang S, Lin H, Huang J, Watkins PA, et al. (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37: 343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5
  • 53
    • 19644362702 scopus 로고    scopus 로고
    • Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials
    • Andraws R, Berger JS, Brown DL, (2005) Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA 293: 2641-2647.
    • (2005) JAMA , vol.293 , pp. 2641-2647
    • Andraws, R.1    Berger, J.S.2    Brown, D.L.3
  • 54
    • 77956330642 scopus 로고    scopus 로고
    • Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet
    • Stepankova R, Tonar Z, Bartova J, Nedorost L, Rossman P, et al. (2010) Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet. J Atheroscler Thromb 17: 796-804.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 796-804
    • Stepankova, R.1    Tonar, Z.2    Bartova, J.3    Nedorost, L.4    Rossman, P.5
  • 55
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli A, Renga B, Migliorati M, Cipriani S, Distrutti E, et al. (2009) The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 183: 6657-6666.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3    Cipriani, S.4    Distrutti, E.5
  • 56
    • 77958004743 scopus 로고    scopus 로고
    • Counter-regulatory role of bile acid activated receptors in immunity and inflammation
    • Fiorucci S, Cipriani S, Mencarelli A, Renga B, Distrutti E, et al. (2010) Counter-regulatory role of bile acid activated receptors in immunity and inflammation. Curr Mol Med 10(6): 579-595.
    • (2010) Curr Mol Med , vol.10 , Issue.6 , pp. 579-595
    • Fiorucci, S.1    Cipriani, S.2    Mencarelli, A.3    Renga, B.4    Distrutti, E.5
  • 57
    • 84857752421 scopus 로고    scopus 로고
    • Biology and therapeutic applications of peroxisome proliferator- activated receptors
    • Menendez-Gutierrez MP, Roszer T, Ricote M, (2012) Biology and therapeutic applications of peroxisome proliferator- activated receptors. Curr Top Med Chem 12(6): 548-584.
    • (2012) Curr Top Med Chem , vol.12 , Issue.6 , pp. 548-584
    • Menendez-Gutierrez, M.P.1    Roszer, T.2    Ricote, M.3
  • 58
    • 76549086983 scopus 로고    scopus 로고
    • Bile acid-activated receptors in the treatment of dyslipidemia and related disorders
    • Fiorucci S, Cipriani S, Baldelli F, Mencarelli A, (2010) Bile acid-activated receptors in the treatment of dyslipidemia and related disorders. Prog Lipid Res 49: 171-185.
    • (2010) Prog Lipid Res , vol.49 , pp. 171-185
    • Fiorucci, S.1    Cipriani, S.2    Baldelli, F.3    Mencarelli, A.4
  • 59
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S, (2009) The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 183(10): 6251-6261.
    • (2009) J Immunol , vol.183 , Issue.10 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3    Distrutti, E.4    Fiorucci, S.5
  • 60
    • 4444280899 scopus 로고    scopus 로고
    • Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    • Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, et al. (2004) Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127: 777-791.
    • (2004) Gastroenterology , vol.127 , pp. 777-791
    • Bassaganya-Riera, J.1    Reynolds, K.2    Martino-Catt, S.3    Cui, Y.4    Hennighausen, L.5
  • 61
    • 78149439749 scopus 로고    scopus 로고
    • The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
    • Mencarelli A, Cipriani S, Renga B, Francisci D, Palladino G, et al. (2010) The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. PLoS One 5(10): e13238.
    • (2010) PLoS One , vol.5 , Issue.10
    • Mencarelli, A.1    Cipriani, S.2    Renga, B.3    Francisci, D.4    Palladino, G.5
  • 62
    • 77951942185 scopus 로고    scopus 로고
    • FXR an emerging therapeutic target for the treatment of atherosclerosis
    • Mencarelli A, Fiorucci S, (2010) FXR an emerging therapeutic target for the treatment of atherosclerosis. J Cell Mol Med 14(1-2): 79-92.
    • (2010) J Cell Mol Med , vol.14 , Issue.1-2 , pp. 79-92
    • Mencarelli, A.1    Fiorucci, S.2
  • 64
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2(4): 217-225.
    • (2005) Cell Metab , vol.2 , Issue.4 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5
  • 65
    • 84859529243 scopus 로고    scopus 로고
    • Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3
    • Li H, Gao Z, Zhang J, Ye X, Xu A, et al. (2012) Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes 61(4): 797-806.
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 797-806
    • Li, H.1    Gao, Z.2    Zhang, J.3    Ye, X.4    Xu, A.5
  • 66
    • 79960617989 scopus 로고    scopus 로고
    • Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA
    • Fiorucci S, Cipriani S, Mencarelli A, Baldelli F, Bifulco G, et al. (2011) Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA. Mini Rev Med Chem 11(9): 753-762.
    • (2011) Mini Rev Med Chem , vol.11 , Issue.9 , pp. 753-762
    • Fiorucci, S.1    Cipriani, S.2    Mencarelli, A.3    Baldelli, F.4    Bifulco, G.5
  • 67
    • 84859612475 scopus 로고    scopus 로고
    • Vitamin D receptor ligands: the impact of crystal structures
    • Carlberg C, Molnár F, Mouriño A, (2012) Vitamin D receptor ligands: the impact of crystal structures. Expert Opin Ther Pat 22(4): 417-435.
    • (2012) Expert Opin Ther Pat , vol.22 , Issue.4 , pp. 417-435
    • Carlberg, C.1    Molnár, F.2    Mouriño, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.