Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis

Frontiers in Cellular and Infection Microbiology

Volumn 2, Issue , 2012, Pages 1-4

  Alisi, Anna ^a   Ceccarelli, Sara ^a   Panera, Nadia ^a   Nobili, Valerio ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHILD; DIET; FATTY LIVER; FEMALE; GASTROINTESTINAL TRACT; HUMAN; MALE; METHODOLOGY; MICROBIOLOGY; MICROFLORA; NONALCOHOLIC FATTY LIVER;

ADULT; CHILD; DIET; FATTY LIVER; FEMALE; GASTROINTESTINAL TRACT; HUMANS; MALE; MICROBIOTA;

EID: 84875501815     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2012.00132     Document Type: Article

References (31)

1. Alisi, A., Carsetti, R., and Nobili, V. (2011). Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development. Hepatology 54, 1500-1502.
2. Alisi, A., Manco, M., Devito, R., Piemonte, F., and Nobili, V. (2010). Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. J. Pediatr. Gastroenterol. Nutr. 50, 645-649.
3. Alisi, A., Manco, M., Vania, A., and Nobili, V. (2009). Pediatric nonalcoholic fatty liver disease in 2009. J. Pediatr. 155, 469-474.
4. Alisi, A., and Nobili, V. (2011). Nonalcoholic fatty liver disease: Targeted therapy in children-what is the right way? Nat. Rev. Gastroenterol. Hepatol. 8, 425-426.
5. Brunt, E. M. (2010). Pathology of nonalcoholic fatty liver disease. Nat. Rev. Gastroenterol. Hepatol. 7, 195-203.
6. Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., et al. (2007a). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772.
7. Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R. G., Tuohy, K. M., et al. (2007b). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50, 2374-2383.
8. Cani, P. D., and Delzenne, N. M. (2009). The role of the gut microbiota in energy metabolism and metabolic disease. Curr. Pharm. Des. 15, 1546-1458.
9. Clemente, J. C., Ursell, L. K., Parfrey, L. W., and Knight, R. (2012). The impact of the gut microbiota on human health: An integrative view. Cell 148, 1258-1270.
10. Compare, D., Coccoli, P., Rocco, A., Nardone, O. M., De Maria, S., Carteni, M., et al. (2012). Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease. Nut. Metab. Cardiovasc. Dis. 22, 471-476.
11. De Gottardi, A., and McCoy, K. D. (2011). Evaluation of the gut barrier to intestinal bacteria in non-alcoholic fatty liver disease. J. Hepatol. 55, 1391-1399.
12. Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E, Dethlefsen, L., Sargent, M., et al. (2005). Diversity of the human intestinal microbial flora. Science 308, 1635-1638.
13. Iacono, A., Raso, G. M., Canani, R. B., Calignano, A., and Meli, R. (2011). Probiotics as an emerging therapeutic strategy to treat NAFLD: Focus on molecular and biochemical mechanisms. J. Nutr. Biochem. 22, 699-711.
14. Kalliomaki, M., Collado, M. C., Salminen, S., and Isolauri, E. (2008). Early differences in fecal microbiota composition in children may predict overweight. Am. J. Clin. Nutr. 87, 534-538.
15. Larkin, T. A., Astheimer, L. B., and Price, W. E. (2009). Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 63, 238-245.
16. Loguercio, C., Federico, A., Tuccillo, C., Terracciano, F, D’Auria, M. V., De Simone, C., et al. (2005). Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J. Clin. Gastroenterol. 39, 540-543.
17. Malaguarnera, M., Di Rosa, M., Nicoletti, F., and Malaguarnera, L. (2009). Molecular mechanisms involved in NAFLD progression. J. Mol. Med. 87, 679-695.
18. Miele, L., Valenza, V., La Torre, G., Montalto, M., Cammarota, G., Ricci, R., et al. (2009). Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49, 1877-1887.
19. Milic, S., and Stimac, D. (2012). Nonalcoholic fatty liver disease/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment. Dig. Dis. 30, 158-162.
20. Musso, G., Gambino, R., and Cassader, M. (2010a). Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: Mechanisms and implications for metabolic disorders. Curr. Opin. Lipidol. 21, 76-83.
21. Musso, G., Gambino, R., and Cassader, M. (2010b). Obesity diabetes and gut microbiota: The hygiene hypothesis expanded? Diabetes Care 33, 2277-2284.
22. Othman, M., Agüero, R., and Lin, H. C. (2008). Alterations in intestinal microbial flora and human disease. Curr. Opin. Gastroenterol. 24, 11-16.
23. Schwabe, R. F., Seki, E., and Brenner, D. A. (2006). Toll-like receptor signalling in the liver. Gastroenterology 130, 1886-1900.
24. Spencer, M. D., Hamp, T. J., Reid, R. W., Fischer, L. M., Zeisel, S. H., and Fodor, A. A. (2011). Association between composition of the human gastrointestinal microbiome and development of fattyliver with choline deficiency. Gastroenterology 140, 976-986.
25. Tannock, G. W. (2004). A special fondness for lactobacilli. Appl. Environ. Microbiol. 70, 3189-3194.
26. Tilg, H., and Moschen, A. R. (2008). Insulin resistance, inflammation, and non-alcoholic fatty liver disease. Trends Endocrinol. Metab. 19, 371-379.
27. Vajro, P., Mandato, C., Licenziati, M. R., Franzese, A., Vitale, D. F., Lenta, S., et al. (2011). Effects of Lactobacillus rhamnosus strain GG in pediatric obesity-related liver disease. J. Pediatr. Gastroenterol. Nutr. 52, 740-743.
28. Vanni, E., Bugianesi, E., Kotronen, A., De Minicis, S., Yki-Jarvinen, H., and Svegliati-Baroni, G. (2010). From the metabolic syndrome to NAFLD or vice versa? Dig. LiverDis. 42, 320-330.
29. Vernon, G., Baranova, A., and Younossi, Z. M. (2011). Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 34, 274-285.
30. Vreugdenhil, A. C., Rousseau, C. H., Hartung, T., Greve, J. W., van’t Veer, C., and Buurman, W. A. (2003). Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J. Immunol. 170, 1399-1405
31. Xiao, J. Z., Kondo, S., Takahashi, N., Miyaji, K., Oshida, K., Hiramatsu, A., et al. (2003). Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J. Dairy Sci. 86, 2452-2461.