메뉴 건너뛰기




Volumn 10, Issue 6, 2009, Pages 505-512

Liver fibrosis and therapeutic strategies: The goal for improving metabolism

Author keywords

HCV; Hepatic fibrosis; Insulin resistance; Metabolic syndrome; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis

Indexed keywords

GLITAZONE DERIVATIVE; INTERFERON; METFORMIN; PIOGLITAZONE; ROSIGLITAZONE;

EID: 68349125150     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945009788488459     Document Type: Review
Times cited : (29)

References (116)
  • 2
    • 0037371468 scopus 로고    scopus 로고
    • Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal
    • Bataller R, North KE, Brenner DA. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 2003; 37: 493-503.
    • (2003) Hepatology , vol.37 , pp. 493-503
    • Bataller, R.1    North, K.E.2    Brenner, D.A.3
  • 3
    • 42149193788 scopus 로고    scopus 로고
    • Review article: Nonalcoholic fatty liver disease and hepatitis C virus - partners in crime
    • Blonsky JJ, Harrison SA. Review article: nonalcoholic fatty liver disease and hepatitis C virus - partners in crime. Aliment Pharmacol Ther 2008; 27: 855-65.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 855-865
    • Blonsky, J.J.1    Harrison, S.A.2
  • 4
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: The mist gradually clears
    • de Alwis NM, Day CP. Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol 2008; 48(Suppl 1): S104-12.
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • de Alwis, N.M.1    Day, C.P.2
  • 5
    • 36249009634 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease
    • Yeh MM, Brunt EM. Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol 2007; 128: 837-47.
    • (2007) Am J Clin Pathol , vol.128 , pp. 837-847
    • Yeh, M.M.1    Brunt, E.M.2
  • 6
    • 35748966692 scopus 로고    scopus 로고
    • Molecular genetics of NASH: The role of polymorphisms
    • Alisi A, Nobili V. Molecular genetics of NASH: the role of polymorphisms. J Hepatol 2007; 47: 868-9.
    • (2007) J Hepatol , vol.47 , pp. 868-869
    • Alisi, A.1    Nobili, V.2
  • 7
    • 33947221617 scopus 로고    scopus 로고
    • Lifestyle advice in non-alcoholic fatty liver disease
    • Manco M, Marcellini M, Nobili V. Lifestyle advice in non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2007; 22: 604-5.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 604-605
    • Manco, M.1    Marcellini, M.2    Nobili, V.3
  • 8
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • vii
    • Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 2007; 11: 1-16, vii.
    • (2007) Clin Liver Dis , vol.11 , pp. 1-16
    • Ong, J.P.1    Younossi, Z.M.2
  • 9
    • 38749152419 scopus 로고    scopus 로고
    • Evolving trends in nonalcoholic fatty liver disease
    • Delgado JS. Evolving trends in nonalcoholic fatty liver disease. Eur J Intern Med 2008; 19: 75-82.
    • (2008) Eur J Intern Med , vol.19 , pp. 75-82
    • Delgado, J.S.1
  • 10
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43(2 Suppl 1): S99-112.
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Farrell, G.C.1    Larter, C.Z.2
  • 11
    • 84909590801 scopus 로고    scopus 로고
    • Available at:, Accessed January 15, 2008
    • World Health Organisation. Initiative for vaccine research (IVR); hepatitis C page. Available at: http://www.who.int/vaccine_research/ diseases/viral_cancers. Accessed January 15, 2008.
    • Initiative for vaccine research (IVR); hepatitis C page
  • 12
    • 29244484291 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Why does it really matter?
    • Asselah T, Rubbia-Brandt L, Marcellin P, Negro, F. Steatosis in chronic hepatitis C: why does it really matter? Gut 2006; 55: 123-30.
    • (2006) Gut , vol.55 , pp. 123-130
    • Asselah, T.1    Rubbia-Brandt, L.2    Marcellin, P.3    Negro, F.4
  • 13
    • 39549085977 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Friend or foe?
    • Negro F. Steatosis in chronic hepatitis C: friend or foe? Liver Int 2008; 28: 294-6.
    • (2008) Liver Int , vol.28 , pp. 294-296
    • Negro, F.1
  • 14
    • 33644593865 scopus 로고    scopus 로고
    • Prevalence of liver steatosis in patients with chronic hepatitis B: A study of associated factors and of relationship with fibrosis
    • Thomopoulos KC, Arvaniti V, Tsamantas AC, Dimitropoulou D, Gogos CA, Siagris D, et al. Prevalence of liver steatosis in patients with chronic hepatitis B: a study of associated factors and of relationship with fibrosis. Eur J Gastroenterol Hepatol 2006; 18: 233-7.
    • (2006) Eur J Gastroenterol Hepatol , vol.18 , pp. 233-237
    • Thomopoulos, K.C.1    Arvaniti, V.2    Tsamantas, A.C.3    Dimitropoulou, D.4    Gogos, C.A.5    Siagris, D.6
  • 15
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-64.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 17
    • 0036727323 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol
    • Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002; 36: 729-36.
    • (2002) Hepatology , vol.36 , pp. 729-736
    • Monto, A.1    Alonzo, J.2    Watson, J.J.3    Grunfeld, C.4    Wright, T.L.5
  • 19
    • 27644499523 scopus 로고    scopus 로고
    • Review article: Non-alcoholic fatty liver disease and hepatitis C - risk factors and clinical implications
    • Sanyal AJ. Review article: non-alcoholic fatty liver disease and hepatitis C - risk factors and clinical implications. Aliment Pharmacol Ther 2005; 22(Suppl 2): 48-51.
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.SUPPL. 2 , pp. 48-51
    • Sanyal, A.J.1
  • 20
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006; 43: 682-9.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3    Luketic, V.A.4    Sterling, R.K.5    Stravitz, R.T.6
  • 21
    • 49649091383 scopus 로고    scopus 로고
    • Preiss D, Sattar. Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. N Clin Sci (Lond) 2008; 115: 141-50.
    • Preiss D, Sattar. Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. N Clin Sci (Lond) 2008; 115: 141-50.
  • 23
    • 34249733066 scopus 로고    scopus 로고
    • Surgical treatment for obesity and its impact on nonalcoholic steatohepatitis
    • ix-x
    • Dixon JB. Surgical treatment for obesity and its impact on nonalcoholic steatohepatitis. Clin Liver Dis 2007; 11: 141-54, ix-x.
    • (2007) Clin Liver Dis , vol.11 , pp. 141-154
    • Dixon, J.B.1
  • 24
    • 39249083049 scopus 로고    scopus 로고
    • Matrix metalloproteinase gene delivery for liver fibrosis
    • Iimuro Y, Brenner DA. Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res 2008; 25: 249-58.
    • (2008) Pharm Res , vol.25 , pp. 249-258
    • Iimuro, Y.1    Brenner, D.A.2
  • 25
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-69.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 28
    • 35648963655 scopus 로고    scopus 로고
    • Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality
    • Gressner OA, Weiskirchen R, Gressner AM. Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality. J Cell Mol Med 2007; 11: 1031-51.
    • (2007) J Cell Mol Med , vol.11 , pp. 1031-1051
    • Gressner, O.A.1    Weiskirchen, R.2    Gressner, A.M.3
  • 29
    • 3543098600 scopus 로고    scopus 로고
    • Liver fibrosis: From the bench to clinical targets
    • Pinzani M, Rombouts K. Liver fibrosis: from the bench to clinical targets. Digest Liver Dis 2004; 36: 231-42.
    • (2004) Digest Liver Dis , vol.36 , pp. 231-242
    • Pinzani, M.1    Rombouts, K.2
  • 30
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
    • Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 2007; 46: 582-9.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 32
    • 29144492553 scopus 로고    scopus 로고
    • Pathology of nonalcoholic steatohepatitis
    • Brunt EM. Pathology of nonalcoholic steatohepatitis. Hepatol Res 2005; 33: 68-71.
    • (2005) Hepatol Res , vol.33 , pp. 68-71
    • Brunt, E.M.1
  • 33
    • 0036679061 scopus 로고    scopus 로고
    • NASH-related liver failure: One hit too many?
    • Day CP. NASH-related liver failure: one hit too many? Am J Gastroenterol 2002; 97: 1872-4.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1872-1874
    • Day, C.P.1
  • 34
    • 33749597707 scopus 로고    scopus 로고
    • Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease
    • Day CP. Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 2006; 26: 1021-8.
    • (2006) Liver Int , vol.26 , pp. 1021-1028
    • Day, C.P.1
  • 35
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • dela Pena A, Leclercq I, Field J, Gorge J, Jones B, Farrell G. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 2005; 129: 1663-74.
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • dela Pena, A.1    Leclercq, I.2    Field, J.3    Gorge, J.4    Jones, B.5    Farrell, G.6
  • 37
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study
    • Bedogni G, Miglioli L. Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005; 42: 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 38
    • 33745637207 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and the metabolic syndrome
    • Marchesini G, Babini M. Nonalcoholic fatty liver disease and the metabolic syndrome. Minerva Cardioangiol 2006; 54: 229-39.
    • (2006) Minerva Cardioangiol , vol.54 , pp. 229-239
    • Marchesini, G.1    Babini, M.2
  • 39
    • 51549099280 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease as a component of the metabolic syndrome
    • Khashab MA, Liangpunsakul S, Chalasani N. Nonalcoholic fatty liver disease as a component of the metabolic syndrome. Curr. Gastroenterol Rep 2008; 10: 73-80.
    • (2008) Curr. Gastroenterol Rep , vol.10 , pp. 73-80
    • Khashab, M.A.1    Liangpunsakul, S.2    Chalasani, N.3
  • 41
    • 0035897696 scopus 로고    scopus 로고
    • Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 42
    • 39849099669 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and the metabolic syndrome: An update
    • Rector RS, Thyfault JP, Wei Y, Ibdah JA. Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J. Gastroenterol 2008; 14: 185-92.
    • (2008) World J. Gastroenterol , vol.14 , pp. 185-192
    • Rector, R.S.1    Thyfault, J.P.2    Wei, Y.3    Ibdah, J.A.4
  • 43
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005; 42: 987-1000.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 44
    • 0142088836 scopus 로고    scopus 로고
    • Metabolic Syndrome: Epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study
    • Bonora E, Kiechl S, Willeit J, Oberhollenzer F. Egger G, Bonadonna RC, et al. Metabolic Syndrome: epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study. Int J Obes 2003; 27: 1283-9.
    • (2003) Int J Obes , vol.27 , pp. 1283-1289
    • Bonora, E.1    Kiechl, S.2    Willeit, J.3    Oberhollenzer, F.4    Egger, G.5    Bonadonna, R.C.6
  • 45
    • 50249151997 scopus 로고    scopus 로고
    • Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
    • Manco M, Bedogni G. Marcellini M, Devito R, Ciampalini P, Sartorelli MR, et al. Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis Gut 2008; 57: 1283-87.
    • (2008) Gut , vol.57 , pp. 1283-1287
    • Manco, M.1    Bedogni, G.2    Marcellini, M.3    Devito, R.4    Ciampalini, P.5    Sartorelli, M.R.6
  • 46
    • 18144401968 scopus 로고    scopus 로고
    • Associations between liver histology and severity of the metabolic syndrome in subjects with nonalcoholic fatty liver disease
    • Ryan MC, Wilson AM, Slavin J, Best JD, Jenkins AJ, Desmond PV. Associations between liver histology and severity of the metabolic syndrome in subjects with nonalcoholic fatty liver disease. Diabetes Care 2005; 28: 1222-4.
    • (2005) Diabetes Care , vol.28 , pp. 1222-1224
    • Ryan, M.C.1    Wilson, A.M.2    Slavin, J.3    Best, J.D.4    Jenkins, A.J.5    Desmond, P.V.6
  • 49
    • 43249083481 scopus 로고    scopus 로고
    • Free fatty acids and skeletal muscle insulin resistance
    • Kraegen EW, Cooney GJ. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol 2008; 19: 235-41.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 235-241
    • Kraegen, E.W.1    Cooney, G.J.2
  • 51
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with nonalcoholic fatty liver disease: Sites and mechanisms
    • Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, et al. Insulin resistance in non-diabetic patients with nonalcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005; 48: 634-42.
    • (2005) Diabetologia , vol.48 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3    Gambino, R.4    Cassader, M.5    Baldi, S.6
  • 52
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005; 19: 136-38.
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3
  • 53
    • 44849125451 scopus 로고    scopus 로고
    • Genes and nonalcoholic fatty liver disease
    • Wilfred de Alwis NM, Day CP. Genes and nonalcoholic fatty liver disease. Curr Diab Rep 2008; 8: 156-63.
    • (2008) Curr Diab Rep , vol.8 , pp. 156-163
    • Wilfred de Alwis, N.M.1    Day, C.P.2
  • 54
    • 54549102155 scopus 로고    scopus 로고
    • Disease-specific mechanisms of fibrosis: Hepatitis C virus and nonalcoholic steatohepatitis
    • ix
    • van der Poorten D, George J. Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis. Clin Liver Dis 2008; 12(4): 805-24, ix.
    • (2008) Clin Liver Dis , vol.12 , Issue.4 , pp. 805-824
    • van der Poorten, D.1    George, J.2
  • 57
    • 33646382082 scopus 로고    scopus 로고
    • Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis
    • Mirandola S, Realdon S, Iqbal J, Gerotto M, Dal Pero F, Bortoletto G, et al. Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology 2006; 130: 1661-9.
    • (2006) Gastroenterology , vol.130 , pp. 1661-1669
    • Mirandola, S.1    Realdon, S.2    Iqbal, J.3    Gerotto, M.4    Dal Pero, F.5    Bortoletto, G.6
  • 58
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
    • Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chrétien Y, et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB 2002, 16: 185-94.
    • (2002) FASEB , vol.16 , pp. 185-194
    • Perlemuter, G.1    Sabile, A.2    Letteron, P.3    Vona, G.4    Topilco, A.5    Chrétien, Y.6
  • 59
    • 0032883325 scopus 로고    scopus 로고
    • Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates
    • Sabile A, Perlemuter G, Bono F, Kohara K, Demaugre F, Kohara M, et al. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates. Hepatology 1999; 30: 1064-76.
    • (1999) Hepatology , vol.30 , pp. 1064-1076
    • Sabile, A.1    Perlemuter, G.2    Bono, F.3    Kohara, K.4    Demaugre, F.5    Kohara, M.6
  • 60
    • 18344370950 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity
    • Tsutsumi, T, Suzuki T, Shimoike T, Suzuki R, Moriya K, Shintani Y, et al. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology 2002; 35: 937-46.
    • (2002) Hepatology , vol.35 , pp. 937-946
    • Tsutsumi, T.1    Suzuki, T.2    Shimoike, T.3    Suzuki, R.4    Moriya, K.5    Shintani, Y.6
  • 62
    • 10744224572 scopus 로고    scopus 로고
    • Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: Indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
    • Castéra L, Hezode C, Roudot-Thoraval F, Lonjon I, Zafrani ES, Pawlotsky JM, et al. Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis. Gut 2004; 53: 420-4.
    • (2004) Gut , vol.53 , pp. 420-424
    • Castéra, L.1    Hezode, C.2    Roudot-Thoraval, F.3    Lonjon, I.4    Zafrani, E.S.5    Pawlotsky, J.M.6
  • 63
    • 0036830436 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    • Kumar D, Farrell GC, Fung C, George J. Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response. Hepatology 2002; 36: 1266-72.
    • (2002) Hepatology , vol.36 , pp. 1266-1272
    • Kumar, D.1    Farrell, G.C.2    Fung, C.3    George, J.4
  • 64
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T, Ratziu V, McHutchison J, Manns M, Goodman Z, Zeuzem S, et al. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003; 38: 75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3    Manns, M.4    Goodman, Z.5    Zeuzem, S.6
  • 65
    • 0032146915 scopus 로고    scopus 로고
    • Host- and disease-specific factors affecting steatosis in chronic hepatitis C
    • Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Host- and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol 1998; 29: 198-206.
    • (1998) J Hepatol , vol.29 , pp. 198-206
    • Czaja, A.J.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 66
    • 11244323975 scopus 로고    scopus 로고
    • Impact of steatosis on progression of fibrosis in patients with mild hepatitis C
    • Fartoux L, Chazouilleres O, Wendum D, Poupon R, Serfaty L. Impact of steatosis on progression of fibrosis in patients with mild hepatitis C. Hepatology 2005; 41: 82-7.
    • (2005) Hepatology , vol.41 , pp. 82-87
    • Fartoux, L.1    Chazouilleres, O.2    Wendum, D.3    Poupon, R.4    Serfaty, L.5
  • 67
    • 34249723678 scopus 로고    scopus 로고
    • Steatosis as a cofactor in other liver diseases: Hepatitis C virus, alcohol, hemochromatosis, and others
    • Clouston AD, Jonsson JR, Powell EE, Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clin Liver Dis 2007; 11: 173-89.
    • (2007) Clin Liver Dis , vol.11 , pp. 173-189
    • Clouston, A.D.1    Jonsson, J.R.2    Powell, E.E.3
  • 68
    • 0348134685 scopus 로고    scopus 로고
    • LIDO Study Group. Fibrogenic impact of high serum glucose in chronic hepatitis C
    • Ratziu V, Munteanu M, Charlotte, F, Bonyhay L, Poynard T, LIDO Study Group. Fibrogenic impact of high serum glucose in chronic hepatitis C. J Hepatol 2003; 39: 1049-55.
    • (2003) J Hepatol , vol.39 , pp. 1049-1055
    • Ratziu, V.1    Munteanu, M.2    Charlotte, F.3    Bonyhay, L.4    Poynard, T.5
  • 70
    • 19544378172 scopus 로고    scopus 로고
    • The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
    • Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 2005; 166: 1655-69.
    • (2005) Am J Pathol , vol.166 , pp. 1655-1669
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Xu, A.4    Srinivasan, S.5    Anania, F.A.6
  • 71
    • 1942487847 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells.Am
    • Sung CK, She H, Xiong S, Tsukamoto H. Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells.Am. J. Physiol. Gastrointest. Liver Physiol 2004; 286: G722-9.
    • (2004) J. Physiol. Gastrointest. Liver Physiol , vol.286
    • Sung, C.K.1    She, H.2    Xiong, S.3    Tsukamoto, H.4
  • 72
    • 54049122690 scopus 로고    scopus 로고
    • Hepatic steatosis: A benign disease or a silent killer
    • El-Zayadi AR, Hepatic steatosis: a benign disease or a silent killer. World J Gastroenterol 2008; 14: 4120-6.
    • (2008) World J Gastroenterol , vol.14 , pp. 4120-4126
    • El-Zayadi, A.R.1
  • 73
    • 0036052019 scopus 로고    scopus 로고
    • Chronic liver disease in diabetes mellitus
    • Amarapurkar D, Das HS, Chronic liver disease in diabetes mellitus. Trop Gastroenterol 2002; 23: 3-5.
    • (2002) Trop Gastroenterol , vol.23 , pp. 3-5
    • Amarapurkar, D.1    Das, H.S.2
  • 74
    • 33845489288 scopus 로고    scopus 로고
    • Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    • Simó R, Lecube A, Genescà J, Esteban JI, Hernández C. Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection Diabetes Care 2006; 29: 2462-6.
    • (2006) Diabetes Care , vol.29 , pp. 2462-2466
    • Simó, R.1    Lecube, A.2    Genescà, J.3    Esteban, J.I.4    Hernández, C.5
  • 75
    • 29244461999 scopus 로고    scopus 로고
    • Hyperglycemia among persons with hepatitis C: Not the classical diabetic phenotype
    • Behrendt CE, Ruiz RB. Hyperglycemia among persons with hepatitis C: not the classical diabetic phenotype. Diabetes Res Clin Pract 2006; 71: 68-74.
    • (2006) Diabetes Res Clin Pract , vol.71 , pp. 68-74
    • Behrendt, C.E.1    Ruiz, R.B.2
  • 76
    • 10744227418 scopus 로고    scopus 로고
    • The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients
    • Patton HM, Patel K, Behling C, Bylund D, Blatt LM, Vallée M, et al. The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J. Hepatol 2004; 40: 484-90.
    • (2004) J. Hepatol , vol.40 , pp. 484-490
    • Patton, H.M.1    Patel, K.2    Behling, C.3    Bylund, D.4    Blatt, L.M.5    Vallée, M.6
  • 77
    • 10744220759 scopus 로고    scopus 로고
    • Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C
    • Asselah T, Boyer N, Guimont MC, Cazals-Hatem D, Tubach F, Nahon K, et al. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Gut 2003; 52: 1638-43.
    • (2003) Gut , vol.52 , pp. 1638-1643
    • Asselah, T.1    Boyer, N.2    Guimont, M.C.3    Cazals-Hatem, D.4    Tubach, F.5    Nahon, K.6
  • 78
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease Hepatology 2006; 44: 27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 79
    • 2342559886 scopus 로고    scopus 로고
    • Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury
    • Walsh MJ, Vanags DM, Clouston AD, Richardson MM, Purdie DM, Jonsson, JR, et al. Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury. Hepatology 2004; 39: 1230-8.
    • (2004) Hepatology , vol.39 , pp. 1230-1238
    • Walsh, M.J.1    Vanags, D.M.2    Clouston, A.D.3    Richardson, M.M.4    Purdie, D.M.5    Jonsson, J.R.6
  • 80
    • 0346874154 scopus 로고    scopus 로고
    • In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: Implications for therapy
    • Hickman IJ, Powell EE, Prins JB, Clouston AD, Ash S, Purdie DM, et al. In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy. J. Hepatol 2003; 39: 1042-8.
    • (2003) J. Hepatol , vol.39 , pp. 1042-1048
    • Hickman, I.J.1    Powell, E.E.2    Prins, J.B.3    Clouston, A.D.4    Ash, S.5    Purdie, D.M.6
  • 81
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001; 34: 738-44.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3    Dargere, D.4    Parfait, B.5    Vidaud, M.6
  • 82
    • 7044220856 scopus 로고    scopus 로고
    • Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
    • Bantel H, Lugering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP, et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004; 40: 1078-87.
    • (2004) Hepatology , vol.40 , pp. 1078-1087
    • Bantel, H.1    Lugering, A.2    Heidemann, J.3    Volkmann, X.4    Poremba, C.5    Strassburg, C.P.6
  • 83
    • 35148819146 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV): An RNA virus with a pro-oncogenic potential
    • Balsano C, Alisi A. Hepatitis C virus (HCV): an RNA virus with a pro-oncogenic potential. Dig Liver Dis 2007; 39(Suppl 1): S46-51.
    • (2007) Dig Liver Dis , vol.39 , Issue.SUPPL. 1
    • Balsano, C.1    Alisi, A.2
  • 84
    • 0141682739 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    • Sanyal A, Contos M, Sterling RK, Luketic VA, Shiffman ML, Stravitz RT, et al. Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome. Am J Gastroenterol 2003; 98: 2064-71.
    • (2003) Am J Gastroenterol , vol.98 , pp. 2064-2071
    • Sanyal, A.1    Contos, M.2    Sterling, R.K.3    Luketic, V.A.4    Shiffman, M.L.5    Stravitz, R.T.6
  • 85
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
    • Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004; 126: 840-8.
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6
  • 86
    • 42149193788 scopus 로고    scopus 로고
    • Review article: Nonalcoholic fatty liver disease and hepatitis C virus - partners in crime
    • Blonsky JJ, Harrison SA. Review article: nonalcoholic fatty liver disease and hepatitis C virus - partners in crime. Aliment Pharmacol Ther 2008; 27: 855-865.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 855-865
    • Blonsky, J.J.1    Harrison, S.A.2
  • 87
    • 33750023645 scopus 로고    scopus 로고
    • Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients
    • Durante-Mangoni E, Zampino R, Marrone A, Tripodi MF, Rinaldi L, Restivo L, et al. Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients. Aliment Pharmacol Ther 2006; 24: 1349-57.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1349-1357
    • Durante-Mangoni, E.1    Zampino, R.2    Marrone, A.3    Tripodi, M.F.4    Rinaldi, L.5    Restivo, L.6
  • 88
    • 43549124805 scopus 로고    scopus 로고
    • Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
    • Petta S, Cammà C, Marco VD, Alessi N, Cabibi D, Caldarella R, et al. Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection. Am J Gastroenterol 2008; 103: 1136-44.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1136-1144
    • Petta, S.1    Cammà, C.2    Marco, V.D.3    Alessi, N.4    Cabibi, D.5    Caldarella, R.6
  • 89
    • 21044456174 scopus 로고    scopus 로고
    • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C
    • Fartoux L, Poujol-Robert A, Guechot J, Wendum D, Poupon R, Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut 2005; 54: 1003-8.
    • (2005) Gut , vol.54 , pp. 1003-1008
    • Fartoux, L.1    Poujol-Robert, A.2    Guechot, J.3    Wendum, D.4    Poupon, R.5    Serfaty, L.6
  • 90
    • 46749149198 scopus 로고    scopus 로고
    • Hepatitis C infection and nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Hepatitis C infection and nonalcoholic fatty liver disease. Clin Liver Dis 2008; 12: 573-585.
    • (2008) Clin Liver Dis , vol.12 , pp. 573-585
    • Cheung, O.1    Sanyal, A.J.2
  • 91
    • 42249105690 scopus 로고    scopus 로고
    • Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection
    • Sterling RK, Contos MJ, Smith PG, Stravitz, RT, Luketic VA, Fuchs M, et al. Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection. Hepatology 2008; 47: 1118-27.
    • (2008) Hepatology , vol.47 , pp. 1118-1127
    • Sterling, R.K.1    Contos, M.J.2    Smith, P.G.3    Stravitz, R.T.4    Luketic, V.A.5    Fuchs, M.6
  • 92
    • 33748117772 scopus 로고    scopus 로고
    • Insulin resistance and HCV: Will new knowledge modify clinical management?
    • Negro F. Insulin resistance and HCV: will new knowledge modify clinical management? J Hepatol 2006; 45: 514-9.
    • (2006) J Hepatol , vol.45 , pp. 514-519
    • Negro, F.1
  • 93
    • 58149494657 scopus 로고    scopus 로고
    • Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation
    • Eguchi Y, Mizuta T, Ishibashi E, Kitajima Y, Oza N, Nakashita S, et al. Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation. Liver Int 2009; 29: 213-20.
    • (2009) Liver Int , vol.29 , pp. 213-220
    • Eguchi, Y.1    Mizuta, T.2    Ishibashi, E.3    Kitajima, Y.4    Oza, N.5    Nakashita, S.6
  • 94
    • 33646851743 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and hepatitis C infection
    • Bondini S, Younossi ZM. Non-alcoholic fatty liver disease and hepatitis C infection. Minerva Gastroenterol Dietol 2006; 52: 135-43.
    • (2006) Minerva Gastroenterol Dietol , vol.52 , pp. 135-143
    • Bondini, S.1    Younossi, Z.M.2
  • 95
    • 0034100952 scopus 로고    scopus 로고
    • Is liver fibrosis reversible?
    • Benyon RC, Iredale JP. Is liver fibrosis reversible? Gut 2000; 46: 443-6.
    • (2000) Gut , vol.46 , pp. 443-446
    • Benyon, R.C.1    Iredale, J.P.2
  • 96
    • 34249776715 scopus 로고    scopus 로고
    • Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
    • Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol 2007; 22(Suppl 1): S73-8.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.SUPPL. 1
    • Kisseleva, T.1    Brenner, D.A.2
  • 99
    • 0141643293 scopus 로고    scopus 로고
    • Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study
    • Uusitupa M, Lindi V, Louheranta A, Salopuro T, Lindström J, Tuomilehto J, et al. Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study. Diabetes 2003; 52: 2532-8.
    • (2003) Diabetes , vol.52 , pp. 2532-2538
    • Uusitupa, M.1    Lindi, V.2    Louheranta, A.3    Salopuro, T.4    Lindström, J.5    Tuomilehto, J.6
  • 100
    • 33750122264 scopus 로고    scopus 로고
    • Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
    • Thomas EL, Brynes AE, Hamilton G, Patel N, Spong A, Goldin RD, et al. Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World J Gastroenterol 2006; 12: 5813-9.
    • (2006) World J Gastroenterol , vol.12 , pp. 5813-5819
    • Thomas, E.L.1    Brynes, A.E.2    Hamilton, G.3    Patel, N.4    Spong, A.5    Goldin, R.D.6
  • 102
    • 0141515773 scopus 로고    scopus 로고
    • The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis
    • Sabuncu T, Nazligul Y, Karaoglanoglu M, Ucar E, Kilic FB. The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Rom J Gastroenterol 2003; 12: 189-92.
    • (2003) Rom J Gastroenterol , vol.12 , pp. 189-192
    • Sabuncu, T.1    Nazligul, Y.2    Karaoglanoglu, M.3    Ucar, E.4    Kilic, F.B.5
  • 103
    • 7644229827 scopus 로고    scopus 로고
    • Bariatric surgery worldwide 2003
    • Buchwald H, Williams SE. Bariatric surgery worldwide 2003. Obes Surg 2004; 14: 1157-64.
    • (2004) Obes Surg , vol.14 , pp. 1157-1164
    • Buchwald, H.1    Williams, S.E.2
  • 104
    • 34249745682 scopus 로고    scopus 로고
    • Medical treatment of nonalcoholic steatohepatitis
    • ix
    • Kadayifci A, Merriman RB, Bass NM. Medical treatment of nonalcoholic steatohepatitis. Clin Liver Dis 2007; 11: 119-40, ix.
    • (2007) Clin Liver Dis , vol.11 , pp. 119-140
    • Kadayifci, A.1    Merriman, R.B.2    Bass, N.M.3
  • 107
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with non-alcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with non-alcoholic steatohepatitis. N Engl J Med 2006; 355: 2297-307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 108
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V, Giral P, Jacqueminet S, Charlotte F, Hartemann-Heurtier A, Serfaty L, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008; 135: 100-10.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3    Charlotte, F.4    Hartemann-Heurtier, A.5    Serfaty, L.6
  • 109
    • 40749116561 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP
    • Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 2008; 57: 306-14.
    • (2008) Diabetes , vol.57 , pp. 306-314
    • Kim, Y.D.1    Park, K.G.2    Lee, Y.S.3    Park, Y.Y.4    Kim, D.K.5    Nedumaran, B.6
  • 111
    • 0034881431 scopus 로고    scopus 로고
    • Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s)
    • Solomon SS, Usdan LS, Palazzolo MR. Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s). Am J Med Sci 2001; 322: 75-8.
    • (2001) Am J Med Sci , vol.322 , pp. 75-78
    • Solomon, S.S.1    Usdan, L.S.2    Palazzolo, M.R.3
  • 112
    • 16444378976 scopus 로고    scopus 로고
    • A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis
    • Schwimmer JB, Middleton MS, Deutsch R, Lavine JE. A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2005; 21: 871-9.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 871-879
    • Schwimmer, J.B.1    Middleton, M.S.2    Deutsch, R.3    Lavine, J.E.4
  • 114
    • 47149111845 scopus 로고    scopus 로고
    • Metformin use in children with nonalcoholic fatty liver disease: An open-label, 24-month, observational pilot study
    • Nobili V, Manco M, Ciampalini P, Alisi A, Devito R, Bugianesi E, et al. Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. Clin Ther 2008; 30: 1168-76.
    • (2008) Clin Ther , vol.30 , pp. 1168-1176
    • Nobili, V.1    Manco, M.2    Ciampalini, P.3    Alisi, A.4    Devito, R.5    Bugianesi, E.6
  • 115
    • 33845737858 scopus 로고    scopus 로고
    • Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection
    • Westin J, Lagging M, Dhillon AP, Norkrans G, Romero AI, Pawlotsky JM, et al. Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection. J Viral Hepat 2007; 14: 29-35.
    • (2007) J Viral Hepat , vol.14 , pp. 29-35
    • Westin, J.1    Lagging, M.2    Dhillon, A.P.3    Norkrans, G.4    Romero, A.I.5    Pawlotsky, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.